Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein fromEnterococcus faecalisand Crystal Structure of the Activator-Substrate Complex

(2011) Ivan I. Vorontsov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dominant Mutations of the TREX1 Exonuclease Gene in Lupus and Aicardi-Goutières Syndrome

(2011) Jason M. Fye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Consequences of the RNase H2A Subunit Mutations That Cause Aicardi-Goutières Syndrome

(2011) Stephanie R. Coffin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TREX1 Exonuclease R114H Mutation in Aicardi-Goutières Syndrome and Lupus Reveals Dimeric Structure Requirements for DNA Degradation Activity

(2011) Clinton D. Orebaugh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Gaining a foothold: how HIV avoids innate immune recognition

(2010) Nan Yan et al.   CURRENT OPINION IN IMMUNOLOGY

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1

(2010) Nan Yan et al.   NATURE IMMUNOLOGY

Limelight on two HIV/SIV accessory proteins in macrophage infection: Is Vpx overshadowing Vpr?

(2010) Diana Ayinde et al.   Retrovirology

A Cellular Restriction Dictates the Permissivity of Nondividing Monocytes/Macrophages to Lentivirus and Gammaretrovirus Infection

(2009) Rajnish Kaushik et al.   Cell Host & Microbe

Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity

(2009) Y. J. Crow et al.   HUMAN MOLECULAR GENETICS

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

Accessories to the crime: Recent advances in HIV accessory protein biology

(2009) Thomas Gramberg et al.   Current HIV/AIDS Reports

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

HIV-1 Accessory Proteins—Ensuring Viral Survival in a Hostile Environment

(2008) Michael H. Malim et al.   Cell Host & Microbe

The TREX1 Double-stranded DNA Degradation Activity Is Defective in Dominant Mutations Associated with Autoimmune Disease

(2008) Duane A. Lehtinen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNaseH2 mutants that cause Aicardi–Goutieres syndrome are active nucleases

(2008) Fred W. Perrino et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Characterization of Simian Immunodeficiency Virus SIVSM/Human Immunodeficiency Virus Type 2 Vpx Function in Human Myeloid Cells

(2008) C. Goujon et al.   JOURNAL OF VIROLOGY

Dendritic cell-derived interferon-γ-induced protein mediates tumor necrosis factor-α stimulation of human lung fibroblasts

(2008) Wupeng Liao et al.   PROTEOMICS

Inhibition of G1P3 expression found in the differential display study on respiratory syncytial virus infection

(2008) Dong-chi Zhao et al.   Virology Journal