Mitophagy in Acute Kidney Injury and Kidney Repair

FUN14 domain-containing 1 promotes breast cancer proliferation and migration by activating calcium-NFATC1-BMI1 axis

(2019) Lianpin Wu et al.   EBioMedicine

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

(2019) Man J. Livingston et al.   Autophagy

Mitophagy and mitochondrial integrity in cardiac ischemia-reperfusion injury

(2019) Mingjie Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Impact of Acute Kidney Injury and Its Duration on Long-term Renal Function After Partial Nephrectomy

(2019) Carlo Andrea Bravi et al.   EUROPEAN UROLOGY

Tetramethylpyrazine Prevents Contrast-Induced Nephropathy via Modulating Tubular Cell Mitophagy and Suppressing Mitochondrial Fragmentation, CCL2/CCR2-Mediated Inflammation, and Intestinal Injury

(2019) Xuezhong Gong et al.   Oxidative Medicine and Cellular Longevity

UCP2 alleviates tubular epithelial cell apoptosis in lipopolysaccharide-induced acute kidney injury by decreasing ROS production

(2019) Xiaoyi Zhong et al.   BIOMEDICINE & PHARMACOTHERAPY

Autophagy-Independent Functions of the Autophagy Machinery

(2019) Lorenzo Galluzzi et al.   CELL

PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy

(2019) Di Zhou et al.   Cell Death & Disease

Enhanced efficiency of mitochondria-targeted peptide SS-31 for acute kidney injury by pH-responsive and AKI-kidney targeted nanopolyplexes

(2019) Di Liu et al.   BIOMATERIALS

Radiocontrast Agent Diatrizoic Acid Induces Mitophagy and Oxidative Stress via Calcium Dysregulation

(2019) Dakota B. Ward et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ginkgolic Acids Impair Mitochondrial Function by Decreasing Mitochondrial Biogenesis and Promoting FUNDC1-Dependent Mitophagy

(2019) Wenjun Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Activation of BNIP3-mediated mitophagy protects against renal ischemia–reperfusion injury

(2019) Chengyuan Tang et al.   Cell Death & Disease

PINK1 Deficiency Ameliorates Cisplatin-Induced Acute Kidney Injury in Rats

(2019) Li Zhou et al.   Frontiers in Physiology

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

(2019) Qisheng Lin et al.   Redox Biology

Defending stressed mitochondria: uncovering the role of MUL1 in suppressing neuronal mitophagy

(2019) Rajat Puri et al.   Autophagy

Involvement of phosphatase and tensin homolog-induced putative kinase 1–Parkin-mediated mitophagy in septic acute kidney injury

(2019) Xin-Gui Dai et al.   CHINESE MEDICAL JOURNAL

The anti-nephritic activity of a polysaccharide from okra (Abelmoschus esculentus (L.) Moench) via modulation of AMPK-Sirt1-PGC-1α signaling axis mediated anti-oxidative in type 2 diabetes model mice

(2019) Zhengzheng Liao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Disturbance of mitochondrial dynamics and mitophagy in sepsis-induced acute kidney injury

(2019) Jian-xing Liu et al.   LIFE SCIENCES

NAD+ homeostasis in renal health and disease

(2019) Kenneth M. Ralto et al.   Nature Reviews Nephrology

A small molecule protects mitochondrial integrity by inhibiting mTOR activity

(2019) Ran Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparison of iohexol and iodixanol induced nephrotoxicity, mitochondrial damage and mitophagy in a new contrast-induced acute kidney injury rat model

(2018) Wei Cheng et al.   ARCHIVES OF TOXICOLOGY

PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury

(2018) Chengyuan Tang et al.   Autophagy

BNIP3L/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming

(2018) Lorena Esteban-Martínez et al.   Autophagy

Mitophagy Plays a Protective Role in Iodinated Contrast-Induced Acute Renal Tubular Epithelial Cells Injury

(2018) Rong Lei et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Renal ischemia/reperfusion-induced mitophagy protects against renal dysfunction via Drp1-dependent-pathway

(2018) Nan Li et al.   EXPERIMENTAL CELL RESEARCH

Atg9 establishes Atg2-dependent contact sites between the endoplasmic reticulum and phagophores

(2018) Rubén Gómez-Sánchez et al.   JOURNAL OF CELL BIOLOGY

Building and decoding ubiquitin chains for mitophagy

(2018) J. Wade Harper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) in Kidney Disease

(2018) Szu-Yuan Li et al.   SEMINARS IN NEPHROLOGY

Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy

(2018) Masashi Sugo et al.   EMBO JOURNAL

Regulation of Endoplasmic Reticulum-Mitochondria contacts by Parkin via Mfn2

(2018) Valentina Basso et al.   PHARMACOLOGICAL RESEARCH

Fragmentation of kidney epithelial cell primary cilia occurs by cisplatin and these cilia fragments are excreted into the urine

(2018) Min Jung Kong et al.   Redox Biology

Rapamycin attenuates mitochondrial injury and renal tubular cell apoptosis in experimental contrast-induced acute kidney injury in rats

(2018) Xueyan Yang et al.   BIOSCIENCE REPORTS

Renal Fibrosis and Mitochondrial Damage

(2018) Jiao Qin et al.   CHINESE MEDICAL JOURNAL

Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid

(2018) Omar Emiliano Aparicio-Trejo et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial quality control in cardiac cells: Mechanisms and role in cardiac cell injury and disease

(2018) Farzaneh G. Tahrir et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin attenuates myocardial ischemia reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK-OPA1 signaling pathways

(2018) Ying Zhang et al.   JOURNAL OF PINEAL RESEARCH

PINK1/Parkin-mediated mitophagy is activated in cisplatin nephrotoxicity to protect against kidney injury

(2018) Ying Wang et al.   Cell Death & Disease

Peripheral Blood Mononuclear Cells Antioxidant Adaptations to Regular Physical Activity in Elderly People

(2018) Carla Busquets-Cortés et al.   Nutrients

Inflammasome-Independent Role of NLRP3 Mediates Mitochondrial Regulation in Renal Injury

(2018) Su-Mi Kim et al.   Frontiers in Immunology

Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies

(2018) Hasnaa A. Elfawy et al.   LIFE SCIENCES

Pink1/Parkin-mediated mitophagy play a protective role in cisplatin induced renal tubular epithelial cells injury

(2017) Chuanyan Zhao et al.   EXPERIMENTAL CELL RESEARCH

Renal recovery after acute kidney injury

(2017) L. G. Forni et al.   INTENSIVE CARE MEDICINE

Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI

(2017) Heather M. Perry et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AKI on CKD: heightened injury, suppressed repair, and the underlying mechanisms

(2017) Liyu He et al.   KIDNEY INTERNATIONAL

Understanding and preventing contrast-induced acute kidney injury

(2017) Michael Fähling et al.   Nature Reviews Nephrology

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

Panax notoginseng saponins mitigate cisplatin induced nephrotoxicity by inducing mitophagy via HIF-1α

(2017) Xueyan Liang et al.   Oncotarget

Drp1-dependent mitophagy protects against cisplatin-induced apoptosis of renal tubular epithelial cells by improving mitochondrial function

(2017) Chuanyan Zhao et al.   Oncotarget

Oxidant Mechanisms in Renal Injury and Disease

(2016) Brian B. Ratliff et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy

(2016) Ming Chen et al.   Autophagy

UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness

(2016) Chitoku Toda et al.   CELL

Melatonin pretreatment enhances the therapeutic effects of exogenous mitochondria against hepatic ischemia-reperfusion injury in rats through suppression of mitochondrial permeability transition

(2016) Hong-Hwa Chen et al.   JOURNAL OF PINEAL RESEARCH

Beneficial Effects ofMyo-Inositol Oxygenase Deficiency in Cisplatin-Induced AKI

(2016) Rajesh K. Dutta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1βand IL-18 and Arrests CKD

(2016) Hazel H. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cellular and Molecular Mechanisms of AKI

(2016) A. Agarwal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI

(2016) R. Lan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy in acute kidney injury

(2016) Gur P. Kaushal et al.   KIDNEY INTERNATIONAL

Orchestrating the network of molecular pathways affecting aging: Role of nonselective autophagy and mitophagy

(2016) Laura Knuppertz et al.   MECHANISMS OF AGEING AND DEVELOPMENT

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Protective Roles of ROS-Mediated Mitophagy on125I Seeds Radiation Induced Cell Death in HCT116 Cells

(2016) Lelin Hu et al.   Oxidative Medicine and Cellular Longevity

Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy

(2016) Mengqi Lv et al.   Protein & Cell

Indoxyl sulfate enhances IL-1β-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFκB/AP-1 pathway

(2015) Wen-Ching Shen et al.   ARCHIVES OF TOXICOLOGY

Autophagy machinery in the context of mammalian mitophagy

(2015) Saori R. Yoshii et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration

(2015) Durga Praveen Meka et al.   JOURNAL OF CLINICAL INVESTIGATION

Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury

(2015) Jianping Peng et al.   KIDNEY INTERNATIONAL

Assays for the biochemical and ultrastructural measurement of selective and nonselective types of autophagy in the yeast Saccharomyces cerevisiae

(2015) Rodrigo Soares Guimaraes et al.   METHODS

Regulation of endoplasmic reticulum turnover by selective autophagy

(2015) Aliaksandr Khaminets et al.   NATURE

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

(2015) David A. Ferenbach et al.   Nature Reviews Nephrology

Mitochondrial Function and Disturbances in the Septic Kidney

(2015) Samir M. Parikh et al.   SEMINARS IN NEPHROLOGY

Protecting the mitochondrial powerhouse

(2015) Morten Scheibye-Knudsen et al.   TRENDS IN CELL BIOLOGY

Diet impact on mitochondrial bioenergetics and dynamics

(2015) Rosalba Putti et al.   Frontiers in Physiology

Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

(2015) Anna J. Dare et al.   Redox Biology

Mitochondrial dysregulation and protection in cisplatin nephrotoxicity

(2014) Yuan Yang et al.   ARCHIVES OF TOXICOLOGY

NIX induces mitochondrial autophagy in reticulocytes

(2014) Ji Zhang et al.   Autophagy

ER-mitochondria contacts as sites of mitophagosome formation

(2014) Stefan Böckler et al.   Autophagy

The Parasitophorous Vacuole Membrane of Toxoplasma gondii Is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy

(2014) Jayoung Choi et al.   IMMUNITY

Mitochondrial Biogenesis in the Acutely Injured Kidney

(2014) Mei Tran et al.   NEPHRON CLINICAL PRACTICE

Emerging role of selective autophagy in human diseases

(2014) Kenji Mizumura et al.   Frontiers in Pharmacology

Mechanisms of Cardiac and Renal Dysfunction in Patients Dying of Sepsis

(2013) Osamu Takasu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Regulation and function of mitophagy in development and cancer

(2013) Haiqi Lu et al.   Autophagy

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Choice of renal replacement therapy modality and dialysis dependence after acute kidney injury: a systematic review and meta-analysis

(2013) Antoine G. Schneider et al.   INTENSIVE CARE MEDICINE

Acute kidney injury after cardiac surgery according to Risk/Injury/Failure/Loss/End-stage, Acute Kidney Injury Network, and Kidney Disease: Improving Global Outcomes classifications

(2013) Anthony J. Bastin et al.   JOURNAL OF CRITICAL CARE

Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology

(2013) Ming Zhan et al.   KIDNEY INTERNATIONAL

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Autophagy in Acute Kidney Injury

(2013) Man J. Livingston et al.   SEMINARS IN NEPHROLOGY

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

(2013) B.E. Riley et al.   Nature Communications

Recent advances into the understanding of mitochondrial fission

(2012) Kirstin Elgass et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

(2012) Lei Liu et al.   NATURE CELL BIOLOGY

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice

(2011) Mei Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury

(2011) Ion D. Bucaloiu et al.   KIDNEY INTERNATIONAL

Indoxyl Sulfate Stimulates Monocyte Chemoattractant Protein-1 Expression in Human Umbilical Vein Endothelial Cells by Inducing Oxidative Stress Through Activation of the NADPH Oxidase-Nuclear Factor-κB Pathway

(2010) Natsumi Masai et al.   CIRCULATION JOURNAL

PINK1 cleavage at position A103 by the mitochondrial protease PARL

(2010) Emma Deas et al.   HUMAN MOLECULAR GENETICS

Autophagy and adaptive immunity

(2010) Victoria L. Crotzer et al.   IMMUNOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of BNIP3 and NIX in cell death, autophagy and mitophagy

(2009) J Zhang et al.   CELL DEATH AND DIFFERENTIATION

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

(2009) Craig Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

Nix-Mediated Apoptosis Links Myocardial Fibrosis, Cardiac Remodeling, and Hypertrophy Decompensation

(2008) Abhinav Diwan et al.   CIRCULATION

Mitofusin 2 tethers endoplasmic reticulum to mitochondria

(2008) Olga Martins de Brito et al.   NATURE