Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 121, Issue 38, Pages 8926-8934Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcb.7b06675
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Funding
- MINECO [CTQ2014-59544-P]
- Generalitat de Catalunya [2014SGR-482]
- Universitat Autonoma de Barcelona
- ICREA Academia Award
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Alzheimer's disease is a challenge of the utmost importance for contemporary society. An early diagnosis is essential for the development of treatments and for establishing a network of support for the patient. In this light, the deposition in the brain of amyloid-beta fibrillar aggregates, which is a distinctive feature of Alzheimer, is key for an early detection of this disease. In this work we propose an atomistic study of the interaction of amyloid tracers with recently published polymorphic models of amyloid-beta 1-40 and 1-42 fibrils, highlighting the relationship between marker architectures and binding affinity. This work uncovers the importance of quaternary structure, and in particular of junctions between amyloid-beta protofilaments, as the key areas for marker binding.
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