Mechanisms of podocyte injury and implications for diabetic nephropathy

A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance

(2021) Yuan Liu et al.   Nature Chemical Biology

Pathophysiology of diabetic kidney disease: impact of SGLT2 inhibitors

(2021) Ralph A. DeFronzo et al.   Nature Reviews Nephrology

Relevance of the Pyroptosis-Related Inflammasome Pathway in the Pathogenesis of Diabetic Kidney Disease

(2021) Pan Liu et al.   Frontiers in Immunology

Deficiency of mitochondrial glycerol 3-phosphate dehydrogenase exacerbates podocyte injury and the progression of diabetic kidney disease

(2021) Hua Qu et al.   DIABETES

Mitochondrial Dysfunction in Podocytes Caused by CRIF1 Deficiency Leads to Progressive Albuminuria and Glomerular Sclerosis in Mice

(2021) Ki Ryang Na et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective Role of the M-Sec–Tunneling Nanotube System in Podocytes

(2021) Federica Barutta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Single-cell RNA sequencing reveals the mesangial identity and species diversity of glomerular cell transcriptomes

(2021) Bing He et al.   Nature Communications

Microfluidic platform accelerates tissue processing into single cells for molecular analysis and primary culture models

(2021) Jeremy A. Lombardo et al.   Nature Communications

Glomerular Endothelial Cell Crosstalk With Podocytes in Diabetic Kidney Disease

(2021) Nassim Mahtal et al.   Frontiers in Medicine

Vaccination Against Receptor for Advanced Glycation End Products Attenuates the Progression of Diabetic Kidney Disease

(2021) Tatsuhiko Azegami et al.   DIABETES

JAK/STAT pathway promotes the progression of diabetic kidney disease via autophagy in podocytes

(2021) Dandan Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Kidney disease in diabetes: from mechanisms to clinical presentation and treatment strategies

(2021) Carlo Alberto Ricciardi et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes

(2021) Bertram Pitt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Pass through the Filtration Barrier and Protect Podocytes in a 3D Glomerular Model under Continuous Perfusion

(2021) Linda Bellucci et al.   Tissue Engineering and Regenerative Medicine

Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease

(2021) Matthew B. Wright et al.   Nature Communications

Twist1 in podocytes ameliorates podocyte injury and proteinuria by limiting CCL2-dependent macrophage infiltration

(2021) Jiafa Ren et al.   JCI Insight

Quantification of Glomerular Structural Lesions: Associations With Clinical Outcomes and Transcriptomic Profiles in Nephrotic Syndrome

(2021) Jeffrey B. Hodgin et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Hyperglycemia alters mitochondrial respiration efficiency and mitophagy in human podocytes

(2021) Irena Audzeyenka et al.   EXPERIMENTAL CELL RESEARCH

A glomerular transcriptomic landscape of apolipoprotein L1 in Black patients with focal segmental glomerulosclerosis

(2021) Michelle T. McNulty et al.   KIDNEY INTERNATIONAL

Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS

(2020) Jinhua Li et al.   EMBO REPORTS

The therapeutic potential of second and third generation CB1R antagonists

(2020) Resat Cinar et al.   PHARMACOLOGY & THERAPEUTICS

Exosomal miRNA-215-5p Derived from Adipose-Derived Stem Cells Attenuates Epithelial–Mesenchymal Transition of Podocytes by Inhibiting ZEB2

(2020) Juan Jin et al.   Biomed Research International

Reconsidering Garth Robinson

(2020) William H. Fissell   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease

(2020) Satoshi Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria Matter: A Critical Role of ADCK4 in Stabilizing the CoQ Complex in Podocytes in Steroid-Resistant Nephrotic Syndrome

(2020) Ilse S. Daehn   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment

(2020) Eugen Widmeier et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Integrated multi-omics approaches to improve classification of chronic kidney disease

(2020) Sean Eddy et al.   Nature Reviews Nephrology

Podocytopathy and Nephrotic Syndrome in Mice with Podocyte-Specific Deletion of the Asah1 Gene

(2020) Guangbi Li et al.   AMERICAN JOURNAL OF PATHOLOGY

The diabetic microenvironment causes mitochondrial oxidative stress in glomerular endothelial cells and pathological crosstalk with podocytes

(2020) Gabriella A. Casalena et al.   Cell Communication and Signaling

Adipose mesenchymal stem cell-derived extracellular vesicles containing microRNA-26a-5p target TLR4 and protect against diabetic nephropathy

(2020) Yurui Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug Testing for Residual Progression of Diabetic Kidney Disease in Mice Beyond Therapy with Metformin, Ramipril, and Empagliflozin

(2020) Manga Motrapu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy in kidney homeostasis and disease

(2020) Chengyuan Tang et al.   Nature Reviews Nephrology

Podocytopathies

(2020) Jeffrey B. Kopp et al.   Nature Reviews Disease Primers

Soluble RARRES1 induces podocyte apoptosis to promote glomerular disease progression

(2020) Anqun Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Rho GTPase regulatory proteins in podocytes

(2020) Jun Matsuda et al.   KIDNEY INTERNATIONAL

Complexities of the glomerular basement membrane

(2020) Richard W. Naylor et al.   Nature Reviews Nephrology

Dapagliflozin in Patients with Chronic Kidney Disease

(2020) Hiddo J.L. Heerspink et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

(2020) George L. Bakris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased long noncoding RNA maternally expressed gene 3 contributes to podocyte injury induced by high glucose through regulation of mitochondrial fission

(2020) Qiongxia Deng et al.   Cell Death & Disease

Sphingosine-1-Phosphate Metabolism and Signaling in Kidney Diseases

(2020) Yelena Drexler et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondrial quality control in kidney injury and repair

(2020) Chengyuan Tang et al.   Nature Reviews Nephrology

CoQ10 ameliorates mitochondrial dysfunction in diabetic nephropathy through mitophagy

(2019) Jia Sun et al.   JOURNAL OF ENDOCRINOLOGY

Exosome secreted from adipose-derived stem cells attenuates diabetic nephropathy by promoting autophagy flux and inhibiting apoptosis in podocyte

(2019) Juan Jin et al.   Stem Cell Research & Therapy

Dual lineage tracing shows that glomerular parietal epithelial cells can transdifferentiate towards the adult podocyte fate

(2019) Natalya V. Kaverina et al.   KIDNEY INTERNATIONAL

Deregulation of long noncoding RNA (TUG1) contributes to excessive podocytes apoptosis by activating endoplasmic reticulum stress in the development of diabetic nephropathy

(2019) Hongchun Shen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SGLT2 inhibition to address the unmet needs in diabetic nephropathy

(2019) Federica Barutta et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Endothelin receptor-A mediates degradation of the glomerular endothelial surface layer via pathologic crosstalk between activated podocytes and glomerular endothelial cells

(2019) Kerstin Ebefors et al.   KIDNEY INTERNATIONAL

Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria

(2019) Lili Zhou et al.   KIDNEY INTERNATIONAL

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

(2019) Hiddo J L Heerspink et al.   LANCET

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

(2019) Vlado Perkovic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics

(2019) Paul T. Brinkkoetter et al.   Cell Reports

499-P: The Relative Roles of Pro-oxidant Enzymes Nox4 and Nox5 in Diabetic Kidney Disease

(2019) JAY C. JHA et al.   DIABETES

Endothelial or vascular smooth muscle cell-specific expression of human NOX5 exacerbates renal inflammation, fibrosis and albuminuria in the Akita mouse

(2019) Jay C. Jha et al.   DIABETOLOGIA

Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice

(2019) Daniel L. Galvan et al.   JOURNAL OF CLINICAL INVESTIGATION

ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes

(2019) G. Michelle Ducasa et al.   JOURNAL OF CLINICAL INVESTIGATION

PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy

(2019) Di Zhou et al.   Cell Death & Disease

Increased mitochondrial fission of glomerular podocytes in diabetic nephropathy

(2019) Yiqiong Ma et al.   Endocrine Connections

Human kidney organoids: progress and remaining challenges

(2019) Ryuichi Nishinakamura   Nature Reviews Nephrology

Diabetic kidney disease: new clinical and therapeutic issues. Joint position statement of the Italian Diabetes Society and the Italian Society of Nephrology on “The natural history of diabetic kidney disease and treatment of hyperglycemia in patients with type 2 diabetes and impaired renal function”

(2019) Giuseppe Pugliese et al.   JOURNAL OF NEPHROLOGY

Lysosome restoration to activate podocyte autophagy: a new therapeutic strategy for diabetic kidney disease

(2019) Wei Jing Liu et al.   Cell Death & Disease

Regulation of Respiration and Apoptosis by Cytochrome c Threonine 58 Phosphorylation

(2019) Junmei Wan et al.   Scientific Reports

Podocytes maintain high basal levels of autophagy independent of mtor signaling

(2019) Tillmann Bork et al.   Autophagy

Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway

(2019) Huiwen Ren et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A Review of Podocyte Biology

(2018) Puneet Garg   AMERICAN JOURNAL OF NEPHROLOGY

Advanced glycation end-products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB

(2018) Xingchen Zhao et al.   JOURNAL OF PATHOLOGY

FPS-ZM1 and valsartan combination protects better against glomerular filtration barrier damage in streptozotocin-induced diabetic rats

(2018) Davoud Sanajou et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury

(2018) Quan Hong et al.   KIDNEY INTERNATIONAL

Advanced glycation end products in the pathogenesis of chronic kidney disease

(2018) Naila Rabbani et al.   KIDNEY INTERNATIONAL

Detection of renin lineage cell transdifferentiation to podocytes in the kidney glomerulus with dual lineage tracing

(2018) Diana G. Eng et al.   KIDNEY INTERNATIONAL

The role of cannabinoid signaling in acute and chronic kidney diseases

(2018) Federica Barutta et al.   KIDNEY INTERNATIONAL

Glucagon‑like peptide‑1 protects mouse podocytes against high glucose‑induced apoptosis, and suppresses reactive oxygen species production and proinflammatory cytokine secretion, through sirtuin 1 activation in�vitro

(2018) Jian‑Xia Shi et al.   Molecular Medicine Reports

Single-cell RNA sequencing for the study of development, physiology and disease

(2018) S. Steven Potter   Nature Reviews Nephrology

JAK1/JAK2 inhibition by baricitinib in diabetic kidney disease: results from a Phase 2 randomized controlled clinical trial

(2018) Katherine R Tuttle et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice

(2018) Zhimei Lv et al.   Cell Death & Disease

Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial

(2018) Katherine R Tuttle et al.   Lancet Diabetes & Endocrinology

Glucose Transporters in Diabetic Kidney Disease—Friends or Foes?

(2018) Anita A. Wasik et al.   Frontiers in Endocrinology

REVERSAL OF ALBUMINURIA BY COMBINED AM6545 AND PERINDOPRIL THERAPY IN EXPERIMENTAL DIABETIC NEPHROPATHY

(2018) F Barutta et al.   BRITISH JOURNAL OF PHARMACOLOGY

JAK-STAT signaling is activated in the kidney and peripheral blood cells of patients with focal segmental glomerulosclerosis

(2018) Jianling Tao et al.   KIDNEY INTERNATIONAL

ARP3 Controls the Podocyte Architecture at the Kidney Filtration Barrier

(2018) Christoph Schell et al.   DEVELOPMENTAL CELL

DUET: A Phase 2 Study Evaluating the Efficacy and Safety of Sparsentan in Patients with FSGS

(2018) Howard Trachtman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

CXCL12 blockade preferentially regenerates lost podocytes in cortical nephrons by targeting an intrinsic podocyte-progenitor feedback mechanism

(2018) Simone Romoli et al.   KIDNEY INTERNATIONAL

FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway

(2017) Wen Li et al.   ENDOCRINOLOGY

High glucose repatterns human podocyte energy metabolism during differentiation and diabetic nephropathy

(2017) Toshiyuki Imasawa et al.   FASEB JOURNAL

Advanced glycation end products induce the apoptosis of and inflammation in mouse podocytes through CXCL9-mediated JAK2/STAT3 pathway activation

(2017) Jing Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

(2017) Jonathon L. Burman et al.   JOURNAL OF CELL BIOLOGY

Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome

(2017) Rathi Prasad et al.   JOURNAL OF CLINICAL INVESTIGATION

Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment

(2017) Lennart Tonneijck et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Rac1 activation in podocytes induces the spectrum of nephrotic syndrome

(2017) Richard Robins et al.   KIDNEY INTERNATIONAL

Podocyte-specific chemokine (C-C motif) receptor 2 overexpression mediates diabetic renal injury in mice

(2017) Hanning You et al.   KIDNEY INTERNATIONAL

Potential relevance of shear stress for slit diaphragm and podocyte function

(2017) Wilhelm Kriz et al.   KIDNEY INTERNATIONAL

Podocyte-specific JAK2 overexpression worsens diabetic kidney disease in mice

(2017) Hongyu Zhang et al.   KIDNEY INTERNATIONAL

Retinoic acid improves nephrotoxic serum–induced glomerulonephritis through activation of podocyte retinoic acid receptor α

(2017) Yan Dai et al.   KIDNEY INTERNATIONAL

Real-time in vivo mitochondrial redox assessment confirms enhanced mitochondrial reactive oxygen species in diabetic nephropathy

(2017) Daniel L. Galvan et al.   KIDNEY INTERNATIONAL

A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease

(2017) Salim S Hayek et al.   NATURE MEDICINE

The diabetes pandemic suggests unmet needs for ‘CKD with diabetes’ in addition to ‘diabetic nephropathy’–implications for pre-clinical research and drug testing

(2017) Lidia Anguiano Gómez et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Dual therapy targeting the endocannabinoid system prevents experimental diabetic nephropathy

(2017) Federica Barutta et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Single-Nephron Glomerular Filtration Rate in Healthy Adults

(2017) Aleksandar Denic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Liraglutide and Renal Outcomes in Type 2 Diabetes

(2017) Johannes F.E. Mann et al.   NEW ENGLAND JOURNAL OF MEDICINE

WT1 Is Necessary for the Proliferation and Migration of Cells of Renin Lineage Following Kidney Podocyte Depletion

(2017) Natalya V. Kaverina et al.   Stem Cell Reports

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Intra- and Intercellular Quality Control Mechanisms of Mitochondria

(2017) et al.   Cells

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Angiotensin II induces cholesterol accumulation and injury in podocytes

(2017) Yingjie Yang et al.   Scientific Reports

Diabetes and Kidney Disease: Role of Oxidative Stress

(2016) Jay C. Jha et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of overexpressing FoxO1 on apoptosis in glomeruli of diabetic mice and in podocytes cultured in high glucose medium

(2016) Wen Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Therapeutic potential of NADPH oxidase 1/4 inhibitors

(2016) G Teixeira et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glomerular Endothelial Mitochondrial Dysfunction Is Essential and Characteristic of Diabetic Kidney Disease Susceptibility

(2016) Haiying Qi et al.   DIABETES

Atrasentan Reduces Albuminuria by Restoring the Glomerular Endothelial Glycocalyx Barrier in Diabetic Nephropathy

(2016) Margien G.S. Boels et al.   DIABETES

Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury

(2016) Christopher E. Pedigo et al.   JOURNAL OF CLINICAL INVESTIGATION

Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy

(2016) Jianyin Long et al.   JOURNAL OF CLINICAL INVESTIGATION

Endothelin-1 Induces Proteinuria by Heparanase-Mediated Disruption of the Glomerular Glycocalyx

(2016) M. Garsen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Association between Mitochondrial DNA Copy Number in Peripheral Blood and Incident CKD in the Atherosclerosis Risk in Communities Study

(2016) A. Tin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cathepsin D in Podocytes Is Important in the Pathogenesis of Proteinuria and CKD

(2016) K. Yamamoto-Nonaka et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy

(2016) B. A. Ayanga et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intravital and Kidney Slice Imaging of Podocyte Membrane Dynamics

(2016) S. Bra hler et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Validation of a Three-Dimensional Method for Counting and Sizing Podocytes in Whole Glomeruli

(2016) V. G. Puelles et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mice with mutant Inf2 show impaired podocyte and slit diaphragm integrity in response to protamine-induced kidney injury

(2016) Balajikarthick Subramanian et al.   KIDNEY INTERNATIONAL

Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury

(2016) Hazel H. Szeto et al.   KIDNEY INTERNATIONAL

Reproducibility of the NEPTUNE descriptor-based scoring system on whole-slide images and histologic and ultrastructural digital images

(2016) Laura Barisoni et al.   MODERN PATHOLOGY

Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis

(2016) Vivette D. D'Agati et al.   Nature Reviews Nephrology

Mitochondrial dysfunction in inherited renal disease and acute kidney injury

(2016) Francesco Emma et al.   Nature Reviews Nephrology

Nephron Protection in Diabetic Kidney Disease

(2016) Hans-Joachim Anders et al.   NEW ENGLAND JOURNAL OF MEDICINE

Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes

(2016) Steven P. Marso et al.   NEW ENGLAND JOURNAL OF MEDICINE

Generation of functional podocytes from human induced pluripotent stem cells

(2016) Osele Ciampi et al.   Stem Cell Research

Mitochondrial Dynamics and Metabolic Regulation

(2016) Timothy Wai et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy

(2016) J Liu et al.   Cell Death & Disease

Instigation of NLRP3 inflammasome activation and glomerular injury in mice on the high fat diet: role of acid sphingomyelinase gene

(2016) Krishna M. Boini et al.   Oncotarget

Induction of Proteinuria by Cannabinoid Receptors 1 Signaling Activation in CB1 Transgenic Mice

(2015) Yung-Chien Hsu et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis

(2015) Olivia Lenoir et al.   Autophagy

Role of the endocannabinoid system in diabetes and diabetic complications

(2015) G Gruden et al.   BRITISH JOURNAL OF PHARMACOLOGY

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy

(2015) Jay C. Jha et al.   DIABETOLOGIA

The cell biology of renal filtration

(2015) Rizaldy P. Scott et al.   JOURNAL OF CELL BIOLOGY

Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease

(2015) R. J. Tan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Human Induced Pluripotent Stem Cell-Derived Podocytes Mature into Vascularized Glomeruli upon Experimental Transplantation

(2015) S. Sharmin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease

(2015) Y.-H. You et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cannabinoid receptor 1 is a major mediator of renal fibrosis

(2015) Lola Lecru et al.   KIDNEY INTERNATIONAL

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

(2015) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

The urinary proteome and metabonome differ from normal in adults with mitochondrial disease

(2015) Andrew M. Hall et al.   KIDNEY INTERNATIONAL

The phenotypes of podocytes and parietal epithelial cells may overlap in diabetic nephropathy

(2015) Nicole K. Andeen et al.   KIDNEY INTERNATIONAL

Reduced Activity of Sphingosine-1-Phosphate Lyase Induces Podocyte-related Glomerular Proteinuria, Skin Irritation, and Platelet Activation

(2015) Jens Schümann et al.   TOXICOLOGIC PATHOLOGY

Endocannabinoid signaling at the periphery: 50 years after THC

(2015) Mauro Maccarrone et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial

(2015) Dick de Zeeuw et al.   Lancet Diabetes & Endocrinology

Podocyte Regeneration Driven by Renal Progenitors Determines Glomerular Disease Remission and Can Be Pharmacologically Enhanced

(2015) Laura Lasagni et al.   Stem Cell Reports

In Vivo RNA Interference Models of Inducible and Reversible Sirt1 Knockdown in Kidney Cells

(2014) Peter Y. Chuang et al.   AMERICAN JOURNAL OF PATHOLOGY

Activation of inflammasomes in podocyte injury of mice on the high fat diet: Effects of ASC gene deletion and silencing

(2014) Krishna M. Boini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of Transcription Factor Acetylation in Diabetic Kidney Disease

(2014) R. Liu et al.   DIABETES

Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control

(2014) Gian-Luca McLelland et al.   EMBO JOURNAL

Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis

(2014) Ilse Daehn et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

(2014) J. C. Jha et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Integrative Biology Identifies Shared Transcriptional Networks in CKD

(2014) S. Martini et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Global Analysis Reveals the Complexity of the Human Glomerular Extracellular Matrix

(2014) R. Lennon et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sphingomyelinase-Like Phosphodiesterase 3b Expression Levels Determine Podocyte Injury Phenotypes in Glomerular Disease

(2014) T.-H. Yoo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Potential Role for Mechanical Forces in the Detachment of Podocytes and the Progression of CKD

(2014) W. Kriz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Single-Gene Cause in 29.5% of Cases of Steroid-Resistant Nephrotic Syndrome

(2014) C. E. Sadowski et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice

(2014) Federica Barutta et al.   KIDNEY INTERNATIONAL

High Glucose Induces Podocyte Injury via Enhanced (Pro)renin Receptor-Wnt-β-Catenin-Snail Signaling Pathway

(2014) Caixia Li et al.   PLoS One

cAMP Signaling Prevents Podocyte Apoptosis via Activation of Protein Kinase A and Mitochondrial Fusion

(2014) Xiaoying Li et al.   PLoS One

Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy

(2014) Tony Jourdan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting mitochondrial cardiolipin and the cytochromec/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis

(2013) A V Birk et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders

(2013) Cristoforo Silvestri et al.   Cell Metabolism

Cyclodextrin Protects Podocytes in Diabetic Kidney Disease

(2013) S. Merscher-Gomez et al.   DIABETES

High glucose induces autophagy in podocytes

(2013) Tean Ma et al.   EXPERIMENTAL CELL RESEARCH

ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling

(2013) Heon Yung Gee et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of the TRPC5 ion channel protects the kidney filter

(2013) Thomas Schaldecker et al.   JOURNAL OF CLINICAL INVESTIGATION

AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function

(2013) Laura L. Dugan et al.   JOURNAL OF CLINICAL INVESTIGATION

The purinergic 2X7receptor participates in renal inflammation and injury induced by high-fat diet: possible role of NLRP3 inflammasome activation

(2013) Anna Solini et al.   JOURNAL OF PATHOLOGY

Proteinuria Impairs Podocyte Regeneration by Sequestering Retinoic Acid

(2013) A. Peired et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Reversibility of Structural and Functional Damage in a Model of Advanced Diabetic Nephropathy

(2013) W. Pichaiwong et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal Lesions Predict Progression of Diabetic Nephropathy in Type 1 Diabetes

(2013) M. L. Caramori et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nephropathy and Elevated BP in Mice with Podocyte-Specific NADPH Oxidase 5 Expression

(2013) C. E. Holterman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease

(2013) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury

(2013) Simone M. Blattner et al.   KIDNEY INTERNATIONAL

Rac1 Activation in Podocytes Induces Rapid Foot Process Effacement and Proteinuria

(2013) H. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

The podocyte slit diaphragm—from a thin grey line to a complex signalling hub

(2013) Florian Grahammer et al.   Nature Reviews Nephrology

Blockade of CCL2/CCR2 signalling ameliorates diabetic nephropathy in db/db mice

(2013) S. J. Seok et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mechanisms of Diabetic Complications

(2013) Josephine M. Forbes et al.   PHYSIOLOGICAL REVIEWS

Rapamycin Upregulates Autophagy by Inhibiting the mTOR-ULK1 Pathway, Resulting in Reduced Podocyte Injury

(2013) Lingling Wu et al.   PLoS One

Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach

(2013) Larisa V Fedorova et al.   BMC Nephrology

Recent advances into the understanding of mitochondrial fission

(2012) Kirstin Elgass et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondrial Fission Triggered by Hyperglycemia Is Mediated by ROCK1 Activation in Podocytes and Endothelial Cells

(2012) Wenjian Wang et al.   Cell Metabolism

Podocyte Mitosis - A Catastrophe

(2012) L. Lasagni et al.   CURRENT MOLECULAR MEDICINE

Identification of Cross-Species Shared Transcriptional Networks of Diabetic Nephropathy in Human and Mouse Glomeruli

(2012) Jeffrey B. Hodgin et al.   DIABETES

Podocyte-specific overexpression of metallothionein mitigates diabetic complications in the glomerular filtration barrier and glomerular histoarchitecture: a transmission electron microscopy stereometric analysis

(2012) Edward C. Carlson et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Blockade of Cannabinoid Receptor 1 Improves Insulin Resistance, Lipid Metabolism, and Diabetic Nephropathy in db/db Mice

(2012) D. H. Nam et al.   ENDOCRINOLOGY

Shear stress induces cell apoptosis via a c-Src-phospholipase D-mTOR signaling pathway in cultured podocytes

(2012) Chunfa Huang et al.   EXPERIMENTAL CELL RESEARCH

Angiotensin II induces tumor necrosis factor-α expression and release from cultured human podocytes

(2012) Arianna Carolina Rosa et al.   INFLAMMATION RESEARCH

Podocyte-Specific Loss of Cdc42 Leads to Congenital Nephropathy

(2012) R. P. Scott et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis

(2012) Li Li Zhou et al.   KIDNEY INTERNATIONAL

Mechanisms of the proteinuria induced by Rho GTPases

(2012) Liming Wang et al.   KIDNEY INTERNATIONAL

Retinoids Augment the Expression of Podocyte Proteins by Glomerular Parietal Epithelial Cells in Experimental Glomerular Disease

(2012) Jiong Zhang et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Podocytes and Disease: Introduction

(2012) Wilhelm Kriz et al.   SEMINARS IN NEPHROLOGY

The Challenge and Response of Podocytes to Glomerular Hypertension

(2012) Nicole Endlich et al.   SEMINARS IN NEPHROLOGY

Multifaceted Roles of Tunneling Nanotubes in Intercellular Communication

(2012) Ludovica Marzo et al.   Frontiers in Physiology

Inhibiting Angiotensin-Converting Enzyme Promotes Renal Repair by Limiting Progenitor Cell Proliferation and Restoring the Glomerular Architecture

(2011) Ariela Benigni et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial Regulation of Cell Cycle and Proliferation

(2011) Valeria Gabriela Antico Arciuch et al.   ANTIOXIDANTS & REDOX SIGNALING

The MCP-1/CCR2 axis in podocytes is involved in apoptosis induced by diabetic conditions

(2011) Bo Young Nam et al.   APOPTOSIS

Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy

(2011) F. Barutta et al.   DIABETES

Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis

(2011) Shreeram Akilesh et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

(2011) Markus Gödel et al.   JOURNAL OF CLINICAL INVESTIGATION

mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

(2011) Ken Inoki et al.   JOURNAL OF CLINICAL INVESTIGATION

COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness

(2011) Saskia F. Heeringa et al.   JOURNAL OF CLINICAL INVESTIGATION

Prorenin Receptor Is Essential for Normal Podocyte Structure and Function

(2011) Y. Oshima et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activation of RhoA in Podocytes Induces Focal Segmental Glomerulosclerosis

(2011) L. Zhu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes

(2011) Sufyan G. Sayyed et al.   KIDNEY INTERNATIONAL

MYO1EMutations and Childhood Familial Focal Segmental Glomerulosclerosis

(2011) Caterina Mele et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy

(2010) F. Barutta et al.   DIABETES

AMP-activated Protein Kinase (AMPK) Negatively Regulates Nox4-dependent Activation of p53 and Epithelial Cell Apoptosis in Diabetes

(2010) Assaad A. Eid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

(2010) Björn Hartleben et al.   JOURNAL OF CLINICAL INVESTIGATION

 -Catenin mediates adriamycin-induced albuminuria and podocyte injury in adult mouse kidneys

(2010) E. Heikkila et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels

(2010) D. Tian et al.   Science Signaling

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes

(2010) Robert B. Hamanaka et al.   TRENDS IN BIOCHEMICAL SCIENCES

Influence of metformin on GLUT1 gene and protein expression in rat streptozotocindiabetes mellitusmodel

(2010) Jelizaveta Sokolovska et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Prostaglandin E2 is crucial in the response of podocytes to fluid flow shear stress

(2010) Tarak Srivastava et al.   Journal of Cell Communication and Signaling

Effect of the Monocyte Chemoattractant Protein-1/CC Chemokine Receptor 2 System on Nephrin Expression in Streptozotocin-Treated Mice and Human Cultured Podocytes

(2009) E. Tarabra et al.   DIABETES

Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy

(2009) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Signaling at the Slit: Podocytes Chat by Synaptic Transmission

(2009) T. Weide et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt/ -Catenin Signaling Promotes Podocyte Dysfunction and Albuminuria

(2009) C. Dai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Accumulation of advanced oxidation protein products induces podocyte apoptosis and deletion through NADPH-dependent mechanisms

(2009) Li Li Zhou et al.   KIDNEY INTERNATIONAL

Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis

(2009) Elizabeth J Brown et al.   NATURE GENETICS

Mechanical forces and TGF 1 reduce podocyte adhesion through  3 1 integrin downregulation

(2009) C. Dessapt et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Late Onset of Ccl2 Blockade with the Spiegelmer mNOX-E36–3′PEG Prevents Glomerulosclerosis and Improves Glomerular Filtration Rate in db/db Mice

(2008) Volha Ninichuk et al.   AMERICAN JOURNAL OF PATHOLOGY

Activated macrophages down-regulate podocyte nephrin and podocin expression via stress-activated protein kinases

(2008) Yohei Ikezumi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Transcriptional control of mitochondrial biogenesis: the central role of PGC-1 

(2008) R. Ventura-Clapier et al.   CARDIOVASCULAR RESEARCH

Enhanced Expression of Janus Kinase-Signal Transducer and Activator of Transcription Pathway Members in Human Diabetic Nephropathy

(2008) C. C. Berthier et al.   DIABETES

Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes

(2008) J. M. Forbes et al.   DIABETES

The Role of Advanced Glycation End Products in Progression and Complications of Diabetes

(2008) Su-Yen Goh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Failure to phosphorylate AKT in podocytes from mice with early diabetic nephropathy promotes cell death

(2008) T. Tejada et al.   KIDNEY INTERNATIONAL

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Early Coenzyme Q10 Supplementation in Primary Coenzyme Q10 Deficiency

(2008) Giovanni Montini et al.   NEW ENGLAND JOURNAL OF MEDICINE

Primary Coenzyme Q Deficiency in Pdss2 Mutant Mice Causes Isolated Renal Disease

(2008) Min Peng et al.   PLoS Genetics

Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes

(2007) J. Zhu et al.   KIDNEY INTERNATIONAL