Fibroblast growth factor 15/19 expression, regulation, and function: An overview

Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function

(2021) Courtney M. Williams et al.   FASEB JOURNAL

FGF19 in the Hindbrain Lowers Blood Glucose and Alters Excitability of Vagal Motor Neurons in Hyperglycemic Mice

(2021) Jordan B Wean et al.   ENDOCRINOLOGY

FGF19 protects skeletal muscle against obesity‐induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT‐1/PGC‐α pathway

(2021) Ai Guo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

FGF19 and FGFR4 promotes the progression of gallbladder carcinoma in an autocrine pathway dependent on GPBAR1-cAMP-EGR1 axis

(2021) Tianli Chen et al.   ONCOGENE

FGF15/FGF19 alleviates insulin resistance and upregulates placental IRS1/GLUT expression in pregnant mice fed a high-fat diet

(2021) Shanshan Zhao et al.   PLACENTA

Tissue-specific mechanisms of bile acid homeostasis and activation of FXR-FGF19 signaling in preterm and term neonatal pigs

(2021) Caitlin Vonderohe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Regulation of bile acid metabolism in biliary atresia: reduction of FGF19 by Kasai portoenterostomy and possible relation to early outcome

(2020) H. Johansson et al.   JOURNAL OF INTERNAL MEDICINE

Enhanced autocrine FGF19/FGFR4 signaling drives the progression of lung squamous cell carcinoma, which responds to mTOR inhibitor AZD2104

(2020) Fan Li et al.   ONCOGENE

Parenteral lipids shape gut bile acid pools and microbiota profiles in the prevention of cholestasis in preterm pigs

(2020) Lee Call et al.   JOURNAL OF LIPID RESEARCH

Teneligliptin Promotes Bile Acid Synthesis and Attenuates Lipid Accumulation in Obese Mice by Targeting the KLF15-Fgf15 Pathway

(2020) Guang Wang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis

(2020) Stephen A. Harrison et al.   GASTROENTEROLOGY

An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

(2020) Yifeng Wang et al.   Nature Communications

Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A

(2020) Young-Chae Kim et al.   Nature Communications

FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptations

(2020) Samantha Morón-Ros et al.   Molecular Metabolism

Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity

(2019) Ekaterina S. Kuzina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obeticholic acid may increase the risk of gallstone formation in susceptible patients

(2019) Samer Al-Dury et al.   JOURNAL OF HEPATOLOGY

The anti-obesity effect of FGF19 does not require UCP1-dependent thermogenesis

(2019) Patrick J. Antonellis et al.   Molecular Metabolism

Rifampicin, Not Vitamin E, Suppresses Parenteral Nutrition Associated Liver Disease Development through Pregnane X Receptor Pathway in Piglets

(2019) Gregory Guthrie et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Developmental regulation of the intestinal FGF19 system in domestic pigs

(2018) Aleix Gavaldà-Navarro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants

(2018) Jessica M. Lee et al.   JOURNAL OF LIPID RESEARCH

NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

(2018) Stephen A Harrison et al.   LANCET

Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

(2018) Sangwon Byun et al.   Nature Communications

Characterization of Hepatocellular Carcinoma Patients with FGF19 Amplification Assessed by Fluorescence in situ Hybridization: A Large Cohort Study

(2018) Hyo Jeong Kang et al.   Liver Cancer

Differential receptor selectivity of the FGF15/FGF19 orthologues determines distinct metabolic activities in db/db mice

(2018) Ann Maria K. Hansen et al.   BIOCHEMICAL JOURNAL

Targeting FXR and FGF19 to Treat Metabolic Diseases—Lessons Learned From Bariatric Surgery

(2018) Nadejda Bozadjieva et al.   DIABETES

CYP7A1 expression in hepatocytes is retained with upregulated fibroblast growth factor 19 in pediatric biliary atresia

(2018) Yasuhiro Hasegawa et al.   HEPATOLOGY RESEARCH

Rosuvastatin improves the FGF19 analogue NGM282-associated lipid changes in patients with non-alcoholic steatohepatitis

(2018) Mary E. Rinella et al.   JOURNAL OF HEPATOLOGY

Effect of NGM282, an FGF19 analogue, in primary sclerosing cholangitis: A multicenter, randomized, double-blind, placebo-controlled phase II trial

(2018) Gideon M. Hirschfield et al.   JOURNAL OF HEPATOLOGY

FGF19 amplification reveals an oncogenic dependency upon autocrine FGF19/FGFR4 signaling in head and neck squamous cell carcinoma

(2018) Lixia Gao et al.   ONCOGENE

Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration

(2017) Gloria Alvarez-Sola et al.   GUT

Roux-en-Y Gastric Bypass Surgery Has Unique Effects on Postprandial FGF21 but Not FGF19 Secretion

(2017) Lydia-Ann L S Harris et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15

(2017) Mei Zhou et al.   JOURNAL OF HEPATOLOGY

Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice

(2017) Bérengère Benoit et al.   NATURE MEDICINE

The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis

(2017) J.D. Schumacher et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mechanistic target of rapamycin complex 1 is an essential mediator of metabolic and mitogenic effects of fibroblast growth factor 19 in hepatoma cells

(2016) Zhi Yi Wan et al.   HEPATOLOGY

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans

(2016) Shogo Takahashi et al.   JOURNAL OF LIPID RESEARCH

Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival

(2016) Kai Hung Tiong et al.   Oncotarget

TGR5, Not Only a Metabolic Regulator

(2016) Cong Guo et al.   Frontiers in Physiology

Impaired Hepatic Adaptation to Chronic Cholestasis induced by Primary Sclerosing Cholangitis

(2016) Malgorzata Milkiewicz et al.   Scientific Reports

Detection of FGF15 in Plasma by Stable Isotope Standards and Capture by Anti-peptide Antibodies and Targeted Mass Spectrometry

(2015) Takeshi Katafuchi et al.   Cell Metabolism

Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2 -deficient mice

(2015) Mei Zhou et al.   HEPATOLOGY

Improvements in Glucose Metabolism Early After Gastric Bypass Surgery Are Not Explained by Increases in Total Bile Acids and Fibroblast Growth Factor 19 Concentrations

(2015) Nils B. Jørgensen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

FGF 19 and Bile Acids Increase Following Roux-en-Y Gastric Bypass but Not After Medical Management in Patients with Type 2 Diabetes

(2015) Saachi Sachdev et al.   OBESITY SURGERY

Circadian control of bile acid synthesis by a KLF15-Fgf15 axis

(2015) Shuxin Han et al.   Nature Communications

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis

(2015) Rachel J. Perry et al.   Nature Communications

FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3β/β- catenin signaling cascade via FGFR4 activation

(2015) Huakan Zhao et al.   Oncotarget

Expression of hepatic Fibroblast Growth Factor 19 is enhanced in Primary Biliary Cirrhosis and correlates with severity of the disease

(2015) Ewa Wunsch et al.   Scientific Reports

Fibroblast growth factor 15 deficiency impairs liver regeneration in mice

(2014) Bo Kong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19

(2014) M. Zhou et al.   CANCER RESEARCH

Cytoplasmic Tyrosine Phosphatase Shp2 Coordinates Hepatic Regulation of Bile Acid and FGF15/19 Signaling to Repress Bile Acid Synthesis

(2014) Shuangwei Li et al.   Cell Metabolism

Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice

(2014) Susagna Padrissa-Altés et al.   GUT

Genomic portrait of resectable hepatocellular carcinomas: Implications ofRB1andFGF19aberrations for patient stratification

(2014) Sung-Min Ahn et al.   HEPATOLOGY

Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients

(2014) J M Gallego-Escuredo et al.   INTERNATIONAL JOURNAL OF OBESITY

Isoforms of Receptors of Fibroblast Growth Factors

(2014) Siew-Ging Gong   JOURNAL OF CELLULAR PHYSIOLOGY

A nontumorigenic variant of FGF19 treats cholestatic liver diseases

(2014) J. Luo et al.   Science Translational Medicine

SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells

(2013) Masaaki Miyata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diet1 Functions in the FGF15/19 Enterohepatic Signaling Axis to Modulate Bile Acid and Lipid Levels

(2013) Laurent Vergnes et al.   Cell Metabolism

Identification of FGFR4 as a Potential Therapeutic Target for Advanced-Stage, High-Grade Serous Ovarian Cancer

(2013) T. M. Zaid et al.   CLINICAL CANCER RESEARCH

A Role for Fibroblast Growth Factor 19 and Bile Acids in Diabetes Remission After Roux-en-Y Gastric Bypass

(2013) G. S. Gerhard et al.   DIABETES CARE

Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice

(2013) Iker Uriarte et al.   GUT

FGF19 action in the brain induces insulin-independent glucose lowering

(2013) Gregory J. Morton et al.   JOURNAL OF CLINICAL INVESTIGATION

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis

(2013) Anouk A.J.J. van der Lans et al.   JOURNAL OF CLINICAL INVESTIGATION

FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels

(2013) Quan Shang et al.   JOURNAL OF LIPID RESEARCH

Exploring mechanisms of FGF signalling through the lens of structural biology

(2013) Regina Goetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway

(2013) Dongju Jung et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism

(2013) Ewa C. S. Ellis et al.   PLoS One

Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism

(2013) Geneviève Marcelin et al.   Molecular Metabolism

FGF19(fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress

(2012) Makoto Shimizu et al.   BIOCHEMICAL JOURNAL

Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma

(2012) Seiki Miura et al.   BMC CANCER

Differential Effects of Polymorphic Alleles of FGF Receptor 4 on Colon Cancer Growth and Metastasis

(2012) C. Heinzle et al.   CANCER RESEARCH

The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control

(2012) Dimitri J. Pournaras et al.   ENDOCRINOLOGY

Fibroblast Growth Factor-19 Action in the Brain Reduces Food Intake and Body Weight and Improves Glucose Tolerance in Male Rats

(2012) Karen K. Ryan et al.   ENDOCRINOLOGY

Conversion of a Paracrine Fibroblast Growth Factor into an Endocrine Fibroblast Growth Factor

(2012) Regina Goetz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual actions of fibroblast growth factor 19 on lipid metabolism

(2012) Xinle Wu et al.   JOURNAL OF LIPID RESEARCH

Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19

(2012) Masaaki Miyata et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models

(2012) Dorothy M. French et al.   PLoS One

Regulation of Amphiregulin Gene Expression by β-Catenin Signaling in Human Hepatocellular Carcinoma Cells: A Novel Crosstalk between FGF19 and the EGFR System

(2012) Maria U. Latasa et al.   PLoS One

Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor  -Klotho

(2012) T. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody-Mediated Inhibition of Fibroblast Growth Factor 19 Results in Increased Bile Acids Synthesis and Ileal Malabsorption of Bile Acids in Cynomolgus Monkeys

(2012) Rama Pai et al.   TOXICOLOGICAL SCIENCES

Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family

(2011) Wilber Romero-Fernandez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening

(2011) Eric T. Sawey et al.   CANCER CELL

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

(2011) Matthew J. Potthoff et al.   Cell Metabolism

Alterations of Hormonally Active Fibroblast Growth Factors after Roux-en-Y Gastric Bypass Surgery

(2011) Peter L.M. Jansen et al.   DIGESTIVE DISEASES

Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes

(2011) Elaine Studer et al.   HEPATOLOGY

The human gallbladder secretes fibroblast growth factor 19 into bile: Towards defining the role of fibroblast growth factor 19 in the enterobiliary tract

(2011) Serge J.L.B. Zweers et al.   HEPATOLOGY

Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes

(2011) Xuan Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

(2011) S. Kir et al.   SCIENCE

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Carbon monoxide enhance colonic epithelial restitution via FGF15 derived from colonic myofibroblasts

(2009) Kazuhiko Uchiyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation

(2009) J. Miao et al.   GENES & DEVELOPMENT

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of Fibroblast Growth Factor 19 Reduces Tumor Growth by Modulating  -Catenin Signaling

(2008) R. Pai et al.   CANCER RESEARCH

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7α-hydroxylase gene expression

(2008) Kwang-Hoon Song et al.   HEPATOLOGY

C-terminal Tail of FGF19 Determines Its Specificity toward Klotho Co-receptors

(2008) Xinle Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2

(2008) Hitoshi Ikeda et al.   JOURNAL OF LIPID RESEARCH