Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction
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Title
Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 288, Issue 12, Pages 8101-8110
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2013-01-31
DOI
10.1074/jbc.m112.431148
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- Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase
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- (2011) David C. Goldstone et al. NATURE
- SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
- (2011) Nadine Laguette et al. NATURE
- Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
- (2011) Kasia Hrecka et al. NATURE
- The Intrinsic Antiviral Defense to Incoming HSV-1 Genomes Includes Specific DNA Repair Proteins and Is Counteracted by the Viral Protein ICP0
- (2011) Caroline E. Lilley et al. PLoS Pathogens
- SAMHD1-Deficient CD14+ Cells from Individuals with Aicardi-Goutières Syndrome Are Highly Susceptible to HIV-1 Infection
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- Genomes in Conflict: Maintaining Genome Integrity During Virus Infection
- (2010) Matthew D. Weitzman et al. Annual Review of Microbiology
- The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1
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- SAM as a protein interaction domain involved in developmental regulation
- (2010) Jörg Schultz et al. PROTEIN SCIENCE
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- (2009) Joseph M. Watts et al. NATURE
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