Three‐Component, One‐Pot Tandem Sonogashira/Suzuki‐Miyaura Coupling Reactions for the Synthesis of a Library of Ceramide‐Transport Protein Inhibitors Designed In Silico

A chemoenzymatic synthesis of ceramide trafficking inhibitor HPA-12

(2019) Seema V Kanojia et al.   Beilstein Journal of Organic Chemistry

Lipid-transfer proteins rectify inter-organelle flux and accurately deliver lipids at membrane contact sites

(2018) Kentaro Hanada   JOURNAL OF LIPID RESEARCH

A domino Kornblum-DeLaMare/aza-Michael reaction of 3,6-dihydro-1,2-dioxines and application to the synthesis of the ceramide transport inhibitor (±)-HPA-12

(2018) Sarah V.A.-M. Legendre et al.   TETRAHEDRON

Palladium-Catalyzed Oxidative Carbonylation of Aryl Hydrazines with CO and O2 at Atmospheric Pressure

(2017) Yongliang Tu et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of β-Amino Ketones by Addition of Aryl Methyl Ketones to Sulfinimines: Application to the Total Synthesis of HPA-12, Norsedamine, and Sedamine

(2017) Arava Amaranadha Reddy et al.   JOURNAL OF ORGANIC CHEMISTRY

An Efficient One-Pot Catalyzed Synthesis of 2,4-Disubstituted 5-Nitroimidazoles Displaying Antiparasitic and Antibacterial Activities

(2017) Fanny Mathias et al.   MOLECULES

Pd-Catalyzed one-pot sequential cross-coupling reactions of tetrabromothiophene

(2017) Kapil Mohan Saini et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Advances on the Transfer of Lipids by Lipid Transfer Proteins

(2017) Louise H. Wong et al.   TRENDS IN BIOCHEMICAL SCIENCES

Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Polysilane/SiO2 -Supported Palladium Catalyst under Continuous-Flow Conditions

(2017) Yuki Saito et al.   ChemistryOpen

Zinc Iodide-Mediated Direct Synthesis of 2,3-Dihydroisoxazoles from Alkynes and Nitrones

(2016) Zu-Feng Xiao et al.   ADVANCED SYNTHESIS & CATALYSIS

Asymmetric Synthesis and Binding Study of New Long-Chain HPA-12 Analogues as Potent Ligands of the Ceramide Transfer Protein CERT

(2016) Andrej Ďuriš et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis and In Vitro Cytotoxic Properties of Polycarbo-Substituted 4-(Arylamino)quinazolines

(2016) Hugues Paumo et al.   MOLECULES

Pd-catalyzed one-pot sequential unsymmetrical cross-coupling reactions of aryl/heteroaryl 1,2-dihalides

(2016) Abhinandan K. Danodia et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Organocatalytic route to enantioselective synthesis of ceramide trafficking inhibitor HPA-12

(2016) Komal G. Lalwani et al.   TETRAHEDRON LETTERS

Catalytic Hydrogenation of Aliphatic Nitro Compounds with Polysilane/Bone Charcoal-Supported Palladium Catalysts under Continuous-Flow Conditions

(2016) Yuki Saito et al.   Asian Journal of Organic Chemistry

The CERT antagonist HPA-12: First practical synthesis and individual binding evaluation of the four stereoisomers

(2015) Cécile Santos et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Powerful Continuous-Flow Hydrogenation by using Poly(dimethyl)silane-Supported Palladium Catalysts

(2015) Shū Kobayashi et al.   ChemCatChem

BF3-Mediated cis-Selective Cycloaddition of O-Silyloxime with Alkenes

(2015) Nobuyoshi Morita et al.   JOURNAL OF ORGANIC CHEMISTRY

A facile palladium-catalyzed route to 2,5,7-trisubstituted indoles

(2015) Sandro Cacchi et al.   TETRAHEDRON

A straightforward synthesis of the CERT inhibitor (1′R,3′S)-HPA-12

(2015) José-Luis Abad et al.   TETRAHEDRON LETTERS

Identification of Novel CERT Ligands as Potential Ceramide Trafficking Inhibitors

(2014) Cécile Santos et al.   CHEMBIOCHEM

Large-scale discovery of novel genetic causes of developmental disorders

(2014) T. W. Fitzgerald et al.   NATURE

Lipid landscapes and pipelines in membrane homeostasis

(2014) Joost C.M. Holthuis et al.   NATURE

A surface-bound molecule that undergoes optically biased Brownian rotation

(2014) James A. Hutchison et al.   Nature Nanotechnology

Catalytic Flow Hydrogenation of Aromatic Nitro Compounds Using Polysilane-Supported Palladium

(2014) Masaharu Ueno et al.   Journal of Flow Chemistry

On the Way Towards Greener Transition-Metal-Catalyzed Processes as Quantified by E Factors

(2013) Bruce H. Lipshutz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Co-evolution of sphingomyelin and the ceramide transport protein CERT

(2013) Kentaro Hanada   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cu-catalyzed in situ generation of thiol using xanthate as a thiol surrogate for the one-pot synthesis of benzothiazoles and benzothiophenes

(2013) D. J. C. Prasad et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Revised Stereochemistry of Ceramide-Trafficking Inhibitor HPA-12 by X-ray Crystallography Analysis

(2013) Masaharu Ueno et al.   ORGANIC LETTERS

Multisubstituted benzo[b]furans through a copper- and/or palladium-catalyzed assembly and functionalization process

(2013) Antonio Arcadi et al.   TETRAHEDRON

Rewiring Chemistry: Algorithmic Discovery and Experimental Validation of One-Pot Reactions in the Network of Organic Chemistry

(2012) Chris M. Gothard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Conjugated metallorganic macrocycles: opportunities for coordination-driven planarization of bidentate, pyridine-based ligands

(2012) Danielle C. Hamm et al.   DALTON TRANSACTIONS

Continuous flow hydrogenation using polysilane-supported palladium/alumina hybrid catalysts

(2011) Hidekazu Oyamada et al.   Beilstein Journal of Organic Chemistry

Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916)

(2011) Graeme Semple et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Facile Regio- and Stereoselective Hydrometalation of Alkynes with a Combination of Carboxylic Acids and Group 10 Transition Metal Complexes: Selective Hydrogenation of Alkynes with Formic Acid

(2011) Ruwei Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Expedient and Practical Synthesis of CERT-Dependent Ceramide Trafficking Inhibitor HPA-12 and Its Analogues

(2011) Andrej Ďuriš et al.   ORGANIC LETTERS

Synthesis, SAR, and Biological Evaluation of α-Sulfonylphosphonic Acids as Selective Matrix Metalloproteinase Inhibitors

(2009) Maria Teresa Rubino et al.   ChemMedChem

Synthesis and Evaluation of New Antagonists of Bacterial Quorum Sensing inVibrio harveyi

(2009) Hanjing Peng et al.   ChemMedChem

Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice

(2009) Xin Wang et al.   JOURNAL OF CELL BIOLOGY

Crystal Structures of the CERT START Domain with Inhibitors Provide Insights into the Mechanism of Ceramide Transfer

(2009) Norio Kudo et al.   JOURNAL OF MOLECULAR BIOLOGY

A New Approach to the Synthesis of 4-Hydroxyethylsulfonylstyrene

(2009) Christophe Grosjean et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Development of microchannel reactors using polysilane-supported palladium catalytic systems in capillaries

(2008) Masaharu Ueno et al.   CHEMICAL COMMUNICATIONS

Goodpasture Antigen-binding Protein and Its Spliced Variant, Ceramide Transfer Protein, Have Different Functions in the Modulation of Apoptosis during Zebrafish Development

(2008) Froilán Granero-Moltó et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide

(2008) N. Kudo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of polysilane-supported palladium/alumina hybrid catalysts and their application to hydrogenation

(2007) Hidekazu Oyamada et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of multiply functionalized benzenes via ruthenium-catalyzed cycloaddition of diiododiynes

(2007) Yoshihiko Yamamoto et al.   TETRAHEDRON