The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration

Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine

(2019) Zifu Zhong et al.   Vaccines

A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation

(2018) Kalina Paunovska et al.   NANO LETTERS

Dendritic Cell Targeting mRNA Lipopolyplexes Combine Strong Antitumor T-Cell Immunity with Improved Inflammatory Safety

(2018) Kevin Van der Jeught et al.   ACS Nano

Treatment with mRNA coding for the necroptosis mediator MLKL induces antitumor immunity directed against neo-epitopes

(2018) Lien Van Hoecke et al.   Nature Communications

Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design

(2017) Timothy Pepini et al.   JOURNAL OF IMMUNOLOGY

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

(2017) Kapil Bahl et al.   MOLECULAR THERAPY

Immunological effects of a novel RNA-based adjuvant in liver cancer patients

(2016) Luisa Circelli et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Type I Interferons Interfere with the Capacity of mRNA Lipoplex Vaccines to Elicit Cytolytic T Cell Responses

(2016) Ans De Beuckelaer et al.   MOLECULAR THERAPY

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon

(2016) Katrijn Broos et al.   Molecular Therapy-Nucleic Acids

Space and time: New considerations about the relationship between Toll-like receptors (TLRs) and type I interferons (IFNs)

(2015) Darren J. Perkins et al.   CYTOKINE

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma

(2015) Joal D Beane et al.   MOLECULAR THERAPY

mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-receptor CCR5

(2015) U. Mock et al.   NUCLEIC ACIDS RESEARCH

Lipid-based mRNA vaccine delivery systems

(2014) Patrick Midoux et al.   Expert Review of Vaccines

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

mRNA vaccine CV9103 and CV9104 for the treatment of prostate cancer

(2014) Steffen Rausch et al.   Human Vaccines & Immunotherapeutics

Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1

(2013) Nicole A de Weerd et al.   NATURE IMMUNOLOGY

Resistance to Germline RNA Interference in a Caenorhabditis elegans Wild Isolate Exhibits Complexity and Nonadditivity

(2013) Daniel A. Pollard et al.   G3-Genes Genomes Genetics

mRNA

(2013) Sandra Van Lint et al.   Human Vaccines & Immunotherapeutics

Preclinical Evaluation of TriMix and Antigen mRNA-Based Antitumor Therapy

(2012) S. Van Lint et al.   CANCER RESEARCH

Modulation of T-cell function by type I interferon

(2012) David F Tough   IMMUNOLOGY AND CELL BIOLOGY

Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

(2012) Charlotte Pollard et al.   MOLECULAR THERAPY

Direct Effects of Type I Interferons on Cells of the Immune System

(2011) S. Hervas-Stubbs et al.   CLINICAL CANCER RESEARCH

Type-I IFN drives the differentiation of short-lived effector CD8+T cells in vivo

(2011) Melanie Wiesel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

(2011) Nadine Honke et al.   NATURE IMMUNOLOGY

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients

(2010) Susanne M Rittig et al.   MOLECULAR THERAPY

Gene Regulation and Chromatin Remodeling by IL-12 and Type I IFN in Programming for CD8 T Cell Effector Function and Memory

(2009) P. Agarwal et al.   JOURNAL OF IMMUNOLOGY

Novel Reporter Mouse Reveals Constitutive and Inflammatory Expression of IFN-  In Vivo

(2009) S. Lienenklaus et al.   JOURNAL OF IMMUNOLOGY

Plasmid DNA- and messenger RNA-based anti-cancer vaccination

(2007) Benjamin Weide et al.   IMMUNOLOGY LETTERS