A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease

Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

(2017) Pazit Beckerman et al.   NATURE MEDICINE

The evolving science of apolipoprotein-L1 and kidney disease

(2016) Teresa K. Chen et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

APOL1-G0 or APOL1-G2 Transgenic Models Develop Preeclampsia but Not Kidney Disease

(2016) L. A. Bruggeman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Renal-Risk Variants Induce Mitochondrial Dysfunction

(2016) Lijun Ma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Most ApoL1 Is Secreted by the Liver

(2016) Khuloud Shukha et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1-G1 in Nephrocytes Induces Hypertrophy and Accelerates Cell Death

(2016) Yulong Fu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1–Mediated Cell Injury Involves Disruption of Conserved Trafficking Processes

(2016) Etty Kruzel-Davila et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease

(2016) Eunsil Hahm et al.   NATURE MEDICINE

Apolipoprotein L1 and Kidney Disease in African Americans

(2016) David J. Friedman et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Characterization of circulating APOL1 protein complexes in African Americans

(2015) Allison Weckerle et al.   JOURNAL OF LIPID RESEARCH

Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1

(2015) Brendan Nichols et al.   KIDNEY INTERNATIONAL

Soluble Urokinase Receptor and Chronic Kidney Disease

(2015) Salim S. Hayek et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force

(2015) Cheng-han Yu et al.   Nature Communications

In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress

(2015) Blair R. Anderson et al.   PLoS Genetics

Urine soluble urokinase-type plasminogen activator receptor levels correlate with proteinuria in Puumala hantavirus infection

(2014) T. K. Outinen et al.   JOURNAL OF INTERNAL MEDICINE

Rapamycin Promotes Podocyte Migration Through the Up-regulation of Urokinase Receptor

(2014) M.-J. Wu et al.   TRANSPLANTATION PROCEEDINGS

Soluble Urokinase Plasminogen Activator Receptor Level Is an Independent Predictor of the Presence and Severity of Coronary Artery Disease and of Future Adverse Events

(2014) Danny J. Eapen et al.   Journal of the American Heart Association

A New Equation to Estimate Glomerular Filtration Rate

(2013) Andrew S. Levey et al.   ANNALS OF INTERNAL MEDICINE

suPAR: The Molecular Crystal Ball

(2013) Maria Thunø et al.   DISEASE MARKERS

Plasma Apolipoprotein L1 Levels Do Not Correlate with CKD

(2013) L. A. Bruggeman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Variants Associate with Increased Risk of CKD among African Americans

(2013) M. C. Foster et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Risk Variants, Race, and Progression of Chronic Kidney Disease

(2013) Afshin Parsa et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reducing agents affect inhibitory activities of compounds: Results from multiple drug targets

(2012) Hyun Lee et al.   ANALYTICAL BIOCHEMISTRY

CD2AP in mouse and human podocytes controls a proteolytic program that regulates cytoskeletal structure and cellular survival

(2011) Suma Yaddanapudi et al.   JOURNAL OF CLINICAL INVESTIGATION

APOL1 Variants Increase Risk for FSGS and HIVAN but Not IgA Nephropathy

(2011) N. Papeta et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

APOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy

(2011) J. B. Kopp et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis

(2011) Changli Wei et al.   NATURE MEDICINE

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene

(2010) Shay Tzur et al.   HUMAN GENETICS

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

(2010) G. Genovese et al.   SCIENCE

Apolipoprotein L1, a Novel Bcl-2 Homology Domain 3-only Lipid-binding Protein, Induces Autophagic Cell Death

(2008) Guanghua Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MYH9 is associated with nondiabetic end-stage renal disease in African Americans

(2008) W H Linda Kao et al.   NATURE GENETICS

Clathrin and LRP-1-Independent Constitutive Endocytosis and Recycling of uPAR

(2008) Katia Cortese et al.   PLoS One