Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles

Rapamycin prevents bronchiolitis obliterans through increasing infiltration of regulatory B cells in a murine tracheal transplantation model

(2016) Yunge Zhao et al.   JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY

CRIM-negative infantile Pompe disease: characterization of immune responses in patients treated with ERT monotherapy

(2015) Kathryn L. Berrier et al.   GENETICS IN MEDICINE

Poor correlation between T-cell activation assays and HLA-DR binding prediction algorithms in an immunogenic fragment of Pseudomonas exotoxin A

(2015) Ronit Mazor et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Engineered binding to erythrocytes induces immunological tolerance to E. coli asparaginase

(2015) K. M. Lorentz et al.   Science Advances

Detection of Innate Immune Response Modulating Impurities in Therapeutic Proteins

(2015) Lydia Asrat Haile et al.   PLoS One

New FDA Draft Guidance on Immunogenicity

(2014) Ashwin Parenky et al.   AAPS Journal

Inhibitors - cellular aspects and novel approaches for tolerance

(2014) D. W. Scott   HAEMOPHILIA

Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation

(2014) Masanori Matsumoto et al.   IMMUNITY

Siglecs Induce Tolerance to Cell Surface Antigens by BIM-Dependent Deletion of the Antigen-Reactive B Cells

(2014) Matthew S. Macauley et al.   JOURNAL OF IMMUNOLOGY

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

(2014) R. Mazor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

(2014) Roberto A. Maldonado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pegloticase immunogenicity: the relationship between efficacy and antibody development in patients treated for refractory chronic gout

(2014) Peter E Lipsky et al.   ARTHRITIS RESEARCH & THERAPY

The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus

(2013) Rachael Keating et al.   NATURE IMMUNOLOGY

Engineering synthetic vaccines using cues from natural immunity

(2013) Darrell J. Irvine et al.   NATURE MATERIALS

Challenges and approaches for the development of safer immunomodulatory biologics

(2013) Jean G. Sathish et al.   NATURE REVIEWS DRUG DISCOVERY

Immunogenicity of anti-TNF biologic therapies for rheumatoid arthritis

(2013) Pauline A. van Schouwenburg et al.   Nature Reviews Rheumatology

The Immunogenicity of Polyethylene Glycol: Facts and Fiction

(2013) Huub Schellekens et al.   PHARMACEUTICAL RESEARCH

Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy

(2012) Narendra Chirmule et al.   AAPS Journal

Akt and mTOR in B Cell Activation and Differentiation

(2012) Jose J. Limon et al.   Frontiers in Immunology

Pegloticase and Chronic Gout--Reply

(2011) J. S. Sundy et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Development of Antidrug Antibodies Against Adalimumab and Association With Disease Activity and Treatment Failure During Long-term Follow-up

(2011) Geertje M. Bartelds   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

State of the art in PEGylation: The great versatility achieved after forty years of research

(2011) Gianfranco Pasut et al.   JOURNAL OF CONTROLLED RELEASE

Comparative study of clinical grade human tolerogenic dendritic cells

(2011) M Naranjo-Gómez et al.   Journal of Translational Medicine

Targeted nanotherapy for induction of therapeutic immune responses

(2011) Su M. Metcalfe et al.   TRENDS IN MOLECULAR MEDICINE

Prediction of Immunogenicity of Therapeutic Proteins

(2010) Christine J. Bryson et al.   BIODRUGS

Immune tolerance induction to enzyme-replacement therapy by co-administration of short-term, low-dose methotrexate in a murine Pompe disease model

(2010) A. Joseph et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Immunogenicity of biologic therapies—we need tolerance

(2010) Charlotte L. M. Krieckaert et al.   Nature Reviews Rheumatology

Reducing the Immunogenicity of Protein Therapeutics

(2009) Masanori Onda   CURRENT DRUG TARGETS

Sales of biologics to show robust growth through to 2013

(2009) Michael Goodman   NATURE REVIEWS DRUG DISCOVERY

Elimination of Antibodies to Recombinant Enzyme in Pompe's Disease

(2009) Nancy J. Mendelsohn et al.   NEW ENGLAND JOURNAL OF MEDICINE