The Potential of LPS-Binding Protein to Reverse Amyloid Formation in Plasma Fibrin of Individuals With Alzheimer-Type Dementia

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases

(2018) Douglas B. Kell et al.   BIOLOGICAL REVIEWS

MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer’s Disease

(2018) Yu-on Jeong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker™ stains

(2018) Etheresia Pretorius et al.   Journal of the Royal Society Interface

Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease

(2018) Etheresia Pretorius et al.   PLoS One

Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer’s Disease Brain: A Review

(2018) Xinhua Zhan et al.   Frontiers in Aging Neuroscience

Microbiome-Mediated Upregulation of MicroRNA-146a in Sporadic Alzheimer’s Disease

(2018) Yuhai Zhao et al.   Frontiers in Neurology

Fibrinogen and Altered Hemostasis in Alzheimer's Disease

(2018) Marta Cortes-Canteli et al.   JOURNAL OF ALZHEIMERS DISEASE

Oral Infections and Orofacial Pain in Alzheimer's Disease: A Case-Control Study

(2018) Thaís de Souza Rolim et al.   JOURNAL OF ALZHEIMERS DISEASE

Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue

(2018) Sophie Poole et al.   JOURNAL OF ALZHEIMERS DISEASE

Oral Inflammation, Tooth Loss, Risk Factors, and Association with Progression of Alzheimer's Disease

(2018) Sim K. Singhrao et al.   JOURNAL OF ALZHEIMERS DISEASE

Epidemiological and Economic Burden of Alzheimer's Disease: A Systematic Literature Review of Data across Europe and the United States of America

(2018) Claire Takizawa et al.   JOURNAL OF ALZHEIMERS DISEASE

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

(2017) Alan T. Tang et al.   NATURE

Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting

(2017) Douglas B. Kell et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?

(2017) Etheresia Pretorius et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Blood clot parameters: Thromboelastography and scanning electron microscopy in research and clinical practice

(2017) Etheresia Pretorius et al.   THROMBOSIS RESEARCH

Lipopolysaccharide (LPS) Accumulates in Neocortical Neurons of Alzheimer’s Disease (AD) Brain and Impairs Transcription in Human Neuronal-Glial Primary Co-cultures

(2017) Yuhai Zhao et al.   Frontiers in Aging Neuroscience

Microbiome-Derived Lipopolysaccharide Enriched in the Perinuclear Region of Alzheimer’s Disease Brain

(2017) Yuhai Zhao et al.   Frontiers in Immunology

Chronic Inflammation and Amyloidogenesis in Alzheimer's Disease -- Role of Spirochetes1

(2017) Judith Miklossy   JOURNAL OF ALZHEIMERS DISEASE

Alzheimer's Disease and Peripheral Infections: The Possible Contribution from Periodontal Infections, Model and Hypothesis

(2017) Angela R. Kamer et al.   JOURNAL OF ALZHEIMERS DISEASE

Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular co-morbidities

(2017) Etheresia Pretorius et al.   Scientific Reports

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Thioflavin T: Electronic Circular Dichroism and Circularly Polarized Luminescence Induced by Amyloid Fibrils

(2016) Anna Rybicka et al.   CHEMPHYSCHEM

A Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease

(2016) Etheresia Pretorius et al.   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide

(2016) Etheresia Pretorius et al.   Journal of the Royal Society Interface

Gram-negative bacterial molecules associate with Alzheimer disease pathology

(2016) Xinhua Zhan et al.   NEUROLOGY

High Fluorescence Anisotropy of Thioflavin T in Aqueous Solution Resulting from Its Molecular Rotor Nature

(2015) Irina M. Kuznetsova et al.   ANALYTICAL CHEMISTRY

A Comparison of Three Fluorophores for the Detection of Amyloid Fibers and Prefibrillar Oligomeric Assemblies. ThT (Thioflavin T); ANS (1-Anilinonaphthalene-8-sulfonic Acid); and bisANS (4,4′-Dianilino-1,1′-binaphthyl-5,5′-disulfonic Acid)

(2015) Nadine D. Younan et al.   BIOCHEMISTRY

Using Small Molecules to Dissect Non-apoptotic Programmed Cell Death: Necroptosis, Ferroptosis, and Pyroptosis

(2015) Ting Dong et al.   CHEMBIOCHEM

Carbon Monoxide and Iron Modulate Plasmatic Coagulation in Alzheimer’s disease

(2015) Vance Nielsen et al.   CURRENT NEUROVASCULAR RESEARCH

A Novel Prescription for Alzheimer’s Disease: Targeting Hypercoagulable States

(2015) Kenneth Maiese   CURRENT NEUROVASCULAR RESEARCH

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)

(2015) Douglas B. Kell et al.   Integrative Biology

On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death

(2015) Douglas B. Kell et al.   Integrative Biology

Lipopolysaccharide-induced blood-brain barrier disruption: roles of cyclooxygenase, oxidative stress, neuroinflammation, and elements of the neurovascular unit

(2015) William A. Banks et al.   Journal of Neuroinflammation

Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS)

(2015) Janette Bester et al.   Oncotarget

Microglial cell dysregulation in brain aging and neurodegeneration

(2015) Rommy von Bernhardi et al.   Frontiers in Aging Neuroscience

Historic evidence to support a causal relationship between spirochetal infections and Alzheimer’s disease

(2015) Judith Miklossy   Frontiers in Aging Neuroscience

How Do Periodontal Infections Affect the Onset and Progression of Alzheimer’s Disease?

(2014) Munvar Shaik et al.   CNS & Neurological Disorders-Drug Targets

The Role of Viruses in Neurodegenerative and Neurobehavioral Diseases

(2014) Sajjad Karim et al.   CNS & Neurological Disorders-Drug Targets

Alzheimer's disease and chronic periodontitis: Is there an association?

(2014) Sumit Gaur et al.   Geriatrics & Gerontology International

Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases

(2014) Etheresia Pretorius et al.   Integrative Biology

Distinct cytokine pattern in response to different bacterial pathogens in human brain abscess

(2014) Anamika Bajpai et al.   JOURNAL OF NEUROIMMUNOLOGY

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

(2014) Douglas B. Kell et al.   Metallomics

Herpes simplex virus type 1 and Alzheimer’s disease: increasing evidence for a major role of the virus

(2014) Ruth F. Itzhaki   Frontiers in Aging Neuroscience

Inflammasomes in neuroinflammation and changes in brain function: a focused review

(2014) Gaurav Singhal et al.   Frontiers in Neuroscience

Inflammation in neurodegenerative diseases - an update

(2013) Sandra Amor et al.   IMMUNOLOGY

Lipopolysaccharide-induced blood brain barrier permeability is enhanced by alpha-synuclein expression

(2013) Adam Jangula et al.   NEUROSCIENCE LETTERS

High ferritin levels have major effects on the morphology of erythrocytes in Alzheimer's disease

(2013) Janette Bester et al.   Frontiers in Aging Neuroscience

Could antivirals be used to treat Alzheimer’s disease?

(2012) Ruth F Itzhaki et al.   Future Microbiology

Interaction of Thioflavin T with Amyloid Fibrils: Fluorescence Quantum Yield of Bound Dye

(2012) Anna I. Sulatskaya et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Analyzing Thioflavin T Binding to Amyloid Fibrils by an Equilibrium Microdialysis-Based Technique

(2012) Irina M. Kuznetsova et al.   PLoS One

Emerging roles of pathogens in Alzheimer disease

(2011) Judith Miklossy   EXPERT REVIEWS IN MOLECULAR MEDICINE

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria

(2011) Judith Miklossy   Journal of Neuroinflammation

Interaction of Thioflavin T with Amyloid Fibrils: Stoichiometry and Affinity of Dye Binding, Absorption Spectra of Bound Dye

(2011) Anna I. Sulatskaya et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Urinary tract infection in very old women is associated with delirium

(2010) Irene Eriksson et al.   INTERNATIONAL PSYCHOGERIATRICS

Alzheimer's disease and infection: Do infectious agents contribute to progression of Alzheimer's disease?

(2009) Kie Honjo et al.   Alzheimers & Dementia

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

(2009) Douglas B Kell   BMC Medical Genomics

Lipopolysaccharide alters the blood–brain barrier transport of amyloid β protein: A mechanism for inflammation in the progression of Alzheimer’s disease

(2009) Laura B. Jaeger et al.   BRAIN BEHAVIOR AND IMMUNITY

Profile for Amyloid-β and Tau Expression in Primary Cortical Cultures from 3xTg-AD Mice

(2009) Carmen Vale et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Molecular Mechanism of Thioflavin-T Binding to the Surface of β-Rich Peptide Self-Assemblies

(2008) Matthew Biancalana et al.   JOURNAL OF MOLECULAR BIOLOGY

Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)

(2008) Rongzhen Zhang et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation

Inflammation and Alzheimer's disease: Possible role of periodontal diseases

(2007) Angela R. Kamer et al.   Alzheimers & Dementia

Molecular consequences of activated microglia in the brain: overactivation induces apoptosis

(2003) Bin Liu et al.   JOURNAL OF NEUROCHEMISTRY