Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular co-morbidities

Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting

(2017) Douglas B. Kell et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Lipopolysaccharide-binding protein is bound and internalized by host cells and colocalizes with LPS in the cytoplasm: Implications for a role of LBP in intracellular LPS-signaling

(2016) Franziska Kopp et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Intestinal Dysbiosis, Gut Hyperpermeability and Bacterial Translocation: Missing Links Between Depression, Obesity and Type 2 Diabetes

(2016) Anastasiya Slyepchenko et al.   CURRENT PHARMACEUTICAL DESIGN

A Bacterial Component to Alzheimer’s-Type Dementia Seen via a Systems Biology Approach that Links Iron Dysregulation and Inflammagen Shedding to Disease

(2016) Etheresia Pretorius et al.   JOURNAL OF ALZHEIMERS DISEASE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Serum amyloid a and risk of death and end-stage renal disease in diabetic kidney disease

(2016) Brad P. Dieter et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide

(2016) Etheresia Pretorius et al.   Journal of the Royal Society Interface

Valsartan inhibits amylin-induced podocyte damage

(2016) Fengjuan Huang et al.   MICROVASCULAR RESEARCH

The genetic architecture of type 2 diabetes

(2016) Christian Fuchsberger et al.   NATURE

Interplay between ultrastructural findings and atherothrombotic complications in type 2 diabetes mellitus

(2015) Prashilla Soma et al.   Cardiovascular Diabetology

Cardiovascular Complications in Inflammatory Bowel Disease

(2015) Rudolf Schicho et al.   CURRENT DRUG TARGETS

Gut microorganisms as promising targets for the management of type 2 diabetes

(2015) Nathalie M. Delzenne et al.   DIABETOLOGIA

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)

(2015) Douglas B. Kell et al.   Integrative Biology

On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death

(2015) Douglas B. Kell et al.   Integrative Biology

Visualization of fibrinogen αC regions and their arrangement during fibrin network formation by high-resolution AFM

(2015) A. D. Protopopova et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The role for gut permeability in the pathogenesis of type 1 diabetes - a solid or leaky concept?

(2015) Xia Li et al.   PEDIATRIC DIABETES

Coagulation factor XIII: a multifunctional transglutaminase with clinical potential in a range of conditions

(2015) Heiko Herwald et al.   THROMBOSIS AND HAEMOSTASIS

Amyloid Fibres: Inert End-Stage Aggregates or Key Players in Disease?

(2015) Kevin W. Tipping et al.   TRENDS IN BIOCHEMICAL SCIENCES

The architecture of amyloid-like peptide fibrils revealed by X-ray scattering, diffraction and electron microscopy

(2015) Annette E. Langkilde et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Experimental and Imaging Techniques for Examining Fibrin Clot Structures in Normal and Diseased States

(2015) Natalie K. Fan et al.   Jove-Journal of Visualized Experiments

Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis

(2014) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Platelets in Rheumatic Diseases: Friend or Foe?

(2014) Armen Gasparyan et al.   CURRENT PHARMACEUTICAL DESIGN

Photophysical study of Thioflavin T as fluorescence marker of amyloid fibrils

(2014) Sonia Freire et al.   DYES AND PIGMENTS

The pathogenic mechanism of diabetes varies with the degree of overexpression and oligomerization of human amylin in the pancreatic islet β cells

(2014) Shaoping Zhang et al.   FASEB JOURNAL

Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases

(2014) Etheresia Pretorius et al.   Integrative Biology

Serum amyloid A and inflammation in diabetic kidney disease and podocytes

(2014) Robert J Anderberg et al.   LABORATORY INVESTIGATION

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

(2014) Douglas B. Kell et al.   Metallomics

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Profound Morphological Changes in the Erythrocytes and Fibrin Networks of Patients with Hemochromatosis or with Hyperferritinemia, and Their Normalization by Iron Chelators and Other Agents

(2014) Etheresia Pretorius et al.   PLoS One

Epidemiological associations between iron and cardiovascular disease and diabetes

(2014)   Frontiers in Pharmacology

Molecular Structures of Amyloid and Prion Fibrils: Consensus versus Controversy

(2013) Robert Tycko et al.   ACCOUNTS OF CHEMICAL RESEARCH

Dose-dependent effect of aspirin on the level of sphingolipids in human blood

(2013) M Knapp et al.   Advances in Medical Sciences

Antiplatelet and Anticoagulant Therapy for Atherothrombotic Disease: The Role of Current and Emerging Agents

(2013) Dominick J. Angiolillo et al.   American Journal of Cardiovascular Drugs

Hereditary amyloidosis caused by R554L fibrinogen Aα-chain mutation in a Spanish family and review of the literature

(2013) Michael Haidinger et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Aspirin for Prevention and Treatment of Cardiovascular Disease

(2013) Shamir R. Mehta   ANNALS OF INTERNAL MEDICINE

Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness

(2013) Michael Berk et al.   BMC Medicine

Islet Amyloid Polypeptide and Diabetes

(2013) Gunilla Westermark et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Fibrin(ogen) and thrombotic disease

(2013) R. A. S. Ariëns   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Parkinson's Disease and Alpha Synuclein: Is Parkinson's Disease a Prion-Like Disorder?

(2013) C. Warren Olanow et al.   MOVEMENT DISORDERS

Effect of Lipopolysaccharide on Inflammation and Insulin Action in Human Muscle

(2013) Hanyu Liang et al.   PLoS One

The Age-Specific Quantitative Effects of Metabolic Risk Factors on Cardiovascular Diseases and Diabetes: A Pooled Analysis

(2013) Gitanjali M. Singh et al.   PLoS One

Prolonged duration of type 2 diabetes is associated with increased thrombin generation, prothrombotic fibrin clot phenotype and impaired fibrinolysis

(2013) Malgorzata Konieczynska et al.   THROMBOSIS AND HAEMOSTASIS

A novel method for assessing the role of iron and its functional chelation in fibrin fibril formation: the use of scanning electron microscopy

(2013) Etheresia Pretorius et al.   TOXICOLOGY MECHANISMS AND METHODS

Evidence for metabolic endotoxemia in obese and diabetic Gambian women

(2013) S Hawkesworth et al.   Nutrition & Diabetes

Amylin Uncovered: A Review on the Polypeptide Responsible for Type II Diabetes

(2013) Karen Pillay et al.   Biomed Research International

Acetylation and glycation of fibrinogen in vitro occur at specific lysine residues in a concentration dependent manner: A mass spectrometric and isotope labeling study

(2012) Jan Svensson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Fibrin Clot Structure and Mechanics Associated with Specific Oxidation of Methionine Residues in Fibrinogen

(2012) Katie M. Weigandt et al.   BIOPHYSICAL JOURNAL

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Determinants of fibrin formation, structure, and function

(2012) Alisa S. Wolberg   CURRENT OPINION IN HEMATOLOGY

Altered fibrin-clot properties are associated with retinopathy in type 2 diabetes mellitus

(2012) M. Walus-Miarka et al.   DIABETES & METABOLISM

Acute-Phase Serum Amyloid A Protein and Its Implication in the Development of Type 2 Diabetes in the KORA S4/F4 Study

(2012) C. Marzi et al.   DIABETES CARE

Association of serum amyloid A with subclinical atherosclerosis in women with gestational diabetes

(2012) Mehmet Ali Eren et al.   GYNECOLOGICAL ENDOCRINOLOGY

Gender-Specific Alterations in Fibrin Structure Function in Type 2 Diabetes: Associations with Cardiometabolic and Vascular Markers

(2012) Saad H. Alzahrani et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Type 2 diabetes as a modifier of fibrin clot properties in patients with coronary artery disease

(2012) Maciej Bochenek et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Iron enhances generation of fibrin fibers in human blood: Implications for pathogenesis of stroke

(2012) Boguslaw Lipinski et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Amyloid Neuropathies

(2012) Susan C. Shin et al.   MOUNT SINAI JOURNAL OF MEDICINE

Intraocular Expression of Serum Amyloid A and Interleukin-6 in Proliferative Diabetic Retinopathy

(2011) Yan Ma et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Current perspectives on cardiac amyloidosis

(2011) Jian Guan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Fibrin Clot Structure and Function

(2011) Anetta Undas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The potential effects of anti-diabetic medications on myocardial ischemia–reperfusion injury

(2011) Yumei Ye et al.   BASIC RESEARCH IN CARDIOLOGY

Qualitative scanning electron microscopy analysis of fibrin networks and platelet abnormalities in diabetes

(2011) Etheresia Pretorius et al.   BLOOD COAGULATION & FIBRINOLYSIS

Differences in fibrin fiber diameters in healthy individuals and thromboembolic ischemic stroke patients

(2011) Etheresia Pretorius et al.   BLOOD COAGULATION & FIBRINOLYSIS

Bacterial Endotoxin Activity in Human Serum Is Associated With Dyslipidemia, Insulin Resistance, Obesity, and Chronic Inflammation

(2011) Mariann I. Lassenius et al.   DIABETES CARE

A novel mechanism for hypofibrinolysis in diabetes: the role of complement C3

(2011) K. Hess et al.   DIABETOLOGIA

A Study of Plasma Fibrinogen Level in Type-2 Diabetes Mellitus and its Relation to Glycemic Control

(2011) Archana Sachin Bembde   INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION

Cardiac amyloidosis: the heart of the matter

(2011) Federico Perfetto et al.   Internal and Emergency Medicine

Interaction of Thioflavin T with Amyloid Fibrils: Stoichiometry and Affinity of Dye Binding, Absorption Spectra of Bound Dye

(2011) Anna I. Sulatskaya et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Leaky gut and diabetes mellitus: what is the link?

(2011) S. de Kort et al.   Obesity Reviews

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Impaired glucose metabolism and type 2 diabetes are associated with hypercoagulability: potential role of central adiposity and low-grade inflammation – The Hoorn Study

(2011) Hanneke J.B.H. Beijers et al.   THROMBOSIS RESEARCH

Survival of an islet β-cell in type-2 diabetes: Curbing the effects of amyloid cytotoxicity

(2011) Kerry M. Loomes   Islets

The effect of curcumin on human islet amyloid polypeptide misfolding and toxicity

(2010) Marie Daval et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

(2010) Douglas B. Kell   ARCHIVES OF TOXICOLOGY

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

High-Resolution Visualization of Fibrinogen Molecules and Fibrin Fibers with Atomic Force Microscopy

(2010) Ivan S. Yermolenko et al.   BIOMACROMOLECULES

Fibrinogen amyloidosis: the clot thickens!

(2010) M. M. Picken   BLOOD

Review article: Coagulation and fibrinolysis in diabetes

(2010) SH Alzahrani et al.   Diabetes & Vascular Disease Research

Hypercoagulability in patients with type 2 diabetes mellitus detected by a thrombin generation assay

(2010) Armando Tripodi et al.   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Viewing Ageing Eyes: Diverse Sites of Amyloid Beta Accumulation in the Ageing Mouse Retina and the Up-Regulation of Macrophages

(2010) Jaimie Hoh Kam et al.   PLoS One

Amyloid fibrils

(2010) Roma N. Rambaran et al.   Prion

Structural polymorphism of Alzheimer Aβ and other amyloid fibrils

(2010) Marcus Fändrich et al.   Prion

Flow profoundly influences fibrin network structure: Implications for fibrin formation and clot stability in haemostasis

(2010) Robert A. Campbell et al.   THROMBOSIS AND HAEMOSTASIS

Comparison of Plasminogen Activator Inhibitor-1, Tissue Type Plasminogen Activator Antigen, Fibrinogen, and D-Dimer Levels in Various Age Decades in Patients With Type 2 Diabetes Mellitus and Stable Coronary Artery Disease (from the BARI 2D Trial)

(2009) Robert D. McBane et al.   AMERICAN JOURNAL OF CARDIOLOGY

Hereditary fibrinogen A  -chain amyloidosis: phenotypic characterization of a systemic disease and the role of liver transplantation

(2009) A. J. Stangou et al.   BLOOD

Changes in endotoxin levels in T2DM subjects on anti-diabetic therapies

(2009) Omar S Al-Attas et al.   Cardiovascular Diabetology

Serum Amyloid A, C-Reactive Protein, and Retinal Microvascular Changes in Hypertensive Diabetic and Nondiabetic Individuals: An Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) substudy

(2009) C. Stettler et al.   DIABETES CARE

Serum Lipopolysaccharide Activity Is Associated With the Progression of Kidney Disease in Finnish Patients With Type 1 Diabetes

(2009) M. Nymark et al.   DIABETES CARE

Structure-activity relationship of amyloid fibrils

(2009) Samir K. Maji et al.   FEBS LETTERS

The "Perfect Storm" for Type 1 Diabetes: The Complex Interplay Between Intestinal Microbiota, Gut Permeability, and Mucosal Immunity

(2008) O. Vaarala et al.   DIABETES

Molecular and cellular aspects of protein misfolding and disease

(2008) Eszter Herczenik et al.   FASEB JOURNAL

Molecular Mechanism of Thioflavin-T Binding to the Surface of β-Rich Peptide Self-Assemblies

(2008) Matthew Biancalana et al.   JOURNAL OF MOLECULAR BIOLOGY

Residual platelet thromboxane A2and prothrombotic effects of erythrocytes are important determinants of aspirin resistance in patients with vascular disease

(2008) M. T. SANTOS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Complexity of “A−a” Knob−Hole Fibrin Interaction Revealed by Atomic Force Spectroscopy

(2008) Laurel E. Averett et al.   LANGMUIR

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

(2008) Judith Miklossy et al.   NEUROBIOLOGY OF AGING

The fold of  -synuclein fibrils

(2008) M. Vilar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycaemic control improves fibrin network characteristics in type 2 diabetes – A purified fibrinogen model

(2008) Namukolo Covic et al.   THROMBOSIS AND HAEMOSTASIS