Mitochondrial division, fusion and degradation

Clinical-genetic features and peculiar muscle histopathology in infantile DNM1L -related mitochondrial epileptic encephalopathy

(2019) Daniela Verrigni et al.   HUMAN MUTATION

Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease

(2019) María Isabel Hernández-Alvarez et al.   CELL

Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline

(2019) Toby Lieber et al.   NATURE

Ultrastructure and dynamics of the actin−myosin II cytoskeleton during mitochondrial fission

(2019) Changsong Yang et al.   NATURE CELL BIOLOGY

SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy

(2019) Tatsuya Yamada et al.   Autophagy

Mitochondrial antigen presentation: a mechanism linking Parkinson’s disease to autoimmunity

(2019) Ahmed M. Fahmy et al.   CURRENT OPINION IN IMMUNOLOGY

Mitochondrial fission requires DRP1 but not dynamins

(2019) Tiago Branco Fonseca et al.   NATURE

Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice

(2019) Diana Matheoud et al.   NATURE

The enigma of an interconnected mitochondrial reticulum: new insights into mitochondrial fusion

(2019) Sevan Mattie et al.   CURRENT OPINION IN CELL BIOLOGY

Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

(2019) Kie Itoh et al.   eLife

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

(2018) Tatsuya Yamada et al.   Cell Metabolism

Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles

(2018) Luwen Wang et al.   Cell Metabolism

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

A brain-enriched Drp1 isoform associates with lysosomes, late endosomes and the plasma membrane

(2018) Kie Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A

(2018) Agostinho G. Rocha et al.   SCIENCE

Mitochondrial dynamics: The dynamin superfamily and execution by collusion

(2018) Rajesh Ramachandran   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Phosphatidic Acid and Cardiolipin Coordinate Mitochondrial Dynamics

(2018) Shoichiro Kameoka et al.   TRENDS IN CELL BIOLOGY

Mitofusin 2: from functions to disease

(2018) Riccardo Filadi et al.   Cell Death & Disease

Aberrant Drp1-mediated mitochondrial division presents in humans with variable outcomes

(2018) Brittany N Whitley et al.   HUMAN MOLECULAR GENETICS

Structural basis of mitochondrial receptor binding and constriction by DRP1

(2018) Raghav Kalia et al.   NATURE

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Here, there, and everywhere: The importance of ER membrane contact sites

(2018) Haoxi Wu et al.   SCIENCE

No Parkin Zone: Mitophagy without Parkin

(2018) Elodie Villa et al.   TRENDS IN CELL BIOLOGY

Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales

(2018) Yuting Guo et al.   CELL

Dynamin-related protein 1 has membrane constricting and severing abilities sufficient for mitochondrial and peroxisomal fission

(2018) Sukrut C. Kamerkar et al.   Nature Communications

Clinical and Biochemical Features in a Patient With Mitochondrial Fission Factor Gene Alteration

(2018) Alessia Nasca et al.   Frontiers in Genetics

A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space

(2017) Sevan Mattie et al.   JOURNAL OF CELL BIOLOGY

INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division

(2017) Rajarshi Chakrabarti et al.   JOURNAL OF CELL BIOLOGY

Receptor-mediated Drp1 oligomerization on endoplasmic reticulum

(2017) Wei-Ke Ji et al.   JOURNAL OF CELL BIOLOGY

The constriction and scission machineries involved in mitochondrial fission

(2017) Felix Kraus et al.   JOURNAL OF CELL SCIENCE

The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans

(2017) Miyuki Sato et al.   NATURE CELL BIOLOGY

Molecular basis of selective mitochondrial fusion by heterotypic action between OPA1 and cardiolipin

(2017) Tadato Ban et al.   NATURE CELL BIOLOGY

Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division

(2017) Bongki Cho et al.   Nature Communications

Cryo-EM Studies of Drp1 Reveal Cardiolipin Interactions that Activate the Helical Oligomer

(2017) Christopher A. Francy et al.   Scientific Reports

A novel de novo dominant negative mutation inDNM1Limpairs mitochondrial fission and presents as childhood epileptic encephalopathy

(2016) Jill A. Fahrner et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Proliferation and fission of peroxisomes — An update

(2016) Michael Schrader et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

(2016) Diana Matheoud et al.   CELL

DNM1L -related encephalopathy in infancy with Leigh syndrome-like phenotype and suppression-burst

(2016) K. Zaha et al.   CLINICAL GENETICS

Missense variants in the middle domain ofDNM1Lin cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed inDrosophila

(2016) Yu-Hsin Chao et al.   HUMAN MOLECULAR GENETICS

Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy

(2016) Shun-ichi Yamashita et al.   JOURNAL OF CELL BIOLOGY

Disturbed mitochondrial and peroxisomal dynamics due to loss of MFF causes Leigh-like encephalopathy, optic atrophy and peripheral neuropathy

(2016) Johannes Koch et al.   JOURNAL OF MEDICAL GENETICS

The Emerging Network of Mitochondria-Organelle Contacts

(2016) Andrew Murley et al.   MOLECULAR CELL

Coincident Phosphatidic Acid Interaction Restrains Drp1 in Mitochondrial Division

(2016) Yoshihiro Adachi et al.   MOLECULAR CELL

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

Correcting mitochondrial fusion by manipulating mitofusin conformations

(2016) Antonietta Franco et al.   NATURE

Multiple dynamin family members collaborate to drive mitochondrial division

(2016) Jason E. Lee et al.   NATURE

Critical reappraisal confirms that Mitofusin 2 is an endoplasmic reticulum–mitochondria tether

(2016) Deborah Naon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

(2016) Samantha C. Lewis et al.   SCIENCE

Mechanisms of influenza viral membrane fusion

(2016) Jelle S. Blijleven et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dynamic actin cycling through mitochondrial subpopulations locally regulates the fission–fusion balance within mitochondrial networks

(2016) Andrew S. Moore et al.   Nature Communications

Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1

(2016) Rebecca Rojansky et al.   eLife

Mitochondrial division and fusion in metabolism

(2015) Madhuparna Roy et al.   CURRENT OPINION IN CELL BIOLOGY

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

The Mechanoenzymatic Core of Dynamin-related Protein 1 Comprises the Minimal Machinery Required for Membrane Constriction

(2015) Christopher A. Francy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiolipin's propensity for phase transition and its reorganization by dynamin-related protein 1 form a basis for mitochondrial membrane fission

(2015) Natalia Stepanyants et al.   MOLECULAR BIOLOGY OF THE CELL

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

(2015) Alicia M. Pickrell et al.   NEURON

Mitofusin 2 ablation increases endoplasmic reticulum–mitochondria coupling

(2015) Riccardo Filadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Actin filaments target the oligomeric maturation of the dynamin GTPase Drp1 to mitochondrial fission sites

(2015) Wei-ke Ji et al.   eLife

A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division

(2015) Uri Manor et al.   eLife

p62/SQSTM1 at the interface of aging, autophagy, and disease

(2014) Alessandro Bitto et al.   AGE

A Role for Myosin II in Mammalian Mitochondrial Fission

(2014) Farida Korobova et al.   CURRENT BIOLOGY

A new pathway for mitochondrial quality control: mitochondrial-derived vesicles

(2014) A. Sugiura et al.   EMBO JOURNAL

Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain

(2014) Yusuke Kageyama et al.   EMBO JOURNAL

Dynamin-related Protein 1 (Drp1) Promotes Structural Intermediates of Membrane Division

(2014) Begoña Ugarte-Uribe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Contraction of Mitochondria Induces Depolarization through the Inner Membrane Dynamin OPA1 Protein

(2014) Hakjoo Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of mitochondrial lipids in guiding fission and fusion

(2014) Michael A. Frohman   JOURNAL OF MOLECULAR MEDICINE-JMM

A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission

(2014) Patrick J. Macdonald et al.   MOLECULAR BIOLOGY OF THE CELL

Specific Interaction with Cardiolipin Triggers Functional Activation of Dynamin-Related Protein 1

(2014) Itsasne Bustillo-Zabalbeitia et al.   PLoS One

Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein

(2013) Chris Fröhlich et al.   EMBO JOURNAL

Clinical and histological determinants of nonalcoholic steatohepatitis and advanced fibrosis in elderly patients

(2013) Mazen Noureddin et al.   HEPATOLOGY

A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis

(2013) Hongmei Li et al.   NATURE CELL BIOLOGY

An Actin-Dependent Step in Mitochondrial Fission Mediated by the ER-Associated Formin INF2

(2013) F. Korobova et al.   SCIENCE

Mitochondrial Trafficking in Neurons

(2013) T. L. Schwarz   Cold Spring Harbor Perspectives in Biology

A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes

(2012) Vincent Soubannier et al.   CURRENT BIOLOGY

Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage

(2012) Yusuke Kageyama et al.   JOURNAL OF CELL BIOLOGY

Mitofusin-2 Independent Juxtaposition of Endoplasmic Reticulum and Mitochondria: An Ultrastructural Study

(2012) Pierre Cosson et al.   PLoS One

Mitochondrial dynamics in neurodegeneration

(2012) Kie Itoh et al.   TRENDS IN CELL BIOLOGY

SnapShot: Mitochondrial Dynamics

(2011) Yasushi Tamura et al.   CELL

The Soluble Form of Bax Regulates Mitochondrial Fusion via MFN2 Homotypic Complexes

(2011) Suzanne Hoppins et al.   MOLECULAR CELL

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

Degradation of Paternal Mitochondria by Fertilization-Triggered Autophagy in C. elegans Embryos

(2011) M. Sato et al.   SCIENCE

Postfertilization Autophagy of Sperm Organelles Prevents Paternal Mitochondrial DNA Transmission

(2011) S. Al Rawi et al.   SCIENCE

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission

(2010) Jason A Mears et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Mitochondrial ‘kiss-and-run’: interplay between mitochondrial motility and fusion–fission dynamics

(2009) Xingguo Liu et al.   EMBO JOURNAL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE