The Potential of Nanomedicine to Unlock the Limitless Applications of mRNA

SARS-CoV-2 Omicron Variant Neutralization in Serum from Vaccinated and Convalescent Persons

(2022) Annika Rössler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of Lipid Nanoparticles Containing Ionizable Cationic Lipids Using Design-of-Experiments Approach

(2021) Takeshi Terada et al.   LANGMUIR

Advances in the development of personalized neoantigen-based therapeutic cancer vaccines

(2021) Eryn Blass et al.   Nature Reviews Clinical Oncology

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

(2021) Christina Krienke et al.   SCIENCE

mRNA vaccine for cancer immunotherapy

(2021) Lei Miao et al.   Molecular Cancer

Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine — Preliminary Report

(2021) Kai Wu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conjugation of Mannans to Enhance the Potency of Liposome Nanoparticles for the Delivery of RNA Vaccines

(2021) Roshan Goswami et al.   Pharmaceutics

An Update on Self-Amplifying mRNA Vaccine Development

(2021) Anna K. Blakney et al.   Vaccines

Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

(2021) Federica Sebastiani et al.   ACS Nano

mRNA-lipid nanoparticle COVID-19 vaccines: Structure and stability

(2021) Linde Schoenmaker et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Effectiveness of the BNT162b2 Covid-19 Vaccine against the B.1.1.7 and B.1.351 Variants

(2021) Laith J. Abu-Raddad et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunogenicity and efficacy of mRNA COVID-19 vaccine MRT5500 in preclinical animal models

(2021) Kirill V. Kalnin et al.   npj Vaccines

The investigation of mRNA vaccines formulated in liposomes administrated in multiple routes against SARS-CoV-2

(2021) Hai Huang et al.   JOURNAL OF CONTROLLED RELEASE

CureVac COVID vaccine let-down spotlights mRNA design challenges

(2021) Elie Dolgin   NATURE

The current landscape of nucleic acid therapeutics

(2021) Jayesh A. Kulkarni et al.   Nature Nanotechnology

mRNA vaccines for infectious diseases: principles, delivery and clinical translation

(2021) Namit Chaudhary et al.   NATURE REVIEWS DRUG DISCOVERY

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

(2021) Julian D. Gillmore et al.   NEW ENGLAND JOURNAL OF MEDICINE

Vaccine Effectiveness Studies in the Field

(2021) Stephen J.W. Evans et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evaluation of mRNA-1273 SARS-CoV-2 Vaccine in Adolescents

(2021) Kashif Ali et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents

(2021) Robert W. Frenck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine through 6 Months

(2021) Stephen J. Thomas et al.   NEW ENGLAND JOURNAL OF MEDICINE

CVnCoV and CV2CoV protect human ACE2 transgenic mice from ancestral B BavPat1 and emerging B.1.351 SARS-CoV-2

(2021) Donata Hoffmann et al.   Nature Communications

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

(2021) Mohamad-Gabriel Alameh et al.   IMMUNITY

Polymeric and lipid nanoparticles for delivery of self-amplifying RNA vaccines

(2021) Anna K. Blakney et al.   JOURNAL OF CONTROLLED RELEASE

A multiclade env–gag VLP mRNA vaccine elicits tier-2 HIV-1-neutralizing antibodies and reduces the risk of heterologous SHIV infection in macaques

(2021) Peng Zhang et al.   NATURE MEDICINE

Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines

(2021) Ai-ris Y. Collier et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evaluation of the BNT162b2 Covid-19 Vaccine in Children 5 to 11 Years of Age

(2021) Emmanuel B. Walter et al.   NEW ENGLAND JOURNAL OF MEDICINE

On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles

(2021) Sean A. Dilliard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel mechanism for the loss of mRNA activity in lipid nanoparticle delivery systems

(2021) Meredith Packer et al.   Nature Communications

BNT162b2 vaccination induces durable SARS-CoV-2–specific T cells with a stem cell memory phenotype

(2021) Gisella Guerrera et al.   Science Immunology

The challenge and prospect of mRNA therapeutics landscape

(2020) Yuhua Weng et al.   BIOTECHNOLOGY ADVANCES

New approaches to genetic therapies for cystic fibrosis

(2020) A. Christopher Boyd et al.   Journal of Cystic Fibrosis

An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

(2020) Katharina Reinhard et al.   SCIENCE

Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA

(2020) Siddharth Patel et al.   Nature Communications

The solid progress of nanomedicine

(2020) João Pedro Martins et al.   Drug Delivery and Translational Research

Sphingomyelin-Based Nanosystems (SNs) for the Development of Anticancer miRNA Therapeutics

(2020) Surasa Nagachinta et al.   Pharmaceutics

Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer

(2020) Anna K. Blakney et al.   ACS Nano

Next-generation immuno-oncology agents: current momentum shifts in cancer immunotherapy

(2020) Chongxian Pan et al.   Journal of Hematology & Oncology

Intranasal Delivery and Transfection of mRNA Therapeutics in the Brain Using Cationic Liposomes

(2020) Harkiranpreet Kaur Dhaliwal et al.   MOLECULAR PHARMACEUTICS

Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery

(2020) Yulia Eygeris et al.   NANO LETTERS

Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria

(2020) Dipak K. Raj et al.   NATURE

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

Lipid nanoparticles for nucleic acid delivery: Current perspectives

(2020) Eleni Samaridou et al.   ADVANCED DRUG DELIVERY REVIEWS

The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy

(2020) Valentina Francia et al.   BIOCONJUGATE CHEMISTRY

Clinical and biochemical characteristics of patients with ornithine transcarbamylase deficiency

(2020) Min-Zhi Peng et al.   CLINICAL BIOCHEMISTRY

Molecular dynamics simulation of siRNA loading into a nanoemulsion as a potential carrier

(2020) Somayeh Pirhadi et al.   JOURNAL OF MOLECULAR MODELING

Efficient Colorectal Cancer Gene Therapy with IL-15 mRNA Nano-formulation

(2020) Sibei Lei et al.   MOLECULAR PHARMACEUTICS

Nonclinical safety assessment of repeated administration and biodistribution of a novel rabies self-amplifying mRNA vaccine in rats

(2020) Alan Stokes et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

An Alphavirus-derived replicon RNA vaccine induces SARS-CoV-2 neutralizing antibody and T cell responses in mice and nonhuman primates

(2020) Jesse H. Erasmus et al.   Science Translational Medicine

Development of a potent Zika virus vaccine using self-amplifying messenger RNA

(2020) Kate Luisi et al.   Science Advances

Modified mRNA as a Therapeutic Tool for the Heart

(2020) Keerat Kaur et al.   CARDIOVASCULAR DRUGS AND THERAPY

Treating Cystic Fibrosis with mRNA and CRISPR

(2020) Alejandro Da Silva Sanchez et al.   HUMAN GENE THERAPY

Immuno-oncology drug development forges on despite COVID-19

(2020) Samik Upadhaya et al.   NATURE REVIEWS DRUG DISCOVERY

Dual mRNA therapy restores metabolic function in long-term studies in mice with propionic acidemia

(2020) Lei Jiang et al.   Nature Communications

A new generation of vaccines based on alphavirus self-amplifying RNA

(2020) María Cristina Ballesteros-Briones et al.   Current Opinion in Virology

Nanotheranostics for Cancer Therapy and Detection: State of the Art

(2020) Shivani Rai Paliwal et al.   CURRENT PHARMACEUTICAL DESIGN

DP7-C-modified liposomes enhance immune responses and the antitumor effect of a neoantigen-based mRNA vaccine

(2020) Rui Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine

(2020) Lindsey R. Baden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel therapeutic approaches for the management of cystic fibrosis

(2020) Ryan Jaques et al.   MULTIDISCIPLINARY RESPIRATORY MEDICINE

The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration

(2020) Lien Van Hoecke et al.   Molecular Therapy-Nucleic Acids

The case for an HIV cure and how to get there

(2020) Mark Dybul et al.   Lancet HIV

Manufacturing Considerations for the Development of Lipid Nanoparticles Using Microfluidics

(2020) Carla B. Roces et al.   Pharmaceutics

Effect of complexing lipids on cellular uptake and expression of messenger RNA in human skin explants

(2020) Anna K. Blakney et al.   JOURNAL OF CONTROLLED RELEASE

Self-Amplifying RNA Vaccines for Venezuelan Equine Encephalitis Virus Induce Robust Protective Immunogenicity in Mice

(2019) Marcelo M. Samsa et al.   MOLECULAR THERAPY

Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs

(2019) Susannah L. Hewitt et al.   Science Translational Medicine

Antigen-specific therapeutic approaches for autoimmunity

(2019) Pau Serra et al.   NATURE BIOTECHNOLOGY

Improved Efficacy in a Fabry Disease Model Using a Systemic mRNA Liver Depot System as Compared to Enzyme Replacement Therapy

(2019) Frank DeRosa et al.   MOLECULAR THERAPY

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

(2019) Piotr S. Kowalski et al.   MOLECULAR THERAPY

How mRNA therapeutics are entering the monoclonal antibody field

(2019) Lien Van Hoecke et al.   Journal of Translational Medicine

Messenger RNA therapy for rare genetic metabolic diseases

(2019) Pedro Berraondo et al.   GUT

Systemic mRNA Therapy for the Treatment of Fabry Disease: Preclinical Studies in Wild-Type Mice, Fabry Mouse Model, and Wild-Type Non-human Primates

(2019) Xuling Zhu et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Local and systemic delivery of mRNA encoding survivin-T34A by lipoplex for efficient colon cancer gene therapy

(2019) Xueyan Zhang et al.   International Journal of Nanomedicine

MRNA Delivery For Therapeutic Anti-Her2 Antibody Expression In Vivo

(2019) Yulia Rybakova et al.   MOLECULAR THERAPY

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

(2019) Anna K. Blakney et al.   GENE THERAPY

Current Applications of Nanoemulsions in Cancer Therapeutics

(2019) Elena Sánchez-López et al.   Nanomaterials

Mannosylation of LNP Results in Improved Potency for Self-Amplifying RNA (SAM) Vaccines

(2019) Roshan Goswami et al.   ACS Infectious Diseases

Recent advances in polymeric materials for the delivery of RNA therapeutics

(2019) David Ulkoski et al.   Expert Opinion on Drug Delivery

Development of a lipoplex-type mRNA carrier composed of an ionizable lipid with a vitamin E scaffold and the KALA peptide for use as an ex vivo dendritic cell-based cancer vaccine

(2019) Naho Tateshita et al.   JOURNAL OF CONTROLLED RELEASE

Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach

(2019) J. H. Azambuja et al.   MOLECULAR NEUROBIOLOGY

Endocytic Profiling of Cancer Cell Models Reveals Critical Factors Influencing LNP-Mediated mRNA Delivery and Protein Expression

(2019) Edward J. Sayers et al.   MOLECULAR THERAPY

mRNA structure regulates protein expression through changes in functional half-life

(2019) David M. Mauger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

(2019) Marco Maugeri et al.   Nature Communications

The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs

(2019) Akin Akinc et al.   Nature Nanotechnology

On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA

(2018) Jayesh A. Kulkarni et al.   ACS Nano

Emergence of synthetic mRNA: In vitro synthesis of mRNA and its applications in regenerative medicine

(2018) Hyokyoung Kwon et al.   BIOMATERIALS

Revisiting Interleukin-12 as a Cancer Immunotherapy Agent

(2018) Pedro Berraondo et al.   CLINICAL CANCER RESEARCH

Preclinical evaluation of mRNA trimannosylated lipopolyplexes as therapeutic cancer vaccines targeting dendritic cells

(2018) A. Le Moignic et al.   JOURNAL OF CONTROLLED RELEASE

Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectroscopy

(2018) Jasmine Viger-Gravel et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Incorporation of mRNA in Lamellar Lipid Matrices for Parenteral Administration

(2018) Antje Ziller et al.   MOLECULAR PHARMACEUTICS

Targeted mRNA Therapy for Ornithine Transcarbamylase Deficiency

(2018) Mary G. Prieve et al.   MOLECULAR THERAPY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

(2018) Marianna Yanez Arteta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection

(2018) Alvaro Baeza Garcia et al.   Nature Communications

Progress and challenges towards targeted delivery of cancer therapeutics

(2018) Daniel Rosenblum et al.   Nature Communications

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

(2018) Jonathan D. Finn et al.   Cell Reports

Delivery approaches for CRISPR/Cas9 therapeutics in vivo: advances and challenges

(2018) D.C. Luther et al.   Expert Opinion on Drug Delivery

An RNA toolbox for cancer immunotherapy

(2018) Fernando Pastor et al.   NATURE REVIEWS DRUG DISCOVERY

Therapeutic Tolerance in Autoimmune Disease

(2018) Fiona Rayner et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Optimization of the Linker Length of Mannose-Cholesterol Conjugates for Enhanced mRNA Delivery to Dendritic Cells by Liposomes

(2018) Fazhan Wang et al.   Frontiers in Pharmacology

Cytokines in clinical cancer immunotherapy

(2018) Pedro Berraondo et al.   BRITISH JOURNAL OF CANCER

mRNA-Based Protein Replacement Therapy for the Heart

(2018) Ajit Magadum et al.   MOLECULAR THERAPY

Systemic messenger RNA as an etiological treatment for acute intermittent porphyria

(2018) Lei Jiang et al.   NATURE MEDICINE

Lipid nanoparticles that deliver IL-12 messenger RNA suppress tumorigenesis in MYC oncogene-driven hepatocellular carcinoma

(2018) Ian Lai et al.   Journal for ImmunoTherapy of Cancer

Factors influencing transfection efficiency of pIDUA/nanoemulsion complexes in a mucopolysaccharidosis type I murine model

(2017) Michelle Fraga et al.   International Journal of Nanomedicine

Cationic nanoemulsions as nucleic acids delivery systems

(2017) Helder Ferreira Teixeira et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease

(2017) Michelle Meyer et al.   JOURNAL OF INFECTIOUS DISEASES

Lipid Nanoparticle Systems for Enabling Gene Therapies

(2017) Pieter R. Cullis et al.   MOLECULAR THERAPY

Dendrimers as Nanocarriers for Nucleic Acid and Drug Delivery in Cancer Therapy

(2017) Livia Palmerston Mendes et al.   MOLECULES

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

(2017) Hao Yin et al.   NATURE BIOTECHNOLOGY

Elimination of large tumors in mice by mRNA-encoded bispecific antibodies

(2017) Christiane R Stadler et al.   NATURE MEDICINE

Porphyria

(2017) D. Montgomery Bissell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

(2017) Norbert Pardi et al.   Nature Communications

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia

(2017) Ding An et al.   Cell Reports

Cationic Nanoliposomes Meet mRNA: Efficient Delivery of Modified mRNA Using Hemocompatible and Stable Vectors for Therapeutic Applications

(2017) Tatjana Michel et al.   Molecular Therapy-Nucleic Acids

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Current approaches to increase CAR T cell potency in solid tumors: targeting the tumor microenvironment

(2017) Irene Scarfò et al.   Journal for ImmunoTherapy of Cancer

Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA

(2016) Jason B. Miller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Methylmalonic and propionic acidemias

(2016) Jamie L. Fraser et al.   CURRENT OPINION IN PEDIATRICS

Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization

(2016) Rebecca Ball et al.   International Journal of Nanomedicine

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

(2016) Hao Yin et al.   NATURE BIOTECHNOLOGY

Treatment of Fabry’s Disease with the Pharmacologic Chaperone Migalastat

(2016) Dominique P. Germain et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

(2016) Malwina Strenkowska et al.   NUCLEIC ACIDS RESEARCH

Understanding Ebola: the 2014 epidemic

(2016) Jolie Kaner et al.   Globalization and Health

PEGylated cationic nanoemulsions can efficiently bind and transfect pIDUA in a mucopolysaccharidosis type I murine model

(2015) Michelle Fraga et al.   JOURNAL OF CONTROLLED RELEASE

Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin

(2015) Michela Brazzoli et al.   JOURNAL OF VIROLOGY

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

The modern era of HIV-1 vaccine development

(2015) J. R. Mascola   SCIENCE

Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells

(2015) S. Van Lint et al.   Cancer Immunology Research

Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery

(2015) Hidetaka Akita et al.   ACS Biomaterials-Science & Engineering

Molecular Tuning of a Vitamin E-Scaffold pH-Sensitive and Reductive Cleavable Lipid-like Material for Accelerated in Vivo Hepatic siRNA Delivery

(2015) Hidetaka Akita et al.   ACS Biomaterials Science & Engineering

Optimization of stearylamine-based nanoemulsions obtained by spontaneous emulsification process as nucleic acids delivery systems

(2015) M. Fraga et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

(2014) Srinivas Ganta et al.   AAPS PHARMSCITECH

Potent Immune Responses in Rhesus Macaques Induced by Nonviral Delivery of a Self-amplifying RNA Vaccine Expressing HIV Type 1 Envelope With a Cationic Nanoemulsion

(2014) W. M. Bogers et al.   JOURNAL OF INFECTIOUS DISEASES

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

(2014) Luis A Brito et al.   MOLECULAR THERAPY

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

(2014) Y. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

(2013) Martin A Maier et al.   MOLECULAR THERAPY

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Cas9 as a versatile tool for engineering biology

(2013) Prashant Mali et al.   NATURE METHODS

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

(2013) Barbara L Mui et al.   Molecular Therapy-Nucleic Acids

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transfection efficiency boost of cholesterol-containing lipoplexes

(2012) Daniela Pozzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core

(2012) Alex K. K. Leung et al.   Journal of Physical Chemistry C

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

(2012) Charlotte Pollard et al.   MOLECULAR THERAPY

A Plasmodium-encoded cytokine suppresses T-cell immunity during malaria

(2012) T. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA

(2012) Nathan M Belliveau et al.   Molecular Therapy-Nucleic Acids

Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery

(2011) Rahau S. Shirazi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

Nanoemulsions versus microemulsions: terminology, differences, and similarities

(2011) David Julian McClements   Soft Matter

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Regulation of mRNA decapping

(2010) You Li et al.   Wiley Interdisciplinary Reviews-RNA

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY