GTP Is the Primary Activator of the Anti-HIV Restriction Factor SAMHD1
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Title
GTP Is the Primary Activator of the Anti-HIV Restriction Factor SAMHD1
Authors
Keywords
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Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 288, Issue 35, Pages 25001-25006
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2013-07-25
DOI
10.1074/jbc.c113.493619
References
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Note: Only part of the references are listed.- The Retroviral Restriction Ability of SAMHD1, but Not Its Deoxynucleotide Triphosphohydrolase Activity, Is Regulated by Phosphorylation
- (2013) Tommy E. White et al. Cell Host & Microbe
- Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction
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- Anti-HIV Host Factor SAMHD1 Regulates Viral Sensitivity to Nucleoside Reverse Transcriptase Inhibitors via Modulation of Cellular Deoxyribonucleoside Triphosphate (dNTP) Levels
- (2013) Sarah M. Amie et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells
- (2013) E. Franzolin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylation of SAMHD1 by Cyclin A2/CDK1 Regulates Its Restriction Activity toward HIV-1
- (2013) Alexandra Cribier et al. Cell Reports
- Tight Interplay among SAMHD1 Protein Level, Cellular dNTP Levels, and HIV-1 Proviral DNA Synthesis Kinetics in Human Primary Monocyte-derived Macrophages
- (2012) Baek Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
- (2012) Hichem Lahouassa et al. NATURE IMMUNOLOGY
- SAMHD1 restricts HIV-1 infection in resting CD4+ T cells
- (2012) Hanna-Mari Baldauf et al. NATURE MEDICINE
- SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons
- (2012) Corine St Gelais et al. Retrovirology
- Endonuclease substrate selectivity characterized with full-length PA of influenza A virus polymerase
- (2012) Erin Noble et al. VIROLOGY
- Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1
- (2012) Tommy E. White et al. VIROLOGY
- Structure and activity of theSaccharomyces cerevisiaedUTP pyrophosphatase DUT1, an essential housekeeping enzyme
- (2011) Anatoli Tchigvintsev et al. BIOCHEMICAL JOURNAL
- Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase
- (2011) Rebecca D. Powell et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
- (2011) David C. Goldstone et al. NATURE
- SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
- (2011) Nadine Laguette et al. NATURE
- Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
- (2011) Kasia Hrecka et al. NATURE
- Modifications to the dNTP triphosphate moiety: From mechanistic probes for DNA polymerases to antiviral and anti-cancer drug design
- (2010) Charles E. McKenna et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Ribonucleoside Triphosphates as Substrate of Human Immunodeficiency Virus Type 1 Reverse Transcriptase in Human Macrophages
- (2010) Edward M. Kennedy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nucleic acid-mediated inflammatory diseases
- (2008) Rachel E. Rigby et al. BIOESSAYS
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