Mitochondrial Quality and Quantity Control: Mitophagy Is a Potential Therapeutic Target for Ischemic Stroke

Redox Biology of Melatonin: Discriminating Between Circadian and Noncircadian Functions

(2022) Rüdiger Hardeland   ANTIOXIDANTS & REDOX SIGNALING

Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association

(2021) Salim S. Virani et al.   CIRCULATION

Role of Polyphenols as Antioxidant Supplementation in Ischemic Stroke

(2021) Yuan Zhou et al.   Oxidative Medicine and Cellular Longevity

Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes

(2021) Weimin Fan et al.   Journal of Inflammation Research

Protective Effects of Hyperbaric Oxygen Therapy on Brain Injury by Regulating the Phosphorylation of Drp1 Through ROS/PKC Pathway in Heatstroke Rats

(2020) Xiao-xiao Ni et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Curcumin attenuates cerebral ischemia-reperfusion injury through regulating mitophagy and preserving mitochondrial function

(2020) Weiwei Wang et al.   CURRENT NEUROVASCULAR RESEARCH

Deletion of a neuronal Drp1 activator protects against cerebral ischemia

(2020) Kyle H. Flippo et al.   JOURNAL OF NEUROSCIENCE

The PINK1–Parkin axis: An Overview

(2020) Keiji Tanaka   NEUROSCIENCE RESEARCH

Suppression of DRP1‑mediated mitophagy increases the apoptosis of hepatocellular carcinoma cells in the setting of chemotherapy

(2020) Min Ma et al.   ONCOLOGY REPORTS

Mitochondrial Quality Control: Role in Cardiac Models of Lethal Ischemia-Reperfusion Injury

(2020) Andrew R. Kulek et al.   Cells

Mitophagy in Acute Kidney Injury and Kidney Repair

(2020) Ying Wang et al.   Cells

Garciesculenxanthone B induces PINK1-Parkin-mediated mitophagy and prevents ischemia-reperfusion brain injury in mice

(2020) Man Wu et al.   ACTA PHARMACOLOGICA SINICA

Rehmapicroside ameliorates cerebral ischemia-reperfusion injury via attenuating peroxynitrite-mediated mitophagy activation

(2020) Yifan Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of chrysophanol on hippocampal damage and mitochondrial autophagy in mice with cerebral ischemia reperfusion

(2020) Wei-Hua Cui et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Luteolin Protects Against CIRI, Potentially via Regulation of the SIRT3/AMPK/mTOR Signaling Pathway

(2020) Shuwen Liu et al.   NEUROCHEMICAL RESEARCH

FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury

(2020) Ying Cai et al.   Redox Biology

Mitophagy protects β cells from inflammatory damage in diabetes

(2020) Vaibhav Sidarala et al.   JCI Insight

Pharmacodynamic effects and molecular mechanisms of lignans from Schisandra chinensis Turcz. (Baill.), a current review

(2020) Yuan Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Effects of melatonin on acute brain reperfusion stress: role of Hippo signaling pathway and MFN2-related mitochondrial protection

(2019) Song Lan et al.   CELL STRESS & CHAPERONES

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Emerging views of mitophagy in immunity and autoimmune diseases

(2019) Ye Xu et al.   Autophagy

Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

(2019) Ruth Scherz‐Shouval et al.   EMBO JOURNAL

Global brain ischemia in rats is associated with mitochondrial release and downregulation of Mfn2 in the cerebral cortex, but not the hippocampus

(2019) Katarina Klacanova et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Small-molecule inhibitors of cyclophilins block opening of the mitochondrial permeability transition pore and protect mice from hepatic ischemia–reperfusion injury

(2019) Mathieu Panel et al.   GASTROENTEROLOGY

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation

(2019) Cristina Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

Ginkgetin attenuates cerebral ischemia–reperfusion induced autophagy and cell death via modulation of the NF-κB/p53 signaling pathway

(2019) Jianqing Pan et al.   BIOSCIENCE REPORTS

Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma

(2019) Jinkyu Jung et al.   CANCER RESEARCH

Parkin-Dependent Mitophagy is Required for the Inhibition of ATF4 on NLRP3 Inflammasome Activation in Cerebral Ischemia-Reperfusion Injury in Rats

(2019) He et al.   Cells

Defending stressed mitochondria: uncovering the role of MUL1 in suppressing neuronal mitophagy

(2019) Rajat Puri et al.   Autophagy

Esculetin improves cognitive impairments induced by transient cerebral ischaemia and reperfusion in mice via regulation of mitochondrial fragmentation and mitophagy

(2019) Bingru Xu et al.   BEHAVIOURAL BRAIN RESEARCH

Mitochondria as a therapeutic target for ischemic stroke

(2019) Zhi He et al.   FREE RADICAL BIOLOGY AND MEDICINE

Emerging role of mitophagy in cardiovascular physiology and pathology

(2019) Pablo E. Morales et al.   MOLECULAR ASPECTS OF MEDICINE

Resveratrol Activates Neuronal Autophagy Through AMPK in the Ischemic Brain

(2019) Narayana Pineda-Ramírez et al.   MOLECULAR NEUROBIOLOGY

Electroacupuncture ameliorates neuronal injury by Pink1/Parkin-mediated mitophagy clearance in cerebral ischemia-reperfusion

(2019) Huanyuan Wang et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts

(2019) Rajat Puri et al.   Nature Communications

Drp1-regulated PARK2-dependent mitophagy protects against renal fibrosis in unilateral ureteral obstruction

(2019) Shu Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial division, fusion and degradation

(2019) Daisuke Murata et al.   JOURNAL OF BIOCHEMISTRY

Ginkgolic acid promotes autophagy-dependent clearance of intracellular alpha-synuclein aggregates

(2019) Shamini Vijayakumaran et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Xiao-Xu-Ming Decoction Reduced Mitophagy Activation and Improved Mitochondrial Function in Cerebral Ischemia and Reperfusion Injury

(2018) Rui Lan et al.   BEHAVIOURAL NEUROLOGY

Hydrogen exerts neuroprotective effects on OGD/R damaged neurons in rat hippocampal by protecting mitochondrial function via regulating mitophagy mediated by PINK1/Parkin signaling pathway

(2018) Xinwei Wu et al.   BRAIN RESEARCH

Mitophagy is activated in brain damage induced by cerebral ischemia and reperfusion via the PINK1/Parkin/p62 signalling pathway

(2018) Rui Lan et al.   BRAIN RESEARCH BULLETIN

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

(2018) Meng-Yu Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

PINK1 autophosphorylation is required for ubiquitin recognition

(2018) Shafqat Rasool et al.   EMBO REPORTS

Mitochondrial dynamics: overview of molecular mechanisms

(2018) Lisa Tilokani et al.   Essays in Biochemistry

Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias

(2018) Kyle Denton et al.   HUMAN MOLECULAR GENETICS

Mdivi-1 alleviates blood-brain barrier disruption and cell death in experimental traumatic brain injury by mitigating autophagy dysfunction and mitophagy activation

(2018) Qiong Wu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Photobiomodulation for Global Cerebral Ischemia: Targeting Mitochondrial Dynamics and Functions

(2018) Ruimin Wang et al.   MOLECULAR NEUROBIOLOGY

Mechanism and Therapies of Oxidative Stress-Mediated Cell Death in Ischemia Reperfusion Injury

(2018) Haobo Li et al.   Oxidative Medicine and Cellular Longevity

Mitochondrial mechanisms and therapeutics in ischaemia reperfusion injury

(2018) Jack L. Martin et al.   PEDIATRIC NEPHROLOGY

Heat Shock Protein B8 (HSPB8) Reduces Oxygen-Glucose Deprivation/Reperfusion Injury via the Induction of Mitophagy

(2018) Fazhao Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Effects of Endurance Exercise and Diet on Atherosclerosis in Young and Aged ApoE–/– and Wild-Type Mice

(2018) Bojana Jakic et al.   GERONTOLOGY

The role of mitochondria in NLRP3 inflammasome activation

(2018) Qiuyun Liu et al.   MOLECULAR IMMUNOLOGY

Panax Notoginseng Saponins Attenuate Myocardial Ischemia Reperfusion Injury via the HIF-1α/BNIP3 Pathway of Autophagy

(2018) Xin-Wen Liu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction

(2017) Qi He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The pharmacological regulation of cellular mitophagy

(2017) Nikolaos D Georgakopoulos et al.   Nature Chemical Biology

Mitophagy in neurodegeneration and aging

(2017) Elayne M. Fivenson et al.   NEUROCHEMISTRY INTERNATIONAL

Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins

(2017) Vladimir V. Rogov et al.   Scientific Reports

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

(2016) Lena Pernas et al.   Annual Review of Physiology

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy

(2016) Yao Kuang et al.   Autophagy

FUNDC1 is a novel mitochondrial-associated-membrane (MAM) protein required for hypoxia-induced mitochondrial fission and mitophagy

(2016) Wenxian Wu et al.   Autophagy

Plant phenols and autophagy

(2016) N. K. Zenkov et al.   BIOCHEMISTRY-MOSCOW

The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation

(2016) Koji Yamano et al.   EMBO REPORTS

Mitochondrial dynamics following global cerebral ischemia

(2016) Rita Kumar et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Extending the Time Window for Endovascular and Pharmacological Reperfusion

(2016) Nils Henninger et al.   Translational Stroke Research

Molecular Mechanisms of Mitochondrial Autophagy/Mitophagy in the Heart

(2015) T. Saito et al.   CIRCULATION RESEARCH

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

Phosphorylated ubiquitin chain is the genuine Parkin receptor

(2015) Kei Okatsu et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial DNA Oxidative Damage Contributes to Cardiomyocyte Ischemia/Reperfusion-Injury in Rats: Cardioprotective Role of Lycopene

(2015) Rongchuan Yue et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mechanism of phospho-ubiquitin-induced PARKIN activation

(2015) Tobias Wauer et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke

(2014) Qiang Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

BNIP3 Interacting with LC3 Triggers Excessive Mitophagy in Delayed Neuronal Death in Stroke

(2014) Ruo-Yang Shi et al.   CNS Neuroscience & Therapeutics

Amelioration of Ischemic Mitochondrial Injury and Bax-Dependent Outer Membrane Permeabilization by Mdivi-1

(2014) Yan-Xin Zhao et al.   CNS Neuroscience & Therapeutics

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy

(2014) Guo Chen et al.   MOLECULAR CELL

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Mitochondria autophagy is induced after hypoxic/ischemic stress in a Drp1 dependent manner: The role of inhibition of Drp1 in ischemic brain damage

(2014) Wei Zuo et al.   NEUROPHARMACOLOGY

Modulation of Mitochondrial Function and Autophagy Mediates Carnosine Neuroprotection Against Ischemic Brain Damage

(2014) Seung-Hoon Baek et al.   STROKE

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

(2013) Masahiro Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

(2013) Michalis Papadakis et al.   NATURE MEDICINE

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy

(2012) Yuqing Wang et al.   Autophagy

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

AMP-Activated Protein Kinase Regulation and Biological Actions in the Heart

(2012) Vlad G. Zaha et al.   CIRCULATION RESEARCH

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Mitochondria: master regulators of danger signalling

(2012) Lorenzo Galluzzi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibitors of Phosphatidylinositol 3′-Kinases Promote Mitotic Cell Death in HeLa Cells

(2012) Heli Hou et al.   PLoS One

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Fine-Tuning of Drp1/Fis1 Availability by AKAP121/Siah2 Regulates Mitochondrial Adaptation to Hypoxia

(2011) Hyungsoo Kim et al.   MOLECULAR CELL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Expression of mitofusin 2R94Q in a transgenic mouse leads to Charcot–Marie–Tooth neuropathy type 2A

(2010) Romain Cartoni et al.   BRAIN

PINK1 cleavage at position A103 by the mitochondrial protease PARL

(2010) Emma Deas et al.   HUMAN MOLECULAR GENETICS

Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming

(2010) Wen-Xing Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

(2010) A. Alexander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Nix is a selective autophagy receptor for mitochondrial clearance

(2009) Ivana Novak et al.   EMBO REPORTS

The PINK1/Parkin pathway: a mitochondrial quality control system?

(2009) Alexander J. Whitworth et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy

(2008) Ligia C. Gomes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

(2008) M. Kundu et al.   BLOOD

Tissue Plasminogen Activator (tPA) and Matrix Metalloproteinases in the Pathogenesis of Stroke: Therapeutic Strategies

(2008) Rao Adibhatla et al.   CNS & Neurological Disorders-Drug Targets

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Short- and long-term alterations of mitochondrial morphology, dynamics and mtDNA after transient oxidative stress

(2008) Marina Jendrach et al.   MITOCHONDRION

Essential role for Nix in autophagic maturation of erythroid cells

(2008) Hector Sandoval et al.   NATURE

Bioenergetics of cerebral ischemia: A cellular perspective

(2008) Leif Hertz   NEUROPHARMACOLOGY

The PINK1/Parkin pathway regulates mitochondrial morphology

(2008) A. C. Poole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA