MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Prolonged lifespan with enhanced exploratory behavior in mice overexpressing the oxidized nucleoside triphosphatase hMTH1

(2013) Gabriele De Luca et al.   AGING CELL

Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair

(2013) Peter German et al.   DNA REPAIR

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Substrate ambiguity among the nudix hydrolases: biologically significant, evolutionary remnant, or both?

(2012) Alexander G. McLennan   CELLULAR AND MOLECULAR LIFE SCIENCES

Redox Control of the Survival of Healthy and Diseased Cells

(2011) Yuxing Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Crystal structure of human MTH1 and the 8-oxo-dGMP product complex

(2011) Linda M. Svensson et al.   FEBS LETTERS

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence

(2010) P Rai et al.   ONCOGENE

ATM Activation by Oxidative Stress

(2010) Z. Guo et al.   SCIENCE

Redox Regulation of DNA Repair: Implications for Human Health and Cancer Therapeutic Development

(2009) Meihua Luo et al.   ANTIOXIDANTS & REDOX SIGNALING

Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence

(2009) P. Rai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs

(2008) Sugako Oka et al.   EMBO JOURNAL

Validation of a Rapid Equilibrium Dialysis Approach for the Measurement of Plasma Protein Binding

(2008) Nigel J. Waters et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats

(2008) M. J. Herold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for Oxidized DNA Precursors in Huntington's Disease–Like Striatal Neurodegeneration

(2008) Gabriele De Luca et al.   PLoS Genetics

Oxidation of mitochondrial deoxynucleotide pools by exposure to sodium nitroprusside induces cell death

(2007) Junji Ichikawa et al.   DNA REPAIR