Biomaterial and Therapeutic Approaches for the Manipulation of Macrophage Phenotype in Peripheral and Central Nerve Repair
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Title
Biomaterial and Therapeutic Approaches for the Manipulation of Macrophage Phenotype in Peripheral and Central Nerve Repair
Authors
Keywords
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Journal
Pharmaceutics
Volume 13, Issue 12, Pages 2161
Publisher
MDPI AG
Online
2021-12-16
DOI
10.3390/pharmaceutics13122161
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Note: Only part of the references are listed.- Extracellular vesicle-encapsulated microRNA-23a from dorsal root ganglia neurons binds to A20 and promotes inflammatory macrophage polarization following peripheral nerve injury
- (2021) Yamei Zhang et al. Aging-US
- Macrophage roles in peripheral nervous system injury and pathology: Allies in neuromuscular junction recovery
- (2021) Rachel Rios et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Materials for peripheral nerve repair constructs: Natural proteins or synthetic polymers?
- (2021) Holly Gregory et al. NEUROCHEMISTRY INTERNATIONAL
- Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies
- (2021) Karen E Martin et al. Acta Biomaterialia
- Macrophage as a Peripheral Pain Regulator
- (2021) Risa Domoto et al. Cells
- Matrix stiffness mechanosensing modulates the expression and distribution of transcription factors in Schwann cells
- (2021) Gonzalo Rosso et al. Bioengineering & Translational Medicine
- Surface-Anchored Graphene Oxide Nanosheets on Cell-Scale Micropatterned Poly(d,l-lactide-co-caprolactone) Conduits Promote Peripheral Nerve Regeneration
- (2020) Deteng Zhang et al. ACS Applied Materials & Interfaces
- M2 Phenotype Macrophages Colocalize with Schwann Cells in Human Dental Pulp
- (2020) N. Yoshiba et al. JOURNAL OF DENTAL RESEARCH
- Peripheral nerve repair throughout the body with processed nerve allografts: Results from a large multicenter study
- (2020) Bauback Safa et al. MICROSURGERY
- Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model
- (2020) Dominique R. Smith et al. TISSUE ENGINEERING PART A
- A novel hydrogel-based treatment for complete transection spinal cord injury repair is driven by microglia/macrophages repopulation
- (2020) Dezun Ma et al. BIOMATERIALS
- Directional axonal regrowth induced by an aligned fibrin nanofiber hydrogel contributes to improved motor function recovery in canine L2 spinal cord injury
- (2020) Zheng Cao et al. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
- Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury
- (2020) Elke Ydens et al. NATURE NEUROSCIENCE
- Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury
- (2020) Tuo Yang et al. Frontiers in Cellular Neuroscience
- Designer, injectable gels to prevent transplanted Schwann cell loss during spinal cord injury therapy
- (2020) Laura M. Marquardt et al. Science Advances
- The effect of a nanofiber-hydrogel composite on neural tissue repair and regeneration in the contused spinal cord
- (2020) Xiaowei Li et al. BIOMATERIALS
- Effects of Surface-Bound Collagen-Mimetic Peptides on Macrophage Uptake and Immunomodulation
- (2020) Andrew T. Rowley et al. Frontiers in Bioengineering and Biotechnology
- Thrombomodulin facilitates peripheral nerve regeneration through regulating M1/M2 switching
- (2020) Tzu-Chieh Huang et al. Journal of Neuroinflammation
- Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology
- (2020) Aleksandra Zielińska et al. MOLECULES
- Lentiviral Interleukin-10 Gene Therapy Preserves Fine Motor Circuitry and Function After a Cervical Spinal Cord Injury in Male and Female Mice
- (2020) Jessica Y. Chen et al. Neurotherapeutics
- Collagen‐rich deposit formation in the sciatic nerve after injury and surgical repair: A study of collagen‐producing cells in a rabbit model
- (2020) Jolanta Fertala et al. Brain and Behavior
- Natural-Based Biomaterials for Peripheral Nerve Injury Repair
- (2020) Benedetta E. Fornasari et al. Frontiers in Bioengineering and Biotechnology
- Highly elastic, electroconductive, immunomodulatory graphene crosslinked collagen cryogel for spinal cord regeneration
- (2020) Gopal Agarwal et al. Materials Science & Engineering C-Materials for Biological Applications
- Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions
- (2020) Timothy M. OʼShea et al. Nature Communications
- Graphene-based conductive fibrous scaffold boosts sciatic nerve regeneration and functional recovery upon electrical stimulation
- (2020) Chanjuan Dong et al. Applied Materials Today
- Macrophage and Fibroblast Interactions in Biomaterial-Mediated Fibrosis
- (2019) Claire E. Witherel et al. Advanced Healthcare Materials
- Extracellular Matrix-Based Strategies for Immunomodulatory Biomaterials Engineering
- (2019) Andrew T. Rowley et al. Advanced Healthcare Materials
- Graphene-Based Nanocomposites for Neural Tissue Engineering
- (2019) Ho Bei et al. MOLECULES
- Applications of nanotechnology in drug delivery to the central nervous system
- (2019) Majid Saeedi et al. BIOMEDICINE & PHARMACOTHERAPY
- Macroporous nanofiber wraps promote axonal regeneration and functional recovery in nerve repair by limiting fibrosis
- (2019) Karim A. Sarhane et al. Acta Biomaterialia
- Evaluation of the host immune response and functional recovery in peripheral nerve autografts and allografts
- (2019) Kelly Cristine Santos Roballo et al. TRANSPLANT IMMUNOLOGY
- Collagen Nerve Conduits and Processed Nerve Allografts for the Reconstruction of Digital Nerve Gaps: A Single-Institution Case Series and Review of the Literature
- (2019) Nadia Rbia et al. World Neurosurgery
- Peripheral Nerve Conduit: Materials and Structures
- (2019) Shadi Houshyar et al. ACS Chemical Neuroscience
- Human hair keratins promote the regeneration of peripheral nerves in a rat sciatic nerve crush model
- (2019) Jianyi Gao et al. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
- The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function
- (2019) James W. Fawcett et al. NATURE REVIEWS NEUROSCIENCE
- Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury
- (2019) Jonghyuck Park et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regeneration of Spinal Cord Connectivity Through Stem Cell Transplantation and Biomaterial Scaffolds
- (2019) Hiroyuki Katoh et al. Frontiers in Cellular Neuroscience
- Multilayered spraying and gradient dotting of nanodiamond–polycaprolactone guidance channels for restoration of immune homeostasis
- (2019) Yun Qian et al. NPG Asia Materials
- The accumulation of T cells within acellular nerve allografts is length-dependent and critical for nerve regeneration
- (2019) Deng Pan et al. EXPERIMENTAL NEUROLOGY
- The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?
- (2019) James W. Fawcett NEUROCHEMICAL RESEARCH
- MSC-Derived Exosomes-Based Therapy for Peripheral Nerve Injury: A Novel Therapeutic Strategy
- (2019) Ruiqi Dong et al. Biomed Research International
- Miconazole alleviates peripheral nerve crush injury by mediating a macrophage phenotype change through the NF‐κB pathway
- (2019) Liangliang Zhang et al. Brain and Behavior
- Self-Assembling Peptides and Their Application in the Treatment of Diseases
- (2019) Lee et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Moving beyond the glial scar for spinal cord repair
- (2019) Elizabeth J. Bradbury et al. Nature Communications
- Decellularized brain matrix enhances macrophage polarization and functional improvements in rat spinal cord injury
- (2019) Jin Young Hong et al. Acta Biomaterialia
- Vitamin B Complex Treatment Attenuates Local Inflammation after Peripheral Nerve Injury
- (2019) Adil Ehmedah et al. MOLECULES
- Mechanical Response of Neural Cells to Physiologically Relevant Stiffness Gradients
- (2019) Céline Kayal et al. Advanced Healthcare Materials
- Cell therapy for spinal cord injury using induced pluripotent stem cells
- (2019) Narihito Nagoshi et al. Regenerative Therapy
- Gelatin promotes rapid restoration of the blood brain barrier after acute brain injury
- (2018) Lucas S. Kumosa et al. Acta Biomaterialia
- Biological activities of laminin-111-derived peptide-chitosan matrices in a primary culture of rat cortical neurons
- (2018) Hideki Hayashi et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Effect of hyaluronic acid hydrogels containing astrocyte-derived extracellular matrix and/or V2a interneurons on histologic outcomes following spinal cord injury
- (2018) Russell E. Thompson et al. BIOMATERIALS
- Temporal changes in macrophage phenotype after peripheral nerve injury
- (2018) Joy E. Tomlinson et al. Journal of Neuroinflammation
- Local Immunomodulation with Anti-inflammatory Cytokine-Encoding Lentivirus Enhances Functional Recovery after Spinal Cord Injury
- (2018) Jonghyuck Park et al. MOLECULAR THERAPY
- Biomaterial Cues to Direct a Pro-regenerative Phenotype in Macrophages and Schwann Cells
- (2018) Melissa R. Wrobel et al. NEUROSCIENCE
- Biomaterial-Supported Cell Transplantation Treatments for Spinal Cord Injury: Challenges and Perspectives
- (2018) Shengwen Liu et al. Frontiers in Cellular Neuroscience
- Transplantation of Neural Precursor Cells Attenuates Chronic Immune Environment in Cervical Spinal Cord Injury
- (2018) Lennart Riemann et al. Frontiers in Neurology
- Inflammaging impairs peripheral nerve maintenance and regeneration
- (2018) Robert Büttner et al. AGING CELL
- Internal decompression of the acutely contused spinal cord: Differential effects of irrigation only versus biodegradable scaffold implantation
- (2018) James D. Guest et al. BIOMATERIALS
- Biocompatibility of PEG-Based Hydrogels in Primate Brain
- (2018) K. B. Bjugstad et al. CELL TRANSPLANTATION
- Nerve repair and regeneration: Biological tubulization limits and future perspectives
- (2018) Michele Riccio et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Fibronectin aggregates promote features of a classically and alternatively activated phenotype in macrophages
- (2018) Arend H. Sikkema et al. Journal of Neuroinflammation
- Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model
- (2018) Giuseppe Locatelli et al. NATURE NEUROSCIENCE
- Response of macrophages and neural cells in contact with reduced graphene oxide microfibers
- (2018) M. C. Serrano et al. Biomaterials Science
- Nanofiber arrangement regulates peripheral nerve regeneration through differential modulation of macrophage phenotypes
- (2018) Yachao Jia et al. Acta Biomaterialia
- Devising micro/nano-architectures in multi-channel nerve conduits towards a pro-regenerative matrix for the repair of spinal cord injury
- (2018) Xiumin Sun et al. Acta Biomaterialia
- Biomaterial Approaches to Modulate Reactive Astroglial Response
- (2018) Jonathan M. Zuidema et al. CELLS TISSUES ORGANS
- Villainous role of estrogen in macrophage-nerve interaction in endometriosis
- (2018) Yanchun Liang et al. Reproductive Biology and Endocrinology
- Macrophage Polarization in Response to Collagen Scaffold Stiffness Is Dependent on Cross-Linking Agent Used To Modulate the Stiffness
- (2018) Rukmani Sridharan et al. ACS Biomaterials-Science & Engineering
- Basement membrane and blood–brain barrier
- (2018) Lingling Xu et al. JOURNAL OF INVESTIGATIVE MEDICINE
- Sustained release of collagen VI potentiates sciatic nerve regeneration by modulating macrophage phenotype
- (2017) Dan Lv et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Reactive Astrocytes: Production, Function, and Therapeutic Potential
- (2017) Shane A. Liddelow et al. IMMUNITY
- Transcriptome analysis of IL-10-stimulated (M2c) macrophages by next-generation sequencing
- (2017) Emily B. Lurier et al. IMMUNOBIOLOGY
- Protective effect of biodegradable nerve conduit against peripheral nerve adhesion after neurolysis
- (2017) Kosuke Shintani et al. JOURNAL OF NEUROSURGERY
- Promotion of neurological recovery in rat spinal cord injury by mesenchymal stem cells loaded on nerve-guided collagen scaffold through increasing alternatively activated macrophage polarization
- (2017) Zhan Peng et al. Journal of Tissue Engineering and Regenerative Medicine
- Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin–N-cadherin pathway after spinal cord injury
- (2017) Masamitsu Hara et al. NATURE MEDICINE
- A view from the ending: Axonal dieback and regeneration following SCI
- (2017) Caitlin E. Hill NEUROSCIENCE LETTERS
- Immunoengineering nerve repair
- (2017) Nassir Mokarram et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Defining recovery neurobiology of injured spinal cord by synthetic matrix-assisted hMSC implantation
- (2017) Alexander E. Ropper et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling
- (2017) Le Thi Anh Hong et al. Nature Communications
- Exosomal cargo including microRNA regulates sensory neuron to macrophage communication after nerve trauma
- (2017) Raffaele Simeoli et al. Nature Communications
- Instructing Human Macrophage Polarization by Stiffness and Glycosaminoglycan Functionalization in 3D Collagen Networks
- (2017) Markus Friedemann et al. Advanced Healthcare Materials
- Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair
- (2017) Sandra Zárate et al. Frontiers in Aging Neuroscience
- The Effects of Epidermal Neural Crest Stem Cells on Local Inflammation Microenvironment in the Defected Sciatic Nerve of Rats
- (2017) Yue Li et al. Frontiers in Molecular Neuroscience
- Advances in Nerve Guidance Conduit-Based Therapeutics for Peripheral Nerve Repair
- (2017) William A. Lackington et al. ACS Biomaterials-Science & Engineering
- Advances in Nerve Guidance Conduit-Based Therapeutics for Peripheral Nerve Repair
- (2017) William A. Lackington et al. ACS Biomaterials Science & Engineering
- Glial responses to implanted electrodes in the brain
- (2017) Joseph W. Salatino et al. Nature Biomedical Engineering
- ECM hydrogel for the treatment of stroke: Characterization of the host cell infiltrate
- (2016) Harmanvir Ghuman et al. BIOMATERIALS
- A new three dimensional biomimetic hydrogel to deliver factors secreted by human mesenchymal stem cells in spinal cord injury
- (2016) Ilaria Caron et al. BIOMATERIALS
- Immunomodulatory and angiogenic responses induced by graphene oxide scaffolds in chronic spinal hemisected rats
- (2016) Elisa López-Dolado et al. BIOMATERIALS
- Tissue Engineering Approaches to Modulate the Inflammatory Milieu following Spinal Cord Injury
- (2016) Courtney M. Dumont et al. CELLS TISSUES ORGANS
- Recent advances in synthetic polymer based hydrogels for spinal cord repair
- (2016) Thomas Trimaille et al. COMPTES RENDUS CHIMIE
- The glial scar is more than just astrocytes
- (2016) Jerry Silver EXPERIMENTAL NEUROLOGY
- Autograft Substitutes
- (2016) Bauback Safa et al. HAND CLINICS
- Solubilized extracellular matrix bioscaffolds derived from diverse source tissues differentially influence macrophage phenotype
- (2016) Jenna L. Dziki et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
- Chitosan polyplex mediated delivery of miRNA-124 reduces activation of microglial cells in vitro and in rat models of spinal cord injury
- (2016) Andrew M. Louw et al. Nanomedicine-Nanotechnology Biology and Medicine
- Origin, fate and dynamics of macrophages at central nervous system interfaces
- (2016) Tobias Goldmann et al. NATURE IMMUNOLOGY
- Macrophage polarization in nerve injury: do Schwann cells play a role?
- (2016) JoAnne Stratton et al. Neural Regeneration Research
- Injectable Extracellular Matrix Hydrogels as Scaffolds for Spinal Cord Injury Repair
- (2016) Dmitry Tukmachev et al. TISSUE ENGINEERING PART A
- A Hydrogel Bridge Incorporating Immobilized Growth Factors and Neural Stem/Progenitor Cells to Treat Spinal Cord Injury
- (2016) Hang Li et al. Advanced Healthcare Materials
- Approaches to Peripheral Nerve Repair: Generations of Biomaterial Conduits Yielding to Replacing Autologous Nerve Grafts in Craniomaxillofacial Surgery
- (2016) Robert Gaudin et al. Biomed Research International
- The Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation
- (2016) Wenbin Wan et al. Journal of Immunology Research
- Stem Cell-Based Therapies for Spinal Cord Injury
- (2016) Rishi S. Nandoe Tewarie et al. JOURNAL OF SPINAL CORD MEDICINE
- Nanocarrier-Mediated Inhibition of Macrophage Migration Inhibitory Factor Attenuates Secondary Injury after Spinal Cord Injury
- (2015) Tarun Saxena et al. ACS Nano
- Biocompatibility of a coacervate-based controlled release system for protein delivery to the injured spinal cord
- (2015) Britta M. Rauck et al. Acta Biomaterialia
- Cell-seeded alginate hydrogel scaffolds promote directed linear axonal regeneration in the injured rat spinal cord
- (2015) Manuel Ingo Günther et al. Acta Biomaterialia
- Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury
- (2015) Peiwen Chen et al. ACTA NEUROPATHOLOGICA
- Macrophage-derived microvesicles promote proliferation and migration of Schwann cell on peripheral nerve repair
- (2015) Chuan Zhan et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Macrophage activation and its role in repair and pathology after spinal cord injury
- (2015) John C. Gensel et al. BRAIN RESEARCH
- Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves
- (2015) Anne-Laure Cattin et al. CELL
- The immunomodulatory properties of adult skin-derived precursor Schwann cells: implications for peripheral nerve injury therapy
- (2015) Jo Anne Stratton et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Age decreases macrophage IL-10 expression: Implications for functional recovery and tissue repair in spinal cord injury
- (2015) Bei Zhang et al. EXPERIMENTAL NEUROLOGY
- Resident microglia, rather than blood-derived macrophages, contribute to the earlier and more pronounced inflammatory reaction in the immature compared with the adult hippocampus after hypoxia-ischemia
- (2015) Takashi Umekawa et al. GLIA
- Interleukin-10 conjugated electrospun polycaprolactone (PCL) nanofibre scaffolds for promoting alternatively activated (M2) macrophages around the peripheral nerve in vivo
- (2015) Jason R. Potas et al. JOURNAL OF IMMUNOLOGICAL METHODS
- Crosstalk between macrophages and astrocytes affects proliferation, reactive phenotype and inflammatory response, suggesting a role during reactive gliosis following spinal cord injury
- (2015) Niels Haan et al. Journal of Neuroinflammation
- Toll-Like Receptors and Dectin-1, a C-Type Lectin Receptor, Trigger Divergent Functions in CNS Macrophages
- (2015) J. C. Gensel et al. JOURNAL OF NEUROSCIENCE
- Decellularized grafts with axially aligned channels for peripheral nerve regeneration
- (2015) Rukmani Sridharan et al. Journal of the Mechanical Behavior of Biomedical Materials
- Biomaterial based modulation of macrophage polarization: a review and suggested design principles
- (2015) Rukmani Sridharan et al. Materials Today
- Neurotrauma and Inflammation: CNS and PNS Responses
- (2015) Bruno Siqueira Mietto et al. MEDIATORS OF INFLAMMATION
- Astrocyte barriers to neurotoxic inflammation
- (2015) Michael V. Sofroniew NATURE REVIEWS NEUROSCIENCE
- Hematogenous macrophage depletion reduces the fibrotic scar and increases axonal growth after spinal cord injury
- (2015) Y. Zhu et al. NEUROBIOLOGY OF DISEASE
- Early Transplantation of Mesenchymal Stem Cells After Spinal Cord Injury Relieves Pain Hypersensitivity Through Suppression of Pain-Related Signaling Cascades and Reduced Inflammatory Cell Recruitment
- (2015) Shuji Watanabe et al. STEM CELLS
- Positively Charged Oligo[Poly(Ethylene Glycol) Fumarate] Scaffold Implantation Results in a Permissive Lesion Environment after Spinal Cord Injury in Rat
- (2015) Jeffrey S. Hakim et al. TISSUE ENGINEERING PART A
- Schwann Cells: Development and Role in Nerve Repair
- (2015) Kristján R. Jessen et al. Cold Spring Harbor Perspectives in Biology
- Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials
- (2015) Zeeshan Sheikh et al. Materials
- Subacute Tissue Response to 3D Graphene Oxide Scaffolds Implanted in the Injured Rat Spinal Cord
- (2015) Elisa López-Dolado et al. Advanced Healthcare Materials
- High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation
- (2015) Jamie E. Rayahin et al. ACS Biomaterials-Science & Engineering
- High and Low Molecular Weight Hyaluronic Acid Differentially Influence Macrophage Activation
- (2015) Jamie E. Rayahin et al. ACS Biomaterials Science & Engineering
- In vitro response of macrophage polarization to a keratin biomaterial
- (2014) Bailey V. Fearing et al. Acta Biomaterialia
- Collagen VI regulates peripheral nerve regeneration by modulating macrophage recruitment and polarization
- (2014) Peiwen Chen et al. ACTA NEUROPATHOLOGICA
- Axoplasmic reticulum Ca2+release causes secondary degeneration of spinal axons
- (2014) David P. Stirling et al. ANNALS OF NEUROLOGY
- Repair of spinal cord injury by inhibition of astrocyte growth and inflammatory factor synthesis through local delivery of flavopiridol in PLGA nanoparticles
- (2014) Hao Ren et al. BIOMATERIALS
- Repair of the injured spinal cord by implantation of a synthetic degradable block copolymer in rat
- (2014) Vincent Pertici et al. BIOMATERIALS
- Poly(lactic-co-glycolic) acid microspheres encapsulated in Pluronic F-127 prolong hirudin delivery and improve functional recovery from a demyelination lesion
- (2014) Drew L. Sellers et al. BIOMATERIALS
- Macrophage polarization in response to ECM coated polypropylene mesh
- (2014) Matthew T. Wolf et al. BIOMATERIALS
- The roles of blood-derived macrophages and resident microglia in the neuroinflammatory response to implanted Intracortical microelectrodes
- (2014) Madhumitha Ravikumar et al. BIOMATERIALS
- The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system
- (2014) Pouria Moshayedi et al. BIOMATERIALS
- Neural tissue engineering options for peripheral nerve regeneration
- (2014) Xiaosong Gu et al. BIOMATERIALS
- Microglia of medicinal leech (Hirudo medicinalis) express a specific activation marker homologous to vertebrate ionized calcium-binding adapter molecule 1 (Iba1/alias aif-1)
- (2014) Francesco Drago et al. Developmental Neurobiology
- Improving peripheral nerve regeneration: From molecular mechanisms to potential therapeutic targets
- (2014) K. Ming Chan et al. EXPERIMENTAL NEUROLOGY
- Functional regeneration beyond the glial scar
- (2014) Jared M. Cregg et al. EXPERIMENTAL NEUROLOGY
- High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury
- (2014) Teresa A. Evans et al. EXPERIMENTAL NEUROLOGY
- Tissue engineering of the peripheral nervous system
- (2014) Víctor Carriel et al. Expert Review of Neurotherapeutics
- Tissue integrity signals communicated by high-molecular weight hyaluronan and the resolution of inflammation
- (2014) S. M. Ruppert et al. IMMUNOLOGIC RESEARCH
- Ontogeny and Functions of Central Nervous System Macrophages
- (2014) Atsuko Katsumoto et al. JOURNAL OF IMMUNOLOGY
- Calcium Release from Intra-Axonal Endoplasmic Reticulum Leads to Axon Degeneration through Mitochondrial Dysfunction
- (2014) R. Villegas et al. JOURNAL OF NEUROSCIENCE
- Differences in the Phagocytic Response of Microglia and Peripheral Macrophages after Spinal Cord Injury and Its Effects on Cell Death
- (2014) A. D. Greenhalgh et al. JOURNAL OF NEUROSCIENCE
- TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord
- (2014) Antje Kroner et al. NEURON
- Diminished Schwann Cell Repair Responses Underlie Age-Associated Impaired Axonal Regeneration
- (2014) Michio W. Painter et al. NEURON
- Collagen scaffolds modified with collagen-binding bFGF promotes the neural regeneration in a rat hemisected spinal cord injury model
- (2014) Qin Shi et al. Science China-Life Sciences
- Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles
- (2014) D. R. Getts et al. Science Translational Medicine
- Self-assembling peptide nanofiber hydrogels for central nervous system regeneration
- (2014) Xi Liu et al. Frontiers of Materials Science
- Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance
- (2014) Nan Wang et al. Frontiers in Immunology
- Selective Nanovector Mediated Treatment of Activated Proinflammatory Microglia/Macrophages in Spinal Cord Injury
- (2013) Simonetta Papa et al. ACS Nano
- Impact of 3-D printed PLA- and chitosan-based scaffolds on human monocyte/macrophage responses: Unraveling the effect of 3-D structures on inflammation
- (2013) Catarina R. Almeida et al. Acta Biomaterialia
- Porous Implants Modulate Healing and Induce Shifts in Local Macrophage Polarization in the Foreign Body Reaction
- (2013) Eric M. Sussman et al. ANNALS OF BIOMEDICAL ENGINEERING
- Pilot Study: Elevated Circulating Levels of the Proinflammatory Cytokine Macrophage Migration Inhibitory Factor in Patients With Chronic Spinal Cord Injury
- (2013) Adam Stein et al. ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
- The Use of Poly(N-[2-Hydroxypropyl]-Methacrylamide) Hydrogel to Repair a T10 Spinal Cord Hemisection in Rat: A Behavioural, Electrophysiological and Anatomical Examination
- (2013) Vincent Pertici et al. ASN Neuro
- The reduction in immunogenicity of neurotrophin overexpressing stem cells after intra-striatal transplantation by encapsulation in an in situ gelling collagen hydrogel
- (2013) Deirdre B. Hoban et al. BIOMATERIALS
- Channel density and porosity of degradable bridging scaffolds on axon growth after spinal injury
- (2013) Aline M. Thomas et al. BIOMATERIALS
- The effect of a polyurethane-based reverse thermal gel on bone marrow stromal cell transplant survival and spinal cord repair
- (2013) Gaby J. Ritfeld et al. BIOMATERIALS
- Lentivirus delivery of IL-10 to promote and sustain macrophage polarization towards an anti-inflammatory phenotype
- (2013) R.M. Boehler et al. BIOTECHNOLOGY AND BIOENGINEERING
- Improved axonal regeneration of transected spinal cord mediated by multichannel collagen conduits functionalized with neurotrophin-3 gene
- (2013) L Yao et al. GENE THERAPY
- Evaluation of Mechanical Properties and Therapeutic Effect of Injectable Self-Assembling Hydrogels for Spinal Cord Injury
- (2013) Daniela Cigognini et al. Journal of Biomedical Nanotechnology
- Macrophage phenotypes during tissue repair
- (2013) Margaret L. Novak et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Host reaction to poly(2-hydroxyethyl methacrylate) scaffolds in a small spinal cord injury model
- (2013) Hong Ying Li et al. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
- Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury
- (2013) I. B. Wanner et al. JOURNAL OF NEUROSCIENCE
- Perivascular Fibroblasts Form the Fibrotic Scar after Contusive Spinal Cord Injury
- (2013) C. Soderblom et al. JOURNAL OF NEUROSCIENCE
- SIKVAV-modified highly superporous PHEMA scaffolds with oriented pores for spinal cord injury repair
- (2013) Šárka Kubinová et al. Journal of Tissue Engineering and Regenerative Medicine
- M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
- (2013) Veronique E Miron et al. NATURE NEUROSCIENCE
- Pathophysiology of the brain extracellular matrix: a new target for remyelination
- (2013) Lorraine W. Lau et al. NATURE REVIEWS NEUROSCIENCE
- Review: Manipulating the extracellular matrix and its role in brain and spinal cord plasticity and repair
- (2013) E. R. Burnside et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Modulation of macrophage phenotype by cell shape
- (2013) F. Y. McWhorter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Time-dependent changes in the microenvironment of injured spinal cord affects the therapeutic potential of neural stem cell transplantation for spinal cord injury
- (2013) Soraya Nishimura et al. Molecular Brain
- Managing Inflammation after Spinal Cord Injury through Manipulation of Macrophage Function
- (2013) Yi Ren et al. NEURAL PLASTICITY
- The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain
- (2012) Megan M. Varnum et al. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS
- The influence of substrate stiffness on the behavior and functions of Schwann cells in culture
- (2012) Yun Gu et al. BIOMATERIALS
- Effect of modulating macrophage phenotype on peripheral nerve repair
- (2012) Nassir Mokarram et al. BIOMATERIALS
- Engineering microscale topographies to control the cell–substrate interface
- (2012) Mehdi Nikkhah et al. BIOMATERIALS
- Hydrogels derived from central nervous system extracellular matrix
- (2012) Christopher J. Medberry et al. BIOMATERIALS
- Templated agarose scaffolds for the support of motor axon regeneration into sites of complete spinal cord transection
- (2012) Mingyong Gao et al. BIOMATERIALS
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- (2012) Melania Cusimano et al. BRAIN
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- (2012) Hitoshi Kawano et al. CELL AND TISSUE RESEARCH
- Laminin/β1 integrin signal triggers axon formation by promoting microtubule assembly and stabilization
- (2012) Wen-Liang Lei et al. CELL RESEARCH
- Student award winner in the undergraduate category for the society of biomaterials 9th World Biomaterials Congress, Chengdu, China, June 1-5, 2012
- (2012) Anna K. Blakney et al. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
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- (2012) James W. Austin et al. JOURNAL OF NEUROCHEMISTRY
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- (2012) Leah A. Mawhinney et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
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- (2012) Hideaki Nakajima et al. JOURNAL OF NEUROTRAUMA
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- (2012) Lei Cai et al. LANGMUIR
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- (2012) Zaal Kokaia et al. NATURE NEUROSCIENCE
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- (2012) T-H. Chu et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Reinduced Wnt signaling limits regenerative potential of sensory axons in the spinal cord following conditioning lesion
- (2012) E. R. Hollis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autologous incubated macrophage therapy in acute, complete spinal cord injury: results of the phase 2 randomized controlled multicenter trial
- (2012) D P Lammertse et al. SPINAL CORD
- Effect of Electrospun Fiber Diameter and Alignment on Macrophage Activation and Secretion of Proinflammatory Cytokines and Chemokines
- (2011) Enrica Saino et al. BIOMACROMOLECULES
- The reparative response to cross-linked collagen-based scaffolds in a rat spinal cord gap model
- (2011) Rahmatullah H. Cholas et al. BIOMATERIALS
- Bone Marrow Mesenchymal Stem Cells in a Three-Dimensional Gelatin Sponge Scaffold Attenuate Inflammation, Promote Angiogenesis, and Reduce Cavity Formation in Experimental Spinal Cord Injury
- (2011) Xiang Zeng et al. CELL TRANSPLANTATION
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- (2011) Youngnam Cho et al. EXPERIMENTAL NEUROLOGY
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- (2011) S. Kehoe et al. INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
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- (2011) Chenguang Zeng et al. JOURNAL OF CONTROLLED RELEASE
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- (2011) Anat London et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2011) Zin Z Khaing et al. Journal of Neural Engineering
- Wallerian degeneration: the innate-immune response to traumatic nerve injury
- (2011) Shlomo Rotshenker Journal of Neuroinflammation
- Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury
- (2011) Andrew D Gaudet et al. Journal of Neuroinflammation
- Functional Recovery after Peripheral Nerve Injury is Dependent on the Pro-Inflammatory Cytokines IL-1 and TNF: Implications for Neuropathic Pain
- (2011) S. Nadeau et al. JOURNAL OF NEUROSCIENCE
- Processed nerve allografts for peripheral nerve reconstruction: A multicenter study of utilization and outcomes in sensory, mixed, and motor nerve reconstructions
- (2011) Darrell N. Brooks et al. MICROSURGERY
- Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils
- (2011) Stephen J Galli et al. NATURE IMMUNOLOGY
- Peripheral Nerve Grafts Support Regeneration after Spinal Cord Injury
- (2011) Marie-Pascale Côté et al. Neurotherapeutics
- Evaluation of Early and Late Effects into the Acute Spinal Cord Injury of an Injectable Functionalized Self-Assembling Scaffold
- (2011) Daniela Cigognini et al. PLoS One
- The Glial Scar-Monocyte Interplay: A Pivotal Resolution Phase in Spinal Cord Repair
- (2011) Ravid Shechter et al. PLoS One
- A Pericyte Origin of Spinal Cord Scar Tissue
- (2011) C. Goritz et al. SCIENCE
- Induction of specific macrophage subtypes by defined micro-patterned structures
- (2010) Matthias Bartneck et al. Acta Biomaterialia
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- (2010) Hongwei Yu et al. Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology
- Nanotechnology applications and approaches for neuroregeneration and drug delivery to the central nervous system
- (2010) Gabriel A. Silva Annals of the New York Academy of Sciences
- Polylaminin, a polymeric form of laminin, promotes regeneration after spinal cord injury
- (2010) Karla Menezes et al. FASEB JOURNAL
- P2Y12receptor-mediated integrin-β1 activation regulates microglial process extension induced by ATP
- (2010) Keiko Ohsawa et al. GLIA
- NO mediates microglial response to acute spinal cord injury under ATP control in vivo
- (2010) Payam Dibaj et al. GLIA
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- (2010) M. T. Silva JOURNAL OF LEUKOCYTE BIOLOGY
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- (2010) S. A. Busch et al. JOURNAL OF NEUROSCIENCE
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- (2010) Vicki M. Tysseling et al. JOURNAL OF NEUROSCIENCE RESEARCH
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- (2010) Vivek Patel et al. JOURNAL OF NEUROTRAUMA
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- (2010) A. M. Piccinini et al. MEDIATORS OF INFLAMMATION
- Mesenchymal stem cells for the treatment of neurodegenerative disease
- (2010) Nanette Joyce et al. Regenerative Medicine
- Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
- (2010) F. Ginhoux et al. SCIENCE
- HPMA-RGD Hydrogels Seeded with Mesenchymal Stem Cells Improve Functional Outcome in Chronic Spinal Cord Injury
- (2010) Aleš Hejčl et al. STEM CELLS AND DEVELOPMENT
- Extracellular Matrix: Functions in the Nervous System
- (2010) C. S. Barros et al. Cold Spring Harbor Perspectives in Biology
- Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component
- (2009) Bryan N. Brown et al. BIOMATERIALS
- The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury
- (2009) Stefania Ceruti et al. BRAIN
- Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor/MyD88-dependent fashion
- (2009) Isabelle Pineau et al. BRAIN BEHAVIOR AND IMMUNITY
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- (2009) Debra L. Laskin CHEMICAL RESEARCH IN TOXICOLOGY
- Mesenchymal stem cell–educated macrophages: A novel type of alternatively activated macrophages
- (2009) Jaehyup Kim et al. EXPERIMENTAL HEMATOLOGY
- P2 receptor-mediated stimulation of the PI3-K/Akt-pathwayin vivo
- (2009) H. Franke et al. GLIA
- Microglia processes block the spread of damage in the brain and require functional chloride channels
- (2009) Dustin J. Hines et al. GLIA
- Overcoming Macrophage-Mediated Axonal Dieback Following CNS Injury
- (2009) S. A. Busch et al. JOURNAL OF NEUROSCIENCE
- Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord
- (2009) K. A. Kigerl et al. JOURNAL OF NEUROSCIENCE
- Biomaterial Design Strategies for the Treatment of Spinal Cord Injuries
- (2009) Karin S. Straley et al. JOURNAL OF NEUROTRAUMA
- Porosity of the wall of a Neurolac® nerve conduit hampers nerve regeneration
- (2009) Marcel F. Meek et al. MICROSURGERY
- Chitosan prevents oxidative stress-induced amyloid β formation and cytotoxicity in NT2 neurons: involvement of transcription factors Nrf2 and NF-κB
- (2009) Fariba Khodagholi et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Multiple Channel Bridges for Spinal Cord Injury: Cellular Characterization of Host Response
- (2009) Yang Yang et al. TISSUE ENGINEERING PART A
- Infiltrating Blood-Derived Macrophages Are Vital Cells Playing an Anti-inflammatory Role in Recovery from Spinal Cord Injury in Mice
- (2009) Ravid Shechter et al. PLOS MEDICINE
- Development of a Sialic Acid-Containing Hydrogel of Poly[N-(2-hydroxypropyl) methacrylamide]: Characterization and Implantation Study
- (2008) Stéphane Woerly et al. BIOMACROMOLECULES
- Substrate Modulus Directs Neural Stem Cell Behavior
- (2008) Krishanu Saha et al. BIOPHYSICAL JOURNAL
- Interactions between Schwann cells and macrophages in injury and inherited demyelinating disease
- (2008) Rudolf Martini et al. GLIA
- Neutrophil apoptosis and the resolution of infection
- (2008) Adam D. Kennedy et al. IMMUNOLOGIC RESEARCH
- Artificial Laminin Polymers Assembled in Acidic pH Mimic Basement Membrane Organization
- (2008) Madalena Martins Sant'Ana Barroso et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Another Barrier to Regeneration in the CNS: Activated Macrophages Induce Extensive Retraction of Dystrophic Axons through Direct Physical Interactions
- (2008) K. P. Horn et al. JOURNAL OF NEUROSCIENCE
- Akt activation is involved in P2Y12 receptor-mediated chemotaxis of microglia
- (2008) Yasuhiro Irino et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Macro-Architectures in Spinal Cord Scaffold Implants Influence Regeneration
- (2008) Darice Y. Wong et al. JOURNAL OF NEUROTRAUMA
- Evidence for a novel chemotactic C1q domain-containing factor in the leech nerve cord
- (2008) Muriel Tahtouh et al. MOLECULAR IMMUNOLOGY
- Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory/immune responses
- (2008) H. Ohtaki et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Foreign body reaction to biomaterials
- (2008) James M. Anderson et al. SEMINARS IN IMMUNOLOGY
- Two Faces of Chondroitin Sulfate Proteoglycan in Spinal Cord Repair: A Role in Microglia/Macrophage Activation
- (2008) Asya Rolls et al. PLOS MEDICINE
- Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury
- (2007) Dustin J. Donnelly et al. EXPERIMENTAL NEUROLOGY
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