Indoleamine 2,3-Dioxygenase and Dendritic Cell Tolerogenicity

Cutting Edge: Autocrine TGF-  Sustains Default Tolerogenesis by IDO-Competent Dendritic Cells

(2014) M. L. Belladonna et al.   JOURNAL OF IMMUNOLOGY

Selective CD28 Blockade Attenuates Acute and Chronic Rejection of Murine Cardiac Allografts in a CTLA-4-Dependent Manner

(2011) T. Zhang et al.   AMERICAN JOURNAL OF TRANSPLANTATION

IFN-  and indoleamine 2,3-dioxygenase signaling between donor dendritic cells and T cells regulates graft versus host and graft versus leukemia activity

(2011) Y. Lu et al.   BLOOD

Overactivation of plasmacytoid dendritic cells inhibits antiviral T-cell responses: a model for HIV immunopathogenesis

(2011) A. Boasso et al.   BLOOD

Molecular analysis of melanoma-induced sentinel lymph node immune dysfunction

(2011) Jonathan H. Lee et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Skin delivery of short hairpin RNA of indoleamine 2,3 dioxygenase induces antitumor immunity against orthotopic and metastatic liver cancer

(2011) Tzu-Ting Huang et al.   CANCER SCIENCE

The dendritic cell life cycle

(2011) Francesca Granucci et al.   CELL CYCLE

Plasmacytoid Dendritic Cells Protect Against Atherosclerosis by Tuning T-Cell Proliferation and Activity

(2011) Isabelle T.M.N. Daissormont et al.   CIRCULATION RESEARCH

The role of indoleamine 2, 3-dioxygenase in lepromatous leprosy immunosuppression

(2011) J. de Souza Sales et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Unified immune modulation by 4-1BB triggering leads to diverse effects on disease progression in vivo

(2011) Beom K. Choi et al.   CYTOKINE

A combination of the metabolic enzyme inhibitor APO866 and the immune adjuvant L-1-methyl tryptophan induces additive antitumor activity

(2011) Huei-Jiun Yang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Regulation of Homeostasis and Inflammation in the Intestine

(2011) Thomas T. MacDonald et al.   GASTROENTEROLOGY

FOXO3 programs tumor-associated DCs to become tolerogenic in human and murine prostate cancer

(2011) Stephanie K. Watkins et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunotherapy with Costimulatory Dendritic Cells To Control Autoimmune Inflammation

(2011) Brendan J. O’Sullivan et al.   JOURNAL OF IMMUNOLOGY

Dichotomous Effects of IFN-  on Dendritic Cell Function Determine the Extent of IL-12-Driven Antitumor T Cell Immunity

(2011) J. L. Harden et al.   JOURNAL OF IMMUNOLOGY

CD28 Expressed on Malignant Plasma Cells Induces a Prosurvival and Immunosuppressive Microenvironment

(2011) J. R. Nair et al.   JOURNAL OF IMMUNOLOGY

The Immunosuppressive Role of IL-32 in Lymphatic Tissue during HIV-1 Infection

(2011) A. J. Smith et al.   JOURNAL OF IMMUNOLOGY

Physiologic Control of IDO Competence in Splenic Dendritic Cells

(2011) B. Baban et al.   JOURNAL OF IMMUNOLOGY

IDO and Regulatory T Cell Support Are Critical for Cytotoxic T Lymphocyte-Associated Ag-4 Ig-Mediated Long-Term Solid Organ Allograft Survival

(2011) R. Sucher et al.   JOURNAL OF IMMUNOLOGY

IDO: more than an enzyme

(2011) WanJun Chen   NATURE IMMUNOLOGY

Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells

(2011) Maria T Pallotta et al.   NATURE IMMUNOLOGY

External influences on the immune system via activation of the aryl hydrocarbon receptor

(2011) Brigitta Stockinger et al.   SEMINARS IN IMMUNOLOGY

Dietary Ligands of the Aryl Hydrocarbon Receptor Induce Anti-Inflammatory and Immunoregulatory Effects on Murine Dendritic Cells

(2011) Jenna M. Benson et al.   TOXICOLOGICAL SCIENCES

Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity

(2010) X. Liu et al.   BLOOD

Indoleamine 2,3-Dioxygenase

(2010) Hatem Soliman et al.   CANCER JOURNAL

The aryl hydrocarbon receptor: fine-tuning the immune-response

(2010) Marc Veldhoen et al.   CURRENT OPINION IN IMMUNOLOGY

Lineage-specific transcription factors in unexpected places

(2010) David H. Munn   EUROPEAN JOURNAL OF IMMUNOLOGY

Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction

(2010) G. Matteoli et al.   GUT

High expression of IMPACT protein promotes resistance to indoleamine 2,3-dioxygenase-induced cell death

(2010) Darya Habibi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Absence of IDO Upregulates Type I IFN Production, Resulting in Suppression of Viral Replication in the Retrovirus-Infected Mouse

(2010) M. Hoshi et al.   JOURNAL OF IMMUNOLOGY

IDO Upregulates Regulatory T Cells via Tryptophan Catabolite and Suppresses Encephalitogenic T Cell Responses in Experimental Autoimmune Encephalomyelitis

(2010) Y. Yan et al.   JOURNAL OF IMMUNOLOGY

Human uterine epithelial cell secretions regulate dendritic cell differentiation and responses to TLR ligands

(2010) Daniel O. Ochiel et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human chorionic gonadotropin: A hormone with immunological and angiogenic properties

(2010) Marie Tsampalas et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

B-lymphoid cells with attributes of dendritic cells regulate T cells via indoleamine 2,3-dioxygenase

(2010) B. A. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aryl hydrocarbon receptor negatively regulates dendritic cell immunogenicity via a kynurenine-dependent mechanism

(2010) N. T. Nguyen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis

(2010) F. J. Quintana et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Consequences of AhR Activation in Steady-State Dendritic Cells

(2010) T. Simones et al.   TOXICOLOGICAL SCIENCES

A potential role for indoleamine 2,3-dioxygenase (IDO) in Rhodococcus equi infection

(2010) M.C. Heller et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells

(2009) D. J. Chung et al.   BLOOD

Indoleamine 2,3-dioxygenase controls conversion of Foxp3+ Tregs to TH17-like cells in tumor-draining lymph nodes

(2009) M. D. Sharma et al.   BLOOD

Interferon- -triggered indoleamine 2,3-dioxygenase competence in human monocyte-derived dendritic cells induces regulatory activity in allogeneic T cells

(2009) B. Jurgens et al.   BLOOD

Tumor-Infiltrating Regulatory Dendritic Cells Inhibit CD8+ T Cell Function via L-Arginine Metabolism

(2009) L. A. Norian et al.   CANCER RESEARCH

A Novel Cancer Therapy by Skin Delivery of Indoleamine 2,3-Dioxygenase siRNA

(2009) M.-C. Yen et al.   CLINICAL CANCER RESEARCH

Orchestration of the immune response by dendritic cells

(2009) Matthew R. Buckwalter et al.   CURRENT BIOLOGY

DC expressing transgene Foxp3 are regulatory APC

(2009) Michael W. Lipscomb et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Modulation of dendritic cell maturation and function with mono- and bifunctional small interfering RNAs targeting indoleamine 2,3-dioxygenase

(2009) Gro F. Flatekval et al.   IMMUNOLOGY

Constitutive Expression of IDO by Dendritic Cells of Mesenteric Lymph Nodes: Functional Involvement of the CTLA-4/B7 and CCL22/CCR4 Interactions

(2009) T. Onodera et al.   JOURNAL OF IMMUNOLOGY

Central Role of Tumor-Associated CD8+ T Effector/Memory Cells in Restoring Systemic Antitumor Immunity

(2009) M. O. Kilinc et al.   JOURNAL OF IMMUNOLOGY

Tryptophan Deprivation Induces Inhibitory Receptors ILT3 and ILT4 on Dendritic Cells Favoring the Induction of Human CD4+CD25+ Foxp3+ T Regulatory Cells

(2009) M. Brenk et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Negative Regulation of Dendritic Cells through Acetylation of the Nonhistone Protein STAT-3

(2009) Yaping Sun et al.   JOURNAL OF IMMUNOLOGY

IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

(2009) B. Baban et al.   JOURNAL OF IMMUNOLOGY

CTLA4Ig gene transfer alleviates abortion in mice by expanding CD4+CD25+ regulatory T cells and inducing indoleamine 2,3-dioxygenase

(2009) Weihong Li et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Dendritic cell subsets in primary and secondary T cell responses at body surfaces

(2009) William R Heath et al.   NATURE IMMUNOLOGY

TGF-β and kynurenines as the key to infectious tolerance

(2009) Maria L. Belladonna et al.   TRENDS IN MOLECULAR MEDICINE

Role of Dendritic Cells in the Regulation of Maternal Immune Responses to the Fetus During Mammalian Gestation

(2008) Ulrike Kammerer et al.   IMMUNOLOGICAL INVESTIGATIONS

The missing link between indoleamine 2,3-dioxygenase mediated antibacterial and immunoregulatory effects

(2008) Anika Müller et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chorionic gonadotropin induces dendritic cells to express a tolerogenic phenotype

(2008) H. Wan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2,3 dioxygenase

(2008) A. J. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skin cells, but not T cells, are resistant to indoleamine 2, 3-dioxygenase (IDO) expressed by allogeneic fibroblasts

(2008) Farshad Forouzandeh et al.   WOUND REPAIR AND REGENERATION