Human kidney organoids: progress and remaining challenges

Manipulation of Nephron-Patterning Signals Enables Selective Induction of Podocytes from Human Pluripotent Stem Cells

(2019) Yasuhiro Yoshimura et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Single-cell analysis reveals congruence between kidney organoids and human fetal kidney

(2019) Alexander N. Combes et al.   Genome Medicine

Generation of pluripotent stem cell-derived mouse kidneys in Sall1-targeted anephric rats

(2019) Teppei Goto et al.   Nature Communications

Flow-enhanced vascularization and maturation of kidney organoids in vitro

(2019) Kimberly A. Homan et al.   NATURE METHODS

Reporter‐based fate mapping in human kidney organoids confirms nephron lineage relationships and reveals synchronous nephron formation

(2019) Sara E Howden et al.   EMBO REPORTS

Kidney organoids in translational medicine: Disease modeling and regenerative medicine

(2019) Tomoya Miyoshi et al.   DEVELOPMENTAL DYNAMICS

Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk

(2019) Alexander N. Combes et al.   DEVELOPMENT

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms

(2018) Thomas A. Forbes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

High-Throughput Screening Enhances Kidney Organoid Differentiation from Human Pluripotent Stem Cells and Enables Automated Multidimensional Phenotyping

(2018) Stefan M. Czerniecki et al.   Cell Stem Cell

Cross-platform single cell analysis of kidney development shows stromal cells express Gdnf

(2018) Bliss Magella et al.   DEVELOPMENTAL BIOLOGY

Progressive Recruitment of Mesenchymal Progenitors Reveals a Time-Dependent Process of Cell Fate Acquisition in Mouse and Human Nephrogenesis

(2018) Nils O. Lindström et al.   DEVELOPMENTAL CELL

Interleukin-1βActivates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis

(2018) Dario R. Lemos et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Vascularizing the Kidney in the Embryo and Organoid: Questioning Assumptions about Renal Vasculogenesis

(2018) David A.D. Munro et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Single-cell RNA sequencing for the study of development, physiology and disease

(2018) S. Steven Potter   Nature Reviews Nephrology

Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors

(2018) Ioannis Bantounas et al.   Stem Cell Reports

Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo

(2018) Cathelijne W. van den Berg et al.   Stem Cell Reports

A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells

(2018) Aneta Przepiorski et al.   Stem Cell Reports

Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney

(2018) Rajasree Menon et al.   DEVELOPMENT

Recapitulating kidney development: Progress and challenges

(2018) Melissa H. Little et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dissecting the Global Dynamic Molecular Profiles of Human Fetal Kidney Development by Single-Cell RNA Sequencing

(2018) Ping Wang et al.   Cell Reports

Reproducibility of Molecular Phenotypes after Long-Term Differentiation to Human iPSC-Derived Neurons: A Multi-Site Omics Study

(2018) Viola Volpato et al.   Stem Cell Reports

Organoids from Nephrotic Disease-Derived iPSCs Identify Impaired NEPHRIN Localization and Slit Diaphragm Formation in Kidney Podocytes

(2018) Shunsuke Tanigawa et al.   Stem Cell Reports

Comparative Analysis and Refinement of Human PSC-Derived Kidney Organoid Differentiation with Single-Cell Transcriptomics

(2018) Haojia Wu et al.   Cell Stem Cell

Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis

(2018) Haojia Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Evaluation of variability in human kidney organoids

(2018) Belinda Phipson et al.   NATURE METHODS

Interspecies organogenesis generates autologous functional islets

(2017) Tomoyuki Yamaguchi et al.   NATURE

Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

(2017) Nelly M. Cruz et al.   NATURE MATERIALS

Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development

(2017) Yong Kyun Kim et al.   STEM CELLS

Kidney Organoids: A Translational Journey

(2017) Ryuji Morizane et al.   TRENDS IN MOLECULAR MEDICINE

Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system

(2017) S. Yamanaka et al.   Nature Communications

PAX2 is dispensable for in vitro nephron formation from human induced pluripotent stem cells

(2017) Yusuke Kaku et al.   Scientific Reports

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

3D Culture Supports Long-Term Expansion of Mouse and Human Nephrogenic Progenitors

(2016) Zhongwei Li et al.   Cell Stem Cell

Generation of functional podocytes from human induced pluripotent stem cells

(2016) Osele Ciampi et al.   Stem Cell Research

Selective In Vitro Propagation of Nephron Progenitors Derived from Embryos and Pluripotent Stem Cells

(2016) Shunsuke Tanigawa et al.   Cell Reports

Fat4/Dchs1 signaling between stromal and cap mesenchyme cells influences nephrogenesis and ureteric bud branching

(2015) Yaopan Mao et al.   DEVELOPMENT

StromalFat4acts non-autonomously withDchs1/2to restrict the nephron progenitor pool

(2015) Mazdak Bagherie-Lachidan et al.   DEVELOPMENT

Intrinsic Age-Dependent Changes and Cell-Cell Contacts Regulate Nephron Progenitor Lifespan

(2015) Shuang Chen et al.   DEVELOPMENTAL CELL

A Synthetic Niche for Nephron Progenitor Cells

(2015) Aaron C. Brown et al.   DEVELOPMENTAL CELL

Human Induced Pluripotent Stem Cell-Derived Podocytes Mature into Vascularized Glomeruli upon Experimental Transplantation

(2015) S. Sharmin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nephron reconstitution from pluripotent stem cells

(2015) Atsuhiro Taguchi et al.   KIDNEY INTERNATIONAL

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Nephron organoids derived from human pluripotent stem cells model kidney development and injury

(2015) Ryuji Morizane et al.   NATURE BIOTECHNOLOGY

Urine excretion strategy for stem cell-generated embryonic kidneys

(2015) Shinya Yokote et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

(2015) Benjamin S. Freedman et al.   Nature Communications

Sall1 Maintains Nephron Progenitors and Nascent Nephrons by Acting as Both an Activator and a Repressor

(2014) S. Kanda et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Identification of a Multipotent Self-Renewing Stromal Progenitor Population during Mammalian Kidney Organogenesis

(2014) Akio Kobayashi et al.   Stem Cell Reports

Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells

(2013) Atsuhiro Taguchi et al.   Cell Stem Cell

Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

(2013) M. Takasato et al.   NATURE CELL BIOLOGY

Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys

(2012) Abdul Soofi et al.   DEVELOPMENTAL BIOLOGY

FGF9 and FGF20 Maintain the Stemness of Nephron Progenitors in Mice and Man

(2012) Hila Barak et al.   DEVELOPMENTAL CELL

Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development

(2011) Courtney M. Karner et al.   DEVELOPMENT

An improved kidney dissociation and reaggregation culture system results in nephrons arranged organotypically around a single collecting duct system

(2011) Veronika Ganeva et al.   Organogenesis

Patterning a Complex Organ: Branching Morphogenesis and Nephron Segmentation in Kidney Development

(2010) Frank Costantini et al.   DEVELOPMENTAL CELL

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Non-cell-autonomous retinoid signaling is crucial for renal development

(2009) Carolina Rosselot et al.   DEVELOPMENT

BMP7 promotes proliferation of nephron progenitor cells via a JNK-dependent mechanism

(2009) U. Blank et al.   DEVELOPMENT

Dissociation of embryonic kidneys followed by reaggregation allows the formation of renal tissues

(2009) Mathieu Unbekandt et al.   KIDNEY INTERNATIONAL

Six2 Defines and Regulates a Multipotent Self-Renewing Nephron Progenitor Population throughout Mammalian Kidney Development

(2008) Akio Kobayashi et al.   Cell Stem Cell

A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney

(2008) J. Yu et al.   DEVELOPMENT

Osr1 expression demarcates a multi-potent population of intermediate mesoderm that undergoes progressive restriction to an Osr1-dependent nephron progenitor compartment within the mammalian kidney

(2008) Joshua W. Mugford et al.   DEVELOPMENTAL BIOLOGY