FGF19 and FGFR4 promotes the progression of gallbladder carcinoma in an autocrine pathway dependent on GPBAR1-cAMP-EGR1 axis

Enhanced autocrine FGF19/FGFR4 signaling drives the progression of lung squamous cell carcinoma, which responds to mTOR inhibitor AZD2104

(2020) Fan Li et al.   ONCOGENE

Structural basis of GPBAR activation and bile acid recognition

(2020) Fan Yang et al.   NATURE

Annexin10 promotes extrahepatic cholangiocarcinoma metastasis by facilitating EMT via PLA2G4A/PGE2/STAT3 pathway

(2019) Rongqi Sun et al.   EBioMedicine

Sprouty4 correlates with favorable prognosis in perihilar cholangiocarcinoma by blocking the FGFR-ERK signaling pathway and arresting the cell cycle

(2019) Bo Qiu et al.   EBioMedicine

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(2018) Jianing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

HMGB1 correlates with angiogenesis and poor prognosis of perihilar cholangiocarcinoma via elevating VEGFR2 of vessel endothelium

(2018) Yun-Fei Xu et al.   ONCOGENE

FGF19 amplification reveals an oncogenic dependency upon autocrine FGF19/FGFR4 signaling in head and neck squamous cell carcinoma

(2018) Lixia Gao et al.   ONCOGENE

Gastrointestinal Complications of Obesity

(2017) Michael Camilleri et al.   GASTROENTEROLOGY

Limited Use of Adjuvant Therapy in Patients With Resected Gallbladder Cancer Despite a Strong Association With Survival

(2017) Timur Mitin et al.   JNCI-Journal of the National Cancer Institute

Common genetic variation and risk of gallbladder cancer in India: a case-control genome-wide association study

(2017) Sharayu Mhatre et al.   LANCET ONCOLOGY

New Horizons for Precision Medicine in Biliary Tract Cancers

(2017) Juan W. Valle et al.   Cancer Discovery

Limited Use of Adjuvant Therapy in Patients With Resected Gallbladder Cancer Despite a Strong Association With Survival

(2017) Timur Mitin et al.   JNCI-Journal of the National Cancer Institute

Biliary cancer: Utility of next-generation sequencing for clinical management

(2016) Milind Javle et al.   CANCER

Postprandial Plasma Concentrations of Individual Bile Acids and FGF-19 in Patients With Type 2 Diabetes

(2016) David P. Sonne et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Polyclonal SecondaryFGFR2Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion–Positive Cholangiocarcinoma

(2016) Lipika Goyal et al.   Cancer Discovery

Sprouty2 correlates with favorable prognosis of gastric adenocarcinoma via suppressing FGFR2-induced ERK phosphorylation and cancer progression

(2016) Yunfei Xu et al.   Oncotarget

Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival

(2016) Kai Hung Tiong et al.   Oncotarget

Gallbladder Cancer Incidence and Mortality, United States 1999-2011

(2015) S. J. Henley et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Genomic spectra of biliary tract cancer

(2015) Hiromi Nakamura et al.   NATURE GENETICS

First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway

(2015) M. Hagel et al.   Cancer Discovery

Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies

(2015) K. K. Tsilidis et al.   BMJ-British Medical Journal

Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies

(2015) K. K. Tsilidis et al.   BMJ-British Medical Journal

Fibroblast growth factor receptor 4 promotes progression and correlates to poor prognosis in cholangiocarcinoma

(2014) Yun-Fei Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19

(2014) M. Zhou et al.   CANCER RESEARCH

Regulation of bile acid homeostasis by the intestinal Diet1–FGF15/19 axis

(2014) Karen Reue et al.   CURRENT OPINION IN LIPIDOLOGY

Is Fibroblast Growth Factor Receptor 4 a Suitable Target of Cancer Therapy?

(2014) Christine Heinzle et al.   CURRENT PHARMACEUTICAL DESIGN

Fibroblast Growth Factor Receptor 4 (FGFR4) Deficiency Improves Insulin Resistance and Glucose Metabolism under Diet-induced Obesity Conditions

(2014) Hongfei Ge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Whole-exome and targeted gene sequencing of gallbladder carcinoma identifies recurrent mutations in the ErbB pathway

(2014) Maolan Li et al.   NATURE GENETICS

Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors

(2013) R. Dienstmann et al.   ANNALS OF ONCOLOGY

TGR5 in cholangiocytes

(2013) Verena Keitel et al.   CURRENT OPINION IN GASTROENTEROLOGY

FGF Receptors: Cancer Biology and Therapeutics

(2013) Masaru Katoh et al.   MEDICINAL RESEARCH REVIEWS

Identification of Targetable FGFR Gene Fusions in Diverse Cancers

(2013) Yi-Mi Wu et al.   Cancer Discovery

Fibroblast growth factor receptor 4 regulates proliferation and antiapoptosis during gastric cancer progression

(2011) Yan Wei Ye et al.   CANCER

Therapeutic utilities of fibroblast growth factor 19

(2011) Xinle Wu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The human gallbladder secretes fibroblast growth factor 19 into bile: Towards defining the role of fibroblast growth factor 19 in the enterobiliary tract

(2011) Serge J.L.B. Zweers et al.   HEPATOLOGY

Fibroblast Growth Factor Receptor 4 Regulates Tumor Invasion by Coupling Fibroblast Growth Factor Signaling to Extracellular Matrix Degradation

(2010) N. Sugiyama et al.   CANCER RESEARCH

Diabetes and Cancer: A consensus report

(2010) E. Giovannucci et al.   DIABETES CARE

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7α-hydroxylase gene expression

(2008) Kwang-Hoon Song et al.   HEPATOLOGY

High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis

(2008) Frank G. Schaap et al.   HEPATOLOGY