Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex

(2016) Marcin Ziemniak et al.   RNA

Phosphate-modified analogues of m 7 GTP and m 7 Gppppm 7 G—Synthesis and biochemical properties

(2015) Marcin Ziemniak et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

(2015) Andreas Thess et al.   MOLECULAR THERAPY

Scaffolding along Nucleic Acid Duplexes Using 2′-Amino-Locked Nucleic Acids

(2014) I. Kira Astakhova et al.   ACCOUNTS OF CHEMICAL RESEARCH

Lipophilic nucleic acids — A flexible construction kit for organization and functionalization of surfaces

(2014) Matthias Schade et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Export and Expression: mRNAs Deliver New Messages for Controlling Pluripotency

(2014) Arven Saunders et al.   Cell Stem Cell

Nucleic acid vaccines: prospects for non-viral delivery of mRNA vaccines

(2014) Raquel P Deering et al.   Expert Opinion on Drug Delivery

Nucleoside—2′,3′/3′,5′-Bis(thio)phosphate Analogues Are Promising Antioxidants Acting Mainly via Cu+/Fe2+ Ion Chelation

(2014) Bosmat Levi Hevroni et al.   INORGANIC CHEMISTRY

Nature Biotechnology's academic spinouts of 2013

(2014) Aaron Bouchie et al.   NATURE BIOTECHNOLOGY

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

(2014) Joanna Kowalska et al.   NUCLEIC ACIDS RESEARCH

Potential therapeutic applications of RNA cap analogs

(2013) Marcin Ziemniak et al.   Future Medicinal Chemistry

A P(V)–N Activation Strategy for the Synthesis of Nucleoside Polyphosphates

(2013) Qi Sun et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis

(2012) Anna M. Rydzik et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Spherical Nucleic Acids

(2012) Joshua I. Cutler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Preparation of Synthetically Challenging Nucleotides Using Cyanoethyl P-Imidazolides and Microwaves

(2012) Malwina Strenkowska et al.   ORGANIC LETTERS

Sulfonyl Imidazolium Salts as Reagents for the Rapid and Efficient Synthesis of Nucleoside Polyphosphates and Their Conjugates

(2011) Samy Mohamady et al.   ORGANIC LETTERS

Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH3, Se, and NH

(2011) W. Su et al.   RNA

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

(2010) A N Kuhn et al.   GENE THERAPY

A split active site couples cap recognition by Dcp2 to activation

(2010) Stephen N Floor et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synthetic mRNA cap analogs with a modified triphosphate bridge – synthesis, applications and prospects

(2010) Jacek Jemielity et al.   NEW JOURNAL OF CHEMISTRY

Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications

(2010) Malwina Strenkowska et al.   NEW JOURNAL OF CHEMISTRY

P1,P2-Diimidazolyl derivatives of pyrophosphate and bis-phosphonates – synthesis, properties, and use in preparation of dinucleoside tetraphosphates and analogs

(2010) Ivan B. Yanachkov et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation

(2009) Joanna Kowalska et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

eIF4E: New Family Members, New Binding Partners, New Roles

(2009) Robert E. Rhoads   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5′,5′ bridge containing methylenebis(phosphonate) modification

(2009) Anna Maria Rydzik et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS

(2008) J. Kowalska et al.   RNA