Organ-on-Chip platforms to study tumor evolution and chemosensitivity

Mouse avatars of human cancers: the temporality of translation in precision oncology

(2021) Sara Green et al.   HISTORY AND PHILOSOPHY OF THE LIFE SCIENCES

A Microfluidic Perfusion Platform for In Vitro Analysis of Drug Pharmacokinetic-Pharmacodynamic (PK-PD) Relationships

(2020) Yadir A. Guerrero et al.   AAPS Journal

Organotypic cancer tissue models for drug screening: 3D constructs, bioprinting and microfluidic chips

(2020) Janani Radhakrishnan et al.   DRUG DISCOVERY TODAY

Drug Toxicity Evaluation Based on Organ-on-a-chip Technology: A Review

(2020) Ye Cong et al.   Micromachines

Automated microfluidic cell culture of stem cell derived dopaminergic neurons

(2019) Khalid I. W. Kane et al.   Scientific Reports

A novel microfluidic device capable of maintaining functional thyroid carcinoma specimens ex vivo provides a new drug screening platform

(2019) Andrew Riley et al.   BMC CANCER

On-Chip Anticancer Drug Screening – Recent Progress in Microfluidic Platforms to Address Challenges in Chemotherapy

(2019) Nandini Dhiman et al.   BIOSENSORS & BIOELECTRONICS

The Tumor Microenvironment Innately Modulates Cancer Progression

(2019) Dominique C. Hinshaw et al.   CANCER RESEARCH

Human organotypic bioconstructs from organ-on-chip devices for human-predictive biological insights on drug candidates

(2019) Icilio Cavero et al.   Expert Opinion On Drug Safety

Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics

(2019) Christopher W. McAleer et al.   Science Translational Medicine

A patient tumour-on-a-chip system for personalised investigation of radiotherapy based treatment regimens

(2019) R. Kennedy et al.   Scientific Reports

Addressing Patient Specificity in the Engineering of Tumor Models

(2019) Laura J. Bray et al.   Frontiers in Bioengineering and Biotechnology

Organs‐on‐Chips in Clinical Pharmacology: Putting the Patient Into the Center of Treatment Selection and Drug Development

(2019) Richard W. Peck et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Modeling Living Cells Within Microfluidic Systems Using Cellular Automata Models

(2019) Julia Ballesteros Hernando et al.   Scientific Reports

Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid

(2019) Yuji Nashimoto et al.   BIOMATERIALS

A novel 3D breast-cancer-on-chip platform for therapeutic evaluation of drug delivery systems

(2018) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

Humanized Mouse Models for the Preclinical Assessment of Cancer Immunotherapy

(2018) Anja Kathrin Wege   BIODRUGS

Microfluidic chip for non-invasive analysis of tumor cells interaction with anti-cancer drug doxorubicin by AFM and Raman spectroscopy

(2018) Han Zhang et al.   Biomicrofluidics

Mechanobiology of Tumor Growth

(2018) Parthiv Kant Chaudhuri et al.   CHEMICAL REVIEWS

Emerging Technologies for Cancer Research: towards Personalized Medicine with Microfluidic Platforms and 3D Tumor Models

(2018) Matteo Turetta et al.   CURRENT MEDICINAL CHEMISTRY

Powering ex vivo tissue models in microfluidic systems

(2018) Ian C. McLean et al.   LAB ON A CHIP

A microfluidic gradient generator to simulate the oxygen microenvironment in cancer cell culture

(2018) Louise Orcheston-Findlay et al.   MICROELECTRONIC ENGINEERING

A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy

(2018) Shantanu Pradhan et al.   Scientific Reports

In vitro patient-derived 3D mesothelioma tumor organoids facilitate patient-centric therapeutic screening

(2018) Andrea R. Mazzocchi et al.   Scientific Reports

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

(2018) Amir R. Aref et al.   LAB ON A CHIP

The mice with human tumours: Growing pains for a popular cancer model

(2018) Cassandra Willyard   NATURE

Microfluidic-Based 3D Engineered Microvascular Networks and Their Applications in Vascularized Microtumor Models

(2018) Xiaolin Wang et al.   Micromachines

A multi-site metastasis-on-a-chip microphysiological system for assessing metastatic preference of cancer cells

(2018) Julio Aleman et al.   BIOTECHNOLOGY AND BIOENGINEERING

Glass-based organ-on-a-chip device for restricting small molecular absorption

(2018) Hirotada Hirama et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Dissecting Effects of Anti-cancer Drugs and Cancer-Associated Fibroblasts by On-Chip Reconstitution of Immunocompetent Tumor Microenvironments

(2018) Marie Nguyen et al.   Cell Reports

Next-Generation in vivo Modeling of Human Cancers

(2018) Gaetano Gargiulo   Frontiers in Oncology

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

(2017) Hsieh-Fu Tsai et al.   Journal of the Royal Society Interface

An on-chip cell culturing and combinatorial drug screening system

(2017) Jiahui Sun et al.   Microfluidics and Nanofluidics

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

(2017) Russell W. Jenkins et al.   Cancer Discovery

A novel microfluidic 3D platform for culturing pancreatic ductal adenocarcinoma cells: comparison with in vitro cultures and in vivo xenografts

(2017) Meike Beer et al.   Scientific Reports

Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro

(2017) Bryan A. Hassell et al.   Cell Reports

Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip

(2017) Samira Musah et al.   Nature Biomedical Engineering

Microfluidic Biopsy Trapping Device for the Real-Time Monitoring of Tumor Microenvironment

(2017) Angela Babetski Holton et al.   PLoS One

A reductionist metastasis-on-a-chip platform for in vitro tumor progression modeling and drug screening

(2016) Aleksander Skardal et al.   BIOTECHNOLOGY AND BIOENGINEERING

Micro-dissected tumor tissues on chip: an ex vivo method for drug testing and personalized therapy

(2016) M. Astolfi et al.   LAB ON A CHIP

Organ-Tumor-on-a-Chip for Chemosensitivity Assay: A Critical Review

(2016) Navid Kashaninejad et al.   Micromachines

Co-Culture of Tumor Spheroids and Fibroblasts in a Collagen Matrix-Incorporated Microfluidic Chip Mimics Reciprocal Activation in Solid Tumor Microenvironment

(2016) Su-Yeong Jeong et al.   PLoS One

Drug testing and flow cytometry analysis on a large number of uniform sized tumor spheroids using a microfluidic device

(2016) Bishnubrata Patra et al.   Scientific Reports

3D microtumors in vitro supported by perfused vascular networks

(2016) Agua Sobrino et al.   Scientific Reports

Microfluidic co-culture system for cancer migratory analysis and anti-metastatic drugs screening

(2016) Shengli Mi et al.   Scientific Reports

Development and characterization of a microfluidic model of the tumour microenvironment

(2016) Jose M. Ayuso et al.   Scientific Reports

Drug cytotoxicity and signaling pathway analysis with three-dimensional tumor spheroids in a microwell-based microfluidic chip for drug screening

(2015) Yongli Chen et al.   ANALYTICA CHIMICA ACTA

An optically transparent membrane supports shear stress studies in a three-dimensional microfluidic neurovascular unit model

(2015) Katelyn L. Sellgren et al.   Biomicrofluidics

A microengineered pathophysiological model of early-stage breast cancer

(2015) Yoonseok Choi et al.   LAB ON A CHIP

Organs-on-chips at the frontiers of drug discovery

(2015) Eric W. Esch et al.   NATURE REVIEWS DRUG DISCOVERY

Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell-Based Biosensors

(2014) Rasheena Edmondson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

A microfluidic device to study cancer metastasis under chronic and intermittent hypoxia

(2014) Miguel A. Acosta et al.   Biomicrofluidics

Parallel microfluidic chemosensitivity testing on individual slice cultures

(2014) Tim C. Chang et al.   LAB ON A CHIP

A polydimethylsiloxane–polycarbonate hybrid microfluidic device capable of generating perpendicular chemical and oxygen gradients for cell culture studies

(2014) Chia-Wen Chang et al.   LAB ON A CHIP

The present and future role of microfluidics in biomedical research

(2014) Eric K. Sackmann et al.   NATURE

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

One mouse, one patient paradigm: New avatars of personalized cancer therapy

(2013) Prerna Malaney et al.   CANCER LETTERS

Cell culture monitoring for drug screening and cancer research: a transparent, microfluidic, multi-sensor microsystem

(2013) Andreas Weltin et al.   LAB ON A CHIP

Microfabrication of human organs-on-chips

(2013) Dongeun Huh et al.   Nature Protocols

Tumour-on-a-chip provides an optical window into nanoparticle tissue transport

(2013) Alexandre Albanese et al.   Nature Communications

Comparison of Biocompatibility and Adsorption Properties of Different Plastics for Advanced Microfluidic Cell and Tissue Culture Models

(2012) Paul M. van Midwoud et al.   ANALYTICAL CHEMISTRY

Quantitative Analysis of Molecular Absorption into PDMS Microfluidic Channels

(2012) Jack D. Wang et al.   ANNALS OF BIOMEDICAL ENGINEERING

Application of microfluidic systems in management of head and neck squamous cell carcinoma

(2012) Faiz Tanweer et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Organs-on-chips: breaking the in vitro impasse

(2012) Andries D. van der Meer et al.   Integrative Biology

Microengineered physiological biomimicry: Organs-on-Chips

(2012) Dongeun Huh et al.   LAB ON A CHIP

On-chip anticancer drug test of regular tumor spheroids formed in microwells by a distributive microchannel network

(2012) Choong Kim et al.   LAB ON A CHIP

A Microfluidic System for Testing the Responses of Head and Neck Squamous Cell Carcinoma Tissue Biopsies to Treatment with Chemotherapy Drugs

(2011) Samantha M. Hattersley et al.   ANNALS OF BIOMEDICAL ENGINEERING

High drug attrition rates—where are we going wrong?

(2011) Lisa Hutchinson et al.   Nature Reviews Clinical Oncology