CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice

A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3+ T regulatory cells

(2009) H. Matsui et al.   BLOOD

Hepatic Gene Transfer as a Means of Tolerance Induction to Transgene Products

(2009) Paul LoDuca et al.   CURRENT GENE THERAPY

Anti-CD3 prevents factor VIII inhibitor development in hemophilia A mice by a regulatory CD4+CD25+-dependent mechanism and by shifting cytokine production to favor a Th1 response

(2008) B. Waters et al.   BLOOD

Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice

(2008) B. Peng et al.   BLOOD

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

CD4+FoxP3+regulatory T cells confer infectious tolerance in a TGF-β–dependent manner

(2008) John Andersson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Foxp3+ regulatory T cell: a jack of all trades, master of regulation

(2008) Qizhi Tang et al.   NATURE IMMUNOLOGY