The druggability of intracellular nucleotide-degrading enzymes

Characterization of human disease phenotypes associated with mutations inTREX1,RNASEH2A,RNASEH2B,RNASEH2C,SAMHD1,ADAR, andIFIH1

(2015) Yanick J. Crow et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Determination of the enzymatic activity of cytosolic 5′-nucleotidase cN-II in cancer cells: development of a simple analytical method and related cell line models

(2015) Lars Petter Jordheim et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The purine analog fludarabine acts as a cytosolic 5′-nucleotidase II inhibitor

(2015) F. Cividini et al.   BIOCHEMICAL PHARMACOLOGY

Susceptibility to 6-MP toxicity conferred by aNUDT15variant in Japanese children with acute lymphoblastic leukaemia

(2015) Yoichi Tanaka et al.   BRITISH JOURNAL OF HAEMATOLOGY

Cell proliferation and drug sensitivity of human glioblastoma cells are altered by the stable modulation of cytosolic 5′-nucleotidase II

(2015) F. Cividini et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase

(2015) Elisa Franzolin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592

(2015) Chenxiang Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CyclinA2-Cyclin-dependent Kinase Regulates SAMHD1 Protein Phosphohydrolase Domain

(2015) Junpeng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

InheritedNUDT15Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia

(2015) Jun J. Yang et al.   JOURNAL OF CLINICAL ONCOLOGY

SAMHD1 is a single-stranded nucleic acid binding protein with no active site-associated nuclease activity

(2015) Kyle J. Seamon et al.   NUCLEIC ACIDS RESEARCH

SAMHD1 specifically restricts retroviruses through its RNase activity

(2015) Jongsu Choi et al.   Retrovirology

Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation

(2015) F-f Song et al.   Oncogenesis

CD39: A complementary target to immune checkpoints to counteract tumor-mediated immunosuppression

(2015) Nathalie Bonnefoy et al.   OncoImmunology

Cytosolic 5’-Nucleotidase II Interacts with the Leucin Rich Repeat of NLR Family Member Ipaf

(2015) Federico Cividini et al.   PLoS One

Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

(2015) Lionel Trésaugues et al.   PLoS One

Cancer phenotypic lethality, exemplified by the non-essential MTH1 enzyme being required for cancer survival

(2014) T. Helleday   ANNALS OF ONCOLOGY

SAMHD1 is down regulated in lung cancer by methylation and inhibits tumor cell proliferation

(2014) Jia-lei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells

(2014) Cristina E. Requena et al.   BIOCHEMICAL JOURNAL

Cancer therapy

(2014) Veronique AJ Smits et al.   CELL CYCLE

6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: Synthesis, structural studies and cytotoxic activities

(2014) Claire Amiable et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure–activity relationships of β-hydroxyphosphonate nucleoside analogues as cytosolic 5′-nucleotidase II potential inhibitors: Synthesis, in vitro evaluation and molecular modeling studies

(2014) Maïa Meurillon et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Role of cytidine deaminase in toxicity and efficacy of nucleosidic analogs

(2014) Cindy Serdjebi et al.   Expert Opinion on Drug Metabolism & Toxicology

Allosteric Regulation of the Human and Mouse Deoxyribonucleotide Triphosphohydrolase Sterile α-Motif/Histidine-Aspartate Domain-containing Protein 1 (SAMHD1)

(2014) Cristina Miazzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Cycle Control and HIV-1 Susceptibility Are Linked by CDK6-Dependent CDK2 Phosphorylation of SAMHD1 in Myeloid and Lymphoid Cells

(2014) Eduardo Pauls et al.   JOURNAL OF IMMUNOLOGY

Small Molecule Inhibition of SAMHD1 dNTPase by Tetramer Destabilization

(2014) Kyle J. Seamon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

(2014) Kilian V. M. Huber et al.   NATURE

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

(2014) Helge Gad et al.   NATURE

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

(2014) Suk-Kyun Yang et al.   NATURE GENETICS

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

(2014) Jeongmin Ryoo et al.   NATURE MEDICINE

Standing the test of time: targeting thymidylate biosynthesis in cancer therapy

(2014) Peter M. Wilson et al.   Nature Reviews Clinical Oncology

MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways

(2014) A Patel et al.   ONCOGENE

Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies

(2014) Y Aye et al.   ONCOGENE

Targeting Cancer-Derived Adenosine:New Therapeutic Approaches

(2014) A. Young et al.   Cancer Discovery

Structure of the oncoprotein Rcl bound to three nucleotide analogues

(2013) André Padilla et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

An Organometallic Inhibitor for the Human Repair Enzyme 7,8-Dihydro-8-oxoguanosine Triphosphatase

(2013) Manuel Streib et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

SAMHD1 is mutated recurrently in chronic lymphocytic leukemia and is involved in response to DNA damage

(2013) R. Clifford et al.   BLOOD

The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation

(2013) Tommy E. White et al.   Cell Host & Microbe

Therapeutic Perspectives for cN-II in Cancer.

(2013) Lars Jordheim et al.   CURRENT MEDICINAL CHEMISTRY

The Functional Logic of Cytosolic 5’-Nucleotidases.

(2013) P. Ipata et al.   CURRENT MEDICINAL CHEMISTRY

On the Physiological Role of Cytosolic 5’-nucleotidase II (cN-II): Pathological and Therapeutical Implications.

(2013) M. Tozzi et al.   CURRENT MEDICINAL CHEMISTRY

SAMHD1-dependent retroviral control and escape in mice

(2013) Jan Rehwinkel et al.   EMBO JOURNAL

dCTP pyrophosphohydrase exhibits nucleic accumulation in multiple carcinomas

(2013) Y. Zhang et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

GTP Is the Primary Activator of the Anti-HIV Restriction Factor SAMHD1

(2013) Sarah M. Amie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

(2013) Junpeng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction

(2013) Natalia Beloglazova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-HIV Host Factor SAMHD1 Regulates Viral Sensitivity to Nucleoside Reverse Transcriptase Inhibitors via Modulation of Cellular Deoxyribonucleoside Triphosphate (dNTP) Levels

(2013) Sarah M. Amie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-stranded nucleic acids promote SAMHD1 complex formation

(2013) Victoria Tüngler et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Restriction of Virus Infection but Not Catalytic dNTPase Activity Is Regulated by Phosphorylation of SAMHD1

(2013) S. Welbourn et al.   JOURNAL OF VIROLOGY

Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia

(2013) Julia A Meyer et al.   NATURE GENETICS

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL

(2013) Gannie Tzoneva et al.   NATURE MEDICINE

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanism of allosteric activation of SAMHD1 by dGTP

(2013) Xiaoyun Ji et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Expression of Bovine Cytosolic 5′-Nucleotidase (cN-II) in Yeast: Nucleotide Pools Disturbance and Its Consequences on Growth and Homologous Recombination

(2013) Simone Allegrini et al.   PLoS One

N6-Substituted AMPs Inhibit Mammalian Deoxynucleotide N-Hydrolase DNPH1

(2013) Claire Amiable et al.   PLoS One

The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells

(2013) E. Franzolin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus

(2012) Yukari Koga et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Identification and characterization of inhibitors of cytoplasmic 5′-nucleotidase cN-II issued from virtual screening

(2012) Lars Petter Jordheim et al.   BIOCHEMICAL PHARMACOLOGY

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations

(2012) Adriana Goncalves et al.   HUMAN MUTATION

Human MTH3 (NUDT18) Protein Hydrolyzes Oxidized Forms of Guanosine and Deoxyguanosine Diphosphates

(2012) Yasumitsu Takagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

ENTPD1/CD39 is a promising therapeutic target in oncology

(2012) J Bastid et al.   ONCOGENE

Identification and characterization of naturally occurring splice variants of SAMHD1

(2012) Sarah Welbourn et al.   Retrovirology

CD73: a potent suppressor of antitumor immune responses

(2012) Paul. A. Beavis et al.   TRENDS IN IMMUNOLOGY

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Triptolide Directly Inhibits dCTP Pyrophosphatase

(2011) Timothy W. Corson et al.   CHEMBIOCHEM

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex

(2011) Linda M. Svensson et al.   FEBS LETTERS

Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein

(2011) R. Ito et al.   JOURNAL OF BIOCHEMISTRY

Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

(2011) Rebecca D. Powell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Allosteric Regulation and Substrate Recognition of Human Cytosolic 5′-Nucleotidase II

(2011) Karin Walldén et al.   JOURNAL OF MOLECULAR BIOLOGY

Lowered Nudix type 5 (NUDT5) expression leads to cell cycle retardation in HeLa cells

(2011) Li-Qun Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Diverse substrate recognition and hydrolysis mechanisms of human NUDT5

(2011) Takao Arimori et al.   NUCLEIC ACIDS RESEARCH

MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1

(2011) William CS Cho et al.   RNA Biology

Structural Insights into the Inhibition of Cytosolic 5′-Nucleotidase II (cN-II) by Ribonucleoside 5′-Monophosphate Analogues

(2011) Franck Gallier et al.   PLoS Computational Biology

CD73: A Novel Target for Cancer Immunotherapy

(2010) B. Zhang   CANCER RESEARCH

Suppression of mutagenesis by 8-hydroxy-2′-deoxyguanosine 5′-triphosphate (7,8-dihydro-8-oxo-2′-deoxyguanosine 5′-triphosphate) by human MTH1, MTH2, and NUDT5

(2010) Mika Hori et al.   FREE RADICAL BIOLOGY AND MEDICINE

Forodesine: review of preclinical and clinical data

(2010) Aref Al-Kali et al.   Future Oncology

Probing the Active Site of the DeoxynucleotideN-Hydrolase Rcl Encoded by the Rat Gene c6orf108

(2010) Christelle Dupouy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NUDT16 is a (deoxy)inosine diphosphatase, and its deficiency induces accumulation of single-strand breaks in nuclear DNA and growth arrest

(2010) Teruaki Iyama et al.   NUCLEIC ACIDS RESEARCH

NUDT16 and ITPA play a dual protective role in maintaining chromosome stability and cell growth by eliminating dIDP/IDP and dITP/ITP from nucleotide pools in mammals

(2010) Nona Abolhassani et al.   NUCLEIC ACIDS RESEARCH

Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools

(2010) D. Kumar et al.   NUCLEIC ACIDS RESEARCH

Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence

(2010) P Rai et al.   ONCOGENE

Extracellular adenosine triphosphate and adenosine in cancer

(2010) J Stagg et al.   ONCOGENE

NUDT5 hydrolyzes oxidized deoxyribonucleoside diphosphates with broad substrate specificity

(2009) Hiroyuki Kamiya et al.   DNA REPAIR

Aging and defense against generation of 8-oxo-7,8-dihydro-2′-deoxyguanosine in DNA

(2009) Lone Mikkelsen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural Characterization of the Mammalian Deoxynucleotide N-Hydrolase Rcl and Its Stabilizing Interactions with Two Inhibitors

(2009) Yinshan Yang et al.   JOURNAL OF MOLECULAR BIOLOGY

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

Knockdown of cytosolic 5′-nucleotidase II (cN-II) reveals that its activity is essential for survival in astrocytoma cells

(2008) Maria Giovanna Careddu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Gemcitabine and Cytosine Arabinoside Cytotoxicity: Association with Lymphoblastoid Cell Expression

(2008) L. Li et al.   CANCER RESEARCH

Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors

(2008) Sook Shin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Molecular Mechanism of ADP-Ribose Hydrolysis By Human NUDT5 From Structural and Kinetic Studies

(2008) Manwu Zha et al.   JOURNAL OF MOLECULAR BIOLOGY

Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death

(2007) Junji Ichikawa et al.   DNA REPAIR