CAR-T Regulatory (CAR-Treg) Cells: Engineering and Applications

Engineered antigen-specific regulatory T cells for autoimmune skin conditions

(2021) Zhussipbek Mukhatayev et al.   AUTOIMMUNITY REVIEWS

CD8 + Tregs revisited: A heterogeneous population with different phenotypes and properties

(2021) Veronika Niederlova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cas9-directed immune tolerance in humans—a model to evaluate regulatory T cells in gene therapy?

(2021) Dimitrios Laurin Wagner et al.   GENE THERAPY

Enhancement of liver-directed transgene expression at initial and repeat doses of AAV vectors admixed with ImmTOR nanoparticles

(2021) Petr O. Ilyinskii et al.   Science Advances

CRISPR/Cas-Dependent and Nuclease-FreeIn VivoTherapeutic Gene Editing

(2021) Ishani Dasgupta et al.   HUMAN GENE THERAPY

Type 1 diabetes mellitus: much progress, many opportunities

(2021) Alvin C. Powers   JOURNAL OF CLINICAL INVESTIGATION

CAR- and TRuC-redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII

(2021) Jyoti Rana et al.   MOLECULAR THERAPY

Engineered TCR-T Cell Immunotherapy in Anticancer Precision Medicine: Pros and Cons

(2021) Qijie Zhao et al.   Frontiers in Immunology

GVHD Prophylaxis 2020

(2021) Mahasweta Gooptu et al.   Frontiers in Immunology

Tregitopes Improve Asthma by Promoting Highly Suppressive and Antigen-Specific Tregs

(2021) Marieme Dembele et al.   Frontiers in Immunology

Immunosuppressive PLGA TGF-β1 Microparticles Induce Polyclonal and Antigen-Specific Regulatory T Cells for Local Immunomodulation of Allogeneic Islet Transplants

(2021) Ying Li et al.   Frontiers in Immunology

A Tale of Two Immune Cells in Rheumatoid Arthritis: The Crosstalk Between Macrophages and T Cells in the Synovium

(2021) Jiajie Tu et al.   Frontiers in Immunology

Regulatory T Cells in GVHD Therapy

(2021) Wen-wen Guo et al.   Frontiers in Immunology

Tocilizumab As a Novel Immunomodulatory Regimen for Hemophilia Gene Therapy

(2021) Klaudia Kuranda et al.   BLOOD

Immune Responses to Adeno-Associated Virus-Mediated CRISPR Therapy

(2021) Allison M. Keeler   HUMAN GENE THERAPY

Treg engineers take aim at autoimmunity

(2021) Elie Dolgin   NATURE BIOTECHNOLOGY

Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

(2021) Baptiste Lamarthée et al.   Nature Communications

Cas9-specific immune responses compromise local and systemic AAV CRISPR therapy in multiple dystrophic canine models

(2021) Chady H. Hakim et al.   Nature Communications

Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells

(2021) Motahareh Arjomandnejad et al.   Molecular Therapy-Methods & Clinical Development

‘Off-the-shelf’ allogeneic CAR T cells: development and challenges

(2020) S. Depil et al.   NATURE REVIEWS DRUG DISCOVERY

Altered expression of nuclear factor of activated T cells, forkhead box P3, and immune‐suppressive genes in regulatory T cells of generalized vitiligo patients

(2020) Prashant S. Giri et al.   Pigment Cell & Melanoma Research

Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells

(2020) Ling Wu et al.   Cellular & Molecular Immunology

Human CD83-targeted chimeric antigen receptor T cells prevent and treat graft-versus-host disease

(2020) Bishwas Shrestha et al.   JOURNAL OF CLINICAL INVESTIGATION

The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology

(2020) Yasmin R. Mohseni et al.   Frontiers in Immunology

CAR-T design: Elements and their synergistic function

(2020) Jayapriya Jayaraman et al.   EBioMedicine

CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD

(2020) Yuki Imura et al.   JCI Insight

Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells

(2020) Nicholas A. J. Dawson et al.   Science Translational Medicine

Ulcerative colitis

(2020) Taku Kobayashi et al.   Nature Reviews Disease Primers

Graft-versus-host disease prophylaxis: Pathophysiology-based review on current approaches and future directions

(2020) Nuria Martinez-Cibrian et al.   BLOOD REVIEWS

Towards antigen-specific Tregs for type 1 diabetes: Construction and functional assessment of pancreatic endocrine marker, HPi2-based chimeric antigen receptor

(2020) Ilian A. Radichev et al.   CELLULAR IMMUNOLOGY

CD4+ T cells engineered with FVIII-CAR and murine Foxp3 suppress anti-factor VIII immune responses in hemophilia a mice

(2020) Richard Y. Fu et al.   CELLULAR IMMUNOLOGY

Antigen Specificity Enhances Disease Control by Tregs in Vitiligo

(2020) Zhussipbek Mukhatayev et al.   Frontiers in Immunology

Rheumatoid Arthritis

(2019) Jeffrey A. Sparks   ANNALS OF INTERNAL MEDICINE

Dysfunctional and Proinflammatory Regulatory T-Lymphocytes Are Essential for Adverse Cardiac Remodeling in Ischemic Cardiomyopathy

(2019) Shyam S. Bansal et al.   CIRCULATION

State of Type 1 Diabetes Management and Outcomes from the T1D Exchange in 2016–2018

(2019) Nicole C. Foster et al.   Diabetes Technology & Therapeutics

Engineering and Design of Chimeric Antigen Receptors

(2019) Sonia Guedan et al.   Molecular Therapy-Methods & Clinical Development

The prevalence of MS in the United States

(2019) Mitchell T. Wallin et al.   NEUROLOGY

One-step generation of modular CAR-T cells with AAV–Cpf1

(2019) Xiaoyun Dai et al.   NATURE METHODS

Presenting symptoms in inflammatory bowel disease: descriptive analysis of a community-based inception cohort

(2019) Bryce Perler et al.   BMC GASTROENTEROLOGY

How to discuss gene therapy for haemophilia? A patient and physician perspective

(2019) Wolfgang Miesbach et al.   HAEMOPHILIA

Multifunctional CRISPR-Cas9 with engineered immunosilenced human T cell epitopes

(2019) Shayesteh R. Ferdosi et al.   Nature Communications

Advances and challenges for hemophilia gene therapy

(2019) Paul Batty et al.   HUMAN MOLECULAR GENETICS

Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes

(2019) Michel Tenspolde et al.   JOURNAL OF AUTOIMMUNITY

Specific activation of pro-Infliximab enhances selectivity and safety of rheumatoid arthritis therapy

(2019) Yun-Chi Lu et al.   PLOS BIOLOGY

Immune-orthogonal orthologues of AAV capsids and of Cas9 circumvent the immune response to the administration of gene therapy

(2019) Ana M. Moreno et al.   Nature Biomedical Engineering

Therapeutic use of regulatory T cells for graft‐versus‐host disease

(2019) Shlomo Elias et al.   BRITISH JOURNAL OF HAEMATOLOGY

Parallel comparison of 4-1BB or CD28 co-stimulated CD19-targeted chimeric antigen receptor-T cells for B-cell non-Hodgkin lymphoma

(2019) Zhitao Ying et al.   Molecular Therapy-Oncolytics

Antigen‐specific in vitro expansion of factor VIII‐specific regulatory T cells induces tolerance in hemophilia A mice

(2019) Bryn M. Smith et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Advances in technology for management of type 1 diabetes

(2019) Roy W Beck et al.   LANCET

A Molecular Revolution in the Treatment of Hemophilia

(2019) John S.S. Butterfield et al.   MOLECULAR THERAPY

Engineered T Cell Therapy for Cancer in the Clinic

(2019) Lijun Zhao et al.   Frontiers in Immunology

Emerging therapies for autoimmune myasthenia gravis: Towards treatment without corticosteroids

(2019) Martijn R. Tannemaat et al.   NEUROMUSCULAR DISORDERS

The role of regulatory T cells in graft-versus-host disease management

(2019) Jennifer S. Whangbo et al.   Expert Review of Hematology

A new approach to CAR T-cell gene engineering and cultivation using piggyBac transposon in the presence of IL-4, IL-7 and IL-21

(2018) Pavlína Ptáčková et al.   CYTOTHERAPY

Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells

(2018) Yong Chan Kim et al.   JOURNAL OF AUTOIMMUNITY

Early Diagnosis and Treatment of Rheumatoid Arthritis

(2018) Emily A. Littlejohn et al.   PRIMARY CARE

Association of Regulatory T-Cell Expansion With Progression of Amyotrophic Lateral Sclerosis

(2018) Rebecca K. Sheean et al.   JAMA Neurology

Gene Therapy With Regulatory T Cells: A Beneficial Alliance

(2018) Moanaro Biswas et al.   Frontiers in Immunology

Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma

(2018) Concetta Quintarelli et al.   OncoImmunology

Prevalence of Pre-existing Antibodies to CRISPR-Associated Nuclease Cas9 in the USA Population

(2018) Vijaya L. Simhadri et al.   Molecular Therapy-Methods & Clinical Development

Emerging Issues in AAV-Mediated In Vivo Gene Therapy

(2018) Pasqualina Colella et al.   Molecular Therapy-Methods & Clinical Development

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases

(2018) Maria Grazia Roncarolo et al.   IMMUNITY

Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity

(2018) Tomokazu Sumida et al.   NATURE IMMUNOLOGY

High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population

(2018) Dimitrios L. Wagner et al.   NATURE MEDICINE

Chimeric Antigen Receptor (CAR) Treg: A Promising Approach to Inducing Immunological Tolerance

(2018) Qunfang Zhang et al.   Frontiers in Immunology

Adoptive Induced Antigen-Specific Treg Cells Reverse Inflammation in Collagen-Induced Arthritis Mouse Model

(2017) Guangzhi Sun et al.   INFLAMMATION

Generation of human islet-specific regulatory T cells by TCR gene transfer

(2017) Caroline M. Hull et al.   JOURNAL OF AUTOIMMUNITY

Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management

(2017) Marcus Harbord et al.   Journal of Crohns & Colitis

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

Chimeric Antigen Receptor-Redirected Regulatory T Cells Suppress Experimental Allergic Airway Inflammation, a Model of Asthma

(2017) Jelena Skuljec et al.   Frontiers in Immunology

Innovative Approaches for Immune Tolerance to Factor VIII in the Treatment of Hemophilia A

(2017) Alexandra Sherman et al.   Frontiers in Immunology

Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes

(2017) Wen-I Yeh et al.   Frontiers in Immunology

FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII

(2016) Jeongheon Yoon et al.   BLOOD

Tolerogenic nanoparticles to induce immunologic tolerance: Prevention and reversal of FVIII inhibitor formation

(2016) Ai-Hong Zhang et al.   CELLULAR IMMUNOLOGY

A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation

(2016) Satoru Todo et al.   HEPATOLOGY

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

(2016) Katherine G. MacDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced CAR T-cell engineering using non-viral Sleeping Beauty transposition from minicircle vectors

(2016) R Monjezi et al.   LEUKEMIA

A multifunctional AAV–CRISPR–Cas9 and its host response

(2016) Wei Leong Chew et al.   NATURE METHODS

Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles

(2016) Takashi K. Kishimoto et al.   Nature Nanotechnology

Rituximab in multiple sclerosis

(2016) Jonatan Salzer et al.   NEUROLOGY

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors

(2016) Daniel T. Harris et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Graft-infiltrating host dendritic cells play a key role in organ transplant rejection

(2016) Quan Zhuang et al.   Nature Communications

Regulatory T-Cell Impairment in Cystic Fibrosis Patients with ChronicPseudomonasInfection

(2015) Andreas Hector et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

FOXP3+ regulatory T cells and their functional regulation

(2015) Zhiyuan Li et al.   Cellular & Molecular Immunology

“Difficult Asthma”: Not as Easy as You Think

(2015) Matthew Masoli   CHEST

Adoptive transfer of allogeneic regulatory T cells into patients with chronic graft-versus-host disease

(2015) Anke Theil et al.   CYTOTHERAPY

Adenovirus-Mediated Somatic Genome Editing ofPtenby CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses

(2015) Dan Wang et al.   HUMAN GENE THERAPY

Dendritic cells and innate immunity in kidney transplantation

(2015) Quan Zhuang et al.   KIDNEY INTERNATIONAL

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

Lung function impairment increases with age of diagnosis in adult onset asthma

(2015) Celeste Porsbjerg et al.   RESPIRATORY MEDICINE

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

(2014) Y. C. Kim et al.   BLOOD

Myasthenia Gravis: Paradox versus paradigm in autoimmunity

(2014) Sonia Berrih-Aknin   JOURNAL OF AUTOIMMUNITY

Ex Vivo Generated Regulatory T Cells Modulate Experimental Autoimmune Myasthenia Gravis

(2014) R. Aricha et al.   JOURNAL OF IMMUNOLOGY

Suppression of Murine Colitis and its Associated Cancer by Carcinoembryonic Antigen-Specific Regulatory T Cells

(2014) Dan Blat et al.   MOLECULAR THERAPY

Ex vivo expanded autologous polyclonal regulatory T cells suppress inhibitor formation in hemophilia

(2014) Debalina Sarkar et al.   Molecular Therapy-Methods & Clinical Development

Dendritic cells of myeloid lineage

(2013) Adrian E. Morelli   Current Opinion in Organ Transplantation

Late immune tolerance induction in haemophilia A patients

(2013) S. L. Meeks et al.   HAEMOPHILIA

Immune tolerance induction in haemophilia A patients with inhibitors by treatment with recombinant factor VIII: a retrospective non-interventional study

(2013) G. E. Rivard et al.   HAEMOPHILIA

Effects of Immunosuppression on Circulating Adeno-Associated Virus Capsid-Specific T cells in Humans

(2013) Elizabeth M. Parzych et al.   HUMAN GENE THERAPY

Immune Responses to Intramuscular Administration of Alipogene Tiparvovec (AAV1-LPLS447X) in a Phase II Clinical Trial of Lipoprotein Lipase Deficiency Gene Therapy

(2013) Valerie Ferreira et al.   HUMAN GENE THERAPY

A Quantitative Increase in Regulatory T Cells Controls Development of Vitiligo

(2013) Shilpak Chatterjee et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Induced CD4+Foxp3+ Regulatory T Cells in Immune Tolerance

(2012) Angelina M. Bilate et al.   Annual Review of Immunology

Severe asthma: from characteristics to phenotypes to endotypes

(2012) S. Wenzel   CLINICAL AND EXPERIMENTAL ALLERGY

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

(2012) Moa Fransson et al.   Journal of Neuroinflammation

Adoptive Transfer of Induced-Treg Cells Effectively Attenuates Murine Airway Allergic Inflammation

(2012) Wei Xu et al.   PLoS One

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

The battle against immunopathology: infectious tolerance mediated by regulatory T cells

(2011) David M. Gravano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phase 2 Clinical Trial of a Recombinant Adeno-Associated Viral Vector Expressing α1-Antitrypsin: Interim Results

(2011) Terence R. Flotte et al.   HUMAN GENE THERAPY

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic potential of TGF-β-induced CD4+Foxp3+regulatory T cells in autoimmune diseases

(2010) Xiaohui Zhou et al.   AUTOIMMUNITY

T regulatory cells lacking CD25 are increased in MS during relapse

(2010) Moa Fransson et al.   AUTOIMMUNITY

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

(2010) J. N. Kochenderfer et al.   BLOOD

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Guideline for the diagnosis and management of vitiligo

(2010) D.J. Gawkrodger et al.   BRITISH JOURNAL OF DERMATOLOGY

CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice

(2009) C. H. Miao et al.   BLOOD

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

Curing CNS autoimmune disease with myelin-reactive Foxp3+Treg

(2009) Leigh A. Stephens et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Amelioration of Colitis by Genetically Engineered Murine Regulatory T Cells Redirected by Antigen-Specific Chimeric Receptor

(2009) Eran Elinav et al.   GASTROENTEROLOGY

Selective deregulation in chemokine signaling pathways of CD4+CD25hiCD127lo/− regulatory T cells in human allergic asthma

(2009) Khoa D. Nguyen et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

CTLA4-Ig modifies dendritic cells from mice with collagen-induced arthritis to increase the CD4+CD25+Foxp3+ regulatory T cell population

(2009) Hyeok-Jae Ko et al.   JOURNAL OF AUTOIMMUNITY

Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis

(2009) Mark A.A. Claassen et al.   JOURNAL OF HEPATOLOGY

Sustained transgene expression despite T lymphocyte responses in a clinical trial of rAAV1-AAT gene therapy

(2009) M. L. Brantly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis

(2009) Graham P. Wright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"

(2008) A. S. De Groot et al.   BLOOD

Redirection of Regulatory T Cells With Predetermined Specificity for the Treatment of Experimental Colitis in Mice

(2008) Eran Elinav et al.   GASTROENTEROLOGY

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

Mechanisms of regulatory T-cell suppression – a diverse arsenal for a moving target

(2008) Dorothy K. Sojka et al.   IMMUNOLOGY

Positioning of autoimmune TCR-Ob.2F3 and TCR-Ob.3D1 on the MBP85-99/HLA-DR2 complex

(2008) Z. Kato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA