Role of ceramide/sphingomyelin (SM) balance regulated through “SM cycle” in cancer

Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death

(2021) Nina Meyer et al.   Autophagy

Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis

(2021) Faisal Thayyullathil et al.   Cell Death & Disease

Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti–PD-1 Therapy Efficacy

(2021) Anne Montfort et al.   Cancer Immunology Research

Deficiency of sphingomyelin synthase 2 prolongs survival by the inhibition of lymphoma infiltration through ICAM‐1 reduction

(2020) Makoto Taniguchi et al.   FASEB JOURNAL

Fusion of lysosomes to plasma membrane initiates radiation-induced apoptosis

(2020) Charles S. Ferranti et al.   JOURNAL OF CELL BIOLOGY

Lipid rafts as signaling hubs in cancer cell survival/death and invasion: implications in tumor progression and therapy

(2020) Faustino Mollinedo et al.   JOURNAL OF LIPID RESEARCH

Sphingomyelin phosphodiesterase 3 methylation and silencing in oral squamous cell carcinoma results in increased migration and invasion and altered stress response

(2020) James Jabalee et al.   Oncotarget

Potential therapeutic target for aging and age-related neurodegenerative diseases: the role of acid sphingomyelinase

(2020) Min Hee Park et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Ceramide launches an acute anti‐adhesion pro‐migration cell signaling program in response to chemotherapy

(2020) Daniel Canals et al.   FASEB JOURNAL

Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress

(2020) Mutay Aslan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α

(2020) Fatema Al-Rashed et al.   Scientific Reports

Overriding sorafenib resistance via blocking lipid metabolism and Ras by sphingomyelin synthase 1 inhibition in hepatocellular carcinoma

(2020) Haofeng Lu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Role of sphingomyelin on the interaction of the anticancer drug gemcitabine hydrochloride with cell membrane models

(2020) Elsa M. Materon et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The Opposing Contribution of SMS1 and SMS2 to Glioma Progression and Their Value in the Therapeutic Response to 2OHOA

(2019) Paula Fernández-García et al.   Cancers

Sphingomyelin synthase 2 promotes an aggressive breast cancer phenotype by disrupting the homoeostasis of ceramide and sphingomyelin

(2019) Kehong Zheng et al.   Cell Death & Disease

Advances in determining signaling mechanisms of ceramide and role in disease

(2019) Jeffrey L. Stith et al.   JOURNAL OF LIPID RESEARCH

Sphingolipid/Ceramide Pathways and Autophagy in the Onset and Progression of Melanoma: Novel Therapeutic Targets and Opportunities

(2019) Michele Lai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll‐Like Receptor 4 to Lipid Rafts

(2019) Jing Xue et al.   Journal of the American Heart Association

The Physical Properties of Ceramides in Membranes

(2018) Alicia Alonso et al.   Annual Review of Biophysics

Sphingomyelin in microdomains of the plasma membrane regulates amino acid-stimulated mTOR signal activation

(2018) Kota Zama et al.   CELL BIOLOGY INTERNATIONAL

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Beyond the "Lock and Key" Paradigm: Targeting Lipid Rafts to Induce the Selective Apoptosis of Cancer Cells

(2018) Anna Carolina Schneider Alves et al.   CURRENT MEDICINAL CHEMISTRY

Bcr-Abl regulation of sphingomyelin synthase 1 reveals a novel oncogenic-driven mechanism of protein up-regulation

(2018) Sitapriya Moorthi et al.   FASEB JOURNAL

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

(2018) Anne Gulbins et al.   MOLECULAR PSYCHIATRY

Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells

(2018) Svenja Zielke et al.   Cell Death & Disease

Mechanisms that minimize retinal impact of apolipoprotein E absence

(2018) Aicha Saadane et al.   JOURNAL OF LIPID RESEARCH

Sphingomyelin synthase 2 deficiency inhibits the induction of murine colitis-associated colon cancer

(2017) Toshio Ohnishi et al.   FASEB JOURNAL

Ceramide Nanoliposomes as a MLKL-Dependent, Necroptosis-Inducing, Chemotherapeutic Reagent in Ovarian Cancer

(2017) Xuewei Zhang et al.   MOLECULAR CANCER THERAPEUTICS

Identification and functional analysis of the risk microRNAs associated with cerebral low-grade glioma prognosis

(2017) Xinrui Liu et al.   Molecular Medicine Reports

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Detectors for evaluating the cellular landscape of sphingomyelin- and cholesterol-rich membrane domains

(2016) Takuma Kishimoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Inhibitors of the sphingomyelin cycle: Sphingomyelin synthases and sphingomyelinases

(2016) Mohamad Adada et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Comparative lipid analysis in the normal and cancerous organoids of MDCK cells

(2016) Hisayoshi Yoshizaki et al.   JOURNAL OF BIOCHEMISTRY

Inhibition of Acid Sphingomyelinase Allows for Selective Targeting of CD4+Conventional versus Foxp3+Regulatory T Cells

(2016) Claudia Hollmann et al.   JOURNAL OF IMMUNOLOGY

Inhibition of sphingomyelin synthase 1 affects ceramide accumulation and hydrogen peroxide-induced apoptosis in Neuro-2a cells

(2016) Ranran Tu et al.   NEUROREPORT

Sphingomyelin generated by sphingomyelin synthase 1 is involved in attachment and infection with Japanese encephalitis virus

(2016) Makoto Taniguchi et al.   Scientific Reports

Visualization of Lipid Membrane Reorganization Induced by a Pore-Forming Toxin Using High-Speed Atomic Force Microscopy

(2015) Neval Yilmaz et al.   ACS Nano

Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization

(2015) Vinodh Rajagopalan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Dihydroceramide desaturase 1, the gatekeeper of ceramide induced lipotoxicity

(2015) S. Rodriguez-Cuenca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The traditional Tibetan medicine Yukyung Karne exhibits a potent anti-metastatic activity by inhibiting the epithelial to mesenchymal transition and cell migration

(2015) Tenzin Choedon et al.   BMC Complementary and Alternative Medicine

All members in the sphingomyelin synthase gene family have ceramide phosphoethanolamine synthase activity

(2015) Tingbo Ding et al.   JOURNAL OF LIPID RESEARCH

Ceramide metabolism regulates autophagy and apoptotic cell death induced by melatonin in liver cancer cells

(2015) Raquel Ordoñez et al.   JOURNAL OF PINEAL RESEARCH

Differential changes in sphingolipids between TNF-induced necroptosis and apoptosis in U937 cells and necroptosis-resistant sublines

(2015) Hirofumi Sawai et al.   LEUKEMIA RESEARCH

Sphingomyelin distribution in lipid rafts of artificial monolayer membranes visualized by Raman microscopy

(2015) Jun Ando et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest

(2015) A A Shamseddine et al.   Cell Death & Disease

Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis

(2015) M Taniguchi et al.   Cell Death & Disease

Alkaline sphingomyelinase (NPP7) promotes cholesterol absorption by affecting sphingomyelin levels in the gut: A study with NPP7 knockout mice

(2014) Ping Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Enhanced Colonic Tumorigenesis in Alkaline Sphingomyelinase (NPP7) Knockout Mice

(2014) Y. Chen et al.   MOLECULAR CANCER THERAPEUTICS

Sphingomyelin Synthase 1 Regulates Neuro-2a Cell Proliferation and Cell Cycle Progression Through Modulation of p27 Expression and Akt Signaling

(2014) Umadevi V. Wesley et al.   MOLECULAR NEUROBIOLOGY

Sphingomyelin Synthase 2 Activity and Liver Steatosis

(2013) Yue Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The role of sphingomyelin and sphingomyelin synthases in cell death, proliferation and migration—from cell and animal models to human disorders

(2013) Makoto Taniguchi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Clot retraction is mediated by factor XIII-dependent fibrin- IIb 3-myosin axis in platelet sphingomyelin-rich membrane rafts

(2013) K. Kasahara et al.   BLOOD

Increased Oxidative Stress Impairs Adipose Tissue Function in Sphingomyelin Synthase 1 Null Mice

(2013) Masato Yano et al.   PLoS One

Fingolimod attenuates ceramide-induced blood–brain barrier dysfunction in multiple sclerosis by targeting reactive astrocytes

(2012) Ruben van Doorn et al.   ACTA NEUROPATHOLOGICA

Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis

(2012) Elodie Lafont et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

CD4+ T-cell dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin synthase 1-knockout mice

(2012) L. Dong et al.   INTERNATIONAL IMMUNOLOGY

The Tricyclodecan-9-yl-xanthogenate D609 Triggers Ceramide Increase and Enhances FasL-Induced Caspase-Dependent and -Independent Cell Death in T Lymphocytes

(2012) Delphine Milhas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of Autophagy and Its Associated Cell Death by “Sphingolipid Rheostat”

(2012) Makoto Taniguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Ceramide Synthase Activity via Dimerization

(2012) Elad L. Laviad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingomyelin synthase 1 activity is regulated by theBCR-ABLoncogene

(2012) Tara Ann Burns et al.   JOURNAL OF LIPID RESEARCH

Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice

(2012) Mei-Hong Lu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of Cell Migration by Sphingomyelin Synthases: Sphingomyelin in Lipid Rafts Decreases Responsiveness to Signaling by the CXCL12/CXCR4 Pathway

(2012) S. Asano et al.   MOLECULAR AND CELLULAR BIOLOGY

Visualization of ceramide channels by transmission electron microscopy

(2011) Soumya Samanta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Membrane microdomain sphingolipids are required for anti-CD20-induced death of chronic lymphocytic leukemia B cells

(2011) M. Hammadi et al.   HAEMATOLOGICA

Dynamic Modification of Sphingomyelin in Lipid Microdomains Controls Development of Obesity, Fatty Liver, and Type 2 Diabetes

(2011) Susumu Mitsutake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingomyelin Synthase 1-generated Sphingomyelin Plays an Important Role in Transferrin Trafficking and Cell Proliferation

(2011) Abo Bakr Abdel Shakor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subcellular Targeting Domains of Sphingomyelin Synthase 1 and 2

(2011) Calvin Yeang et al.   Nutrition & Metabolism

Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

(2011) R. D. Schreiber et al.   SCIENCE

Lysosomal Lipid Storage Diseases

(2011) H. Schulze et al.   Cold Spring Harbor Perspectives in Biology

Transforming Growth Factor-β1 Induces Smad3-Dependent β1 Integrin Gene Expression in Epithelial-to-Mesenchymal Transition during Chronic Tubulointerstitial Fibrosis

(2010) Yi-Chun Yeh et al.   AMERICAN JOURNAL OF PATHOLOGY

Sphingomyelin synthase 2 (SMS2) deficiency attenuates LPS-induced lung injury

(2010) Satish Gowda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Selective Reduction in the Sphingomyelin Content of Atherogenic Lipoproteins Inhibits Their Retention in Murine Aortas and the Subsequent Development of Atherosclerosis

(2010) Yifan Fan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Ceramide-rich platforms in transmembrane signaling

(2010) Branka Stancevic et al.   FEBS LETTERS

Mitochondrial Dysfunction and Increased Reactive Oxygen Species Impair Insulin Secretion in Sphingomyelin Synthase 1-null Mice

(2010) Masato Yano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Characterization of Murine Mitochondria-associated Neutral Sphingomyelinase (MA-nSMase), the Mammalian Sphingomyelin Phosphodiesterase 5

(2010) Bill X. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Egg-Sphingomyelin and Cholesterol Form a Stoichiometric Molecular Complex in Bilayers of Egg-Phosphatidylcholine

(2010) Peter J. Quinn et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Stress-Induced Sphingolipid Signaling: Role of Type-2 Neutral Sphingomyelinase in Murine Cell Apoptosis and Proliferation

(2010) Raphael Devillard et al.   PLoS One

Fas/CD95 down-regulation in lymphoma cells through acquired alkyllysophospholipid resistance: partial role of associated sphingomyelin deficiency

(2009) Wim J. van Blitterswijk et al.   BIOCHEMICAL JOURNAL

Roles and regulation of secretory and lysosomal acid sphingomyelinase

(2009) Russell W. Jenkins et al.   CELLULAR SIGNALLING

Macrophage Sphingomyelin Synthase 2 Deficiency Decreases Atherosclerosis in Mice

(2009) Jing Liu et al.   CIRCULATION RESEARCH

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER

(2009) Ana M. Vacaru et al.   JOURNAL OF CELL BIOLOGY

Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase

(2009) Philipp Ternes et al.   JOURNAL OF LIPID RESEARCH

Lysosomal ceramide mediates gemcitabine-induced death of glioma cells

(2009) Claudia A. Dumitru et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities

(2009) G. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sphingomyelin Synthase 2 Deficiency Attenuates NFκB Activation

(2008) Tiruneh K. Hailemariam et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of ceramide and other simple sphingolipids on membrane lateral structure

(2008) Félix M. Goñi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The domain responsible for sphingomyelin synthase (SMS) activity

(2008) Calvin Yeang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Phase diagrams of lipid mixtures relevant to the study of membrane rafts

(2008) Félix M. Goñi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding

(2008) X. Deng et al.   BLOOD

Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease

(2008) S PYNE et al.   CELLULAR SIGNALLING

Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage

(2008) Duska Separovic et al.   EXPERIMENTAL CELL RESEARCH

Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

(2008) Archana Mukhopadhyay et al.   FASEB JOURNAL

Impaired TCR signaling through dysfunction of lipid rafts in sphingomyelin synthase 1 (SMS1)-knockdown T cells

(2008) Z.-X. Jin et al.   INTERNATIONAL IMMUNOLOGY

Caspase‐3 enhances lung metastasis and cell migration in a protease‐independent mechanism through the ERK pathway

(2008) Yu‐Jung Cheng et al.   INTERNATIONAL JOURNAL OF CANCER

Neutral Sphingomyelinase-3 Is a DNA Damage and Nongenotoxic Stress-Regulated Gene That Is Deregulated in Human Malignancies

(2008) C. A. Corcoran et al.   MOLECULAR CANCER RESEARCH

Acid Sphingomyelinase Overexpression Enhances the Antineoplastic Effects of Irradiation In Vitro and In Vivo

(2008) Eric L Smith et al.   MOLECULAR THERAPY