Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations
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Title
Selective ferroptosis vulnerability due to familial Alzheimer’s disease presenilin mutations
Authors
Keywords
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Journal
CELL DEATH AND DIFFERENTIATION
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-04-21
DOI
10.1038/s41418-022-01003-1
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Note: Only part of the references are listed.- Regional brain iron associated with deterioration in Alzheimer's disease: A large cohort study and theoretical significance
- (2021) Scott Ayton et al. Alzheimers & Dementia
- Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease
- (2021) Wen-Dai Bao et al. CELL DEATH AND DIFFERENTIATION
- Ferroptosis and NRF2: an emerging battlefield in the neurodegeneration of Alzheimer's disease
- (2021) Darius J.R. Lane et al. Essays in Biochemistry
- Iron Metabolism, Ferroptosis, and the Links With Alzheimer’s Disease
- (2020) Nao Yan et al. Frontiers in Neuroscience
- Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis
- (2020) Azhaar Ashraf et al. Redox Biology
- Interplay between MTOR and GPX4 signaling modulates autophagy-dependent ferroptotic cancer cell death
- (2020) Yang Liu et al. CANCER GENE THERAPY
- The substrate repertoire of γ-secretase/presenilin
- (2020) Gökhan Güner et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Spotlight on Ferroptosis: Iron-Dependent Cell Death in Alzheimer’s Disease
- (2020) Azhaar Ashraf et al. Frontiers in Aging Neuroscience
- Ferroptosis occurs through an osmotic mechanism and propagates independently of cell rupture
- (2020) Michelle Riegman et al. NATURE CELL BIOLOGY
- A Simple Differentiation Protocol for Generation of Induced Pluripotent Stem Cell-Derived Basal Forebrain-Like Cholinergic Neurons for Alzheimer’s Disease and Frontotemporal Dementia Disease Modeling
- (2020) Sonia Sanz Muñoz et al. Cells
- β-amyloid: The known unknowns
- (2020) Scott Ayton et al. AGEING RESEARCH REVIEWS
- Molecular and Functional Characterization of Neurogenin-2 Induced Human Sensory Neurons
- (2020) Amy J. Hulme et al. Frontiers in Cellular Neuroscience
- Treating Alzheimer's disease by targeting iron
- (2019) Sara Nikseresht et al. BRITISH JOURNAL OF PHARMACOLOGY
- Chaperone-mediated autophagy is involved in the execution of ferroptosis
- (2019) Zheming Wu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Brain iron is associated with accelerated cognitive decline in people with Alzheimer pathology
- (2019) Scott Ayton et al. MOLECULAR PSYCHIATRY
- Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ
- (2019) Cecilia Hurtado et al. Scientific Reports
- A Large Panel of Isogenic APP and PSEN1 Mutant Human iPSC Neurons Reveals Shared Endosomal Abnormalities Mediated by APP β-CTFs, Not Aβ
- (2019) Dylan Kwart et al. NEURON
- The chemical basis of ferroptosis
- (2019) Marcus Conrad et al. Nature Chemical Biology
- Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective
- (2019) Paul J. Derry et al. PROGRESS IN NEUROBIOLOGY
- Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
- (2018) Irina Ingold et al. CELL
- Selenium and GPX4, a vital symbiosis
- (2018) José Pedro Friedmann Angeli et al. FREE RADICAL BIOLOGY AND MEDICINE
- Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms
- (2018) Darius J.R. Lane et al. JOURNAL OF ALZHEIMERS DISEASE
- Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice
- (2018) Ann Van der Jeugd et al. Scientific Reports
- Selenomethionine Ameliorates Cognitive Decline, Reduces Tau Hyperphosphorylation, and Reverses Synaptic Deficit in the Triple Transgenic Mouse Model of Alzheimer's Disease
- (2018) Guoli Song et al. JOURNAL OF ALZHEIMERS DISEASE
- Generation and characterization of human induced pluripotent stem cell lines from a familial Alzheimer's disease PSEN1 A246E patient and a non-demented family member bearing wild-type PSEN1
- (2018) Sonia Sanz Muñoz et al. Stem Cell Research
- Viral-free generation and characterization of a human induced pluripotent stem cell line from dermal fibroblasts
- (2018) Martin Engel et al. Stem Cell Research
- Cerebrospinal fluid ferritin levels predict brain hypometabolism in people with underlying β-amyloid pathology
- (2018) Ibrahima Diouf et al. NEUROBIOLOGY OF DISEASE
- Evidence that iron accelerates Alzheimer’s pathology: a CSF biomarker study
- (2017) Scott Ayton et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model
- (2017) Zhong-Hao Zhang et al. JOURNAL OF NEUROSCIENCE
- Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
- (2017) Vasanthi S. Viswanathan et al. NATURE
- Presenilin 1 mutations influence processing and trafficking of the ApoE receptor apoER2
- (2017) Wei Wang et al. NEUROBIOLOGY OF AGING
- Association of Cerebrospinal Fluid Ferritin Level With Preclinical Cognitive Decline in APOE-ε4 Carriers
- (2017) Scott Ayton et al. JAMA Neurology
- PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease
- (2017) Minna Oksanen et al. Stem Cell Reports
- On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death
- (2017) Omkar Zilka et al. ACS Central Science
- Characterization of AD-like phenotype in aged APPSwe/PS1dE9 mice
- (2016) Huang Huang et al. AGE
- Genome Editing of Lineage Determinants in Human Pluripotent Stem Cells Reveals Mechanisms of Pancreatic Development and Diabetes
- (2016) Zengrong Zhu et al. Cell Stem Cell
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
- (2016) Kenichi Shimada et al. Nature Chemical Biology
- Loss of Aβ43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain
- (2016) Dan Xia et al. NEURON
- Notch1 hallmarks fibrillary depositions in sporadic Alzheimer’s disease
- (2016) Emanuele Brai et al. Acta Neuropathologica Communications
- Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease
- (2016) Rachelle Balez et al. Scientific Reports
- Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease
- (2015) Pravat K. Mandal et al. BIOLOGICAL PSYCHIATRY
- Qualitative changes in human γ-secretase underlie familial Alzheimer’s disease
- (2015) Maria Szaruga et al. JOURNAL OF EXPERIMENTAL MEDICINE
- The Role of Reelin Signaling in Alzheimer’s Disease
- (2015) Nan-Nan Yu et al. MOLECULAR NEUROBIOLOGY
- Presenilin-1 Knockin Mice Reveal Loss-of-Function Mechanism for Familial Alzheimer’s Disease
- (2015) Dan Xia et al. NEURON
- Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling
- (2015) Emanuele Brai et al. Frontiers in Cellular Neuroscience
- Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE
- (2015) Scott Ayton et al. Nature Communications
- Regulation of Ferroptotic Cancer Cell Death by GPX4
- (2014) Wan Seok Yang et al. CELL
- Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration
- (2014) Raymond F. Burk et al. FASEB JOURNAL
- Mice Lacking Selenoprotein P and Selenocysteine Lyase Exhibit Severe Neurological Dysfunction, Neurodegeneration, and Audiogenic Seizures
- (2014) China N. Byrns et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Partial Loss of Presenilin Impairs Age-Dependent Neuronal Survival in the Cerebral Cortex
- (2014) H. Watanabe et al. JOURNAL OF NEUROSCIENCE
- The role of iron in brain ageing and neurodegenerative disorders
- (2014) Roberta J Ward et al. LANCET NEUROLOGY
- Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
- (2014) Jose Pedro Friedmann Angeli et al. NATURE CELL BIOLOGY
- Critical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis
- (2013) H Song et al. CELL DEATH AND DIFFERENTIATION
- Trans-Dominant Negative Effects of Pathogenic PSEN1 Mutations on -Secretase Activity and A Production
- (2013) E. A. Heilig et al. JOURNAL OF NEUROSCIENCE
- A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
- (2013) Rachelle S. Doody et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Presenilin-1 ΔE9 Mutation Results in Reduced γ-Secretase Activity, but Not Total Loss of PS1 Function, in Isogenic Human Stem Cells
- (2013) Grace Woodruff et al. Cell Reports
- Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
- (2012) Scott J. Dixon et al. CELL
- The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
- (2012) Lucía Chávez-Gutiérrez et al. EMBO JOURNAL
- Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain
- (2012) Si-Eun Yoo et al. FREE RADICAL BIOLOGY AND MEDICINE
- SeP, ApoER2 and megalin as necessary factors to maintain Se homeostasis in mammals
- (2012) Magdalena Beata Krol et al. JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
- Elevated Oxidative Stress and Decreased Antioxidant Function in the Human Hippocampus and Frontal Cortex with Increasing Age: Implications for Neurodegeneration in Alzheimer’s Disease
- (2012) C. Venkateshappa et al. NEUROCHEMICAL RESEARCH
- Dissociation between the Processivity and Total Activity of γ-Secretase: Implications for the Mechanism of Alzheimer's Disease-Causing Presenilin Mutations
- (2011) Omar Quintero-Monzon et al. BIOCHEMISTRY
- Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing
- (2011) Stefan F. Lichtenthaler et al. JOURNAL OF NEUROCHEMISTRY
- Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells
- (2011) H. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Presenilin-1 Mutation Identified in Familial Alzheimer Disease with Cotton Wool Plaques Causes a Nearly Complete Loss of γ-Secretase Activity
- (2010) Elizabeth A. Heilig et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of Age-Dependent and Progressive Cortical Neuronal Degeneration in Presenilin Conditional Mutant Mice
- (2010) Mary Wines-Samuelson et al. PLoS One
- Alzheimer’s disease and Notch signaling
- (2009) Ha-Na Woo et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The Notch signaling pathway: Transcriptional regulation at Notch target genes
- (2009) T. Borggrefe et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration
- (2009) K. Tabuchi et al. JOURNAL OF NEUROSCIENCE
- Peripheral levels of glutathione and protein oxidation as markers in the development of Alzheimer's disease from Mild Cognitive Impairment
- (2008) Paloma Bermejo et al. FREE RADICAL RESEARCH
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