Melatonin enhances mitochondrial ATP synthesis, reduces reactive oxygen species formation, and mediates translocation of the nuclear erythroid 2-related factor 2 resulting in activation of phase-2 antioxidant enzymes (γ-GCS, HO-1, NQO1) in ultraviolet rad

Altered Mitochondrial DNA Methylation Pattern in Alzheimer Disease–Related Pathology and in Parkinson Disease

(2016) Marta Blanch et al.   AMERICAN JOURNAL OF PATHOLOGY

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury

(2016) Edward T. Chouchani et al.   Cell Metabolism

Protective role of melatonin in mitochondrial dysfunction and related disorders

(2015) Giuseppe Paradies et al.   ARCHIVES OF TOXICOLOGY

Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca2+ influx activation in mouse pancreatic acinar cells

(2015) Patricia Santofimia-Castaño et al.   FREE RADICAL BIOLOGY AND MEDICINE

Determination of the Action Spectrum of UVR-Induced Mitochondrial DNA Damage in Human Skin Cells

(2015) Jennifer A. Latimer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Melatonin: an ancient molecule that makes oxygen metabolically tolerable

(2015) Lucien C. Manchester et al.   JOURNAL OF PINEAL RESEARCH

Sex difference in the sensitivity of cardiac mitochondrial permeability transition pore to calcium load

(2015) Marie Milerová et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro

(2015) Tae-Kang Kim et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Keap1-Nrf2-antioxidant response element pathway: A review of its regulation by melatonin and the proteasome

(2015) Jerry Vriend et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation shift

(2015) Rubén Torregrosa-Muñumer et al.   MOLECULAR BIOLOGY OF THE CELL

Phytomelatonin: Assisting Plants to Survive and Thrive

(2015) Russel Reiter et al.   MOLECULES

Mitochondrial dysfunction and longevity in animals: Untangling the knot

(2015) Y. Wang et al.   SCIENCE

Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways

(2014) Andrzej Slominski et al.   Anti-Cancer Agents in Medicinal Chemistry

Local Melatoninergic System as the Protector of Skin Integrity

(2014) Andrzej Slominski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin compensates silencing of heat shock protein 70 and suppresses ultraviolet radiation-induced inflammation in human skin ex vivo and cultured keratinocytes

(2014) Konrad Kleszczyński et al.   JOURNAL OF PINEAL RESEARCH

Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review

(2014) Joaquín J. García et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

(2014) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

Cellular localization and kinetics of the rice melatonin biosynthetic enzymes SNAT and ASMT

(2013) Yeong Byeon et al.   JOURNAL OF PINEAL RESEARCH

The role of melatonin in the cells of the innate immunity: a review

(2013) Juan R. Calvo et al.   JOURNAL OF PINEAL RESEARCH

Pulmonary function changes in rats with taurocholate-induced pancreatitis are attenuated by pretreatment with melatonin

(2013) Ting-Ywan Chou et al.   JOURNAL OF PINEAL RESEARCH

Sulforaphane and phenylethyl isothiocyanate protect human skin against UVR-induced oxidative stress and apoptosis: Role of Nrf2-dependent gene expression and antioxidant enzymes

(2013) Konrad Kleszczyński et al.   PHARMACOLOGICAL RESEARCH

Melatonin prevents ultraviolet radiation-induced alterations in plasma membrane potential and intracellular pH in human keratinocytes

(2012) Konrad Kleszczyński et al.   JOURNAL OF PINEAL RESEARCH

Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex vivo human skin

(2012) Tobias W. Fischer et al.   JOURNAL OF PINEAL RESEARCH

Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model

(2012) Zhong Wang et al.   JOURNAL OF PINEAL RESEARCH

Stressed out mitochondria: The role of mitochondria in ageing and cancer focussing on strategies and opportunities in human skin

(2012) Asif S. Tulah et al.   MITOCHONDRION

Melatonin membrane receptors in peripheral tissues: Distribution and functions

(2012) Radomir M. Slominski et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitochondrial function evaluation in epidermal cells ex vivo after ultraviolet irradiation

(2011) Daniel H. González Maglio et al.   EXPERIMENTAL DERMATOLOGY

Investigating the role of melanin in UVA/UVB- and hydrogen peroxide-induced cellular and mitochondrial ROS production and mitochondrial DNA damage in human melanoma cells

(2011) Helen Swalwell et al.   FREE RADICAL BIOLOGY AND MEDICINE

A survey of molecular details in the human pineal gland in the light of phylogeny, structure, function and chronobiological diseases

(2011) Jörg H. Stehle et al.   JOURNAL OF PINEAL RESEARCH

Extrapineal melatonin: analysis of its subcellular distribution and daily fluctuations

(2011) Carmen Venegas et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: The smart killer

(2011) Dave Lanoix et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer

(2011) Gerd P. Pfeifer et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model

(2009) Kyung Hee Jung et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair

(2008) Tobias W. Fischer et al.   EXPERIMENTAL DERMATOLOGY

Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp-9) and effector caspases (casp-3/casp-7) and PARP in UVR-exposed HaCaT keratinocytes

(2008) T. W. Fischer et al.   JOURNAL OF PINEAL RESEARCH