Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker™ stains

Interpreting P values

(2017) Naomi Altman et al.   NATURE METHODS

Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting

(2017) Douglas B. Kell et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?

(2017) Etheresia Pretorius et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Blood clot parameters: Thromboelastography and scanning electron microscopy in research and clinical practice

(2017) Etheresia Pretorius et al.   THROMBOSIS RESEARCH

Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

(2017) Mark Lucanic et al.   Nature Communications

The critical role of toll-like receptors — From microbial recognition to autoimmunity: A comprehensive review

(2016) Maximiliano Javier Jiménez-Dalmaroni et al.   AUTOIMMUNITY REVIEWS

Biochemical and structural analysis of the interaction between  -amyloid and fibrinogen

(2016) D. Zamolodchikov et al.   BLOOD

TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review

(2016) Suprabhat Mukherjee et al.   Brazilian Journal of Infectious Diseases

Binding Modes of Thioflavin T on the Surface of Amyloid Fibrils Studied by NMR

(2016) Valerie A. Ivancic et al.   CHEMPHYSCHEM

Thioflavin T: Electronic Circular Dichroism and Circularly Polarized Luminescence Induced by Amyloid Fibrils

(2016) Anna Rybicka et al.   CHEMPHYSCHEM

Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations

(2016) Sander Greenland et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability

(2016) Etheresia Pretorius et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

A Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease

(2016) Etheresia Pretorius et al.   JOURNAL OF ALZHEIMERS DISEASE

Novel Diagnostic and Monitoring Tools in Stroke: an Individualized Patient-Centered Precision Medicine Approach

(2016) Sulette de Villiers et al.   Journal of Atherosclerosis and Thrombosis

Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide

(2016) Etheresia Pretorius et al.   Journal of the Royal Society Interface

A possible new role for Aβ in vascular and inflammatory dysfunction in Alzheimer's disease

(2016) Daria Zamolodchikov et al.   THROMBOSIS RESEARCH

A High Affinity Red Fluorescence and Colorimetric Probe for Amyloid β Aggregates

(2016) K. Rajasekhar et al.   Scientific Reports

Differential effects of gram-positive and gram-negative bacterial products on morphine induced inhibition of phagocytosis

(2016) Jana Ninkovic et al.   Scientific Reports

Steady-state and time-resolved Thioflavin-T fluorescence can report on morphological differences in amyloid fibrils formed by Aβ(1-40) and Aβ(1-42)

(2015) David J. Lindberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Comparison of Three Fluorophores for the Detection of Amyloid Fibers and Prefibrillar Oligomeric Assemblies. ThT (Thioflavin T); ANS (1-Anilinonaphthalene-8-sulfonic Acid); and bisANS (4,4′-Dianilino-1,1′-binaphthyl-5,5′-disulfonic Acid)

(2015) Nadine D. Younan et al.   BIOCHEMISTRY

Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics

(2015) Etheresia Pretorius et al.   Cardiovascular Diabetology

Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience

(2015) Matteo Staderini et al.   CHEMICAL SOCIETY REVIEWS

A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates

(2015) Hamid Shirani et al.   CHEMISTRY-A EUROPEAN JOURNAL

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)

(2015) Douglas B. Kell et al.   Integrative Biology

On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death

(2015) Douglas B. Kell et al.   Integrative Biology

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

(2015) Xueli Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-based drug design identifies polythiophenes as antiprion compounds

(2015) Uli S. Herrmann et al.   Science Translational Medicine

Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS)

(2015) Janette Bester et al.   Oncotarget

Pentameric Thiophene-Based Ligands that Spectrally Discriminate Amyloid-β and Tau Aggregates Display Distinct Solvatochromism and Viscosity-Induced Spectral Shifts

(2014) Rozalyn A. Simon et al.   CHEMISTRY-A EUROPEAN JOURNAL

Photophysical study of Thioflavin T as fluorescence marker of amyloid fibrils

(2014) Sonia Freire et al.   DYES AND PIGMENTS

Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases

(2014) Etheresia Pretorius et al.   Integrative Biology

A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer’s disease mice

(2014) Hyung Jin Ahn et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

(2014) Douglas B. Kell et al.   Metallomics

Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands

(2014) Karin Magnusson et al.   Prion

Evidence for Age-Dependent in Vivo Conformational Rearrangement within Aβ Amyloid Deposits

(2013) Sofie Nyström et al.   ACS Chemical Biology

Fluorescence detection of cationic amyloid fibrils in human semen

(2013) David Easterhoff et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Concise Guide to PHARMACOLOGY 2013/14: Catalytic Receptors

(2013) Stephen P.H. Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Luminescent Conjugated Oligothiophenes for Sensitive Fluorescent Assignment of Protein Inclusion Bodies

(2013) Therése Klingstedt et al.   CHEMBIOCHEM

Thioflavin-T excimer formation upon interaction with amyloid fibers

(2013) Raimon Sabate et al.   CHEMICAL COMMUNICATIONS

Recent progress in the development of near-infrared fluorescent probes for bioimaging applications

(2013) Zhiqian Guo et al.   CHEMICAL SOCIETY REVIEWS

The Structural Basis for Optimal Performance of Oligothiophene-Based Fluorescent Amyloid Ligands: Conformational Flexibility is Essential for Spectral Assignment of a Diversity of Protein Aggregates

(2013) Therése Klingstedt et al.   CHEMISTRY-A EUROPEAN JOURNAL

TLR2 and TLR4 in Autoimmune Diseases: a Comprehensive Review

(2013) Yu Liu et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Dual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding Proteins

(2013) Xueli Zhang et al.   CURRENT ORGANIC CHEMISTRY

A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy

(2013) Etheresia Pretorius et al.   TOXICOLOGY MECHANISMS AND METHODS

Molecular Rotors: What Lies Behind the High Sensitivity of the Thioflavin-T Fluorescent Marker

(2012) Nadav Amdursky et al.   ACCOUNTS OF CHEMICAL RESEARCH

BODIPY-Based Molecular Probe for Imaging of Cerebral β-Amyloid Plaques

(2012) Masahiro Ono et al.   ACS Chemical Neuroscience

Luminescent conjugated poly- and oligo-thiophenes: optical ligands for spectral assignment of a plethora of protein aggregates

(2012) Therése Klingstedt et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A  delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin

(2012) D. Zamolodchikov et al.   BLOOD

Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging

(2012) Lin Yuan et al.   CHEMICAL SOCIETY REVIEWS

Recognition of bacterial infection by innate immune sensors

(2012) Sushil Kumar et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Nanoscopic and Photonic Ultrastructural Characterization of Two Distinct Insulin Amyloid States

(2012) Katarzyna Maria Psonka-Antonczyk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Polythiophenes Inhibit Prion Propagation by Stabilizing Prion Protein (PrP) Aggregates

(2012) Ilan Margalith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tri- and Pentamethine Cyanine Dyes for Fluorescent Detection of α-Synuclein Oligomeric Aggregates

(2012) V. B. Kovalska et al.   JOURNAL OF FLUORESCENCE

Interaction of Thioflavin T with Amyloid Fibrils: Fluorescence Quantum Yield of Bound Dye

(2012) Anna I. Sulatskaya et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Amyloid Fibril-Induced Structural and Spectral Modifications in the Thioflavin-T Optical Probe

(2012) N. Arul Murugan et al.   Journal of Physical Chemistry Letters

The Role of TLR2 in Infection and Immunity

(2012) Laura Oliveira-Nascimento et al.   Frontiers in Immunology

ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue

(2011) Willy M. Chang et al.   ACS Chemical Neuroscience

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Interaction of Thioflavin T with Amyloid Fibrils: Stoichiometry and Affinity of Dye Binding, Absorption Spectra of Bound Dye

(2011) Anna I. Sulatskaya et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Spectroscopic characterization of diverse amyloid fibrils in vitro by the fluorescent dye Nile red

(2011) Rajesh Mishra et al.   Molecular BioSystems

Synthesis of a library of oligothiophenes and their utilization as fluorescent ligands for spectral assignment of protein aggregates

(2011) Therése Klingstedt et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Vigorous, but differential mononuclear cell response of cirrhotic patients to bacterial ligands

(2011) Varenka J Barbero-Becerra   WORLD JOURNAL OF GASTROENTEROLOGY

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

(2010) Douglas B. Kell   ARCHIVES OF TOXICOLOGY

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies

(2010) Dee Shen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses

(2010) Ina Berg et al.   Nature Protocols

Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease

(2010) Marta Cortes-Canteli et al.   NEURON

Alzheimer's disease peptide  -amyloid interacts with fibrinogen and induces its oligomerization

(2010) H. J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Pentameric Thiophene Derivatives forin Vitroandin VivoOptical Imaging of a Plethora of Protein Aggregates in Cerebral Amyloidoses

(2009) Andreas Åslund et al.   ACS Chemical Biology

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

(2009) Douglas B Kell   BMC Medical Genomics

Activation of coagulation and inhibition of fibrinolysis in the human lung on bronchial instillation of lipoteichoic acid and lipopolysaccharide*

(2009) Jacobien J. Hoogerwerf et al.   CRITICAL CARE MEDICINE

TLR2 – promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity

(2008) Ulrich Zähringer et al.   IMMUNOBIOLOGY

Molecular Mechanism of Thioflavin-T Binding to the Surface of β-Rich Peptide Self-Assemblies

(2008) Matthew Biancalana et al.   JOURNAL OF MOLECULAR BIOLOGY