Mechanism of allosteric activation of SAMHD1 by dGTP

The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation

(2013) Tommy E. White et al.   Cell Host & Microbe

HIV-2 and SIVmac Accessory Virulence Factor Vpx Down-regulates SAMHD1 Enzyme Catalysis Prior to Proteasome-dependent Degradation

(2013) Maria DeLucia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetramerization of SAMHD1 Is Required for Biological Activity and Inhibition of HIV Infection

(2013) Junpeng Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction

(2013) Natalia Beloglazova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of SAMHD1 by Cyclin A2/CDK1 Regulates Its Restriction Activity toward HIV-1

(2013) Alexandra Cribier et al.   Cell Reports

SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations

(2012) Adriana Goncalves et al.   HUMAN MUTATION

Tight Interplay among SAMHD1 Protein Level, Cellular dNTP Levels, and HIV-1 Proviral DNA Synthesis Kinetics in Human Primary Monocyte-derived Macrophages

(2012) Baek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

SAMHD1 restricts HIV-1 infection in resting CD4+ T cells

(2012) Hanna-Mari Baldauf et al.   NATURE MEDICINE

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

(2012) Corine St Gelais et al.   Retrovirology

Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac

(2012) Alberto Brandariz-Nuñez et al.   Retrovirology

SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4+ T-cells

(2012) Benjamin Descours et al.   Retrovirology

Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1

(2012) Tommy E. White et al.   VIROLOGY

Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein fromEnterococcus faecalisand Crystal Structure of the Activator-Substrate Complex

(2011) Ivan I. Vorontsov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

(2011) Rebecca D. Powell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Homozygous mutation in SAMHD1 gene causes cerebral vasculopathy and early onset stroke

(2011) B. Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAMHD1-Deficient CD14+ Cells from Individuals with Aicardi-Goutières Syndrome Are Highly Susceptible to HIV-1 Infection

(2011) André Berger et al.   PLoS Pathogens

Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity

(2009) Y. J. Crow et al.   HUMAN MOLECULAR GENETICS

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

(2009) Gillian I Rice et al.   NATURE GENETICS

The neonatal form of Aicardi-Goutières syndrome masquerading as congenital infection

(2008) H. Jepps et al.   EARLY HUMAN DEVELOPMENT

Structural Insight into the Mechanism of Substrate Specificity and Catalytic Activity of an HD-Domain Phosphohydrolase: The 5′-Deoxyribonucleotidase YfbR from Escherichia coli

(2008) Matthew D. Zimmerman et al.   JOURNAL OF MOLECULAR BIOLOGY