Article
Biology
Mengxing Li, Suryavathi Viswanadhapalli, Bindu Santhamma, Uday P. Pratap, Yiliao Luo, Junhao Liu, Kristin A. Altwegg, Weiwei Tang, Zexuan Liu, Xiaonan Li, Behnam Ebrahimi, Hui Yan, Yi Zou, Swapna Konda, Gangadhara R. Sareddy, Zhenming Xu, Yidong Chen, Manjeet K. Rao, Andrew J. Brenner, Virginia G. Kaklamani, Rajeshwar R. Tekmal, Gulzar Ahmed, Ganesh Raj, Klaus J. Nickisch, Hareesh B. Nair, Ratna K. Vadlamudi
Summary: The study demonstrated that LIFR inhibitor EC359 could enhance the therapeutic efficacy of HDACi against TNBC, with RNA-seq studies showing that the combination therapy attenuated oncogenic/survival signaling pathways activated by HDACi. Importantly, the combination therapy showed potent inhibition of TNBC growth in vivo.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Yoshihisa Numata, Tetsuya Abe, Eiji Higaki, Takahiro Hosoi, Hironori Fujieda, Takuya Nagao, Nobuhiro Hanai, Hidenori Suzuki, Daisuke Nishikawa, Keitaro Matsuo, Tsutomu Fujii, Yasuhiro Shimizu
Summary: Metastases to supraclavicular lymph nodes have a significant impact on the prognosis of patients with cervical esophageal cancer. These lymph nodes may be considered extra-regional in this patient population.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Wenjie Zhu, Xu Chen, Xiangyu Guo, Haiting Liu, Ranran Ma, Yawen Wang, Yahang Liang, Ying Sun, Mengqi Wang, Ruinan Zhao, Peng Gao
Summary: Breast cancer is the most common malignancy in women globally, and understanding its energy metabolism and progression mechanisms is still lacking. The study reveals that the activated long noncoding RNA (lncRNA), HOXC-AS3, plays a critical role in triggering energy metabolism reprogramming in breast cancer cells under glucose deprivation, enabling them to adapt to nutrient stress.
Review
Biochemistry & Molecular Biology
Long Xu, Xiaoyu Yan, Jian Wang, Yuanxin Zhao, Qingqing Liu, Jiaying Fu, Xinyi Shi, Jing Su
Summary: This article provides an overview of ovarian cancer metastasis and the dysregulated expression of HDACs in ovarian cancer. It discusses the roles of HDACs in the regulation of ovarian cancer metastasis and highlights the importance of developing compounds that target HDACs in the future of ovarian cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yu-Long Tang, Bin Wang, Tao Ou-Yang, Wen-Zhi Lv, Shi-Chu Tang, An Wei, Xin-Wu Cui, Jiang-Sheng Huang
Summary: This study uses ultrasound radiomics analysis to establish a model for predicting axillary lymph node metastasis in breast cancer patients, providing essential information for clinical decision-making.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yilin Deng, Jinjin Gao, Guangying Xu, Yuan Yao, Yan Sun, Yehui Shi, Xishan Hao, Liling Niu, Hui Li
Summary: This study found that HDAC6 is highly expressed in metastatic colon cancer tissues and inhibiting or silencing HDAC6 can suppress colon cancer metastasis. The study also revealed the interaction between HDAC6 and AKAP12, and the deacetylation and ubiquitination processes that lead to the degradation of AKAP12.
Article
Cell Biology
Giulio Bontempi, Michela Terri, Sabrina Garbo, Claudia Montaldo, Davide Mariotti, Veronica Bordoni, Sergio Valente, Clemens Zwergel, Antonello Mai, Alessandra Marchetti, Alessandro Domenici, Paolo Mene, Cecilia Battistelli, Marco Tripodi, Raffaele Strippoli
Summary: Histone deacetylase 1 (HDAC1) inhibition plays an important role in reversing fibrosis. The study found that HDAC1 inhibition can reverse cell-to-cell transformation and limit cell migration and invasion by promoting the expression of miR-769-5p. Additionally, miR-769-5p targets and regulates the expression of several crucial genes.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Qiaoyun Hou, Shuohua Chen, Qi An, Boya Li, Yan Fu, Yongzhang Luo
Summary: The study confirms plasma Hsp90 alpha as a biomarker for breast cancer, providing insights into its prognostic value across different clinical stages, and suggests that eHsp90 alpha plays a role in promoting lymphangiogenesis in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rutong Zeng, Xiang Zhang, Chushan Zheng, Jin-Hong Du, Zixiong Gao, Wei Jun, Jun Shen, Yao Lu
Summary: A new decoupling neural network based quantification method for DECT analysis was presented in this study, showing potential as a noninvasive tool to predict metastasis lymph node status for breast cancer. By introducing spectral convolution and focal loss, the AUC on the test set could be improved by 0.15 and 0.01 separately. The proposed approach demonstrated a considerably better performance compared to baseline approaches, with a test set AUC value of 0.837.
Article
Oncology
Haoran Wei, Wenhao Ma, Xiaofei Lu, Haiying Liu, Kashuai Lin, Yinghui Wang, Zijian Ye, Linchong Sun, Zhitong Huang, Tingting Pan, Zilong Zhou, Eric Y. Cheng, Huafeng Zhang, Ping Gao, Xiuying Zhong
Summary: This study identified KDELR2 as a novel target of HDAC3, with aberrant expression indicating poor prognosis in breast cancer patients. The correlation between HDAC3 and KDELR2 in tumor tissues was confirmed. It was found that HDAC3 transactivated KDELR2 via CREB1, promoting cell cycle progression and tumorigenesis. The HDAC3-KDELR2 axis could be a potential therapeutic target for breast cancer.
CANCER COMMUNICATIONS
(2021)
Article
Oncology
Peipei Shan, Feifei Yang, Hongzhao Qi, Yunjie Hu, Sujie Zhu, Zhenqing Sun, Zhe Zhang, Chuanxiao Wang, Caixia Hou, Jie Yu, Lirong Wang, Zhixia Zhou, Peifeng Li, Hua Zhang, Kun Wang
Summary: The study reveals the essential role of MDM2 in TNBC progression, suggesting that targeting the HDAC1-MDM2-MDMX axis with a hydroxamate-based HDAC1 could be a promising therapeutic strategy for TNBC.
Article
Biochemistry & Molecular Biology
Zao-zao Zheng, Lin Xia, Guo-sheng Hu, Jun-yi Liu, Ya-hong Hu, Yu-jie Chen, Jia-yin Peng, Wen-juan Zhang, Wen Liu
Summary: This study uncovers the critical role of a super-enhancer-associated positive feedback loop constituting BRD4/ERα-RET-ERα in ERα-positive breast cancer and suggests that targeting components in this loop would provide a new therapeutic avenue for treating ERα-positive breast cancer in the clinic.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Medicine, General & Internal
Haejung Kim, Boo-Kyung Han, Eun Young Ko, Eun Sook Ko, Ji Soo Choi
Summary: This study evaluated the frequency and location of abnormal lymph nodes (LNs) in breast cancer patients with a single axillary lymph node (ALN) metastasis using breast magnetic resonance imaging (MRI). The findings showed that abnormal LN were commonly located in the lowest or second-lowest position in level I axilla. Pathology reports indicated that the metastases were often sentinel LNs (SLNs), and macrometastases were more prevalent in cases with abnormal LNs. The most frequent morphological feature of metastatic ALNs was diffuse cortical thickening.
Article
Surgery
Raeda Taj, Sophie H. Chung, Nicole H. Goldhaber, Bryan H. Louie, Jordan G. Marganski, Navtej S. Grewal, Zachary S. Rane, Haydee Ojeda -Fournier, Ava Armani, Anne Wallace, Sarah L. Blair
Summary: This study examines the factors that might contribute to the ability to identify the clipped nodes post neoadjuvant therapy. The results suggest that radiologically abnormal lymph nodes on preoperative imaging after neoadjuvant therapy are more likely to be localized. Localization before starting neoadjuvant therapy is suggested.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Oncology
Yu-Chieh Tsai, Tzu-Yin Wang, Chia-Lang Hsu, Wei-Chou Lin, Jyun-Yu Chen, Jia-Hua Li, Yeong-Shiau Pu, Ann-Lii Cheng, Jason Chia-Hsien Cheng, Sheng-Fang Su
Summary: This study found that inhibiting HDAC6 can enhance the radiosensitivity of bladder cancer and reduce the expression of genes related to cell migration, angiogenesis, and metastasis induced by radiotherapy, thereby improving therapeutic efficacy.
BRITISH JOURNAL OF CANCER
(2023)
Article
Nanoscience & Nanotechnology
Youngee Seo, Lida Ghazanfari, Alyssa Master, Hemant M. Vishwasrao, Xiaomeng Wan, Marina Sokolsky-Papkov, Alexander Kabanov
Summary: This study reports the development of a novel theranostic system called NanoFerrogels, which combines magnetic nanoparticles and polymeric micelles for cancer diagnosis and treatment. NanoFerrogels function as imaging agents for magnetic resonance imaging and as drug loading compartments. The experiments demonstrate the potential of NanoFerrogels as a remotely actuated theranostic platform for cancer therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
C. Tilden Hagan, Cameron Bloomquist, Samuel Warner, Nicole M. Knape, Isaiah Kim, Hayley Foley, Kyle T. Wagner, Sue Mecham, Joseph DeSimone, Andrew Z. Wang
Summary: This study utilized advances in 3D printing and drug delivery science to design a novel drug-loaded arrowhead array device (AAD) for localized chemotherapy at the surgical site, aiming to reduce local recurrence of cancer. The results demonstrated that the AAD significantly decreased local recurrence and improved survival in mouse cancer models, and showed potential for personalized treatment in the clinical setting.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Medicine, Research & Experimental
Tao Zhang, Jinghua Cai, Muyun Xu, Xinrui Ma, Hui Wang, Mengzhe Wang, Zhaoguo Han, Jason Wang, Eric Smith, Zibo Li, Zhanhong Wu
Summary: A new series of F-18-labeled PSMA-targeting agents were developed with optimal tumor uptake and contrast. Among them, F-18-PEG(3)-VS-PSMAi demonstrated nearly double the tumor uptake compared to the FDA-approved Ga-68-PSMA-11 in the same animal model.
MOLECULAR PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Wei Chen, Hui Wang, Nicholas E. S. Tay, Vincent A. Pistritto, Kang-Po Li, Tao Zhang, Zhanhong Wu, David A. Nicewicz, Zibo Li
Summary: PET is a powerful imaging technology used to visualize and measure metabolic processes and obtain unique information about drug candidates. The development of new and improved molecular probes in PET is crucial, but progress is restricted by the lack of efficient and simple labeling methods. This study introduces a method for constructing C-F-18 bonds through direct halide/F-18 conversion in electron-rich halo(hetero)arenes, enabling rapid diversification of PET probes.
Article
Immunology
Daniel Michaud, Bhalchandra Mirlekar, Colleen Steward, Gail Bishop, Yuliya Pylayeva-Gupta
Summary: B cells can suppress anti-tumor T cell immunity in pancreatic cancer through the expression of IL-35. The synergy between BCR and TLR4 signaling pathways induces IL-35 expression in B cells. B cell receptor activation, rather than MyD88 signaling, is crucial for B cell-mediated suppression and promotion of pancreatic cancer growth. PKD2 is identified as a key downstream regulator of IL-35 expression in B cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Soha Bazyar, Edward Timothy O'Brien, Thad Benefield, Victoria R. Roberts, Rashmi J. Kumar, Gaorav P. Gupta, Otto Zhou, Yueh Z. Lee
Summary: Radiation therapy is commonly used in cancer treatment, but can have negative effects on normal tissues. Microplanar radiation therapy (MRT) is a novel method that has shown promising results in animal models. Combining MRT with immune checkpoint therapy can enhance the treatment efficacy against tumors.
Article
Materials Science, Biomaterials
Matthew J. Haney, Hong Yuan, Steven T. Shipley, Zhanhong Wu, Yuling Zhao, Kelly Pate, Jonathan E. Frank, Nicole Massoud, Paul W. Stewart, Joel S. Perlmutter, Elena Batrakova
Summary: This study investigated the biodistribution and brain retention of PBMCs and EVs in adult rhesus macaques using PET/MRI imaging. The route of administration had a significant impact on brain retention of the carriers, with PBMCs showing higher brain retention when administered intrathecally. EVs demonstrated superior brain accumulation when administered intraperitoneally and intravenously, respectively. No cytotoxic effects were observed for either carrier in blood samples. Overall, living cells and EVs have great potential for drug delivery to the brain, and the route of administration plays a crucial role in CNS drug delivery.
Article
Chemistry, Multidisciplinary
Benjamin T. Ledford, Adam W. Akerman, Kui Sun, David C. Gillis, Jenna M. Weiss, Johnny Vang, Smaranda Willcox, Tristan D. Clemons, Hiroaki Sai, Ruomeng Qiu, Mark R. Karver, Jack D. Griffith, Nick D. Tsihlis, Samuel Stupp, John S. Ikonomidis, Melina R. Kibbe
Summary: This study reports the development of injectable supramolecular nanofibers that target fragmented elastin, matrix metalloproteinase 2, and membrane type 1 matrix metalloproteinase to reduce the risks associated with a ruptured abdominal aortic aneurysm. The results show that one of the nanofibers was able to better localize to the aneurysm tissue and had an optimal dose.
Article
Chemistry, Multidisciplinary
Limei Shen, Jingjing Li, Qi Liu, Manisit Das, Wantong Song, Xueqiong Zhang, Karthik Tiruthani, Oleksandra Dorosheva, Haiyang Hu, Samuel K. Lai, Rihe Liu, Leaf Huang
Summary: Interaction between different cell types in the tumor microenvironment affects tumor growth. Tumor-associated fibroblasts produce CXCL13, which recruits B cells to the tumor microenvironment. B cells in the tumor microenvironment differentiate into regulatory B cells (Bregs). CXCL13 also stimulates epithelial-mesenchymal transition (EMT) of tumor cells. Using plasmid DNA encoding a CXCL13 trap to reduce Bregs differentiation and normalize EMT suppresses tumor growth.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Anne M. Talkington, Morgan D. McSweeney, Timothy Wessler, Marielle K. Rath, Zibo Li, Tao Zhang, Hong Yuan, Jonathan E. Frank, M. Gregory Forest, Yanguang Cao, Samuel K. Lai
Summary: PEGylation is commonly used to prolong the circulation time of protein therapeutics and nanomedicines. However, individuals exposed to PEGylated therapeutics may develop antibodies specific to PEG, increasing the risk of hypersensitivity and accelerated drug clearance. In this study, a PBPK model was developed to investigate the impact of anti-PEG antibodies on the pharmacokinetics and biodistribution of PEGylated drugs.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Medicine, Research & Experimental
Liu Zhou, Ruiling Long, Mei Hu, Nan Liu, Yue Feng, Lin Qiu, Zibo Li, Yue Chen, Li Wang
Summary: Boron neutron capture therapy (BNCT) is a promising cancer treatment strategy that utilizes boron-containing ligands. In this study, a series of substituted boramino acids were synthesized and evaluated for their potential use in BNCT with integrated positron emission tomography (PET). The compound R-[F-18]-5a demonstrated the best tumor uptake and stability among tested agents, making it a promising candidate for future evaluation in PET and BNCT combination therapy.
MOLECULAR PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Li Wang, Yubai Zhou, Xuedan Wu, Xinrui Ma, Bing Li, Ransheng Ding, Michael A. Stashko, Zhanhong Wu, Xiaodong Wang, Zibo Li
Summary: MerTK is abnormally expressed in various cancers, but the sensitivity of tumors to MerTK suppression may vary. In this study, a radiolabeled agent [F-18]-MerTK-6 was developed and showed prominent uptake in tumors in initial evaluation, suggesting it as a promising PET agent for MerTK imaging.
Article
Biotechnology & Applied Microbiology
Pritha Agarwalla, Edikan A. Ogunnaike, Sarah Ahn, Kristen A. Froehlich, Anton Jansson, Frances S. Ligler, Gianpietro Dotti, Yevgeny Brudno
Summary: This study introduces a novel implantable multifunctional scaffold (MASTER) that streamlines in vivo CAR-T cell manufacturing, resulting in the rapid generation and release of functional CAR-T cells in mice. MASTER shows improved therapeutic efficacy and persistence compared to conventional CAR-T cells, promising to transform CAR-T cell therapy.
NATURE BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Hongxia Li, Emily B. Harrison, Huizhong Li, Koichi Hirabayashi, Jing Chen, Qi-Xiang Li, Jared Gunn, Jared Weiss, Barbara Savoldo, Joel S. Parker, Chad Pecot, Gianpietro Dotti, Hongwei Du
Summary: Therapeutic options for non-small cell lung cancer patients with brain metastases are limited. CAR-T cells targeting B7-H3 and expressing the chemokine receptor CCR2b show improved accumulation in the brain and enhanced anti-tumor activity. This strategy could improve the efficacy of adoptive T-cell therapies in patients with solid tumors presenting with brain metastases.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Nazira El-Hage, Matthew J. Haney, Yuling Zhao, Myosotys Rodriguez, Zhanhong Wu, Mori Liu, Carson J. Swain, Hong Yuan, Elena V. Batrakova
Summary: We have developed a novel EV-based drug delivery system for the treatment of Batten disease (BD) by transporting the lysosomal enzyme TPP1. The EVs were loaded with TPP1 through transfection of parent cells and showed successful delivery to the brain in a mouse model of BD. The TPP1-loaded EVs exhibited therapeutic effects by eliminating lipofuscin aggregates, reducing inflammation, and improving neuronal survival, possibly through activation of the autophagy pathway. Continued research into effective therapies for BD is crucial for improving patient outcomes.