Characterization of AD-like phenotype in aged APPSwe/PS1dE9 mice

Different Expression Patterns of Amyloid-β Protein Precursor Secretases in Human and Mouse Hippocampal Neurons: A Potential Contribution to Species Differences in Neuronal Susceptibility to Amyloid-β Pathogenesis

(2016) Zhi-Qiang Xu et al.   JOURNAL OF ALZHEIMERS DISEASE

Astrogliosis: An integral player in the pathogenesis of Alzheimer's disease

(2016) Lana M. Osborn et al.   PROGRESS IN NEUROBIOLOGY

Neuroimaging of hippocampal atrophy in early recognition of Alzheimer´s disease – a critical appraisal after two decades of research

(2016) Johannes Schröder et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Characterization of Social Behaviors in caspase-3 deficient mice

(2016) Shih-Ching Lo et al.   Scientific Reports

Sigma-2 receptor binding is decreased in female, but not male, APP/PS1 mice

(2015) Kristoffer Sahlholm et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

4Aβ1-15-Derived Monoclonal Antibody Reduces More Aβ Burdens and Neuroinflammation than Homologous Vaccine in APP/PS1 Mice

(2015) Yuwei Zhang et al.   Current Alzheimer Research

Isolation Housing Exacerbates Alzheimer's Disease-Like Pathophysiology in Aged APP/PS1 Mice

(2015) H. Huang et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation

(2015) Jonathan D. Cherry et al.   Journal of Neuroinflammation

Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Aβ accumulation and memory deficits

(2015) Zhiqiang Xu et al.   Molecular Neurodegeneration

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice

(2015) Daijiro Yanagisawa et al.   NEUROBIOLOGY OF AGING

Behavioral abnormalities in APPSwe/PS1dE9 mouse model of AD-like pathology: comparative analysis across multiple behavioral domains

(2015) Christopher Janus et al.   NEUROBIOLOGY OF AGING

Genetics and Underlying Pathology of Dementia

(2015) Beata Ferencz et al.   NEUROPSYCHOLOGY REVIEW

Donepezil improves learning and memory deficits in APP/PS1 mice by inhibition of microglial activation

(2015) H.B. Guo et al.   NEUROSCIENCE

Microglial Malfunction: The Third Rail in the Development of Alzheimer's Disease

(2015) Siddhita D. Mhatre et al.   TRENDS IN NEUROSCIENCES

The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease

(2015) Josiane Budni et al.   Aging and Disease

FIBT versus florbetaben and PiB: a preclinical comparison study with amyloid-PET in transgenic mice

(2015) Behrooz H Yousefi et al.   EJNMMI Research

Microglia as a critical player in both developmental and late-life CNS pathologies

(2014) Noël C. Derecki et al.   ACTA NEUROPATHOLOGICA

Potassium 2-(1-hydroxypentyl)-benzoate promotes long-term potentiation in Aβ1–42-injected rats and APP/PS1 transgenic mice

(2014) Ping-ping Li et al.   ACTA PHARMACOLOGICA SINICA

Risk Factors for Behavioral Abnormalities in Mild Cognitive Impairment and Mild Alzheimer's Disease

(2014) Liana G. Apostolova et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Social Interaction Rescues Memory Deficit in an Animal Model of Alzheimer's Disease by Increasing BDNF-Dependent Hippocampal Neurogenesis

(2014) Ya-Hsin Hsiao et al.   JOURNAL OF NEUROSCIENCE

Multimodality Imaging of Alzheimer Disease and Other Neurodegenerative Dementias

(2014) I. M. Nasrallah et al.   JOURNAL OF NUCLEAR MEDICINE

Association of type 2 diabetes with brain atrophy and cognitive impairment

(2014) R. O. Roberts et al.   NEUROLOGY

Altered cerebral vascular volumes and solute transport at the blood–brain barriers of two transgenic mouse models of Alzheimer's disease

(2014) Tuan Minh Do et al.   NEUROPHARMACOLOGY

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase

(2014) Maho Morishima-Kawashima   Frontiers in Physiology

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

(2014) Scott J. Webster et al.   Frontiers in Genetics

Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer’s disease mouse models

(2013) Michal Arbel-Ornath et al.   ACTA NEUROPATHOLOGICA

Voluntary exercise counteracts Aβ25-35-induced memory impairment in mice

(2013) Qin Wang et al.   BEHAVIOURAL BRAIN RESEARCH

Epidemiology and Etiology of Alzheimer’s disease: From Genetic to Non- Genetic Factors

(2013) Teng Jiang et al.   Current Alzheimer Research

Neuronal and glial alterations, increased anxiety, and cognitive impairment before hippocampal amyloid deposition in PDAPP mice, model of Alzheimer's disease

(2013) Juan Beauquis et al.   HIPPOCAMPUS

Resveratrol increases cerebral glycogen synthase kinase phosphorylation as well as protein levels of drebrin and transthyretin in mice: an exploratory study

(2013) Behzad Varamini et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Oridonin ameliorates neuropathological changes and behavioural deficits in a mouse model of cerebral amyloidosis

(2013) Zhi-Yuan Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Intracranial Injection of Gammagard, a Human IVIg, Modulates the Inflammatory Response of the Brain and Lowers A  in APP/PS1 Mice Along a Different Time Course than Anti-A  Antibodies

(2013) T. L. Sudduth et al.   JOURNAL OF NEUROSCIENCE

Ushering in the study and treatment of preclinical Alzheimer disease

(2013) Jessica B. Langbaum et al.   Nature Reviews Neurology

Long-term social isolation in the adulthood results in CA1 shrinkage and cognitive impairment

(2013) Inmaculada Pereda-Pérez et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

GDNF, NGF and BDNF as therapeutic options for neurodegeneration

(2013) Shelley J. Allen et al.   PHARMACOLOGY & THERAPEUTICS

Genetic mouse models of brain ageing and Alzheimer's disease

(2013) Andras Bilkei-Gorzo   PHARMACOLOGY & THERAPEUTICS

The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer’s Disease

(2013) Tomi Rantamäki et al.   PLoS One

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Increased in Vivo Amyloid- 42 Production, Exchange, and Loss in Presenilin Mutation Carriers

(2013) R. Potter et al.   Science Translational Medicine

Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease

(2013) Scott J Webster et al.   Alzheimers Research & Therapy

Immunocytochemical Characterization of Alzheimer Disease Hallmarks in APP/PS1 Transgenic Mice Treated with a New Anti-Amyloid-βVaccine

(2013) Iván Carrera et al.   Biomed Research International

Age and Rate of Cognitive Decline in Alzheimer Disease

(2012) Charles Bernick et al.   ARCHIVES OF NEUROLOGY

Sensorimotor gating and memory deficits in an APP/PS1 double transgenic mouse model of Alzheimer's disease

(2012) Hongxing Wang et al.   BEHAVIOURAL BRAIN RESEARCH

Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)

(2012) Mohammed Filali et al.   BEHAVIOURAL BRAIN RESEARCH

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

Astrocytes: more than just glue

(2012) PETER BAXTER   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

The value and limitations of transgenic mouse models used in drug discovery for Alzheimer's disease: an update

(2012) Kelly R Bales   Expert Opinion on Drug Discovery

A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice

(2012) Varsha Shukla et al.   FASEB JOURNAL

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG

(2012) S. F. Carter et al.   JOURNAL OF NUCLEAR MEDICINE

Age-dependent disruption in hippocampal theta oscillation in amyloid-β overproducing transgenic mice

(2012) Liam Scott et al.   NEUROBIOLOGY OF AGING

The incretin analogue D-Ala2GIP reduces plaque load, astrogliosis and oxidative stress in an APP/PS1 mouse model of Alzheimer’s disease

(2012) A.M. Duffy et al.   NEUROSCIENCE

Anxiety is related to Alzheimer cerebrospinal fluid markers in subjects with mild cognitive impairment

(2012) I. H. G. B. Ramakers et al.   PSYCHOLOGICAL MEDICINE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

(2012) Demian Obregon et al.   Nature Communications

Reduction of low-density lipoprotein receptor-related protein (LRP1) in hippocampal neurons does not proportionately reduce, or otherwise alter, amyloid deposition in APPswe/PS1dE9 transgenic mice

(2012) Guilian Xu et al.   Alzheimers Research & Therapy

Selective improvement of cognitive function in adult and aged APP/PS1 transgenic mice by continuous non-shock treadmill exercise

(2011) Hsing-Chieh Ke et al.   BRAIN RESEARCH

Recent rodent models for Alzheimer’s disease: clinical implications and basic research

(2011) Nady Braidy et al.   JOURNAL OF NEURAL TRANSMISSION

Ablation of Cellular Prion Protein Does Not Ameliorate Abnormal Neural Network Activity or Cognitive Dysfunction in the J20 Line of Human Amyloid Precursor Protein Transgenic Mice

(2011) M. Cisse et al.   JOURNAL OF NEUROSCIENCE

High throughput object-based image analysis of β-amyloid plaques in human and transgenic mouse brain

(2011) Harry D. Samaroo et al.   JOURNAL OF NEUROSCIENCE METHODS

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Amyloid: Little proteins, big clues

(2011) Jim Schnabel   NATURE

Anomalies in social behaviors and exploratory activities in an APPswe/PS1 mouse model of Alzheimer's disease

(2011) Mohammed Filali et al.   PHYSIOLOGY & BEHAVIOR

Alzheimer's Disease: The Challenge of the Second Century

(2011) D. M. Holtzman et al.   Science Translational Medicine

Treadmill exercise prevents decline in spatial learning and memory in APP/PS1 transgenic mice through improvement of hippocampal long-term potentiation

(2010) Hui-li Liu et al.   BEHAVIOURAL BRAIN RESEARCH

Potential Predictors of Hippocampal Atrophy in Alzheimerʼs Disease

(2010) Vikas Dhikav et al.   DRUGS & AGING

Identification of Low Molecular Weight Pyroglutamate Aβ Oligomers in Alzheimer Disease

(2010) Oliver Wirths et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice

(2010) James J. Donkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Many Neuronal and Behavioral Impairments in Transgenic Mouse Models of Alzheimer's Disease Are Independent of Caspase Cleavage of the Amyloid Precursor Protein

(2010) J. A. Harris et al.   JOURNAL OF NEUROSCIENCE

Brain-Derived Neurotrophic Factor Is Associated with Age-Related Decline in Hippocampal Volume

(2010) K. I. Erickson et al.   JOURNAL OF NEUROSCIENCE

Val(8)GLP-1 rescues synaptic plasticity and reduces dense core plaques in APP/PS1 mice

(2010) Simon Gengler et al.   NEUROBIOLOGY OF AGING

Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice

(2010) X. Mei et al.   NEUROSCIENCE

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

(2010) Kathleen R. Zahs et al.   TRENDS IN NEUROSCIENCES

Visuo-spatial learning and memory deficits on the Barnes maze in the 16-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease

(2009) Timothy P. O’Leary et al.   BEHAVIOURAL BRAIN RESEARCH

A Reporter of Local Dendritic Translocation Shows Plaque- Related Loss of Neural System Function in APP-Transgenic Mice

(2009) M. Meyer-Luehmann et al.   JOURNAL OF NEUROSCIENCE

Decreased Brain-Derived Neurotrophic Factor Depends on Amyloid Aggregation State in Transgenic Mouse Models of Alzheimer's Disease

(2009) S. Peng et al.   JOURNAL OF NEUROSCIENCE

Morphological alterations to neurons of the amygdala and impaired fear conditioning in a transgenic mouse model of Alzheimer's disease

(2009) Shira Knafo et al.   JOURNAL OF PATHOLOGY

Neuroscience: Glia — more than just brain glue

(2009) Nicola J. Allen et al.   NATURE

Multimodal techniques for diagnosis and prognosis of Alzheimer's disease

(2009) Richard J. Perrin et al.   NATURE

Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice

(2009) Monica Garcia-Alloza et al.   NEUROBIOLOGY OF AGING

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

(2009) Jungsu Kim et al.   NEURON

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

(2009) Mark Kilgore et al.   NEUROPSYCHOPHARMACOLOGY

Recent insights into the molecular genetics of dementia

(2009) Rosa Rademakers et al.   TRENDS IN NEUROSCIENCES

Neprilysin: An Enzyme Candidate to Slow the Progression of Alzheimer's Disease

(2008) Salim S. El-Amouri et al.   AMERICAN JOURNAL OF PATHOLOGY

Effects of the genetic background on cognitive performances of TG2576 mice

(2008) Jean Michel Lassalle et al.   BEHAVIOURAL BRAIN RESEARCH

New insights into brain BDNF function in normal aging and Alzheimer disease

(2008) Lucia Tapia-Arancibia et al.   BRAIN RESEARCH REVIEWS

Age-related decrease in stimulated glutamate release and vesicular glutamate transporters in APP/PS1 transgenic and wild-type mice

(2008) R. Minkeviciene et al.   JOURNAL OF NEUROCHEMISTRY

Proteomics-Determined Differences in the Concanavalin-A-Fractionated Proteome of Hippocampus and Inferior Parietal Lobule in Subjects with Alzheimer’s Disease and Mild Cognitive Impairment: Implications for Progression of AD

(2008) Joshua B. Owen et al.   JOURNAL OF PROTEOME RESEARCH

The latest suspect

(2008) Rudolph E. Tanzi et al.   NATURE

Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

(2008) Lars Bertram et al.   NATURE REVIEWS NEUROSCIENCE

Elimination of GD3 synthase improves memory and reduces amyloid-β plaque load in transgenic mice

(2008) Alexandra Bernardo et al.   NEUROBIOLOGY OF AGING

Acquisition of conditioned taste aversion is impaired in the amyloid precursor protein/presenilin 1 mouse model of Alzheimer’s disease

(2008) P.J. Pistell et al.   NEUROSCIENCE