Selenoprotein P and apolipoprotein E receptor-2 interact at the blood-brain barrier and also within the brain to maintain an essential selenium pool that protects against neurodegeneration

Sepp1UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1

(2014) Suguru Kurokawa et al.   FREE RADICAL BIOLOGY AND MEDICINE

Isoform-specific Binding of Selenoprotein P to the β-Propeller Domain of Apolipoprotein E Receptor 2 Mediates Selenium Supply

(2014) Suguru Kurokawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maternal-fetal transfer of selenium in the mouse

(2013) Raymond F. Burk et al.   FASEB JOURNAL

Long Isoform Mouse Selenoprotein P (Sepp1) Supplies Rat Myoblast L8 Cells with Selenium via Endocytosis Mediated by Heparin Binding Properties and Apolipoprotein E Receptor-2 (ApoER2)

(2012) Suguru Kurokawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Production of Selenoprotein P (Sepp1) by Hepatocytes Is Central to Selenium Homeostasis

(2012) Kristina E. Hill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of selenoprotein P results in impaired function of parvalbumin interneurons and alterations in fear learning and sensorimotor gating

(2012) M.W. Pitts et al.   NEUROSCIENCE

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid  

(2012) J. J. Iliff et al.   Science Translational Medicine

ApoER2 Function in the Establishment and Maintenance of Retinal Synaptic Connectivity

(2011) J. H. Trotter et al.   JOURNAL OF NEUROSCIENCE

Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain

(2010) Jazmin Chiu-Ugalde et al.   BIOCHEMICAL JOURNAL

Contribution to selenium speciation in cerebrospinal fluid samples

(2010) Bernhard Michalke et al.   JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY

Selenoprotein P—Expression, functions, and roles in mammals

(2009) Raymond F. Burk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration

(2009) Eva K. Wirth et al.   FASEB JOURNAL

Hepatic selenoprotein P (SePP) expression restores selenium transport and prevents infertility and motor-incoordination inSepp-knockout mice

(2008) Kostja Renko et al.   BIOCHEMICAL JOURNAL

Megalin Mediates Selenoprotein P Uptake by Kidney Proximal Tubule Epithelial Cells

(2008) Gary E. Olson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurodegeneration in Mice Resulting From Loss of Functional Selenoprotein P or Its Receptor Apolipoprotein E Receptor 2

(2008) William M. Valentine et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY