Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells

Geoclimatic, morphological, and temporal effects on Lebanese olive oils composition and classification: A 1 H NMR metabolomic study

(2017) Noelle Merchak et al.   FOOD CHEMISTRY

Characterization of Arbequina virgin olive oils produced in different regions of Brazil and Spain: Physicochemical properties, oxidative stability and fatty acid profile

(2017) Thays H. Borges et al.   FOOD CHEMISTRY

7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD

(2017) Thomas Nury et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Attenuation of 7-ketocholesterol-induced overproduction of reactive oxygen species, apoptosis, and autophagy by dimethyl fumarate on 158 N murine oligodendrocytes

(2017) Amira Zarrouk et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mitochondrial dysfunctions in 7-ketocholesterol-treated 158N oligodendrocytes without or with α-tocopherol: Impacts on the cellular profil of tricarboxylic cycle-associated organic acids, long chain saturated and unsaturated fatty acids, oxysterols, cholesterol and cholesterol precursors

(2017) Valerio Leoni et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Nutrigenomics of extra-virgin olive oil: A review

(2016) Marta Piroddi et al.   BIOFACTORS

Extra virgin olive oil phenolic extracts counteract the pro-oxidant effect of dietary oxidized lipids in human intestinal cells

(2016) Alessandra Incani et al.   FOOD AND CHEMICAL TOXICOLOGY

The Effects of Different Irrigation Treatments on Olive Oil Quality and Composition: A Comparative Study between Treated and Olive Mill Wastewater

(2016) Samia Ben Brahim et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pex9p is a novel yeast peroxisomal import receptor for PTS1-proteins

(2016) Daniel Effelsberg et al.   JOURNAL OF CELL SCIENCE

Extra virgin olive oil modulates brain docosahexaenoic acid level and oxidative damage caused by 2,4-Dichlorophenoxyacetic acid in rats

(2016) Nakbi Amel et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Evaluation of plasma cholestane-3β,5α,6β-triol and 7-ketocholesterol in inherited disorders related to cholesterol metabolism

(2016) Sara Boenzi et al.   JOURNAL OF LIPID RESEARCH

Olive Oil and the Hallmarks of Aging

(2016) Lucía Fernández del Río et al.   MOLECULES

Interdependence of oxysterols with cholesterol profiles in multiple sclerosis

(2016) Shreya Mukhopadhyay et al.   Multiple Sclerosis Journal

Targeting demyelination and virtual hypoxia with high-dose biotin as a treatment for progressive multiple sclerosis

(2016) Frédéric Sedel et al.   NEUROPHARMACOLOGY

A Potential Alternative against Neurodegenerative Diseases: Phytodrugs

(2016) Jesús Pérez-Hernández et al.   Oxidative Medicine and Cellular Longevity

Is Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative Diseases

(2016) Valerio Chiurchiù et al.   Oxidative Medicine and Cellular Longevity

Oxysterols: From cholesterol metabolites to key mediators

(2016) Valentin Mutemberezi et al.   PROGRESS IN LIPID RESEARCH

Interdependence of oxysterols with cholesterol profiles in multiple sclerosis

(2016) Shreya Mukhopadhyay et al.   Multiple Sclerosis Journal

Vitamin E: A Role in Signal Transduction

(2015) Jean-Marc Zingg   Annual Review of Nutrition

Metabolic dysfunctions in multiple sclerosis: implications as to causation, early detection, and treatment, a case control study

(2015) Vijitha K. Senanayake et al.   BMC Neurology

Dietary indicaxanthin from cactus pear (Opuntia ficus-indica L. Mill) fruit prevents eryptosis induced by oxysterols in a hypercholesterolaemia-relevant proportion and adhesion of human erythrocytes to endothelial cell layers

(2015) Luisa Tesoriere et al.   BRITISH JOURNAL OF NUTRITION

Microglial M1/M2 polarization and metabolic states

(2015) Ruben Orihuela et al.   BRITISH JOURNAL OF PHARMACOLOGY

Caenorhabditis elegans DAF-16/FOXO transcription factor and its mammalian homologs associate with age-related disease

(2015) Kylie Hesp et al.   EXPERIMENTAL GERONTOLOGY

Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration

(2015) Stéphane Fourcade et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine

(2015) Aiden Haghikia et al.   IMMUNITY

Indicaxanthin from Opuntia ficus-indica Crosses the Blood–Brain Barrier and Modulates Neuronal Bioelectric Activity in Rat Hippocampus at Dietary-Consistent Amounts

(2015) Mario Allegra et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of cholesterol oxides on cell death induction and calcium increase in human neuronal cells (SK-N-BE) and evaluation of the protective effects of docosahexaenoic acid (DHA; C22:6 n-3)

(2015) Amira Zarrouk et al.   STEROIDS

7-Ketocholesterol and 5,6-secosterol induce human endothelial cell dysfunction by differential mechanisms

(2015) Francesca Luchetti et al.   STEROIDS

Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3)

(2015) Thomas Nury et al.   STEROIDS

Microglia in Health and Disease

(2015) Richard M. Ransohoff et al.   Cold Spring Harbor Perspectives in Biology

The role of p38 MAPK in the induction of intestinal inflammation by dietary oxysterols: modulation by wine phenolics

(2015) Tina Guina et al.   Food & Function

7-Ketocholesterol Increases Retinal Microglial Migration, Activation and Angiogenicity: A Potential Pathogenic Mechanism Underlying Age-related Macular Degeneration

(2015) Maanasa Indaram et al.   Scientific Reports

Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease

(2015) Paola Gamba et al.   Frontiers in Aging Neuroscience

Microglial cell dysregulation in brain aging and neurodegeneration

(2015) Rommy von Bernhardi et al.   Frontiers in Aging Neuroscience

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

The role of microglia in human disease: therapeutic tool or target?

(2014) Nathalie Cartier et al.   ACTA NEUROPATHOLOGICA

Involvement of oxysterols in age-related diseases and ageing processes

(2014) Amira Zarrouk et al.   AGEING RESEARCH REVIEWS

7-ketocholesterol accumulates in ocular tissues as a consequence of aging and is present in high levels in drusen

(2014) Ignacio R. Rodriguez et al.   EXPERIMENTAL EYE RESEARCH

Survival signaling elicited by 27-hydroxycholesterol through the combined modulation of cellular redox state and ERK/Akt phosphorylation

(2014) Beyza Vurusaner et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitochondrial dysfunction in central nervous system white matter disorders

(2014) Laia Morató et al.   GLIA

The central role of mitochondria in axonal degeneration in multiple sclerosis

(2014) Graham R Campbell et al.   Multiple Sclerosis Journal

Oleate rescues INS-1E β-cells from palmitate-induced apoptosis by preventing activation of the unfolded protein response

(2013) Dietlind Sommerweiss et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of oxiapoptophagy, a mixed mode of cell death associated with oxidative stress, apoptosis and autophagy, on 7-ketocholesterol-treated 158N murine oligodendrocytes: Impairment by α-tocopherol

(2013) Thomas Nury et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes

(2013) Kévin Ragot et al.   BIOCHEMICAL PHARMACOLOGY

The effect of oxysterols on the interaction of Alzheimer's amyloid beta with model membranes

(2013) Huong T.T. Phan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Caffeic acid phenethyl ester induces adrenoleukodystrophy (Abcd2) gene in human X-ALD fibroblasts and inhibits the proinflammatory response in Abcd1/2 silenced mouse primary astrocytes

(2013) Jaspreet Singh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Brain peroxisomes

(2013) D. Trompier et al.   BIOCHIMIE

Peroxisomal metabolism and oxidative stress

(2013) Marcus Nordgren et al.   BIOCHIMIE

Fast LC–MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaque

(2013) Christin Helmschrodt et al.   CLINICA CHIMICA ACTA

Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells

(2013) Bo Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease

(2013) Zhiyou Cai et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Reductions in neuronal peroxisomes in multiple sclerosis grey matter

(2013) Elizabeth Gray et al.   Multiple Sclerosis Journal

Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases?

(2012) Elena Galea et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca2+ increase and oxidative stress

(2012) Luisa Tesoriere et al.   BRITISH JOURNAL OF NUTRITION

Analytical evaluation of two monovarietal virgin olive oils cultivated in the south of Tunisia: Jemri-Bouchouka and Chemlali-Tataouin cultivars

(2012) Ghayth Rigane et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Evidence of oxidative stress in very long chain fatty acid – Treated oligodendrocytes and potentialization of ROS production using RNA interference-directed knockdown of ABCD1 and ACOX1 peroxisomal proteins

(2012) M. Baarine et al.   NEUROSCIENCE

The Impact of Peroxisomes on Cellular Aging and Death

(2012) Selvambigai Manivannan et al.   Frontiers in Oncology

Peroxisomal alterations in Alzheimer’s disease

(2011) Jianqiu Kou et al.   ACTA NEUROPATHOLOGICA

Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy

(2011) Jone López-Erauskin et al.   ANNALS OF NEUROLOGY

Mammalian peroxisomal ABC transporters: from endogenous substrates to pathology and clinical significance

(2011) Stephan Kemp et al.   BRITISH JOURNAL OF PHARMACOLOGY

α-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes

(2011) Kévin Ragot et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Pathways of cholesterol oxidation via non-enzymatic mechanisms

(2011) Luigi Iuliano   CHEMISTRY AND PHYSICS OF LIPIDS

Mitochondria targeting of non-peroxidizable triphenylphosphonium conjugated oleic acid protects mouse embryonic cells against apoptosis: Role of cardiolipin remodeling

(2011) Yulia Y. Tyurina et al.   FEBS LETTERS

Vitamins C and E: Beneficial effects from a mechanistic perspective

(2011) Maret G. Traber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization and classification of Western Greek olive oils according to cultivar and geographical origin based on volatile compounds

(2011) Eirini Pouliarekou et al.   JOURNAL OF CHROMATOGRAPHY A

Genesis and development of DPPH method of antioxidant assay

(2011) Sagar B. Kedare et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Evaluation of Neuroinflammation in X-Linked Adrenoleukodystrophy

(2011) Ajay Kumar et al.   PEDIATRIC NEUROLOGY

Contribution of Cholesterol and Oxysterols in the Physiopathology of Cataract: Implication for the Development of Pharmacological Treatments

(2011) Anne Vejux et al.   Journal of Ophthalmology

Detection and manipulation of mitochondrial reactive oxygen species in mammalian cells

(2010) Marleen Forkink et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Pathomechanisms Underlying X-Adrenoleukodystrophy: A Three-Hit Hypothesis

(2010) Inderjit Singh et al.   BRAIN PATHOLOGY

Effects of oxysterols on cell viability, inflammatory cytokines, VEGF, and reactive oxygen species production on human retinal cells: cytoprotective effects and prevention of VEGF secretion by resveratrol

(2010) B. Dugas et al.   EUROPEAN JOURNAL OF NUTRITION

Proinflammatory effect of cholesterol and its oxidation products on CaCo-2 human enterocyte-like cells: effective protection by epigallocatechin-3-gallate

(2010) Cinzia Mascia et al.   FREE RADICAL BIOLOGY AND MEDICINE

Axonal integrity in the absence of functional peroxisomes from projection neurons and astrocytes

(2010) Astrid Bottelbergs et al.   GLIA

Dietary olive oil effect on antioxidant status and fatty acid profile in the erythrocyte of 2,4-D- exposed rats

(2010) Amel Nakbi et al.   Lipids in Health and Disease

Gene-Regulatory Activity of α-Tocopherol

(2010) Gerald Rimbach et al.   MOLECULES

Effects of olive oil and its fractions on oxidative stress and the liver's fatty acid composition in 2,4-Dichlorophenoxyacetic acid-treated rats

(2010) Amel Nakbi et al.   Nutrition & Metabolism

Effect of Irrigation on Quality Attributes of Olive Oil

(2009) Evagelia Stefanoudaki et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

7-Ketocholesterol Incorporation into Sphingolipid/Cholesterol-enriched (Lipid Raft) Domains Is Impaired by Vitamin E

(2009) Marie-Charlotte Royer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the mechanism of oleate transport across human brain microvessel endothelial cells

(2009) Ryan W. Mitchell et al.   JOURNAL OF NEUROCHEMISTRY

Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis

(2009) Anne Vejux et al.   MOLECULAR ASPECTS OF MEDICINE

Peroxisomes, Myelination, and Axonal Integrity in the CNS

(2009) Myriam Baes et al.   NEUROSCIENTIST

Acute lung injury and cell death: how many ways can cells die?

(2008) Peter S. Tang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy?

(2008) Florian S. Eichler et al.   ANNALS OF NEUROLOGY

DPPH antioxidant assay revisited

(2008) Om P. Sharma et al.   FOOD CHEMISTRY

Silencing of Abcd1 and Abcd2 genes sensitizes astrocytes for inflammation: implication for X-adrenoleukodystrophy

(2008) Jaspreet Singh et al.   JOURNAL OF LIPID RESEARCH

Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis

(2008) Anne Vejux et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY