Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
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Title
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses
Authors
Keywords
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Journal
IMMUNITY
Volume 54, Issue 12, Pages 2877-2892.e7
Publisher
Elsevier BV
Online
2021-11-04
DOI
10.1016/j.immuni.2021.11.001
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Note: Only part of the references are listed.- SARS-CoV-2 mRNA Vaccines: Immunological Mechanism and Beyond
- (2021) Emily Bettini et al. Vaccines
- Systems vaccinology of the BNT162b2 mRNA vaccine in humans
- (2021) Prabhu S. Arunachalam et al. NATURE
- SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses
- (2021) Jackson S. Turner et al. NATURE
- Antigen modifications improve nucleoside-modified mRNA-based influenza virus vaccines in mice
- (2021) Alec W. Freyn et al. Molecular Therapy-Methods & Clinical Development
- Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells
- (2020) Marco De Giovanni et al. NATURE IMMUNOLOGY
- The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans
- (2020) John L. Johnson et al. IMMUNITY
- A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice
- (2020) Alec W. Freyn et al. MOLECULAR THERAPY
- A serological assay to detect SARS-CoV-2 seroconversion in humans
- (2020) Fatima Amanat et al. NATURE MEDICINE
- A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice
- (2020) Dorottya Laczkó et al. IMMUNITY
- SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
- (2020) Kizzmekia S. Corbett et al. NATURE
- Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults
- (2020) Mark J. Mulligan et al. NATURE
- Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
- (2020) Kizzmekia S. Corbett et al. NEW ENGLAND JOURNAL OF MEDICINE
- An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
- (2020) Lisa A. Jackson et al. NEW ENGLAND JOURNAL OF MEDICINE
- Lipid Nanoparticle Acts as a Potential Adjuvant for Influenza Split Vaccine without Inducing Inflammatory Responses
- (2020) Seiki Shirai et al. Vaccines
- SARS-CoV-2 vaccines in development
- (2020) Florian Krammer NATURE
- COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses
- (2020) Ugur Sahin et al. NATURE
- Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates
- (2020) Edward E. Walsh et al. NEW ENGLAND JOURNAL OF MEDICINE
- D614G Spike Mutation Increases SARS CoV-2 Susceptibility to Neutralization
- (2020) Drew Weissman et al. Cell Host & Microbe
- SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation
- (2020) Katlyn Lederer et al. IMMUNITY
- Characterization of HIV-1 nucleoside-modified mRNA vaccines in rabbits and rhesus macaques
- (2019) Norbert Pardi et al. Molecular Therapy-Nucleic Acids
- T follicular regulatory (Tfr) cells: Dissecting the complexity of Tfr‐cell compartments
- (2019) Válter R. Fonseca et al. IMMUNOLOGICAL REVIEWS
- Double-Stranded RNA Sensors and Modulators in Innate Immunity
- (2019) Sun Hur Annual Review of Immunology
- T Follicular Helper Cell Biology: A Decade of Discovery and Diseases
- (2019) Shane Crotty IMMUNITY
- Antibody responses to crucial functional epitopes as a novel approach to assess immunogenicity of vaccine adjuvants
- (2019) Sita Awasthi et al. VACCINE
- A Facile Method for the Removal of dsRNA Contaminant from In Vitro-Transcribed mRNA
- (2019) Markus Baiersdörfer et al. Molecular Therapy-Nucleic Acids
- Lipid Nanoparticle Technology for Clinical Translation of siRNA Therapeutics
- (2019) Jayesh A. Kulkarni et al. ACCOUNTS OF CHEMICAL RESEARCH
- Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses
- (2019) Rachel L. Clement et al. NATURE IMMUNOLOGY
- Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes
- (2019) Sita Awasthi et al. Science Immunology
- iReceptor: A platform for querying and analyzing antibody/B-cell and T-cell receptor repertoire data across federated repositories
- (2018) Brian D. Corrie et al. IMMUNOLOGICAL REVIEWS
- Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses
- (2018) Norbert Pardi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- mRNA vaccines — a new era in vaccinology
- (2018) Norbert Pardi et al. NATURE REVIEWS DRUG DISCOVERY
- Correlates of adjuvanticity: A review on adjuvants in licensed vaccines
- (2018) Giuseppe Del Giudice et al. SEMINARS IN IMMUNOLOGY
- A Balancing Act: MDA5 in Antiviral Immunity and Autoinflammation
- (2018) Antonio Gregorio Dias Junior et al. TRENDS IN MICROBIOLOGY
- Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies
- (2018) Norbert Pardi et al. Nature Communications
- ImmuneDB, a Novel Tool for the Analysis, Storage, and Dissemination of Immune Repertoire Sequencing Data
- (2018) Aaron M. Rosenfeld et al. Frontiers in Immunology
- Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem
- (2017) Colin Havenar-Daughton et al. IMMUNOLOGICAL REVIEWS
- Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination
- (2017) Norbert Pardi et al. NATURE
- Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake
- (2017) Frank Liang et al. Science Translational Medicine
- Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells
- (2017) Gustaf Lindgren et al. Frontiers in Immunology
- Exploiting Mucosal Immunity for Antiviral Vaccines
- (2016) Akiko Iwasaki Annual Review of Immunology
- Follicular Helper T Cells
- (2016) Carola G. Vinuesa et al. Annual Review of Immunology
- Water-in-Oil–Only Adjuvants Selectively Promote T Follicular Helper Cell Polarization through a Type I IFN and IL-6–Dependent Pathway
- (2016) Nicolas Riteau et al. JOURNAL OF IMMUNOLOGY
- Activin A programs the differentiation of human TFH cells
- (2016) Michela Locci et al. NATURE IMMUNOLOGY
- A novel lipid nanoparticle adjuvant significantly enhances B cell and T cell responses to sub-unit vaccine antigens
- (2016) Gokul Swaminathan et al. VACCINE
- A Tetravalent Sub-unit Dengue Vaccine Formulated with Ionizable Cationic Lipid Nanoparticle induces Significant Immune Responses in Rodents and Non-Human Primates
- (2016) Gokul Swaminathan et al. Scientific Reports
- Comparative Systems Analyses Reveal Molecular Signatures of Clinically tested Vaccine Adjuvants
- (2016) Thorunn A. Olafsdottir et al. Scientific Reports
- Germinal Center Selection and the Antibody Response to Influenza
- (2015) Gabriel D. Victora et al. CELL
- Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies
- (2015) Cindy S. Ma et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes
- (2015) Norbert Pardi et al. JOURNAL OF CONTROLLED RELEASE
- MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life
- (2015) Beatris Mastelic Gavillet et al. JOURNAL OF IMMUNOLOGY
- Strategies to guide the antibody affinity maturation process
- (2015) Nicole A Doria-Rose et al. Current Opinion in Virology
- pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires
- (2014) Jason A. Vander Heiden et al. BIOINFORMATICS
- T Follicular Helper Cell Differentiation, Function, and Roles in Disease
- (2014) Shane Crotty IMMUNITY
- The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells
- (2014) Nathalie Schmitt et al. NATURE IMMUNOLOGY
- Cutting Edge: STAT1 Is Required for IL-6-Mediated Bcl6 Induction for Early Follicular Helper Cell Differentiation
- (2013) Y. S. Choi et al. JOURNAL OF IMMUNOLOGY
- Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics
- (2013) Martin A Maier et al. MOLECULAR THERAPY
- Defective Viral Genomes Arising In Vivo Provide Critical Danger Signals for the Triggering of Lung Antiviral Immunity
- (2013) Karla Tapia et al. PLoS Pathogens
- The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
- (2013) Devin Sok et al. PLoS Pathogens
- Germinal Centers
- (2012) Gabriel D. Victora et al. Annual Review of Immunology
- Functional STAT3 deficiency compromises the generation of human T follicular helper cells
- (2012) C. S. Ma et al. BLOOD
- Immune Signaling by RIG-I-like Receptors
- (2011) Yueh-Ming Loo et al. IMMUNITY
- Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA
- (2011) Katalin Karikó et al. NUCLEIC ACIDS RESEARCH
- IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation
- (2011) Danelle Eto et al. PLoS One
- From Vaccines to Memory and Back
- (2010) Federica Sallusto et al. IMMUNITY
- In Vivo Regulation of Bcl6 and T Follicular Helper Cell Development
- (2010) A. C. Poholek et al. JOURNAL OF IMMUNOLOGY
- Human Dendritic Cells Induce the Differentiation of Interleukin-21-Producing T Follicular Helper-like Cells through Interleukin-12
- (2009) Nathalie Schmitt et al. IMMUNITY
- Bcl6 Mediates the Development of T Follicular Helper Cells
- (2009) R. I. Nurieva et al. SCIENCE
- Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities
- (2008) F. Eddahri et al. BLOOD
- Toll-like Receptors Activate Innate and Adaptive Immunity by using Dendritic Cell-Intrinsic and -Extrinsic Mechanisms
- (2008) Baidong Hou et al. IMMUNITY
- Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
- (2008) Katalin Karikó et al. MOLECULAR THERAPY
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