Journal
KIDNEY INTERNATIONAL
Volume 91, Issue 6, Pages 1283-1286Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.kint.2017.02.032
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Funding
- Gotthard Schettler Gesellschaft fuer Herz-und Kreislaufforschung
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Filtrate flow through the glomerular barrier produces shear stresses that tend to disconnect podocytes from the glomerular basement membrane. Forces are highest within the filtration slits. The slit diaphragm mechanically balances the lateral components of the shear stresses on opposing foot processes, preventing widening of the slit.
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