7-Ketocholesterol Increases Retinal Microglial Migration, Activation and Angiogenicity: A Potential Pathogenic Mechanism Underlying Age-related Macular Degeneration
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Title
7-Ketocholesterol Increases Retinal Microglial Migration, Activation and Angiogenicity: A Potential Pathogenic Mechanism Underlying Age-related Macular Degeneration
Authors
Keywords
-
Journal
Scientific Reports
Volume 5, Issue 1, Pages -
Publisher
Springer Nature
Online
2015-03-16
DOI
10.1038/srep09144
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- (2014) Jiahn-Dar Huang et al. PLoS One
- Subretinal Drusenoid Deposits
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- The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation
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- (2013) Florian Sennlaub et al. EMBO Molecular Medicine
- On the role of 25-hydroxycholesterol synthesis by glioblastoma cell lines. Implications for chemotactic monocyte recruitment
- (2013) Gerald Eibinger et al. EXPERIMENTAL CELL RESEARCH
- The oxysterol–CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils
- (2013) Laura Raccosta et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Layer V cortical neurons require microglial support for survival during postnatal development
- (2013) Masaki Ueno et al. NATURE NEUROSCIENCE
- 7-Ketocholesterol Induces Inflammation and Angiogenesis In Vivo: A Novel Rat Model
- (2013) Juan Amaral et al. PLoS One
- VEGF Receptor Blockade Markedly Reduces Retinal Microglia/Macrophage Infiltration into Laser-Induced CNV
- (2013) Hu Huang et al. PLoS One
- NLRP3 Inflammasome Blockade Inhibits VEGF-A-Induced Age-Related Macular Degeneration
- (2013) Alexander G. Marneros Cell Reports
- Oxysterols in the pathogenesis of major chronic diseases
- (2013) Giuseppe Poli et al. Redox Biology
- DICER1 Loss and Alu RNA Induce Age-Related Macular Degeneration via the NLRP3 Inflammasome and MyD88
- (2012) Valeria Tarallo et al. CELL
- A2E accumulation influences retinal microglial activation and complement regulation
- (2012) Wenxin Ma et al. NEUROBIOLOGY OF AGING
- Microglia/Macrophages Migrate through Retinal Epithelium Barrier by a Transcellular Route in Diabetic Retinopathy
- (2011) Samy Omri et al. AMERICAN JOURNAL OF PATHOLOGY
- Minocycline Attenuates Photoreceptor Degeneration in a Mouse Model of Subretinal Hemorrhage
- (2011) Lian Zhao et al. AMERICAN JOURNAL OF PATHOLOGY
- The oil spill in ageing Bruch membrane
- (2011) C. A. Curcio et al. BRITISH JOURNAL OF OPHTHALMOLOGY
- Accumulation of murine subretinal macrophages: effects of age, pigmentation and CX3CR1
- (2011) Holly R. Chinnery et al. NEUROBIOLOGY OF AGING
- Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration
- (2011) L. V. Johnson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Age-related alterations in the dynamic behavior of microglia
- (2010) Mausam R. Damani et al. AGING CELL
- A Rat Model for Choroidal Neovascularization Using Subretinal Lipid Hydroperoxide Injection
- (2010) Takayuki Baba et al. AMERICAN JOURNAL OF PATHOLOGY
- Cholesterol oxidation in the retina: implications of 7KCh formation in chronic inflammation and age-related macular degeneration
- (2010) Ignacio R. Rodríguez et al. JOURNAL OF LIPID RESEARCH
- Abundant Lipid and Protein Components of Drusen
- (2010) Lan Wang et al. PLoS One
- Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
- (2010) B. M. Neale et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
- (2010) W. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Do We Need a New Classification for Choroidal Neovascularization in Age-Related Macular Degeneration?
- (2010) K Bailey Freund et al. RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
- Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration
- (2009) Christine A. Curcio et al. JOURNAL OF LIPID RESEARCH
- Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseases☆
- (2009) Sinéad Lordan et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Cytotoxic effects of oxysterols associated with human diseases: Induction of cell death (apoptosis and/or oncosis), oxidative and inflammatory activities, and phospholipidosis
- (2009) Anne Vejux et al. MOLECULAR ASPECTS OF MEDICINE
- Photodamage Generates 7-keto- and 7-hydroxycholesterol in the Rat Retinaviaa Free Radical-mediated Mechanism
- (2009) Ignacio R. Rodriguez et al. PHOTOCHEMISTRY AND PHOTOBIOLOGY
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- (2009) Wenxin Ma et al. PLoS One
- Direct labeling and visualization of blood vessels with lipophilic carbocyanine dye DiI
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- Age-Related Macular Degeneration
- (2008) Rama D. Jager et al. NEW ENGLAND JOURNAL OF MEDICINE
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- (2007) Heping Xu et al. AGING CELL
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