标题
Fibroblast growth factor 15/19 expression, regulation, and function: An overview
作者
关键词
Fibroblast growth factor 19, Bile acid metabolism, Carbohydrate metabolism, Lipid metabolism, Protein synthesis, Farnesoid x receptor
出版物
MOLECULAR AND CELLULAR ENDOCRINOLOGY
Volume 548, Issue -, Pages 111617
出版商
Elsevier BV
发表日期
2022-03-15
DOI
10.1016/j.mce.2022.111617
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Monomeric/dimeric forms of Fgf15/FGF19 show differential activity in hepatocyte proliferation and metabolic function
- (2021) Courtney M. Williams et al. FASEB JOURNAL
- FGF19 in the Hindbrain Lowers Blood Glucose and Alters Excitability of Vagal Motor Neurons in Hyperglycemic Mice
- (2021) Jordan B Wean et al. ENDOCRINOLOGY
- FGF19 protects skeletal muscle against obesity‐induced muscle atrophy, metabolic derangement and abnormal irisin levels via the AMPK/SIRT‐1/PGC‐α pathway
- (2021) Ai Guo et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- FGF19 and FGFR4 promotes the progression of gallbladder carcinoma in an autocrine pathway dependent on GPBAR1-cAMP-EGR1 axis
- (2021) Tianli Chen et al. ONCOGENE
- FGF15/FGF19 alleviates insulin resistance and upregulates placental IRS1/GLUT expression in pregnant mice fed a high-fat diet
- (2021) Shanshan Zhao et al. PLACENTA
- Tissue-specific mechanisms of bile acid homeostasis and activation of FXR-FGF19 signaling in preterm and term neonatal pigs
- (2021) Caitlin Vonderohe et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Regulation of bile acid metabolism in biliary atresia: reduction of FGF19 by Kasai portoenterostomy and possible relation to early outcome
- (2020) H. Johansson et al. JOURNAL OF INTERNAL MEDICINE
- Enhanced autocrine FGF19/FGFR4 signaling drives the progression of lung squamous cell carcinoma, which responds to mTOR inhibitor AZD2104
- (2020) Fan Li et al. ONCOGENE
- Parenteral lipids shape gut bile acid pools and microbiota profiles in the prevention of cholestasis in preterm pigs
- (2020) Lee Call et al. JOURNAL OF LIPID RESEARCH
- Teneligliptin Promotes Bile Acid Synthesis and Attenuates Lipid Accumulation in Obese Mice by Targeting the KLF15-Fgf15 Pathway
- (2020) Guang Wang et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Efficacy and Safety of Aldafermin, an Engineered FGF19 Analog, in a Randomized, Double-Blind, Placebo-Controlled Trial of Patients With Nonalcoholic Steatohepatitis
- (2020) Stephen A. Harrison et al. GASTROENTEROLOGY
- An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis
- (2020) Yifeng Wang et al. Nature Communications
- Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A
- (2020) Young-Chae Kim et al. Nature Communications
- FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptations
- (2020) Samantha Morón-Ros et al. Molecular Metabolism
- Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity
- (2019) Ekaterina S. Kuzina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Obeticholic acid may increase the risk of gallstone formation in susceptible patients
- (2019) Samer Al-Dury et al. JOURNAL OF HEPATOLOGY
- The anti-obesity effect of FGF19 does not require UCP1-dependent thermogenesis
- (2019) Patrick J. Antonellis et al. Molecular Metabolism
- Rifampicin, Not Vitamin E, Suppresses Parenteral Nutrition Associated Liver Disease Development through Pregnane X Receptor Pathway in Piglets
- (2019) Gregory Guthrie et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Developmental regulation of the intestinal FGF19 system in domestic pigs
- (2018) Aleix Gavaldà-Navarro et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants
- (2018) Jessica M. Lee et al. JOURNAL OF LIPID RESEARCH
- NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
- (2018) Stephen A Harrison et al. LANCET
- Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis
- (2018) Sangwon Byun et al. Nature Communications
- Characterization of Hepatocellular Carcinoma Patients with FGF19 Amplification Assessed by Fluorescence in situ Hybridization: A Large Cohort Study
- (2018) Hyo Jeong Kang et al. Liver Cancer
- Differential receptor selectivity of the FGF15/FGF19 orthologues determines distinct metabolic activities in db/db mice
- (2018) Ann Maria K. Hansen et al. BIOCHEMICAL JOURNAL
- Targeting FXR and FGF19 to Treat Metabolic Diseases—Lessons Learned From Bariatric Surgery
- (2018) Nadejda Bozadjieva et al. DIABETES
- CYP7A1 expression in hepatocytes is retained with upregulated fibroblast growth factor 19 in pediatric biliary atresia
- (2018) Yasuhiro Hasegawa et al. HEPATOLOGY RESEARCH
- Rosuvastatin improves the FGF19 analogue NGM282-associated lipid changes in patients with non-alcoholic steatohepatitis
- (2018) Mary E. Rinella et al. JOURNAL OF HEPATOLOGY
- Effect of NGM282, an FGF19 analogue, in primary sclerosing cholangitis: A multicenter, randomized, double-blind, placebo-controlled phase II trial
- (2018) Gideon M. Hirschfield et al. JOURNAL OF HEPATOLOGY
- FGF19 amplification reveals an oncogenic dependency upon autocrine FGF19/FGFR4 signaling in head and neck squamous cell carcinoma
- (2018) Lixia Gao et al. ONCOGENE
- Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration
- (2017) Gloria Alvarez-Sola et al. GUT
- Roux-en-Y Gastric Bypass Surgery Has Unique Effects on Postprandial FGF21 but Not FGF19 Secretion
- (2017) Lydia-Ann L S Harris et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15
- (2017) Mei Zhou et al. JOURNAL OF HEPATOLOGY
- Fibroblast growth factor 19 regulates skeletal muscle mass and ameliorates muscle wasting in mice
- (2017) Bérengère Benoit et al. NATURE MEDICINE
- The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis
- (2017) J.D. Schumacher et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Mechanistic target of rapamycin complex 1 is an essential mediator of metabolic and mitogenic effects of fibroblast growth factor 19 in hepatoma cells
- (2016) Zhi Yi Wan et al. HEPATOLOGY
- Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans
- (2016) Shogo Takahashi et al. JOURNAL OF LIPID RESEARCH
- Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival
- (2016) Kai Hung Tiong et al. Oncotarget
- TGR5, Not Only a Metabolic Regulator
- (2016) Cong Guo et al. Frontiers in Physiology
- Impaired Hepatic Adaptation to Chronic Cholestasis induced by Primary Sclerosing Cholangitis
- (2016) Malgorzata Milkiewicz et al. Scientific Reports
- Detection of FGF15 in Plasma by Stable Isotope Standards and Capture by Anti-peptide Antibodies and Targeted Mass Spectrometry
- (2015) Takeshi Katafuchi et al. Cell Metabolism
- Engineered fibroblast growth factor 19 reduces liver injury and resolves sclerosing cholangitis in Mdr2 -deficient mice
- (2015) Mei Zhou et al. HEPATOLOGY
- Improvements in Glucose Metabolism Early After Gastric Bypass Surgery Are Not Explained by Increases in Total Bile Acids and Fibroblast Growth Factor 19 Concentrations
- (2015) Nils B. Jørgensen et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- FGF 19 and Bile Acids Increase Following Roux-en-Y Gastric Bypass but Not After Medical Management in Patients with Type 2 Diabetes
- (2015) Saachi Sachdev et al. OBESITY SURGERY
- Circadian control of bile acid synthesis by a KLF15-Fgf15 axis
- (2015) Shuxin Han et al. Nature Communications
- FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic–pituitary–adrenal axis
- (2015) Rachel J. Perry et al. Nature Communications
- FGF19 promotes epithelial-mesenchymal transition in hepatocellular carcinoma cells by modulating the GSK3β/β- catenin signaling cascade via FGFR4 activation
- (2015) Huakan Zhao et al. Oncotarget
- Expression of hepatic Fibroblast Growth Factor 19 is enhanced in Primary Biliary Cirrhosis and correlates with severity of the disease
- (2015) Ewa Wunsch et al. Scientific Reports
- Fibroblast growth factor 15 deficiency impairs liver regeneration in mice
- (2014) Bo Kong et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19
- (2014) M. Zhou et al. CANCER RESEARCH
- Cytoplasmic Tyrosine Phosphatase Shp2 Coordinates Hepatic Regulation of Bile Acid and FGF15/19 Signaling to Repress Bile Acid Synthesis
- (2014) Shuangwei Li et al. Cell Metabolism
- Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice
- (2014) Susagna Padrissa-Altés et al. GUT
- Genomic portrait of resectable hepatocellular carcinomas: Implications ofRB1andFGF19aberrations for patient stratification
- (2014) Sung-Min Ahn et al. HEPATOLOGY
- Opposite alterations in FGF21 and FGF19 levels and disturbed expression of the receptor machinery for endocrine FGFs in obese patients
- (2014) J M Gallego-Escuredo et al. INTERNATIONAL JOURNAL OF OBESITY
- Isoforms of Receptors of Fibroblast Growth Factors
- (2014) Siew-Ging Gong JOURNAL OF CELLULAR PHYSIOLOGY
- A nontumorigenic variant of FGF19 treats cholestatic liver diseases
- (2014) J. Luo et al. Science Translational Medicine
- SREBP-2 negatively regulates FXR-dependent transcription of FGF19 in human intestinal cells
- (2013) Masaaki Miyata et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Diet1 Functions in the FGF15/19 Enterohepatic Signaling Axis to Modulate Bile Acid and Lipid Levels
- (2013) Laurent Vergnes et al. Cell Metabolism
- Identification of FGFR4 as a Potential Therapeutic Target for Advanced-Stage, High-Grade Serous Ovarian Cancer
- (2013) T. M. Zaid et al. CLINICAL CANCER RESEARCH
- A Role for Fibroblast Growth Factor 19 and Bile Acids in Diabetes Remission After Roux-en-Y Gastric Bypass
- (2013) G. S. Gerhard et al. DIABETES CARE
- Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice
- (2013) Iker Uriarte et al. GUT
- FGF19 action in the brain induces insulin-independent glucose lowering
- (2013) Gregory J. Morton et al. JOURNAL OF CLINICAL INVESTIGATION
- Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
- (2013) Anouk A.J.J. van der Lans et al. JOURNAL OF CLINICAL INVESTIGATION
- FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels
- (2013) Quan Shang et al. JOURNAL OF LIPID RESEARCH
- Exploring mechanisms of FGF signalling through the lens of structural biology
- (2013) Regina Goetz et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- FXR-induced secretion of FGF15/19 inhibits CYP27 expression in cholangiocytes through p38 kinase pathway
- (2013) Dongju Jung et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism
- (2013) Ewa C. S. Ellis et al. PLoS One
- Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism
- (2013) Geneviève Marcelin et al. Molecular Metabolism
- FGF19(fibroblast growth factor 19) as a novel target gene for activating transcription factor 4 in response to endoplasmic reticulum stress
- (2012) Makoto Shimizu et al. BIOCHEMICAL JOURNAL
- Fibroblast growth factor 19 expression correlates with tumor progression and poorer prognosis of hepatocellular carcinoma
- (2012) Seiki Miura et al. BMC CANCER
- Differential Effects of Polymorphic Alleles of FGF Receptor 4 on Colon Cancer Growth and Metastasis
- (2012) C. Heinzle et al. CANCER RESEARCH
- The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control
- (2012) Dimitri J. Pournaras et al. ENDOCRINOLOGY
- Fibroblast Growth Factor-19 Action in the Brain Reduces Food Intake and Body Weight and Improves Glucose Tolerance in Male Rats
- (2012) Karen K. Ryan et al. ENDOCRINOLOGY
- Conversion of a Paracrine Fibroblast Growth Factor into an Endocrine Fibroblast Growth Factor
- (2012) Regina Goetz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dual actions of fibroblast growth factor 19 on lipid metabolism
- (2012) Xinle Wu et al. JOURNAL OF LIPID RESEARCH
- Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19
- (2012) Masaaki Miyata et al. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models
- (2012) Dorothy M. French et al. PLoS One
- Regulation of Amphiregulin Gene Expression by β-Catenin Signaling in Human Hepatocellular Carcinoma Cells: A Novel Crosstalk between FGF19 and the EGFR System
- (2012) Maria U. Latasa et al. PLoS One
- Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor -Klotho
- (2012) T. Fu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antibody-Mediated Inhibition of Fibroblast Growth Factor 19 Results in Increased Bile Acids Synthesis and Ileal Malabsorption of Bile Acids in Cynomolgus Monkeys
- (2012) Rama Pai et al. TOXICOLOGICAL SCIENCES
- Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family
- (2011) Wilber Romero-Fernandez et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Identification of a Therapeutic Strategy Targeting Amplified FGF19 in Liver Cancer by Oncogenomic Screening
- (2011) Eric T. Sawey et al. CANCER CELL
- FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway
- (2011) Matthew J. Potthoff et al. Cell Metabolism
- Alterations of Hormonally Active Fibroblast Growth Factors after Roux-en-Y Gastric Bypass Surgery
- (2011) Peter L.M. Jansen et al. DIGESTIVE DISEASES
- Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes
- (2011) Elaine Studer et al. HEPATOLOGY
- The human gallbladder secretes fibroblast growth factor 19 into bile: Towards defining the role of fibroblast growth factor 19 in the enterobiliary tract
- (2011) Serge J.L.B. Zweers et al. HEPATOLOGY
- Fibroblast Growth Factor 21 Induces Glucose Transporter-1 Expression through Activation of the Serum Response Factor/Ets-Like Protein-1 in Adipocytes
- (2011) Xuan Ge et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
- (2011) S. Kir et al. SCIENCE
- Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse
- (2010) Klementina Fon Tacer et al. MOLECULAR ENDOCRINOLOGY
- Carbon monoxide enhance colonic epithelial restitution via FGF15 derived from colonic myofibroblasts
- (2009) Kazuhiko Uchiyama et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation
- (2009) J. Miao et al. GENES & DEVELOPMENT
- Cold-Activated Brown Adipose Tissue in Healthy Men
- (2009) Wouter D. van Marken Lichtenbelt et al. NEW ENGLAND JOURNAL OF MEDICINE
- Inhibition of Fibroblast Growth Factor 19 Reduces Tumor Growth by Modulating -Catenin Signaling
- (2008) R. Pai et al. CANCER RESEARCH
- Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7α-hydroxylase gene expression
- (2008) Kwang-Hoon Song et al. HEPATOLOGY
- C-terminal Tail of FGF19 Determines Its Specificity toward Klotho Co-receptors
- (2008) Xinle Wu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2
- (2008) Hitoshi Ikeda et al. JOURNAL OF LIPID RESEARCH
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