Effect of complexing lipids on cellular uptake and expression of messenger RNA in human skin explants

Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer

(2020) Anna K. Blakney et al.   ACS Nano

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

(2020) Qiang Cheng et al.   Nature Nanotechnology

RNA therapeutics on the rise

(2020) Feng Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Developing Covid-19 Vaccines at Pandemic Speed

(2020) Nicole Lurie et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Skin You Are In: Design-of-Experiments Optimization of Lipid Nanoparticle Self-Amplifying RNA Formulations in Human Skin Explants

(2019) Anna K. Blakney et al.   ACS Nano

Cell Subtypes Within the Liver Microenvironment Differentially Interact with Lipid Nanoparticles

(2019) Cory D. Sago et al.   Cellular and Molecular Bioengineering

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

(2019) Anna K. Blakney et al.   GENE THERAPY

Endocytic Profiling of Cancer Cell Models Reveals Critical Factors Influencing LNP-Mediated mRNA Delivery and Protein Expression

(2019) Edward J. Sayers et al.   MOLECULAR THERAPY

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

(2018) Marianna Yanez Arteta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility

(2018) Jayesh A. Kulkarni et al.   Nucleic Acid Therapeutics

Cationic DDA/TDB liposome as a mucosal vaccine adjuvant for uptake by dendritic cells in vitro induces potent humoural immunity

(2018) Wenjing Qu et al.   Artificial Cells Nanomedicine and Biotechnology

Patisiran: First Global Approval

(2018) Sheridan M. Hoy   DRUGS

Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques

(2017) Frank Liang et al.   MOLECULAR THERAPY

Tools for translation: non-viral materials for therapeutic mRNA delivery

(2017) Khalid A. Hajj et al.   Nature Reviews Materials

Uptake of synthetic naked RNA by skin-resident dendritic cells via macropinocytosis allows antigen expression and induction of T-cell responses in mice

(2016) Abderraouf Selmi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines

(2016) Thomas Démoulins et al.   Nanomedicine-Nanotechnology Biology and Medicine

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

(2015) Kevin J. Kauffman et al.   NANO LETTERS

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

(2014) Srinivas Ganta et al.   AAPS PHARMSCITECH

The use of skin models in drug development

(2014) Stephanie H. Mathes et al.   ADVANCED DRUG DELIVERY REVIEWS

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

(2014) Luis A Brito et al.   MOLECULAR THERAPY

Insight into Mechanisms of Cellular Uptake of Lipid Nanoparticles and Intracellular Release of Small RNAs

(2014) Bo Yu et al.   PHARMACEUTICAL RESEARCH

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

(2014) Kathryn A. Whitehead et al.   Nature Communications

Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling

(2013) Gaurav Sahay et al.   NATURE BIOTECHNOLOGY

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo

(2012) Muthusamy Jayaraman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RNA-Based Therapeutics: Current Progress and Future Prospects

(2012) John C. Burnett et al.   CHEMISTRY & BIOLOGY

Small molecule ligands for enhanced intracellular delivery of lipid nanoparticle formulations of siRNA

(2012) Yuen Yi C. Tam et al.   Nanomedicine-Nanotechnology Biology and Medicine

Designer Lipids Advance Systemic siRNA Delivery

(2010) Yang Liu et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymers for Drug Delivery Systems

(2010) William B. Liechty et al.   Annual Review of Chemical and Biomolecular Engineering

Skin immune surveillance by T cells—A new order?

(2009) Jessica Strid et al.   SEMINARS IN IMMUNOLOGY

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY