Engineered antigen-specific regulatory T cells for autoimmune skin conditions

Low-dose Interleukin-2: Biology and therapeutic prospects in rheumatoid arthritis

(2020) Ruihe Wu et al.   AUTOIMMUNITY REVIEWS

Antigen Specificity Enhances Disease Control by Tregs in Vitiligo

(2020) Zhussipbek Mukhatayev et al.   Frontiers in Immunology

The Emerging World of TCR-T Cell Trials Against Cancer: A Systematic Review

(2019) Jianxiang Zhang et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

Emerging role of immune cell network in autoimmune skin disorders: An update on pemphigus, vitiligo and psoriasis

(2019) Dayasagar Das et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Regulatory T‐cells in alopecia areata

(2019) Jodi J. Speiser et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes

(2019) Michel Tenspolde et al.   JOURNAL OF AUTOIMMUNITY

Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease

(2019) Fatma N. Hamed et al.   PLoS One

Current Clinical Trials in Pemphigus and Pemphigoid

(2019) Kentaro Izumi et al.   Frontiers in Immunology

Next-generation regulatory T cell therapy

(2019) Leonardo M. R. Ferreira et al.   NATURE REVIEWS DRUG DISCOVERY

Low-Dose IL-2 Therapy in Transplantation, Autoimmunity, and Inflammatory Diseases

(2019) Maryam Tahvildari et al.   JOURNAL OF IMMUNOLOGY

Cryopreservation timing is a critical process parameter in a thymic regulatory T-cell therapy manufacturing protocol

(2019) Katherine N. MacDonald et al.   CYTOTHERAPY

Genetic Engineering of T Cells for Immune Tolerance

(2019) David W. Scott   Molecular Therapy-Methods & Clinical Development

Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis

(2018) K Furue et al.   ACTA DERMATO-VENEREOLOGICA

Engrafting human regulatory T cells with a flexible modular chimeric antigen receptor technology

(2018) Stefanie Koristka et al.   JOURNAL OF AUTOIMMUNITY

Foxp3+T reg cells control psoriasiform inflammation by restraining an IFN-I–driven CD8+T cell response

(2018) Krista Stockenhuber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chimeric antigen receptor T cell (CAR-T) immunotherapy for solid tumors: lessons learned and strategies for moving forward

(2018) Jian Li et al.   Journal of Hematology & Oncology

HSP70I Q435A -Encoding DNA Repigments Vitiligo Lesions in Sinclair Swine

(2018) Steven W. Henning et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Exosomes derived from exhausted CD8+ T cells impaired the anticancer function of normal CD8+ T cells

(2018) Xiaochen Wang et al.   JOURNAL OF MEDICAL GENETICS

Role of T helper 17 cells and T regulatory cells in alopecia areata: comparison of lesion and serum cytokine between controls and patients

(2018) S.-H. Loh et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Chimeric Antigen Receptor T-Cells (CAR T-Cells) for Cancer Immunotherapy – Moving Target for Industry?

(2018) Paula Salmikangas et al.   PHARMACEUTICAL RESEARCH

A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants

(2018) James M. Mathew et al.   Scientific Reports

Engineered T Regulatory Type 1 Cells for Clinical Application

(2018) Silvia Gregori et al.   Frontiers in Immunology

A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials

(2018) Henrieta Fraser et al.   Molecular Therapy-Methods & Clinical Development

Immunological and clinical effects of low-dose interleukin-2 across 11 autoimmune diseases in a single, open clinical trial

(2018) Michelle Rosenzwajg et al.   ANNALS OF THE RHEUMATIC DISEASES

Recent advances in CAR T-cell toxicity: Mechanisms, manifestations and management

(2018) Jennifer N. Brudno et al.   BLOOD REVIEWS

Treg cells—the next frontier of cell therapy

(2018) Jeffrey A. Bluestone et al.   SCIENCE

Regulatory T Cells Restrain Pathogenic T Helper Cells during Skin Inflammation

(2018) Tom Hartwig et al.   Cell Reports

Replenishing Regulatory T Cells to Halt Depigmentation in Vitiligo

(2017) I. Caroline Le Poole et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

JAK inhibitors in dermatology: The promise of a new drug class

(2017) William Damsky et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Regulatory T Cells Suppress Inflammation and Blistering in Pemphigoid Diseases

(2017) Katja Bieber et al.   Frontiers in Immunology

Antigen-specificity using chimeric antigen receptors: the future of regulatory T-cell therapy?

(2016) Dominic Boardman et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII

(2016) Jeongheon Yoon et al.   BLOOD

Ccl22 Diverts T Regulatory Cells and Controls the Growth of Melanoma

(2016) Jared Klarquist et al.   CANCER RESEARCH

Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris

(2016) Thomas Schmidt et al.   EXPERIMENTAL DERMATOLOGY

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

(2016) Katherine G. MacDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Impaired function of regulatory T cells in patients with psoriasis is mediated by phosphorylation of STAT3

(2016) Luting Yang et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Case of disseminated granuloma annulare with giant plaques

(2016) Ryosuke Saigusa et al.   JOURNAL OF DERMATOLOGY

Macrophage-mediated psoriasis can be suppressed by regulatory T lymphocytes

(2016) Rafael Leite Dantas et al.   JOURNAL OF PATHOLOGY

Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes

(2016) Natalia Marek-Trzonkowska et al.   Journal of Translational Medicine

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

Adoptive T Cell Therapies: A Comparison of T Cell Receptors and Chimeric Antigen Receptors

(2016) Daniel T. Harris et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Regulatory T Cells and Vitamin D Status in Children with Chronic Autoimmune Thyroiditis

(2016) Zeynep Şıklar et al.   Journal of Clinical Research in Pediatric Endocrinology

Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance

(2015) Hanyu Zeng et al.   Cellular & Molecular Immunology

Applications of the Excimer Laser

(2015) Sarah Beggs et al.   DERMATOLOGIC SURGERY

Developing in vitro expanded CD45RA+regulatory T cells as an adoptive cell therapy for Crohn's disease

(2015) James B Canavan et al.   GUT

Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis

(2015) Katherine G. MacDonald et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Fresolimumab treatment decreases biomarkers and improves clinical symptoms in systemic sclerosis patients

(2015) Lisa M. Rice et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetics of autoimmune diseases: insights from population genetics

(2015) Paula S Ramos et al.   JOURNAL OF HUMAN GENETICS

CCL22 to Activate Treg Migration and Suppress Depigmentation in Vitiligo

(2015) Jonathan M. Eby et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Hurdles in therapy with regulatory T cells

(2015) Piotr Trzonkowski et al.   Science Translational Medicine

Pathogenesis of Systemic Sclerosis

(2015) Debendra Pattanaik et al.   Frontiers in Immunology

Coexistent Skin Lesions of Vitiligo and Psoriasis Vulgaris. Immunohistochemical Analyses for IL-17A-producing Cells and Regulatory T cells

(2014) S Ono et al.   ACTA DERMATO-VENEREOLOGICA

Transcriptional Profiling of Rapamycin-Treated Fibroblasts From Hypertrophic and Keloid Scars

(2014) Victor W. Wong et al.   ANNALS OF PLASTIC SURGERY

HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse

(2014) M. F. Martelli et al.   BLOOD

DNA hypermethylation of the forkhead box protein 3 (FOXP3) promoter in CD4+ T cells of patients with systemic sclerosis

(2014) Y.Y. Wang et al.   BRITISH JOURNAL OF DERMATOLOGY

Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up

(2014) Natalia Marek-Trzonkowska et al.   CLINICAL IMMUNOLOGY

Editorial overview: Autoimmunity

(2014) Bana Jabri et al.   CURRENT OPINION IN IMMUNOLOGY

Combination of everolimus and tacrolimus: a potentially effective regimen for recalcitrant psoriasis

(2014) Kai-Che Wei et al.   Dermatologic Therapy

Assessment of tissue FoxP3+, CD4+and CD8+T-cells in active and stable nonsegmental vitiligo

(2014) Marwa Abdallah et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Functional Comparison of Engineered T Cells Carrying a Native TCR versus TCR-like Antibody–Based Chimeric Antigen Receptors Indicates Affinity/Avidity Thresholds

(2014) Ravit Oren et al.   JOURNAL OF IMMUNOLOGY

Decreased expression of Runx1 and lowered proportion of Foxp3+ CD25+ CD4+ regulatory T cells in systemic sclerosis

(2014) Hiroshi Kataoka et al.   Modern Rheumatology

Immune responses in a mouse model of vitiligo with spontaneous epidermal de- and repigmentation

(2014) Jonathan M. Eby et al.   Pigment Cell & Melanoma Research

Increased frequency of Th17 cells in systemic sclerosis is related to disease activity and collagen overproduction

(2014) Xiaoqin Yang et al.   ARTHRITIS RESEARCH & THERAPY

Effects of Low-Dose Recombinant Interleukin 2 to Promote T-Regulatory Cells in Alopecia Areata

(2014) Emeline Castela et al.   JAMA Dermatology

Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation

(2013) A. L. Putnam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Adoptive Transfer of Umbilical Cord Blood-Derived Regulatory T Cells and Early Viral Reactivation

(2013) Claudio G. Brunstein et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Peripheral blood regulatory T cells in patients with diffuse systemic sclerosis (SSc) before and after autologous hematopoietic SCT: a pilot study

(2013) J Baraut et al.   BONE MARROW TRANSPLANTATION

Balance of Treg vs. T-helper cells in the transition from symptomless to lesional psoriatic skin

(2013) R.R.M.C. Keijsers et al.   BRITISH JOURNAL OF DERMATOLOGY

T-helper and regulatory T-cell cytokines in the peripheral blood of patients with active alopecia areata

(2013) M.K. Tembhre et al.   BRITISH JOURNAL OF DERMATOLOGY

T helper and regulatory T cell cytokine profile in active, stable and narrow band ultraviolet B treated generalized vitiligo

(2013) Manoj Kumar Tembhre et al.   CLINICA CHIMICA ACTA

A central role for inducible heat-shock protein 70 in autoimmune vitiligo

(2013) Jeffrey A. Mosenson et al.   EXPERIMENTAL DERMATOLOGY

Autoimmune pancreatitis in MRL/Mp mice is a T cell-mediated disease responsive to cyclosporine A and rapamycin treatment

(2013) Theresa Schwaiger et al.   GUT

Design and development of therapies using chimeric antigen receptor-expressing T cells

(2013) Gianpietro Dotti et al.   IMMUNOLOGICAL REVIEWS

Immunohistochemical analysis of FOXP3+ regulatory T cells in healthy human skin and autoimmune dermatoses

(2013) Sarah Terras et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

Impaired inhibitory function of circulating CD4+CD25+ regulatory T cells in alopecia areata

(2013) Bong Seok Shin et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives

(2013) Ralf Paus et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS

Tolerance induction by hair-specific keratins in murine alopecia areata

(2013) Ulrike Erb et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulatory T cells in skin lesions and blood of patients with bullous pemphigoid

(2013) E. Antiga et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

(2013) Noriko Komatsu et al.   NATURE MEDICINE

Clinical application of regulatory T cells in type 1 diabetes

(2013) Natalia Marek-Trzonkowska et al.   PEDIATRIC DIABETES

Decreased regulatory T-cells and CD4+/CD8+ratio correlate with disease onset and progression in patients with generalized vitiligo

(2013) Mitesh Dwivedi et al.   Pigment Cell & Melanoma Research

Elevated Levels of CD4+CD25+FoxP3+ T Cells in Systemic Sclerosis Patients Contribute to the Secretion of IL-17 and Immunosuppression Dysfunction

(2013) Xinjuan Liu et al.   PLoS One

Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease

(2013) K.-i. Matsuoka et al.   Science Translational Medicine

Donor-specific Regulatory T Cells Generated on Donor B Cells Are Superior to CD4+CD25high Cells in Controlling Alloimmune Responses in Humanized Mice

(2013) F. Noyan et al.   TRANSPLANTATION PROCEEDINGS

Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions

(2012) Alexis Mathian et al.   ANNALS OF THE RHEUMATIC DISEASES

Circulating CD4+ CD25brightFOXP3+ regulatory T-cells are significantly reduced in bullous pemphigoid patients

(2012) P. Quaglino et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ T regulatory cell subpopulations

(2012) C. Scotta et al.   HAEMATOLOGICA

Differential role of regulatory T cells in early and late stages of pulmonary fibrosis

(2012) Daniel Boveda-Ruiz et al.   IMMUNOBIOLOGY

A review of the worldwide prevalence of vitiligo in children/adolescents and adults

(2012) Christian Krüger et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

A Coreceptor-Independent Transgenic Human TCR Mediates Anti-Tumor and Anti-Self Immunity in Mice

(2012) S. Mehrotra et al.   JOURNAL OF IMMUNOLOGY

Circulatory levels of T-cell cytokines (interleukin [IL]-2, IL-4, IL-17, and transforming growth factor-?) in patients with vitiligo

(2012) Rehan Khan et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Systemic analyses of immunophenotypes of peripheral T cells in non-segmental vitiligo: implication of defective natural killer T cells

(2012) Li Zhou et al.   Pigment Cell & Melanoma Research

Global Activation of CD8+ Cytotoxic T Lymphocytes Correlates with an Impairment in Regulatory T Cells in Patients with Generalized Vitiligo

(2012) Yang Lili et al.   PLoS One

T regulatory cell separation for clinical application

(2012) Mauro Di Ianni et al.   TRANSFUSION AND APHERESIS SCIENCE

Molecular Mechanisms of Treg-Mediated T Cell Suppression

(2012) Angelika Schmidt et al.   Frontiers in Immunology

Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis

(2011) Daniela Fenoglio et al.   CLINICAL IMMUNOLOGY

Lesional Th17 cells and regulatory T cells in bullous pemphigoid

(2011) Masataka Arakawa et al.   EXPERIMENTAL DERMATOLOGY

Bifidobacterium infantis35624 administration induces Foxp3 T regulatory cells in human peripheral blood: potential role for myeloid and plasmacytoid dendritic cells

(2011) Patrycja Konieczna et al.   GUT

Tregs in immunotherapy: opportunities and challenges

(2011) WanJun Chen   Immunotherapy

Antigen-independent development of Foxp3+ regulatory T cells suppressing autoantibody production in experimental pemphigus vulgaris

(2011) T. Yokoyama et al.   INTERNATIONAL IMMUNOLOGY

Foxp3+ Regulatory T Cells of Psoriasis Patients Easily Differentiate into IL-17A-Producing Cells and Are Found in Lesional Skin

(2011) H. Jorn Bovenschen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

HSP70i is a critical component of the immune response leading to vitiligo

(2011) Jeffrey A. Mosenson et al.   Pigment Cell & Melanoma Research

Functional defects of peripheral regulatory T lymphocytes in patients with progressive vitiligo

(2011) M. Ben Ahmed et al.   Pigment Cell & Melanoma Research

Retinoic Acid and Rapamycin Differentially Affect and Synergistically Promote the Ex Vivo Expansion of Natural Human T Regulatory Cells

(2011) Tatiana N. Golovina et al.   PLoS One

Altered T-cell and regulatory cell repertoire in patients with diffuse cutaneous systemic sclerosis

(2011) G Papp et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

Role of CD4+CD25high+FOXP3+Regulatory T Cells in Psoriasis

(2010) Woo-Jin Yun et al.   Annals of Dermatology

Impact of Psoriasis on Quality of Life: Relationship between Clinical Response to Therapy and Change in Health-related Quality of Life

(2010) Young Wook Lee et al.   Annals of Dermatology

Reduction of regulatory T cells in skin lesions but not in peripheral blood of patients with systemic scleroderma

(2010) S. Klein et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea

(2010) E. Antiga et al.   BRITISH JOURNAL OF DERMATOLOGY

Regulatory T cells (CD4+CD25brightFoxP3+) expansion in systemic sclerosis correlates with disease activity and severity

(2010) Gleb Slobodin et al.   CELLULAR IMMUNOLOGY

Role of interleukin-17 in the pathogenesis of vitiligo

(2010) D. A. Bassiouny et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

(2010) Lynn Petukhova et al.   NATURE

Reduced skin homing by functional Treg in vitiligo

(2010) Jared Klarquist et al.   Pigment Cell & Melanoma Research

Human Antigen-Specific Regulatory T Cells Generated by T Cell Receptor Gene Transfer

(2010) Todd M. Brusko et al.   PLoS One

Willingness-to-pay and quality of life in patients with vitiligo

(2009) M.A. Radtke et al.   BRITISH JOURNAL OF DERMATOLOGY

Curing CNS autoimmune disease with myelin-reactive Foxp3+Treg

(2009) Leigh A. Stephens et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulatory T cells: how do they suppress immune responses?

(2009) S. Sakaguchi et al.   INTERNATIONAL IMMUNOLOGY

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autoimmune Destruction of Skin Melanocytes by Perilesional T Cells from Vitiligo Patients

(2009) Jasper G. van den Boorn et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis

(2009) Antonella Di Cesare et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Quantification and molecular characterization of regulatory T cells in connective tissue diseases

(2008) Leontina Banica et al.   AUTOIMMUNITY

Expansion of Human Regulatory T-Cells From Patients With Type 1 Diabetes

(2008) A. L. Putnam et al.   DIABETES

Mechanisms of regulatory T-cell suppression – a diverse arsenal for a moving target

(2008) Dorothy K. Sojka et al.   IMMUNOLOGY

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

(2008) Jennifer D. Stone et al.   IMMUNOLOGY

TGF-β–dependent suppressive function of Tregs requires wild-type levels of CD18 in a mouse model of psoriasis

(2008) Honglin Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice

(2008) Julia Yuen-Shan Tsang et al.   JOURNAL OF CLINICAL INVESTIGATION

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Commensal-Induced Regulatory T Cells Mediate Protection against Pathogen-Stimulated NF-κB Activation

(2008) Caitlin O'Mahony et al.   PLoS Pathogens