An FGF15/19-TFEB regulatory loop controls hepatic cholesterol and bile acid homeostasis

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

(2020) Sangwon Byun et al.   Nature Communications

Hepatocyte Sortilin 1 knockout and treatment with a Sortilin 1 inhibitor reduced plasma cholesterol in Western diet-fed mice

(2019) Cheng Chen et al.   JOURNAL OF LIPID RESEARCH

Safety, tolerability and pharmacodynamics of apical sodium-dependent bile acid transporter inhibition with volixibat in healthy adults and patients with type 2 diabetes mellitus: a randomised placebo-controlled trial

(2018) Renger G. Tiessen et al.   BMC GASTROENTEROLOGY

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1

(2018) Daniel J. Drucker   Cell Metabolism

Impaired TFEB-mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-induced Liver Injury and Steatosis in Mice

(2018) Xiaojuan Chao et al.   GASTROENTEROLOGY

NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial

(2018) Stephen A Harrison et al.   LANCET

Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

(2018) Sangwon Byun et al.   Nature Communications

Targeting FXR and FGF19 to Treat Metabolic Diseases—Lessons Learned From Bariatric Surgery

(2018) Nadejda Bozadjieva et al.   DIABETES

Fibroblast Growth Factor 15/19 – From Basic Functions to Therapeutic Perspectives

(2018) Emmanuel Somm et al.   ENDOCRINE REVIEWS

Ileal Bile Acid Transporter Inhibition for the Treatment of Chronic Constipation, Cholestatic Pruritus, and NASH

(2018) Samer Al-Dury et al.   Frontiers in Pharmacology

Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice

(2017) Jibiao Li et al.   TOXICOLOGICAL SCIENCES

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis

(2017) Ismail Sergin et al.   Nature Communications

A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition

(2016) Ju-Xian Song et al.   Autophagy

Glucose and lipid effects of the ileal apical sodium-dependent bile acid transporter inhibitor GSK2330672: double-blind randomized trials with type 2 diabetes subjects taking metformin

(2016) D. J. Nunez et al.   DIABETES OBESITY & METABOLISM

Reduced lysosomal acid lipase activity – A potential role in the pathogenesis of non alcoholic fatty liver disease in pediatric patients

(2016) Praveen Kumar Conjeevaram Selvakumar et al.   DIGESTIVE AND LIVER DISEASE

Mechanistic target of rapamycin complex 1 is an essential mediator of metabolic and mitogenic effects of fibroblast growth factor 19 in hepatoma cells

(2016) Zhi Yi Wan et al.   HEPATOLOGY

Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1

(2016) Jibiao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TFEB at a glance

(2016) Gennaro Napolitano et al.   JOURNAL OF CELL SCIENCE

Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet–fed mice

(2016) Anuradha Rao et al.   Science Translational Medicine

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

(2016) Heidi Martini-Stoica et al.   TRENDS IN NEUROSCIENCES

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

The MITF family of transcription factors: Role in endolysosomal biogenesis, Wnt signaling, and oncogenesis

(2015) Diego Ploper et al.   PHARMACOLOGICAL RESEARCH

Reduced Lysosomal Acid Lipase Activity in Adult Patients With Non-alcoholic Fatty Liver Disease

(2015) Francesco Baratta et al.   EBioMedicine

Deciphering the Developmental Dynamics of the Mouse Liver Transcriptome

(2015) Sumedha S. Gunewardena et al.   PLoS One

Lysosomal acid lipase deficiency – An under-recognized cause of dyslipidaemia and liver dysfunction

(2014) Željko Reiner et al.   ATHEROSCLEROSIS

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver-Specific Cholesteryl Ester Hydrolase Deficiency Attenuates Sterol Elimination in the Feces and Increases Atherosclerosis in Ldlr −/− Mice

(2013) Jinghua Bie et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist

(2013) Sama I. Sayin et al.   Cell Metabolism

Discovery of a Highly Potent, Nonabsorbable Apical Sodium-Dependent Bile Acid Transporter Inhibitor (GSK2330672) for Treatment of Type 2 Diabetes

(2013) Yulin Wu et al.   JOURNAL OF MEDICINAL CHEMISTRY

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice

(2012) Bo Kong et al.   HEPATOLOGY

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Inhibition of apical sodium-dependent bile acid transporter as a novel treatment for diabetes

(2011) Lihong Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway

(2011) Matthew J. Potthoff et al.   Cell Metabolism

Glucose and Insulin Induction of Bile Acid Synthesis

(2011) Tiangang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis

(2011) S. Kir et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Transgenic expression of cholesterol 7α-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice

(2010) Tiangang Li et al.   HEPATOLOGY

Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis

(2010) Tiangang Li et al.   HEPATOLOGY

Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation

(2009) J. Miao et al.   GENES & DEVELOPMENT

Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH

(2009) Francisco Caballero et al.   JOURNAL OF HEPATOLOGY

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Lipotoxicity in nonalcoholic fatty liver disease: not all lipids are created equal

(2009) Naim Alkhouri et al.   Expert Review of Gastroenterology & Hepatology

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7α-hydroxylase gene expression

(2008) Kwang-Hoon Song et al.   HEPATOLOGY

Hepatic overexpression of cholesteryl ester hydrolase enhances cholesterol elimination and in vivo reverse cholesterol transport

(2008) Bin Zhao et al.   JOURNAL OF LIPID RESEARCH