Dysregulation of histone deacetylases in carcinogenesis and tumor progression: a possible link to apoptosis and autophagy

A novel benzamine lead compound of histone deacetylase inhibitor ZINC24469384 can suppresses HepG2 cells proliferation by upregulating NR1H4

(2019) Qiuhang Song et al.   Scientific Reports

Stabilized peptide HDAC inhibitors derived from HDAC1 substrate H3K56 for the treatment of cancer stem-like cells in vivo

(2019) Dongyuan Wang et al.   CANCER RESEARCH

Histone deacetylase inhibitors upregulate Snail via Smad2/3 phosphorylation and stabilization of Snail to promote metastasis of hepatoma cells

(2018) Wei Xu et al.   CANCER LETTERS

Cancer epigenetics: Moving forward

(2018) Angela Nebbioso et al.   PLoS Genetics

Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics

(2018) Prakash P. Praharaj et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Histone Deacetylase Inhibitors as Anticancer Drugs

(2017) Tomas Eckschlager et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Suberoylanilide hydroxamic acid (SAHA) promotes the epithelial mesenchymal transition of triple negative breast cancer cells via HDAC8/FOXA1 signals

(2016) Shao Wu et al.   BIOLOGICAL CHEMISTRY

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy

(2016) V E Kagan et al.   CELL DEATH AND DIFFERENTIATION

Histone deacetylase inhibitors suppress mutant p53 transcription via HDAC8/YY1 signals in triple negative breast cancer cells

(2016) Zhao-Tong Wang et al.   CELLULAR SIGNALLING

Pro-Proliferative Function of Mitochondrial Sirtuin Deacetylase SIRT3 in Human Melanoma

(2016) Jasmine George et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Role of PGC1  in Cancer Metabolism and its Therapeutic Implications

(2016) Z. Tan et al.   MOLECULAR CANCER THERAPEUTICS

The SIRT2 Deacetylase Stabilizes Slug to Control Malignancy of Basal-like Breast Cancer

(2016) Wenhui Zhou et al.   Cell Reports

Mechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer Cells

(2015) Anderly C. Chueh et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT5 regulation of ammonia-induced autophagy and mitophagy

(2015) Lucia Polletta et al.   Autophagy

The novel HDAC inhibitor AR-42-induced anti-colon cancer cell activity is associated with ceramide production

(2015) Weihong Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ceramide induced mitophagy and tumor suppression

(2015) Mohammed Dany et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tumour-suppressive function of SIRT4 in human colorectal cancer

(2015) M Miyo et al.   BRITISH JOURNAL OF CANCER

Loss of SIRT3 Provides Growth Advantage for B Cell Malignancies

(2015) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin 3 inhibits hepatocellular carcinoma growth through the glycogen synthase kinase-3β/BCL2-associated X protein-dependent apoptotic pathway

(2015) C-L Song et al.   ONCOGENE

SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors

(2015) Shivani Malik et al.   Scientific Reports

Overexpression of Sirt7 Exhibits Oncogenic Property and Serves as a Prognostic Factor in Colorectal Cancer

(2014) H. Yu et al.   CLINICAL CANCER RESEARCH

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy

(2014) W. Wu et al.   EMBO REPORTS

New and emerging HDAC inhibitors for cancer treatment

(2014) Alison C. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis

(2014) I-Chieh Chen et al.   Molecular Cancer

Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins

(2014) Yongxing Gong et al.   NATURE GENETICS

SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer

(2014) Weidong Lu et al.   TUMOR BIOLOGY

Epigenetic regulation in cancer progression

(2014) Eva Baxter et al.   Cell and Bioscience

p53 Acetylation: Regulation and Consequences

(2014) Sara Reed et al.   Cancers

Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status

(2013) Su Melser et al.   Cell Metabolism

Histone Deacetylase (HDAC) 10 Suppresses Cervical Cancer Metastasis through Inhibition of Matrix Metalloproteinase (MMP) 2 and 9 Expression

(2013) Chenlin Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuins' modulation of autophagy

(2013) Fanny Ng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Histone Deacetylases

(2013) Sabnam Parbin et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

(2013) Charleen T. Chu et al.   NATURE CELL BIOLOGY

Epigenetic regulation and cancer (Review)

(2013) Q.W. CHEN et al.   ONCOLOGY REPORTS

Histone deacetylase 10 promotes autophagy-mediated cell survival

(2013) I. Oehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Dysfunction in Cancer

(2013) Michelle L. Boland et al.   Frontiers in Oncology

Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation

(2012) Yuan-Yuan Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Histone deacetylase inhibitor induction of epithelial–mesenchymal transitions via up-regulation of Snail facilitates cancer progression

(2012) Guan-Min Jiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Chromatin remodeling in Cancer: A Gateway to regulate gene Transcription

(2012) Sujit S. Nair et al.   Molecular Oncology

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

(2012) R David Sentelle et al.   Nature Chemical Biology

Histone deacetylase inhibitors suppress mutant p53 transcription via histone deacetylase 8

(2012) W Yan et al.   ONCOGENE

SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis

(2012) V Byles et al.   ONCOGENE

Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development

(2012) P. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility

(2011) Xinnan Wang et al.   CELL

Concerted functions of HDAC1 and microRNA-574-5p repress alternatively splicedceramide synthase 1expression in human cancer cells

(2011) Marisa Meyers-Needham et al.   EMBO Molecular Medicine

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

(2011) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

IKK connects autophagy to major stress pathways

(2010) Alfredo Criollo et al.   Autophagy

SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol

(2010) Gnanapragasam Arunachalam et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

(2010) Nirmala Hariharan et al.   CIRCULATION RESEARCH

HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

(2010) Joo-Yong Lee et al.   EMBO JOURNAL

The BH3-only Bnip3 binds to the dynamin Opa1 to promote mitochondrial fragmentation and apoptosis by distinct mechanisms

(2010) Thomas Landes et al.   EMBO REPORTS

Disease-causing mutations in Parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

(2010) Joo-Yong Lee et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

IKK-dependent, NF-κB-independent control of autophagic gene expression

(2010) W C Comb et al.   ONCOGENE

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Mitophagy

(2009) Aviva M. Tolkovsky   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Epigenetics in cancer

(2009) S. Sharma et al.   CARCINOGENESIS

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

(2009) Hyunkyung Jeong et al.   CELL

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

The Changing Face of HDAC Inhibitor Depsipeptide

(2009) Wen Zhou et al.   CURRENT CANCER DRUG TARGETS

The IKK complex contributes to the induction of autophagy

(2009) Alfredo Criollo et al.   EMBO JOURNAL

Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells

(2009) Brian Head et al.   JOURNAL OF CELL BIOLOGY

Histone Deacetylase Inhibitors Prevent p53-Dependent and p53-Independent Bax-Mediated Neuronal Apoptosis through Two Distinct Mechanisms

(2009) T. Uo et al.   JOURNAL OF NEUROSCIENCE

JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity

(2009) Nargis Nasrin et al.   PLoS One

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Chemical mechanisms of histone lysine and arginine modifications

(2008) Brian C. Smith et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antagonism of E2F-1 regulated Bnip3 transcription by NF- B is essential for basal cell survival

(2008) J. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA