Natural Ligand-Mimetic and Nonmimetic Inhibitors of the Ceramide Transport Protein CERT
出版年份 2022 全文链接
标题
Natural Ligand-Mimetic and Nonmimetic Inhibitors of the Ceramide Transport Protein CERT
作者
关键词
-
出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 23, Issue 4, Pages 2098
出版商
MDPI AG
发表日期
2022-02-15
DOI
10.3390/ijms23042098
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mechanisms of nonvesicular lipid transport
- (2021) Karin M. Reinisch et al. JOURNAL OF CELL BIOLOGY
- CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease
- (2021) Simone M. Crivelli et al. Alzheimers Research & Therapy
- Mammalian lipids: structure, synthesis and function
- (2021) Shamshad Cockcroft Essays in Biochemistry
- Trends in kinase drug discovery: targets, indications and inhibitor design
- (2021) Misty M. Attwood et al. NATURE REVIEWS DRUG DISCOVERY
- Role of ceramide/sphingomyelin (SM) balance regulated through “SM cycle” in cancer
- (2021) Makoto Taniguchi et al. CELLULAR SIGNALLING
- Imaging organelle membranes in live cells at the nanoscale with lipid-based fluorescent probes
- (2021) N. Dadina et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Ceramide Transfer Protein (CERT): An Overlooked Molecular Player in Cancer
- (2021) Long Hoa Chung et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Intellectual-disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution
- (2021) Norito Tamura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cell surface sphingomyelin: key role in cancer initiation, progression, and immune evasion
- (2021) Hatem Tallima et al. Lipids in Health and Disease
- Convergent evolution of bacterial ceramide synthesis
- (2021) Gabriele Stankeviciute et al. Nature Chemical Biology
- PMP2/FABP8 induces PI(4,5)P2-dependent transbilayer reorganization of sphingomyelin in the plasma membrane
- (2021) Mitsuhiro Abe et al. Cell Reports
- The role of ceramides in metabolic disorders: when size and localization matters
- (2020) Sarah M. Turpin-Nolan et al. Nature Reviews Endocrinology
- Three‐Component, One‐Pot Tandem Sonogashira/Suzuki‐Miyaura Coupling Reactions for the Synthesis of a Library of Ceramide‐Transport Protein Inhibitors Designed In Silico
- (2020) Masaharu Ueno et al. Asian Journal of Organic Chemistry
- Whole Lotta Lipids—From HCV RNA Replication to the Mature Viral Particle
- (2020) Hanna Bley et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Tether Me, Tether Me Not—Dynamic Organelle Contact Sites in Metabolic Rewiring
- (2020) Maria Bohnert DEVELOPMENTAL CELL
- A liposomal FRET assay identifies potent drug‐like inhibitors of the ceramide transport protein CERT
- (2020) Doaa Samaha et al. CHEMISTRY-A EUROPEAN JOURNAL
- Five structural genes required for ceramide synthesis in Caulobacter and for bacterial survival
- (2020) Roberto Jhonatan Olea‐Ozuna et al. ENVIRONMENTAL MICROBIOLOGY
- Sphingomyelin Is Essential for the Structure and Function of the Double-Membrane Vesicles in the Viral RNA Replication Factories
- (2020) Hossam Gewaid et al. JOURNAL OF VIROLOGY
- Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT
- (2020) Hiroaki Murakami et al. PLoS One
- Limonoids from Citrus: Chemistry, anti-tumor potential, and other bioactivities
- (2020) Yu-Sheng Shi et al. Journal of Functional Foods
- Membrane Heterogeneity Beyond the Plasma Membrane
- (2020) Hong-Yin Wang et al. Frontiers in Cell and Developmental Biology
- Identification of the Interactions Interference Between the PH and START Domain of CERT by Limonoid and HPA Inhibitors
- (2020) Mariem Ghoula et al. Frontiers in Molecular Biosciences
- A perilous path: the inborn errors of sphingolipid metabolism
- (2019) Teresa M. Dunn et al. JOURNAL OF LIPID RESEARCH
- Ceramides bind VDAC2 to trigger mitochondrial apoptosis
- (2019) Shashank Dadsena et al. Nature Communications
- CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity
- (2019) Philipp Hammerschmidt et al. CELL
- Prostaglandin receptor agonists as antiglaucoma agents (a patent review 2013 – 2018)
- (2019) Andrea Angeli et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Biology of Lipid Rafts: Introduction to Thematic Review Series
- (2019) Dmitri Sviridov et al. JOURNAL OF LIPID RESEARCH
- Chlamydia trachomatis ‐infected human cells convert ceramide to sphingomyelin without sphingomyelin synthases 1 and 2
- (2019) Yuriko Tachida et al. FEBS LETTERS
- Ceramide Transporter CERT Is Involved in Muscle Insulin Signaling Defects Under Lipotoxic Conditions
- (2018) Cécile L. Bandet et al. DIABETES
- Lipid-transfer proteins rectify inter-organelle flux and accurately deliver lipids at membrane contact sites
- (2018) Kentaro Hanada JOURNAL OF LIPID RESEARCH
- Sphingolipid biosynthesis in man and microbes
- (2018) Peter J. Harrison et al. NATURAL PRODUCT REPORTS
- Selective targeting of collagen IV in the cancer cell microenvironment reduces tumor burden
- (2018) Fernando Revert et al. Oncotarget
- Both the N- and C- terminal regions of the Chlamydial inclusion protein D (IncD) are required for interaction with the pleckstrin homology domain of the ceramide transport protein CERT
- (2018) Keigo Kumagai et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mechanisms of Fumonisin B1 Toxicity: A Computational Perspective beyond the Ceramide Synthases Inhibition
- (2018) Luca Dellafiora et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Unicellular ancestry and mechanisms of diversification of Goodpasture antigen–binding protein
- (2018) Carl Darris et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes
- (2018) Louise H. Wong et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- C16-ceramide is a natural regulatory ligand of p53 in cellular stress response
- (2018) Baharan Fekry et al. Nature Communications
- Synthesis, Radiosynthesis, and Preliminary in vitro and in vivo Evaluation of the Fluorinated Ceramide Trafficking Inhibitor (HPA-12) for Brain Applications
- (2017) Simone M. Crivelli et al. JOURNAL OF ALZHEIMERS DISEASE
- Interaction between the PH and START domains of ceramide transfer protein competes with phosphatidylinositol 4-phosphate binding by the PH domain
- (2017) Jennifer Prashek et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Both Sphingomyelin and Cholesterol in the Host Cell Membrane Are Essential for Rubella Virus Entry
- (2017) Noriyuki Otsuki et al. JOURNAL OF VIROLOGY
- Sphingolipids and their metabolism in physiology and disease
- (2017) Yusuf A. Hannun et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
- (2016) Sonia Hernández-Tiedra et al. Autophagy
- Asymmetric Synthesis and Binding Study of New Long-Chain HPA-12 Analogues as Potent Ligands of the Ceramide Transfer Protein CERT
- (2016) Andrej Ďuriš et al. CHEMISTRY-A EUROPEAN JOURNAL
- Broad-range inhibition of enterovirus replication by OSW-1, a natural compound targeting OSBP
- (2015) Lucian Albulescu et al. ANTIVIRAL RESEARCH
- The CERT antagonist HPA-12: First practical synthesis and individual binding evaluation of the four stereoisomers
- (2015) Cécile Santos et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Identification of Novel CERT Ligands as Potential Ceramide Trafficking Inhibitors
- (2014) Cécile Santos et al. CHEMBIOCHEM
- Complement Activation by Ceramide Transporter Proteins
- (2014) G. H. Bode et al. JOURNAL OF IMMUNOLOGY
- Phosphatidylinositol-4 kinase III beta and oxysterol-binding protein accumulate unesterified cholesterol on poliovirus-induced membrane structure
- (2014) Minetaro Arita MICROBIOLOGY AND IMMUNOLOGY
- Large-scale discovery of novel genetic causes of developmental disorders
- (2014) T. W. Fitzgerald et al. NATURE
- Lipid landscapes and pipelines in membrane homeostasis
- (2014) Joost C.M. Holthuis et al. NATURE
- Ceramide Transfer Protein Deficiency Compromises Organelle Function and Leads to Senescence in Primary Cells
- (2014) Raghavendra Pralhada Rao et al. PLoS One
- Glucolipotoxicity Impairs Ceramide Flow from the Endoplasmic Reticulum to the Golgi Apparatus in INS-1 β-Cells
- (2014) Enida Gjoni et al. PLoS One
- Sphingolipid Metabolism and Interorganellar Transport: Localization of Sphingolipid Enzymes and Lipid Transfer Proteins
- (2014) Toshiyuki Yamaji et al. TRAFFIC
- De Novo Mutations in Moderate or Severe Intellectual Disability
- (2014) Fadi F. Hamdan et al. PLoS Genetics
- Co-evolution of sphingomyelin and the ceramide transport protein CERT
- (2013) Kentaro Hanada BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP
- (2013) Bruno Mesmin et al. CELL
- Revised Stereochemistry of Ceramide-Trafficking Inhibitor HPA-12 by X-ray Crystallography Analysis
- (2013) Masaharu Ueno et al. ORGANIC LETTERS
- A biologically relevant ceramide fluorescent probe to assess the binding of potential ligands to the CERT transfer protein
- (2013) Stéphanie Combemale et al. RSC Advances
- Correction: Chlamydia trachomatis Co-opts GBF1 and CERT to Acquire Host Sphingomyelin for Distinct Roles during Intracellular Development
- (2013) Cherilyn A. Elwell et al. PLoS Pathogens
- Loss of the Ceramide Transfer Protein Augments EGF Receptor Signaling in Breast Cancer
- (2012) J. Heering et al. CANCER RESEARCH
- Retinoid Receptors and Therapeutic Applications of RAR/RXR Modulators
- (2012) Albane le Maire et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Subcellular localization of sphingomyelin revealed by two toxin-based probes in mammalian cells
- (2012) Rieko Yachi et al. GENES TO CELLS
- Limonoid Compounds Inhibit Sphingomyelin Biosynthesis by Preventing CERT Protein-dependent Extraction of Ceramides from the Endoplasmic Reticulum
- (2012) Françoise Hullin-Matsuda et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Goodpasture Antigen-binding Protein/Ceramide Transporter Binds to Human Serum Amyloid P-Component and Is Present in Brain Amyloid Plaques
- (2012) Chiara Mencarelli et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Basis for the Golgi Association by the Pleckstrin Homology Domain of the Ceramide Trafficking Protein (CERT)
- (2012) Toshihiko Sugiki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Diagnostic Exome Sequencing in Persons with Severe Intellectual Disability
- (2012) Joep de Ligt et al. NEW ENGLAND JOURNAL OF MEDICINE
- Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics
- (2011) Alfred H. Merrill CHEMICAL REVIEWS
- Goodpasture Antigen-binding Protein (GPBP) Directs Myofibril Formation
- (2011) Francisco Revert-Ros et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protein Kinase D Negatively Regulates Hepatitis C Virus Secretion through Phosphorylation of Oxysterol-binding Protein and Ceramide Transfer Protein
- (2011) Yutaka Amako et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Comprehensive analysis of kinase inhibitor selectivity
- (2011) Mindy I Davis et al. NATURE BIOTECHNOLOGY
- Natural products reveal cancer cell dependence on oxysterol-binding proteins
- (2011) Anthony W G Burgett et al. Nature Chemical Biology
- Expedient and Practical Synthesis of CERT-Dependent Ceramide Trafficking Inhibitor HPA-12 and Its Analogues
- (2011) Andrej Ďuriš et al. ORGANIC LETTERS
- The Lipid Transfer Protein CERT Interacts with the Chlamydia Inclusion Protein IncD and Participates to ER-Chlamydia Inclusion Membrane Contact Sites
- (2011) Isabelle Derré et al. PLoS Pathogens
- Newly synthetic ceramide-1-phosphate analogs; their uptake, intracellular localization, and roles as an inhibitor of cytosolic phospholipase A2α and inducer of cell toxicity
- (2010) Tomohiko Makiyama et al. BIOCHEMICAL PHARMACOLOGY
- The intermembrane ceramide transport catalyzed by CERT is sensitive to the lipid environment
- (2010) Jessica Tuuf et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Palmitate-Induced Inhibition of Insulin Gene Expression in Rat Islet β-Cells Involves the Ceramide Transport Protein
- (2010) Jun Guo et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Mammalian ceramide synthases
- (2010) Michal Levy et al. IUBMB LIFE
- Real-time assay method of lipid extraction activity
- (2009) Toshihiko Sugiki et al. ANALYTICAL BIOCHEMISTRY
- Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice
- (2009) Xin Wang et al. JOURNAL OF CELL BIOLOGY
- Crystal Structures of the CERT START Domain with Inhibitors Provide Insights into the Mechanism of Ceramide Transfer
- (2009) Norio Kudo et al. JOURNAL OF MOLECULAR BIOLOGY
- Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling
- (2008) Archana Mukhopadhyay et al. FASEB JOURNAL
- Goodpasture Antigen-binding Protein Is a Soluble Exportable Protein That Interacts with Type IV Collagen
- (2008) Fernando Revert et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Critical Role of Virion-Associated Cholesterol and Sphingolipid in Hepatitis C Virus Infection
- (2008) H. Aizaki et al. JOURNAL OF VIROLOGY
- Casein Kinase Iγ2 Down-Regulates Trafficking of Ceramide in the Synthesis of Sphingomyelin
- (2008) Nario Tomishige et al. MOLECULAR BIOLOGY OF THE CELL
- Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide
- (2008) N. Kudo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started