COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms

Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China

(2020) Zunyou Wu et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury

(2020) Yingxia Liu et al.   Science China-Life Sciences

Autopsy Findings and Venous Thromboembolism in Patients With COVID-19

(2020) Dominic Wichmann et al.   ANNALS OF INTERNAL MEDICINE

COVID‐19 & ABO blood group: another viewpoint

(2020) Christiane Gérard et al.   BRITISH JOURNAL OF HAEMATOLOGY

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis

(2020) Brandon Michael Henry et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Prominent changes in blood coagulation of patients with SARS-CoV-2 infection

(2020) Huan Han et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic

(2020)   EUROPEAN JOURNAL OF HUMAN GENETICS

High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study

(2020) Julie Helms et al.   INTENSIVE CARE MEDICINE

Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

(2020) Safiya Richardson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

DC/L‐SIGNs of Hope in the COVID‐19 Pandemic

(2020) Adam Brufsky et al.   JOURNAL OF MEDICAL VIROLOGY

COVID‐19 and Liver Dysfunction: a systematic review and meta‐analysis of retrospective studies

(2020) Mohanad Youssef et al.   JOURNAL OF MEDICAL VIROLOGY

Fibrinolysis Shutdown Correlates to Thromboembolic Events in Severe COVID-19 Infection

(2020) Franklin L. Wright et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

High incidence of venous thromboembolic events in anticoagulated severe COVID‐19 patients

(2020) Jean‐François Llitjos et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Incidence of venous thromboembolism in hospitalized patients with COVID‐19

(2020) Saskia Middeldorp et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

ISTH interim guidance on recognition and management of coagulopathy in COVID‐19

(2020) Jecko Thachil et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19

(2020) Claire S Whyte et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Human leukocyte antigen susceptibility map for SARS-CoV-2

(2020) Austin Nguyen et al.   JOURNAL OF VIROLOGY

Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study

(2020) Matthew J Cummings et al.   LANCET

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiorgan and Renal Tropism of SARS-CoV-2

(2020) Victor G. Puelles et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hemostatic laboratory derangements in COVID-19 with a focus on platelet count

(2020) Ariunzaya Amgalan et al.   PLATELETS

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

(2020) Annemarie B Docherty et al.   BMJ-British Medical Journal

COVID-19 cytokine storm: the interplay between inflammation and coagulation

(2020) Ricardo J Jose et al.   Lancet Respiratory Medicine

Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence

(2020) Celestino Sardu et al.   Journal of Clinical Medicine

COVID-19-driven endothelial damage: complement, HIF-1, and ABL2 are potential pathways of damage and targets for cure

(2020) Monia Marchetti   ANNALS OF HEMATOLOGY

Platelet Gene Expression and Function in COVID-19 Patients

(2020) Bhanu Kanth Manne et al.   BLOOD

New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis

(2020) Yuan Hou et al.   BMC Medicine

Re The source of elevated plasma D‐dimer levels in COVID‐19 infection

(2020) Beverley J. Hunt et al.   BRITISH JOURNAL OF HAEMATOLOGY

Prevention, Diagnosis, and Treatment of VTE in Patients With Coronavirus Disease 2019

(2020) Lisa K. Moores et al.   CHEST

Immunothrombotic Dysregulation in COVID-19 Pneumonia is Associated with Respiratory Failure and Coagulopathy

(2020) Leo Nicolai et al.   CIRCULATION

Hyperinflammation and derangement of renin-angiotensin-aldosterone system in COVID-19: A novel hypothesis for clinically suspected hypercoagulopathy and microvascular immunothrombosis

(2020) Brandon Michael Henry et al.   CLINICA CHIMICA ACTA

Thrombosis and COVID-19 pneumonia: the clot thickens!

(2020) Laura C. Price et al.   EUROPEAN RESPIRATORY JOURNAL

Endothelial cell dysfunction: a major player in SARS-CoV-2 infection (COVID-19)?

(2020) Alice Huertas et al.   EUROPEAN RESPIRATORY JOURNAL

Dying with SARS-CoV-2 infection—an autopsy study of the first consecutive 80 cases in Hamburg, Germany

(2020) Carolin Edler et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past

(2020) Dimitrios Giannis et al.   JOURNAL OF CLINICAL VIROLOGY

Cytokine storm and leukocyte changes in mild versus severe SARS‐CoV‐2 infection: Review of 3939 COVID‐19 patients in China and emerging pathogenesis and therapy concepts

(2020) Jin Wang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

COVID‐19: a collision of complement, coagulation and inflammatory pathways

(2020) Anoop J. Chauhan et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Fibrinolysis and COVID‐19: A plasmin paradox

(2020) Robert L. Medcalf et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Potential role for tissue factor in the pathogenesis of hypercoagulability associated with in COVID-19

(2020) Mario Bautista-Vargas et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

High D dimers and low global fibrinolysis coexist in COVID19 patients: what is going on in there?

(2020) C. Ibañez et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

COVID-19: the role of excessive cytokine release and potential ACE2 down-regulation in promoting hypercoagulable state associated with severe illness

(2020) Fenghe Du et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

(2020) George Goshua et al.   Lancet Haematology

Vascular occlusion by neutrophil extracellular traps in COVID-19

(2020) Moritz Leppkes et al.   EBioMedicine

Neutrophil extracellular traps in COVID-19

(2020) Yu Zuo et al.   JCI Insight

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19

(2020) Eugenio D. Hottz et al.   BLOOD

The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): Report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities

(2020) Louis Maximilian Buja et al.   CARDIOVASCULAR PATHOLOGY

Comparative analysis of laboratory indexes of severe and non-severe patients infected with COVID-19

(2020) Jinfeng Bao et al.   CLINICA CHIMICA ACTA

Mitochondria and microbiota dysfunction in COVID-19 pathogenesis

(2020) Jumana Saleh et al.   MITOCHONDRION

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Is COVID-19 associated thrombosis caused by overactivation of the complement cascade? A literature review

(2020) Alexander Fletcher-Sandersjöö et al.   THROMBOSIS RESEARCH

Image-proven thromboembolism in patients with severe COVID-19 in a tertiary critical care unit in the United Kingdom

(2020) Michael J.R. Desborough et al.   THROMBOSIS RESEARCH

The Human Platelet as an Innate Immune Cell: Interactions Between Activated Platelets and the Complement System

(2019) Oskar Eriksson et al.   Frontiers in Immunology

The stimulation of thrombosis by hypoxia

(2019) Neha Gupta et al.   THROMBOSIS RESEARCH

DAMPs and NETs in Sepsis

(2019) Naomi-Liza Denning et al.   Frontiers in Immunology

Tissue Factor

(2018) Steven P. Grover et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

NETosis, complement, and coagulation: a triangular relationship

(2018) Cynthia M. de Bont et al.   Cellular & Molecular Immunology

Genomic atlas of the human plasma proteome

(2018) Benjamin B. Sun et al.   NATURE

The role of leukocytes in thrombosis

(2016) Laura L. Swystun et al.   BLOOD

Immunothrombosis in Acute Respiratory Distress Syndrome: Cross Talks between Inflammation and Coagulation

(2016) Frantzeska Frantzeskaki et al.   RESPIRATION

Neutrophil Extracellular Traps Go Viral

(2016) Günther Schönrich et al.   Frontiers in Immunology

Meta-analysis of 65,734 Individuals Identifies TSPAN15 and SLC44A2 as Two Susceptibility Loci for Venous Thromboembolism

(2015) Marine Germain et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Platelet secretion: From haemostasis to wound healing and beyond

(2015) Ewelina M. Golebiewska et al.   BLOOD REVIEWS

Endothelial cell control of thrombosis

(2015) Jonathan W. Yau et al.   BMC Cardiovascular Disorders

von Willebrand Factor Directly Interacts With DNA From Neutrophil Extracellular Traps

(2014) S. Grassle et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HIF Transcription Factors, Inflammation, and Immunity

(2014) Asis Palazon et al.   IMMUNITY

Inflammation, obesity, and thrombosis

(2013) F. Samad et al.   BLOOD

Hypoxia, vascular smooth muscles and endothelium

(2013) Calvin K. Chan et al.   Acta Pharmaceutica Sinica B

Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia

(2012) Ali M. Zaki et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Genome-Wide Association Scan on the Levels of Markers of Inflammation in Sardinians Reveals Associations That Underpin Its Complex Regulation

(2012) Silvia Naitza et al.   PLoS Genetics

P-Selectin Antagonism in Inflammatory Disease

(2011) Kevin J. Woollard et al.   CURRENT PHARMACEUTICAL DESIGN

Neutrophils release brakes of coagulation

(2010) Wolfram Ruf et al.   NATURE MEDICINE

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Extracellular DNA traps promote thrombosis

(2010) T. A. Fuchs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Continuing Education Course #2: Current Understanding of Hemostasis

(2010) Andrew J. Gale   TOXICOLOGIC PATHOLOGY

Inhibition of the interaction between the SARS-CoV Spike protein and its cellular receptor by anti-histo-blood group antibodies

(2008) Patrice Guillon et al.   GLYCOBIOLOGY