The potential remedy of melatonin on osteoarthritis

Melatonin alleviates d ‐galactose‐decreased hyaluronic acid production in synovial membrane cells via Sirt1 signalling

(2021) Na Han et al.   CELL BIOCHEMISTRY AND FUNCTION

New insights into antimetastatic signaling pathways of melatonin in skeletomuscular sarcoma of childhood and adolescence

(2020) Ko-Hsiu Lu et al.   CANCER AND METASTASIS REVIEWS

Immune‐pineal axis protects rat lungs exposed to polluted air

(2020) Claudia Emanuele Carvalho‐Sousa et al.   JOURNAL OF PINEAL RESEARCH

Melatonin activates autophagy via the NF-κB signaling pathway to prevent extracellular matrix degeneration in intervertebral disc

(2020) Fan Chen et al.   OSTEOARTHRITIS AND CARTILAGE

Melatonin receptor ligands: A pharmaco‐chemical perspective

(2020) Jean A. Boutin et al.   JOURNAL OF PINEAL RESEARCH

Injectable gellan gum/lignocellulose nanofibrils hydrogels enriched with melatonin loaded forsterite nanoparticles for cartilage tissue engineering: Fabrication, characterization and cell culture studies

(2020) Monireh Kouhi et al.   Materials Science & Engineering C-Materials for Biological Applications

New insights into molecular and cellular mechanisms of zoledronate in human osteosarcoma

(2020) Ko-Hsiu Lu et al.   PHARMACOLOGY & THERAPEUTICS

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis

(2020) Philip R. Coryell et al.   Nature Reviews Rheumatology

Melatonin attenuates TNF-α and IL-1β expression in synovial fibroblasts and diminishes cartilage degradation: implications for the treatment of rheumatoid arthritis

(2019) Chien-Chung Huang et al.   JOURNAL OF PINEAL RESEARCH

Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep

(2019) Gabriella Gobbi et al.   Frontiers in Endocrinology

Circadian production of melatonin in cartilage modifies rhythmic gene expression

(2019) Shanqi Fu et al.   JOURNAL OF ENDOCRINOLOGY

Melatonin Prevents Osteoarthritis-Induced Cartilage Degradation via Targeting MicroRNA-140

(2019) Yijian Zhang et al.   Oxidative Medicine and Cellular Longevity

Molecular and Cellular Mechanisms of Melatonin in Osteosarcoma

(2019) Ko-Hsiu Lu et al.   Cells

Melatonin-mediated miR-526b-3p and miR-590-5p upregulation promotes chondrogenic differentiation of human mesenchymal stem cells

(2018) Zizhao Wu et al.   JOURNAL OF PINEAL RESEARCH

Cartilage diseases

(2018) Yamini Krishnan et al.   MATRIX BIOLOGY

Melatonin rescued interleukin 1β-impaired chondrogenesis of human mesenchymal stem cells

(2018) Bo Gao et al.   Stem Cell Research & Therapy

Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance

(2018) Karin Golan et al.   Cell Stem Cell

MELATONIN AS A HORMONE: NEW PHYSIOLOGICAL AND CLINICAL INSIGHTS

(2018) José Cipolla-Neto et al.   ENDOCRINE REVIEWS

Exosomal miR-95-5p regulates chondrogenesis and cartilage degradation via histone deacetylase 2/8

(2018) Guping Mao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Altered expression of the core circadian clock component PERIOD2 contributes to osteoarthritis-like changes in chondrocyte activity

(2018) Jing Rong et al.   CHRONOBIOLOGY INTERNATIONAL

Melatonin protects vertebral endplate chondrocytes against apoptosis and calcification via the Sirt1-autophagy pathway

(2018) Zengjie Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Melatonin protects bone marrow mesenchymal stem cells against iron overload-induced aberrant differentiation and senescence

(2017) Fan Yang et al.   JOURNAL OF PINEAL RESEARCH

Osteoarthritis year in review 2016: clinical

(2017) N.E. Lane et al.   OSTEOARTHRITIS AND CARTILAGE

Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats

(2017) H.-b. Si et al.   OSTEOARTHRITIS AND CARTILAGE

Melatonin protects chondrocytes from impairment induced by glucocorticoids via NAD + -dependent SIRT1

(2017) Wei Yang et al.   STEROIDS

Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis

(2017) Jia Yi Guo et al.   Oncotarget

Role of melatonin combined with exercise as a switch-like regulator for circadian behavior in advanced osteoarthritic knee

(2017) Yunkyung Hong et al.   Oncotarget

Cartilage repair in the degenerative ageing knee

(2016) Mats Brittberg et al.   Acta Orthopaedica

RORα is not a receptor for melatonin (response to DOI 10.1002/bies.201600018)

(2016) Andrzej T. Slominski et al.   BIOESSAYS

Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis

(2016) Yingliang Wei et al.   CONNECTIVE TISSUE RESEARCH

Clock GeneBmal1Modulates Human Cartilage Gene Expression by Crosstalk With Sirt1

(2016) Wei Yang et al.   ENDOCRINOLOGY

Melatonin inhibits tumorigenicity of glioblastoma stem-like cells via the AKT-EZH2-STAT3 signaling axis

(2016) Xueran Chen et al.   JOURNAL OF PINEAL RESEARCH

Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin

(2016) Azam Hosseinzadeh et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

Physiological melatonin levels in healthy older people: A systematic review

(2016) Rikie M. Scholtens et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

The brain–joint axis in osteoarthritis: nerves, circadian clocks and beyond

(2016) Francis Berenbaum et al.   Nature Reviews Rheumatology

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

Arthroscopic Lateral Retinacular Release and Modified Elmslie–Trillat Operation Improve Severe Isolated Lateral Patello-Femoral Osteoarthritis

(2016) Renn-Chia Lin et al.   Journal of Knee Surgery

SIRT1 contributes to aldose reductase expression through modulating NFAT5 under osmotic stress: In vitro and in silico insights

(2015) Ahmet Can Timucin et al.   CELLULAR SIGNALLING

Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro

(2015) Fuwu Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Environmental Disruption of Circadian Rhythm Predisposes Mice to Osteoarthritis-Like Changes in Knee Joint

(2015) Ranjan Kc et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity

(2015) Michal Dudek et al.   JOURNAL OF CLINICAL INVESTIGATION

Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation

(2015) Jia-Yi Wei et al.   JOURNAL OF PINEAL RESEARCH

Melatonin inhibits autophagy and endoplasmic reticulum stress in mice with carbon tetrachloride-induced fibrosis

(2015) Beatriz San-Miguel et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reverses H2O2-induced premature senescence in mesenchymal stem cells via the SIRT1-dependent pathway

(2015) Long Zhou et al.   JOURNAL OF PINEAL RESEARCH

Melatonin alleviates brain injury in mice subjected to cecal ligation and puncture via attenuating inflammation, apoptosis, and oxidative stress: the role of SIRT1 signaling

(2015) Lei Zhao et al.   JOURNAL OF PINEAL RESEARCH

Melatonin decreases muscular oxidative stress and inflammation induced by strenuous exercise and stimulates growth factor synthesis

(2015) Leandro da Silva Borges et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

Melatonin decreases breast cancer metastasis by modulating Rho-associated kinase protein-1 expression

(2015) Thaiz Ferraz Borin et al.   JOURNAL OF PINEAL RESEARCH

Osteoarthritis

(2015) S Glyn-Jones et al.   LANCET

Cell-based articular cartilage repair: the link between development and regeneration

(2015) K.L. Caldwell et al.   OSTEOARTHRITIS AND CARTILAGE

Chondrons and the Pericellular Matrix of Chondrocytes

(2015) Zijun Zhang   TISSUE ENGINEERING PART B-REVIEWS

Tumor Necrosis Factor-α– and Interleukin-1β–Dependent Matrix Metalloproteinase-3 Expression in Nucleus Pulposus Cells Requires Cooperative Signaling via Syndecan 4 and Mitogen-Activated Protein Kinase–NF-κB Axis

(2014) Xin Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Synovitis in knee osteoarthritis: a precursor of disease?

(2014) I Atukorala et al.   ANNALS OF THE RHEUMATIC DISEASES

Extrapineal melatonin: sources, regulation, and potential functions

(2014) Darío Acuña-Castroviejo et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Abnormal Response of the Proliferation and Differentiation of Growth Plate Chondrocytes to Melatonin in Adolescent Idiopathic Scoliosis

(2014) William Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin Plays a Role as a Mediator of Nocturnal Pain in Patients with Shoulder Disorders

(2014) Eunyoung Ha et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Melatonin reduces cardiac morbidity and markers of myocardial ischemia after elective abdominal aortic aneurism repair: a randomized, placebo-controlled, clinical trial

(2014) Ismail Gögenur et al.   JOURNAL OF PINEAL RESEARCH

Melatonin enhances the human mesenchymal stem cells motility via melatonin receptor 2 coupling with Gαq in skin wound healing

(2014) Sei-Jung Lee et al.   JOURNAL OF PINEAL RESEARCH

Salutary effects of melatonin combined with treadmill exercise on cartilage damage

(2014) Yunkyung Hong et al.   JOURNAL OF PINEAL RESEARCH

Melatonin and its metabolites as copper chelating agents and their role in inhibiting oxidative stress: a physicochemical analysis

(2014) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

(2014) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

Extracellular osmolarity regulates matrix homeostasis in the intervertebral disc and articular cartilage: Evolving role of TonEBP

(2014) Zariel I. Johnson et al.   MATRIX BIOLOGY

Assessment of hyaline cartilage matrix composition using near infrared spectroscopy

(2014) Uday P. Palukuru et al.   MATRIX BIOLOGY

REV-ERB and ROR nuclear receptors as drug targets

(2014) Douglas J. Kojetin et al.   NATURE REVIEWS DRUG DISCOVERY

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Origin and function of cartilage stem/progenitor cells in osteoarthritis

(2014) Yangzi Jiang et al.   Nature Reviews Rheumatology

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

(2013) Tokio Matsuzaki et al.   ANNALS OF THE RHEUMATIC DISEASES

NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis

(2013) Siyoung Yang et al.   ANNALS OF THE RHEUMATIC DISEASES

The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?

(2013) M A Karsdal et al.   ANNALS OF THE RHEUMATIC DISEASES

The Circadian Clock in Murine Chondrocytes Regulates Genes Controlling Key Aspects of Cartilage Homeostasis

(2013) Nicole Gossan et al.   ARTHRITIS AND RHEUMATISM

Proteomic Analysis of Synovial Fluid From the Osteoarthritic Knee: Comparison With Transcriptome Analyses of Joint Tissues

(2013) Susan Y. Ritter et al.   ARTHRITIS AND RHEUMATISM

Epidemiology and burden of osteoarthritis

(2013) A. Litwic et al.   BRITISH MEDICAL BULLETIN

Rescue of proinflammatory cytokine-inhibited chondrogenesis by the antiarthritic effect of melatonin in synovium mesenchymal stem cells via suppression of reactive oxygen species and matrix metalloproteinases

(2013) Xiaozhen Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of Melatonin on the Proliferation and Differentiation of Chondrocytes from Rat Vertebral Body Growth Plate In Vitro

(2013) Zhao-Ming Zhong et al.   International Journal of Medical Sciences

Melatonin: Buffering the Immune System

(2013) Antonio Carrillo-Vico et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin mediates protective effects on inflammatory response induced by interleukin-1 beta in human mesenchymal stem cells

(2013) Xiaozhen Liu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin enhances chondrogenic differentiation of human mesenchymal stem cells

(2013) Wenjie Gao et al.   JOURNAL OF PINEAL RESEARCH

Melatonin effects on bone: potential use for the prevention and treatment for osteopenia, osteoporosis, and periodontal disease and for use in bone-grafting procedures

(2013) Sifat Maria et al.   JOURNAL OF PINEAL RESEARCH

Biologic agents in osteoarthritis: hopes and disappointments

(2013) Xavier Chevalier et al.   Nature Reviews Rheumatology

Melatonin and the skeleton

(2013) A. K. Amstrup et al.   OSTEOPOROSIS INTERNATIONAL

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis

(2013) K. A. Waller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice

(2012) Odile Gabay et al.   ANNALS OF THE RHEUMATIC DISEASES

Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model

(2012) Odile Gabay et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Clock Genes Influence Gene Expression in Growth Plate and Endochondral Ossification in Mice

(2012) Takeshi Takarada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammasomes in liver diseases

(2012) Gyongyi Szabo et al.   JOURNAL OF HEPATOLOGY

Aging Differentially Affects the Re-entrainment Response of Central and Peripheral Circadian Oscillators

(2012) M. T. Sellix et al.   JOURNAL OF NEUROSCIENCE

The overexpression of SIRT1 inhibited osteoarthritic gene expression changes induced by interleukin-1β in human chondrocytes

(2012) Takehiko Matsushita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex vivo human skin

(2012) Tobias W. Fischer et al.   JOURNAL OF PINEAL RESEARCH

Sustained release of melatonin from poly (lactic-co-glycolic acid) (PLGA) microspheres to induce osteogenesis of human mesenchymal stem cells in vitro

(2012) Liangming Zhang et al.   JOURNAL OF PINEAL RESEARCH

Cytoprotective and anti-inflammatory effects of melatonin in hydrogen peroxide-stimulated CHON-001 human chondrocyte cell line and rabbit model of osteoarthritis via the SIRT1 pathway

(2012) Hyun-Dae Lim et al.   JOURNAL OF PINEAL RESEARCH

Serum melatonin levels and antioxidant capacities after consumption of pineapple, orange, or banana by healthy male volunteers

(2012) Manit Sae-Teaw et al.   JOURNAL OF PINEAL RESEARCH

On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK

(2012) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

Macro view of microRNA function in osteoarthritis

(2012) Shigeru Miyaki et al.   Nature Reviews Rheumatology

SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes

(2012) M.-H. Moon et al.   OSTEOARTHRITIS AND CARTILAGE

NF-AT5 is a critical regulator of inflammatory arthritis

(2011) Hyung-Ju Yoon et al.   ARTHRITIS AND RHEUMATISM

Mitochondria: Sovereign of inflammation?

(2011) Jürg Tschopp   EUROPEAN JOURNAL OF IMMUNOLOGY

Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilage

(2011) Koji Takada et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Nicotinamide Phosphoribosyltransferase Is Essential for Interleukin-1β-mediated Dedifferentiation of Articular Chondrocytes via SIRT1 and Extracellular Signal-regulated Kinase (ERK) Complex Signaling

(2011) Eun-Hee Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin synergistically enhances cisplatin-induced apoptosis via the dephosphorylation of ERK/p90 ribosomal S6 kinase/heat shock protein 27 in SK-OV-3 cells

(2011) Ji-Hyun Kim et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as a natural ally against oxidative stress: a physicochemical examination

(2011) Annia Galano et al.   JOURNAL OF PINEAL RESEARCH

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

(2011) B.Y. Chan et al.   OSTEOARTHRITIS AND CARTILAGE

OARSI-FDA initiative: defining the disease state of osteoarthritis

(2011) N.E. Lane et al.   OSTEOARTHRITIS AND CARTILAGE

Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis

(2011) C. Pauli et al.   OSTEOARTHRITIS AND CARTILAGE

On the direct scavenging activity of melatonin towards hydroxyl and a series of peroxyl radicals

(2011) Annia Galano   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Presence of Cartilage Stem/Progenitor Cells in Adult Mice Auricular Perichondrium

(2011) Shinji Kobayashi et al.   PLoS One

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive mechanically controlled lubrication mechanism found in articular joints

(2011) G. W. Greene et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Catabolic Factors and Osteoarthritis-Conditioned Medium Inhibit Chondrogenesis of Human Mesenchymal Stem Cells

(2011) Genoveva T.H. Heldens et al.   TISSUE ENGINEERING PART A

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

(2010) Mary B. Goldring et al.   Annals of the New York Academy of Sciences

SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway

(2010) Viktoria Gagarina et al.   ARTHRITIS AND RHEUMATISM

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Melatonin: A pleiotropic molecule regulating inflammation

(2010) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

Significance of High Levels of Endogenous Melatonin in Mammalian Cerebrospinal Fluid and in the Central Nervous System

(2010) Dun-Xian Tan et al.   Current Neuropharmacology

MicroRNA-140 plays dual roles in both cartilage development and homeostasis

(2010) S. Miyaki et al.   GENES & DEVELOPMENT

Inhibition of Matrix Metalloproteinase-3 and -13 Synthesis Induced by IL-1  in Chondrocytes from Mice Lacking Microsomal Prostaglandin E Synthase-1

(2010) M. Gosset et al.   JOURNAL OF IMMUNOLOGY

Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPARγ expression and enhancing Runx2 expression

(2010) Liangming Zhang et al.   JOURNAL OF PINEAL RESEARCH

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes

(2010) Isabel García-Arnandis et al.   ARTHRITIS RESEARCH & THERAPY

SIRT1 regulation of apoptosis of human chondrocytes

(2009) Koji Takayama et al.   ARTHRITIS AND RHEUMATISM

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1

(2009) Arjen B. Blom et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses

(2009) Shigeru Miyaki et al.   ARTHRITIS AND RHEUMATISM

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

Interleukin-1β and tumor necrosis factor α inhibit chondrogenesis by human mesenchymal stem cells through NF-κB-dependent pathways

(2009) N. Wehling et al.   ARTHRITIS AND RHEUMATISM

Economic burden of knee and hip osteoarthritis in spain

(2009) Estibaliz Loza et al.   ARTHRITIS AND RHEUMATISM

Ionizing Radiation Induces Cellular Senescence of Articular Chondrocytes via Negative Regulation of SIRT1 by p38 Kinase

(2009) Eun-Hee Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Melatonin inhibits human fibroblast-like synoviocyte proliferation via extracellular signal-regulated protein kinase/P21CIP1/P27KIP1pathways

(2009) Seong-Su Nah et al.   JOURNAL OF PINEAL RESEARCH

Hylan G-F 20 Has Better Pain Relief and Cost-effectiveness than Sodium Hyaluronate in Treating Early Osteoarthritic Knees in Taiwan

(2009) Chi-Wen Chou et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis

(2009) N. Taniguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cartilage homeostasis in health and rheumatic diseases

(2009) Mary B Goldring et al.   ARTHRITIS RESEARCH & THERAPY

The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production

(2008) Mandar Dave et al.   ARTHRITIS AND RHEUMATISM

Joint Diseases and Matrix Metalloproteinases: A Role for MMP-13

(2008) Hironari Takaishi et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Melatonin enhances cartilage matrix synthesis by porcine articular chondrocytes

(2008) Ming Pei et al.   JOURNAL OF PINEAL RESEARCH

The genetics of mammalian circadian order and disorder: implications for physiology and disease

(2008) Joseph S. Takahashi et al.   NATURE REVIEWS GENETICS

Immunomodulation by Melatonin: Its Significance for Seasonally Occurring Diseases

(2008) Venkataramanujam Srinivasan et al.   NEUROIMMUNOMODULATION

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Melatonin in the skin: synthesis, metabolism and functions

(2008) Andrzej Slominski et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Circadian rhythms in arthritis: Hormonal effects on the immune/inflammatory reaction

(2007) Maurizio Cutolo et al.   AUTOIMMUNITY REVIEWS

Naproxen, meloxicam and methylprednisolone inhibit urokinase plasminogen activator and inhibitor and gelatinases expression during the early stage of osteoarthritis

(2007) Shu-Chen Chu et al.   CLINICA CHIMICA ACTA

Effects of nonsteroidal anti-inflammatory drugs on the expression of urokinase plasminogen activator and inhibitor and gelatinases in the early osteoarthritic knee of humans

(2007) Shun-Fa Yang et al.   CLINICAL BIOCHEMISTRY

Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes

(2007) Hee-Jeong Im et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effects of different molecular weight hyaluronan products on the expression of urokinase plasminogen activator and inhibitor and gelatinases during the early stage of osteoarthritis

(2007) Yih-Shou Hsieh et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Novel bromomelatonin derivatives suppress osteoclastic activity and increase osteoblastic activity: implications for the treatment of bone diseases

(2007) Nobuo Suzuki et al.   JOURNAL OF PINEAL RESEARCH