Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies

Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion

(2016) Sudha Mannava et al.   Aging-US

Fludarabine phosphate for the first-line treatment of chronic lymphocytic leukaemia

(2014) S Walker et al.   HEALTH TECHNOLOGY ASSESSMENT

Response to First-Line Chemotherapy in Patients with Non-Small Cell Lung Cancer According to RRM1 Expression

(2014) Xiaopeng Dong et al.   PLoS One

Reversible, Long-Range Radical Transfer in E. coli Class Ia Ribonucleotide Reductase

(2013) Ellen C. Minnihan et al.   ACCOUNTS OF CHEMICAL RESEARCH

Uncoupling of Allosteric and Oligomeric Regulation in a Functional Hybrid Enzyme Constructed from Escherichia coli and Human Ribonucleotide Reductase

(2013) Yuan Fu et al.   BIOCHEMISTRY

Gene aberrations of RRM1 and RRM2B and outcome of advanced breast cancer after treatment with docetaxel with or without gemcitabine

(2013) Charlotte LT Jørgensen et al.   BMC CANCER

Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer

(2013) Katherine M Aird et al.   CELL CYCLE

A 12-Gene Set Predicts Survival Benefits from Adjuvant Chemotherapy in Non-Small Cell Lung Cancer Patients

(2013) H. Tang et al.   CLINICAL CANCER RESEARCH

Ribonucleotide Reductase Association with Mammalian Liver Mitochondria

(2013) Korakod Chimploy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Hypermutability and error catastrophe due to defects in ribonucleotide reductase

(2013) D. Ahluwalia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence

(2013) Katherine M. Aird et al.   Cell Reports

Depletion of Deoxyribonucleotide Pools Is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence

(2012) Sudha Mannava et al.   AMERICAN JOURNAL OF PATHOLOGY

An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma

(2012) Sarah B. Fisher et al.   CANCER

Silencing of ribonucleotide reductase subunit M1 potentiates the antitumor activity of gemcitabine in resistant cancer cells

(2012) Piyanuch Wonganan et al.   CANCER BIOLOGY & THERAPY

Sensitizing Cancer Cells: Is It Really All about U?

(2012) Patrick J. Stover et al.   CANCER CELL

Tumor Cells Require Thymidylate Kinase to Prevent dUTP Incorporation during DNA Repair

(2012) Chun-Mei Hu et al.   CANCER CELL

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair

(2012) Vincenzo D'Angiolella et al.   CELL

A molecular view on signal transduction by the apoptosome

(2012) Thomas F. Reubold et al.   CELLULAR SIGNALLING

Clofarabine Targets the Large Subunit (α) of Human Ribonucleotide Reductase in Live Cells by Assembly into Persistent Hexamers

(2012) Yimon Aye et al.   CHEMISTRY & BIOLOGY

Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal cancers

(2012) Xiyong Liu et al.   CLINICAL SCIENCE

Mechanistic Studies of Semicarbazone Triapine Targeting Human Ribonucleotide Reductasein Vitroand in Mammalian Cells

(2012) Yimon Aye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine Hydroxymethyltransferase Anchorsde NovoThymidylate Synthesis Pathway to Nuclear Lamina for DNA Synthesis

(2012) Donald D. Anderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systemic delivery of siRNA nanoparticles targeting RRM2 suppresses head and neck tumor growth

(2012) Mohammad Aminur Rahman et al.   JOURNAL OF CONTROLLED RELEASE

p53R2 is a prognostic factor of melanoma and regulates proliferation and chemosensitivity of melanoma cells

(2012) Shigeto Matsushita et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells

(2012) G. Pontarin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging roles of the ribonucleotide reductase M2 in colorectal cancer and ultraviolet-induced DNA damage repair

(2012) Ai-Guo Lu   WORLD JOURNAL OF GASTROENTEROLOGY

Class I Ribonucleotide Reductases: Metallocofactor Assembly and Repair In Vitro and In Vivo

(2011) Joseph A. Cotruvo et al.   Annual Review of Biochemistry

Ribonucleotide Reductase Small Subunit M2B Prognoses Better Survival in Colorectal Cancer

(2011) X. Liu et al.   CANCER RESEARCH

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

DNA building blocks: keeping control of manufacture

(2011) Anders Hofer et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Association of RRM1 –37A>C polymorphism with clinical outcome in colorectal cancer patients treated with gemcitabine-based chemotherapy

(2011) J. Rodriguez et al.   EUROPEAN JOURNAL OF CANCER

Ribonucleotide reductase inhibition by metal complexes of Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone): A combined experimental and theoretical study

(2011) Ana Popović-Bijelić et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

RRM1 expression and clinical outcome of gemcitabine-containing chemotherapy for advanced non-small-cell lung cancer: A meta-analysis

(2011) Weiyi Gong et al.   LUNG CANCER

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization

(2011) James Wesley Fairman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit

(2011) Y. Aye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increase in dNTP pool size during the DNA damage response plays a key role in spontaneous and induced-mutagenesis in Escherichia coli

(2011) S. Gon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Staurosporine increases toxicity of gemcitabine in non-small cell lung cancer cells: role of protein kinase C, deoxycytidine kinase and ribonucleotide reductase

(2010) Jennifer Sigmond et al.   ANTI-CANCER DRUGS

Beyond hairy cell: the activity of cladribine in other hematologic malignancies

(2010) D. S. Sigal et al.   BLOOD

Break-induced ATR and Ddb1-Cul4Cdt2 ubiquitin ligase-dependent nucleotide synthesis promotes homologous recombination repair in fission yeast

(2010) J. Moss et al.   GENES & DEVELOPMENT

Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase

(2010) H. Niida et al.   GENES & DEVELOPMENT

Ribonucleotide reductase M2 subunit is a novel diagnostic marker and a potential therapeutic target in bladder cancer

(2010) Teppei Morikawa et al.   HISTOPATHOLOGY

Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro

(2010) Teppei Morikawa et al.   HUMAN PATHOLOGY

The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer

(2010) Lars Petter Jordheim et al.   LANCET ONCOLOGY

MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia

(2010) Manuela Ferracin et al.   Molecular Cancer

Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances

(2010) Chiara Rampazzo et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

siRNA delivery systems for cancer treatment

(2009) Yu-Kyoung Oh et al.   ADVANCED DRUG DELIVERY REVIEWS

A Heterozygous Truncating Mutation in RRM2B Causes Autosomal-Dominant Progressive External Ophthalmoplegia with Multiple mtDNA Deletions

(2009) Henna Tyynismaa et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Phase II study of 3-AP Triapine in patients with recurrent or metastatic head and neck squamous cell carcinoma

(2009) C. M. Nutting et al.   ANNALS OF ONCOLOGY

Thioredoxins and Glutaredoxins: Unifying Elements in Redox Biology

(2009) Yves Meyer et al.   Annual Review of Genetics

Mitochondrial Neurogastrointestinal Encephalopathy Due to Mutations in RRM2B

(2009) Aziz Shaibani et al.   ARCHIVES OF NEUROLOGY

Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase

(2009) Lijun Zhu et al.   BIOCHEMICAL PHARMACOLOGY

Expression of nucleoside transporters, deoxycitidine kinase, ribonucleotide reductase regulatory subunits, and gemcitabine catabolic enzymes in primary ovarian cancer

(2009) Gabriella Ferrandina et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Activity of ribonucleotide reductase helps determine how cells repair DNA double strand breaks

(2009) Martin D. Burkhalter et al.   DNA REPAIR

Implication of Checkpoint Kinase-dependent Up-regulation of Ribonucleotide Reductase R2 in DNA Damage Response

(2009) Yong-Wei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Randomized Phase III Trial of Gemcitabine-Based Chemotherapy With In Situ RRM1 and ERCC1 Protein Levels for Response Prediction in Non–Small-Cell Lung Cancer

(2009) Craig Reynolds et al.   JOURNAL OF CLINICAL ONCOLOGY

Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesis

(2009) Keqiang Zhang et al.   Molecular Cancer

A novel homozygous RRM2B missense mutation in association with severe mtDNA depletion

(2009) Gittan Kollberg et al.   NEUROMUSCULAR DISORDERS

Significance of RRM1 and ERCC1 expression in resectable pancreatic adenocarcinoma

(2009) H Akita et al.   ONCOGENE

Broad Overexpression of Ribonucleotide Reductase Genes in Mice Specifically Induces Lung Neoplasms

(2008) X. Xu et al.   CANCER RESEARCH

Nucleic Acids as Therapeutic Agents

(2008) Luis Alvarez-Salas   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae

(2008) Ewa T. Lis et al.   DNA REPAIR

Clinical Efficacy and Predictive Molecular Markers of Neoadjuvant Gemcitabine and Pemetrexed in Resectable Non-small Cell Lung Cancer

(2008) Gerold Bepler et al.   Journal of Thoracic Oncology

Drug delivery of siRNA therapeutics: potentials and limits of nanosystems

(2008) Daniela Reischl et al.   Nanomedicine-Nanotechnology Biology and Medicine

Replication fork movement sets chromatin loop size and origin choice in mammalian cells

(2008) Sylvain Courbet et al.   NATURE

Upregulation of the p53R2 ribonucleotide reductase subunit by nitric oxide

(2008) Olivier Guittet et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage

(2008) Nasim Sabouri et al.   NUCLEIC ACIDS RESEARCH

Ribonucleotide reductase small subunit p53R2 promotes oral cancer invasion via the E-cadherin/β-catenin pathway

(2008) Souichi Yanamoto et al.   ORAL ONCOLOGY

ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage

(2008) L. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage

(2008) G. Pontarin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA