Natural Ligand-Mimetic and Nonmimetic Inhibitors of the Ceramide Transport Protein CERT

Mechanisms of nonvesicular lipid transport

(2021) Karin M. Reinisch et al.   JOURNAL OF CELL BIOLOGY

CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease

(2021) Simone M. Crivelli et al.   Alzheimers Research & Therapy

Mammalian lipids: structure, synthesis and function

(2021) Shamshad Cockcroft   Essays in Biochemistry

Trends in kinase drug discovery: targets, indications and inhibitor design

(2021) Misty M. Attwood et al.   NATURE REVIEWS DRUG DISCOVERY

Role of ceramide/sphingomyelin (SM) balance regulated through “SM cycle” in cancer

(2021) Makoto Taniguchi et al.   CELLULAR SIGNALLING

Imaging organelle membranes in live cells at the nanoscale with lipid-based fluorescent probes

(2021) N. Dadina et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Ceramide Transfer Protein (CERT): An Overlooked Molecular Player in Cancer

(2021) Long Hoa Chung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intellectual-disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution

(2021) Norito Tamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell surface sphingomyelin: key role in cancer initiation, progression, and immune evasion

(2021) Hatem Tallima et al.   Lipids in Health and Disease

Convergent evolution of bacterial ceramide synthesis

(2021) Gabriele Stankeviciute et al.   Nature Chemical Biology

PMP2/FABP8 induces PI(4,5)P2-dependent transbilayer reorganization of sphingomyelin in the plasma membrane

(2021) Mitsuhiro Abe et al.   Cell Reports

The role of ceramides in metabolic disorders: when size and localization matters

(2020) Sarah M. Turpin-Nolan et al.   Nature Reviews Endocrinology

Three‐Component, One‐Pot Tandem Sonogashira/Suzuki‐Miyaura Coupling Reactions for the Synthesis of a Library of Ceramide‐Transport Protein Inhibitors Designed In Silico

(2020) Masaharu Ueno et al.   Asian Journal of Organic Chemistry

Whole Lotta Lipids—From HCV RNA Replication to the Mature Viral Particle

(2020) Hanna Bley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tether Me, Tether Me Not—Dynamic Organelle Contact Sites in Metabolic Rewiring

(2020) Maria Bohnert   DEVELOPMENTAL CELL

A liposomal FRET assay identifies potent drug‐like inhibitors of the ceramide transport protein CERT

(2020) Doaa Samaha et al.   CHEMISTRY-A EUROPEAN JOURNAL

Five structural genes required for ceramide synthesis in Caulobacter and for bacterial survival

(2020) Roberto Jhonatan Olea‐Ozuna et al.   ENVIRONMENTAL MICROBIOLOGY

Sphingomyelin Is Essential for the Structure and Function of the Double-Membrane Vesicles in the Viral RNA Replication Factories

(2020) Hossam Gewaid et al.   JOURNAL OF VIROLOGY

Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT

(2020) Hiroaki Murakami et al.   PLoS One

Limonoids from Citrus: Chemistry, anti-tumor potential, and other bioactivities

(2020) Yu-Sheng Shi et al.   Journal of Functional Foods

Membrane Heterogeneity Beyond the Plasma Membrane

(2020) Hong-Yin Wang et al.   Frontiers in Cell and Developmental Biology

Identification of the Interactions Interference Between the PH and START Domain of CERT by Limonoid and HPA Inhibitors

(2020) Mariem Ghoula et al.   Frontiers in Molecular Biosciences

A perilous path: the inborn errors of sphingolipid metabolism

(2019) Teresa M. Dunn et al.   JOURNAL OF LIPID RESEARCH

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

(2019) Shashank Dadsena et al.   Nature Communications

CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity

(2019) Philipp Hammerschmidt et al.   CELL

Prostaglandin receptor agonists as antiglaucoma agents (a patent review 2013 – 2018)

(2019) Andrea Angeli et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Biology of Lipid Rafts: Introduction to Thematic Review Series

(2019) Dmitri Sviridov et al.   JOURNAL OF LIPID RESEARCH

Chlamydia trachomatis ‐infected human cells convert ceramide to sphingomyelin without sphingomyelin synthases 1 and 2

(2019) Yuriko Tachida et al.   FEBS LETTERS

Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions

(2018) Cécile L. Bandet et al.   DIABETES

Lipid-transfer proteins rectify inter-organelle flux and accurately deliver lipids at membrane contact sites

(2018) Kentaro Hanada   JOURNAL OF LIPID RESEARCH

Sphingolipid biosynthesis in man and microbes

(2018) Peter J. Harrison et al.   NATURAL PRODUCT REPORTS

Selective targeting of collagen IV in the cancer cell microenvironment reduces tumor burden

(2018) Fernando Revert et al.   Oncotarget

Both the N- and C- terminal regions of the Chlamydial inclusion protein D (IncD) are required for interaction with the pleckstrin homology domain of the ceramide transport protein CERT

(2018) Keigo Kumagai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of Fumonisin B1 Toxicity: A Computational Perspective beyond the Ceramide Synthases Inhibition

(2018) Luca Dellafiora et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Unicellular ancestry and mechanisms of diversification of Goodpasture antigen–binding protein

(2018) Carl Darris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes

(2018) Louise H. Wong et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

C16-ceramide is a natural regulatory ligand of p53 in cellular stress response

(2018) Baharan Fekry et al.   Nature Communications

Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications

(2017) Simone M. Crivelli et al.   JOURNAL OF ALZHEIMERS DISEASE

Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain

(2017) Jennifer Prashek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Both Sphingomyelin and Cholesterol in the Host Cell Membrane Are Essential for Rubella Virus Entry

(2017) Noriyuki Otsuki et al.   JOURNAL OF VIROLOGY

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

(2016) Sonia Hernández-Tiedra et al.   Autophagy

Asymmetric Synthesis and Binding Study of New Long-Chain HPA-12 Analogues as Potent Ligands of the Ceramide Transfer Protein CERT

(2016) Andrej Ďuriš et al.   CHEMISTRY-A EUROPEAN JOURNAL

Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP

(2015) Lucian Albulescu et al.   ANTIVIRAL RESEARCH

The CERT antagonist HPA-12: First practical synthesis and individual binding evaluation of the four stereoisomers

(2015) Cécile Santos et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Identification of Novel CERT Ligands as Potential Ceramide Trafficking Inhibitors

(2014) Cécile Santos et al.   CHEMBIOCHEM

Complement Activation by Ceramide Transporter Proteins

(2014) G. H. Bode et al.   JOURNAL OF IMMUNOLOGY

Phosphatidylinositol-4 kinase III beta and oxysterol-binding protein accumulate unesterified cholesterol on poliovirus-induced membrane structure

(2014) Minetaro Arita   MICROBIOLOGY AND IMMUNOLOGY

Large-scale discovery of novel genetic causes of developmental disorders

(2014) T. W. Fitzgerald et al.   NATURE

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

Ceramide Transfer Protein Deficiency Compromises Organelle Function and Leads to Senescence in Primary Cells

(2014) Raghavendra Pralhada Rao et al.   PLoS One

Glucolipotoxicity Impairs Ceramide Flow from the Endoplasmic Reticulum to the Golgi Apparatus in INS-1 β-Cells

(2014) Enida Gjoni et al.   PLoS One

Sphingolipid Metabolism and Interorganellar Transport: Localization of Sphingolipid Enzymes and Lipid Transfer Proteins

(2014) Toshiyuki Yamaji et al.   TRAFFIC

De Novo Mutations in Moderate or Severe Intellectual Disability

(2014) Fadi F. Hamdan et al.   PLoS Genetics

Co-evolution of sphingomyelin and the ceramide transport protein CERT

(2013) Kentaro Hanada   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

(2013) Bruno Mesmin et al.   CELL

Revised Stereochemistry of Ceramide-Trafficking Inhibitor HPA-12 by X-ray Crystallography Analysis

(2013) Masaharu Ueno et al.   ORGANIC LETTERS

A biologically relevant ceramide fluorescent probe to assess the binding of potential ligands to the CERT transfer protein

(2013) Stéphanie Combemale et al.   RSC Advances

Correction: Chlamydia trachomatis Co-opts GBF1 and CERT to Acquire Host Sphingomyelin for Distinct Roles during Intracellular Development

(2013) Cherilyn A. Elwell et al.   PLoS Pathogens

Loss of the Ceramide Transfer Protein Augments EGF Receptor Signaling in Breast Cancer

(2012) J. Heering et al.   CANCER RESEARCH

Retinoid Receptors and Therapeutic Applications of RAR/RXR Modulators

(2012) Albane le Maire et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Subcellular localization of sphingomyelin revealed by two toxin-based probes in mammalian cells

(2012) Rieko Yachi et al.   GENES TO CELLS

Limonoid Compounds Inhibit Sphingomyelin Biosynthesis by Preventing CERT Protein-dependent Extraction of Ceramides from the Endoplasmic Reticulum

(2012) Françoise Hullin-Matsuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Goodpasture Antigen-binding Protein/Ceramide Transporter Binds to Human Serum Amyloid P-Component and Is Present in Brain Amyloid Plaques

(2012) Chiara Mencarelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Golgi Association by the Pleckstrin Homology Domain of the Ceramide Trafficking Protein (CERT)

(2012) Toshihiko Sugiki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diagnostic Exome Sequencing in Persons with Severe Intellectual Disability

(2012) Joep de Ligt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

(2011) Alfred H. Merrill   CHEMICAL REVIEWS

Goodpasture Antigen-binding Protein (GPBP) Directs Myofibril Formation

(2011) Francisco Revert-Ros et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase D Negatively Regulates Hepatitis C Virus Secretion through Phosphorylation of Oxysterol-binding Protein and Ceramide Transfer Protein

(2011) Yutaka Amako et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Natural products reveal cancer cell dependence on oxysterol-binding proteins

(2011) Anthony W G Burgett et al.   Nature Chemical Biology

Expedient and Practical Synthesis of CERT-Dependent Ceramide Trafficking Inhibitor HPA-12 and Its Analogues

(2011) Andrej Ďuriš et al.   ORGANIC LETTERS

The Lipid Transfer Protein CERT Interacts with the Chlamydia Inclusion Protein IncD and Participates to ER-Chlamydia Inclusion Membrane Contact Sites

(2011) Isabelle Derré et al.   PLoS Pathogens

Newly synthetic ceramide-1-phosphate analogs; their uptake, intracellular localization, and roles as an inhibitor of cytosolic phospholipase A2α and inducer of cell toxicity

(2010) Tomohiko Makiyama et al.   BIOCHEMICAL PHARMACOLOGY

The intermembrane ceramide transport catalyzed by CERT is sensitive to the lipid environment

(2010) Jessica Tuuf et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Palmitate-Induced Inhibition of Insulin Gene Expression in Rat Islet β-Cells Involves the Ceramide Transport Protein

(2010) Jun Guo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Mammalian ceramide synthases

(2010) Michal Levy et al.   IUBMB LIFE

Real-time assay method of lipid extraction activity

(2009) Toshihiko Sugiki et al.   ANALYTICAL BIOCHEMISTRY

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

(2009) Xin Wang et al.   JOURNAL OF CELL BIOLOGY

Crystal Structures of the CERT START Domain with Inhibitors Provide Insights into the Mechanism of Ceramide Transfer

(2009) Norio Kudo et al.   JOURNAL OF MOLECULAR BIOLOGY

Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

(2008) Archana Mukhopadhyay et al.   FASEB JOURNAL

Goodpasture Antigen-binding Protein Is a Soluble Exportable Protein That Interacts with Type IV Collagen

(2008) Fernando Revert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of Virion-Associated Cholesterol and Sphingolipid in Hepatitis C Virus Infection

(2008) H. Aizaki et al.   JOURNAL OF VIROLOGY

Casein Kinase Iγ2 Down-Regulates Trafficking of Ceramide in the Synthesis of Sphingomyelin

(2008) Nario Tomishige et al.   MOLECULAR BIOLOGY OF THE CELL

Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide

(2008) N. Kudo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA