Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA

(2020) Olivier G. de Jong et al.   Nature Communications

Where does the cargo go?: Solutions to provide experimental support for the “extracellular vesicle cargo transfer hypothesis”

(2020) Masaharu Somiya   Journal of Cell Communication and Signaling

Reduction of the therapeutic dose of silencing RNA by packaging it in extracellular vesicles via a pre-microRNA backbone

(2020) Ryan Reshke et al.   Nature Biomedical Engineering

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

(2020) Bhagyashree S. Joshi et al.   ACS Nano

Endocytosis: The Nanoparticle and Submicron Nanocompounds Gateway into the Cell

(2020) Darío Manzanares et al.   Pharmaceutics

Induction of lipid droplets in non-macrophage cells as well as macrophages by liposomes and exosomes

(2019) Kazuyo Fujita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Exosomal delivery of doxorubicin enables rapid cell entry and enhanced in vitro potency

(2019) Christina Schindler et al.   PLoS One

Content release of extracellular vesicles in a cell‐free extract

(2019) Emeline Bonsergent et al.   FEBS LETTERS

The biology of extracellular vesicles: The known unknowns

(2019) Leonid Margolis et al.   PLOS BIOLOGY

Glioblastoma-Associated Microglia Reprogramming Is Mediated by Functional Transfer of Extracellular miR-21

(2019) Erik R. Abels et al.   Cell Reports

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

(2019) Marco Maugeri et al.   Nature Communications

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics

(2018) Aaron D. Springer et al.   Nucleic Acid Therapeutics

Patisiran: First Global Approval

(2018) Sheridan M. Hoy   DRUGS

Comparison of exosome-mimicking liposomes with conventional liposomes for intracellular delivery of siRNA

(2018) Mei Lu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Overcoming cellular barriers for RNA therapeutics

(2017) Steven F Dowdy   NATURE BIOTECHNOLOGY

Extracellular vesicles for drug delivery

(2016) Pieter Vader et al.   ADVANCED DRUG DELIVERY REVIEWS

Exosome-shuttling microRNA-21 promotes cell migration and invasion-targeting PDCD4 in esophageal cancer

(2016) JUAN LIAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

(2016) Wolf Heusermann et al.   JOURNAL OF CELL BIOLOGY

Comparing exosome-like vesicles with liposomes for the functional cellular delivery of small RNAs

(2016) Stephan Stremersch et al.   JOURNAL OF CONTROLLED RELEASE

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions

(2016) F. Pucci et al.   SCIENCE

In Vivo Imaging Reveals Extracellular Vesicle-Mediated Phenocopying of Metastatic Behavior

(2015) Anoek Zomer et al.   CELL

Quantitative and stoichiometric analysis of the microRNA content of exosomes

(2014) J. R. Chevillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

Endocytosis of nanomedicines

(2010) Gaurav Sahay et al.   JOURNAL OF CONTROLLED RELEASE

Elimination Pathways of Systemically Delivered siRNA

(2010) Yuanyu Huang et al.   MOLECULAR THERAPY