Article
Multidisciplinary Sciences
Kenta Kawamura, Masaaki Kobayashi, Kazuhide Tomita
Summary: After cervical cord injury, the adaptation of phrenic motoneurons to their smaller size occurs within weeks. This study investigates whether routine hypercapnic load can alter this adaptation. The findings suggest that a hypercapnic challenge may increase input to phrenic motoneurons and alter their propensity for adaptation.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Hongfei Ke, Hongru Yang, Yijing Zhao, Tingting Li, Danqing Xin, Chengcheng Gai, Zige Jiang, Zhen Wang
Summary: This study introduces a method for constructing and testing 3D gelatin microsphere (GM) scaffolds based on convenient preparation of gelatin microspheres using microfluidic devices. These scaffolds demonstrate good biocompatibility, biodegradability, and porosity. They can effectively bridge injury gaps, establish nerve connections and signal transductions, mitigate inflammatory microenvironments, and reduce glial scar formation.
Article
Neurosciences
Latoya L. Allen, Nicole L. Nichols, Zachary A. Asa, Anna T. Emery, Marissa C. Ciesla, Juliet V. Santiago, Ashley E. Holland, Gordon S. Mitchell, Elisa J. Gonzalez-Rothi
Summary: The study tested the hypothesis that C2 spinal hemisection (C2Hx) minimally impacts phrenic motor neuron (PMN) survival and found no evidence of PMN loss at 2- or 8-weeks post-C2Hx. This insight is crucial for studying strategies for inducing plasticity and/or regeneration within the phrenic motor system after high cervical injury.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Medicine, Research & Experimental
Xiaojing Lin, Tingbao Zhao, Guiping Mei, Ruoxu Liu, Chenyi Li, Xiaowen Wang, Zixuan Qu, Shide Lin, M. J. Walker, Xueqing Yi, Peng Zhang, Kuang-Wen Tseng, Xiao-Ming Xu, Cheng-Hsien Lin, Gang Sun
Summary: This study investigated the therapeutic effects of 7,8-Dihydroxyflavone (DHF) in a rat model of Brown-Sequard Syndrome. The results showed that DHF accelerated the electrical, histological, and functional recovery in animals with Brown-Sequard Syndrome.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Nutrition & Dietetics
Ibrahim Hamad, Jana Van Broeckhoven, Alessio Cardilli, Niels Hellings, Till Strowig, Stefanie Lemmens, Sven Hendrix, Markus Kleinewietfeld
Summary: This study investigated the changes in gut microbiota composition after hemisection injury and the effects of systemic recombinant IL-13 treatment on the gut microbiome and functional recovery in mice. The results showed that rIL-13 treatment promoted changes in gut microbial communities and improved functional recovery.
Article
Neurosciences
Yudong Cao, Ya Shi, Zhifeng Xiao, Xi Chen, Bing Chen, Bin Yang, Muya Shu, Yanyun Yin, Shuyu Wu, Wen Yin, Xianyong Fu, Jun Tan, Quanwei Zhou, Zhaoping Wu, Xingjun Jiang, Jianwu Dai
Summary: The study demonstrated that contralateral corticospinal tract sprouting, rather than ipsilateral neuronal regeneration, is the primary factor responsible for spontaneous locomotor recovery in rats with hemisection spinal cord injury. Neuroregeneration is not substantial through the lesion site, but there is significant sprouting of CST fibers from the contralateral side at the lumbar 4 spinal cord.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Chao Ma, Junpei Wang, Qifeng Tu, Weijuan Bo, Zunlu Hu, Run Zhuo, Ronghua Wu, Zhangji Dong, Liang Qiang, Yan Liu, Mei Liu
Summary: This study demonstrates that depleting fidgetin can enhance axon regeneration after spinal cord injury by augmenting the labile domain of microtubules. The interaction between fidgetin and EB3 leads to the trimming of tyrosinated microtubules, which further promotes axonal regrowth.
NEURAL REGENERATION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Caijie Li, Sudhanshu Sahu, Guanhua Kou, Nataraj Jagadeesan, Thomson Patrick Joseph, Stanley Li Lin, Melitta Schachner
Summary: The study found that chondroitin 6-sulfate (C6S) inhibits neurite outgrowth, but this inhibitory activity can be neutralized by specific C6S-binding peptides. In a mouse model of spinal cord injury, application of C6S-binding peptides led to functional recovery and prevented fibrotic glial scar formation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Sarah E. Mondello, Lisa Young, Viet Dang, Amanda E. Fischedick, Nicholas M. Tolley, Tian Wang, Madison A. Bravo, Dalton Lee, Belinda Tucker, Megan Knoernschild, Benjamin D. Pedigo, Philip J. Horner, Chet T. Moritz
Summary: This study aims to develop a mechanistic understanding of how to promote functional recovery following spinal cord injury. The use of optogenetic stimulation shows promising results in promoting recovery of skilled limb movements and axonal growth. This finding suggests that optogenetic stimulation could be a potential therapy for spinal cord injury.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Neurosciences
Zeynep Balcikanli, Irem Culha, Pelin Dilsiz, Mehmet Serif Aydin, Nilay Ates, Mustafa Caglar Beker, Saltuk Bugra Baltaci, Halil Koc, Ahmet Yigitbasi, Mustafa Gundogar, Thorsten R. Doeppner, Dirk M. Hermann, Ertugrul Kilic
Summary: Spinal cord injury (SCI) can cause long-term neurological deficits, and the current treatments are ineffective. This study investigated the effects of lithium chloride (LiCl) on motor coordination recovery and neuroplasticity in mice with SCI. The results showed that LiCl can enhance motor coordination, reduce tissue atrophy, increase neuronal survival, and promote axonal regeneration.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Andrew R. Brown, Marina Martinez
Summary: Cortical plasticity plays a crucial role in hindlimb recovery after incomplete spinal cord injury, with evidence showing that residual activity in the contralesional hindlimb motor cortex contributes to spontaneous locomotor recovery and map plasticity.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Simon M. Danner, Courtney T. Shepard, Casey Hainline, Natalia A. Shevtsova, Ilya A. Rybak, David S. K. Magnuson
Summary: Thoracic spinal cord injury affects long propriospinal neurons that interconnect the cervical and lumbar enlargements, and these neurons are crucial for coordinating forelimb and hindlimb locomotor movements. Investigating locomotion over the full range of speeds can reveal otherwise hidden aspects of spinal locomotor control and post-injury recovery, which may not be fully exposed by studying recovery over a limited range of speeds.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Jingyuan Li, Yanqiong Wu, Ping Chen, Xiaoxia Huang, Yongli Liu, Minjing Peng, Rong-Qian Wu
Summary: The study illustrated that downregulation of CXCL12 in the spinal cord after SCI induced gliosis and loss of synapse, while intrathecal treatment of CXCL12 promoted functional recovery by inducing neuronal connections and suppressing glia scar. Experimental results on primary cortical neurons showed that CXCL12 peptide promoted axonal elongation, dendrite generation, and synaptogenesis, ultimately increasing functional connections among neurons.
Editorial Material
Clinical Neurology
Ian Fyfe
Summary: Directed axonal regeneration has been successful in restoring walking function in mice with complete spinal cord injury.
NATURE REVIEWS NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Krisztian B. Csomo, Gabor Varga, Andrea A. Belik, Laszlo Hricisak, Zoltan Borbely, Gabor Gerber
Summary: Open spinal cord injury techniques often involve invasive procedures and take a long time. This new technique eliminates the need for laminectomy, making it faster and less burdensome for animals. By removing two spinous processes and tilting the caudal vertebral arch, the surgical area opens up for lateral hemisection, minimizing trauma and bone wounds.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Clinical Neurology
Mathieu Milh, Pierre Roubertoux, Najoua Biba, Julie Chavany, Adeline Spiga Ghata, Camille Fulachier, Stephan Christopher Collins, Christel Wagner, Jean-Christophe Roux, Binnaz Yalcin, Marie-Solenne Felix, Florence Molinari, Pierre-Pascal Lenck-Santini, Laurent Villard
Article
Behavioral Sciences
Annabelle Constans, Caroline Pin-Barre, Florence Molinari, Jean-Jacques Temprado, Thomas Brioche, Christophe Pellegrino, Jerome Laurin
Summary: The study compares the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on aerobic performance and muscular plasticity markers in healthy rats, showing that HIIT can improve aerobic fitness better and increase related markers in muscles. Following 8 weeks of HIIT, key brain plasticity markers increased in the hippocampus but cognitive functions did not improve.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Marta Maria Torre, Antoine Langeard, Nicolas Hugues, Jerome Laurin, Jean-Jacques Temprado
Summary: The study compares the effects of different cognitive-motor training programs on physical and cognitive performance, focusing on the differences between traditional training and fitness gaming technology. Forty-five healthy older adults aged 65-80 will be tested for cognitive functions, motor fitness, and physical fitness.
Review
Biochemistry & Molecular Biology
Nicolas Hugues, Christophe Pellegrino, Claudio Rivera, Eric Berton, Caroline Pin-Barre, Jerome Laurin
Summary: Stroke-induced cognitive impairments can be improved by high-intensity interval training (HIIT) which enhances neuroplasticity processes and cognitive functions. However, there are methodological limitations in studies on exercise recommendations for stroke patients. The potential of HIIT in promoting neurotrophic factors expression, neurogenesis, and synaptic plasticity in stroke rehabilitation is significant.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Marie-Solenne Felix, Emilie Borloz, Khaled Metwally, Ambre Dauba, Benoit Larrat, Valerie Matagne, Yann Ehinger, Laurent Villard, Anthony Novell, Serge Mensah, Jean-Christophe Roux
Summary: Gene therapy is a powerful tool for treating diseased tissues and providing lasting and effective correction. The combination of focused ultrasound and microbubbles appears to be a technological breakthrough for delivering therapeutic agents to the central nervous system.
Article
Psychology, Multidisciplinary
Nicolas Mascret, Olivier Vors, Tanguy Marqueste, Francois Cury
Summary: This study used the TSST as an experimental stress paradigm to investigate its impact on free-throw performance of skilled basketball players. The results showed that free-throw performance remained stable when players were put in a competition immediately after the TSST, and other-approach goals were significant predictors of performance in the competition condition.
PSYCHOLOGICAL REPORTS
(2022)
Review
Medicine, General & Internal
C. Jaloux, M. Witters, J. Veran, L. Giraudo, F. Sabatier, R. Lacroix, F. Dignat-George, M. Bonnet, T. Marqueste, P. Decherchi, M. Montava, G. Guiraudie Capraz, F. Feron
Summary: The research team focuses on the potential of olfactory stem cells for treating peripheral nerve injuries and has validated the effectiveness of this treatment method. Through clinical trials and animal model studies, olfactory stem cell grafting is beneficial for nerve regeneration and has a lower potential carcinogenic risk.
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE
(2021)
Article
Neurosciences
Nicolas Hugues, Caroline Pin-Barre, Christophe Pellegrino, Claudio Rivera, Eric Berton, Jerome Laurin
Summary: The temporal pattern of cortical plasticity induced by high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) was investigated in this study. The results showed that HIIT led to early and superior endurance improvement compared to MICT. Meanwhile, MICT had a greater influence on neurotrophic and angiogenic/metabolic markers in the early stages. Both HIIT and MICT are effective in a time-dependent manner, suggesting their complementary effects for maintaining brain health.
Article
Neurosciences
Marie-Helene Canu, Valerie Montel, Julie Dereumetz, Tanguy Marqueste, Tanguy Decherchi, Jacques-Olivier Coq, Erwan Dupont, Bruno Bastide
Summary: Research indicates that early movement restriction can lead to severe atrophy and functional disorganization in the soleus muscle of rats, resulting in issues such as sensorimotor restriction and increased neuromuscular excitability. However, some of these changes can be reversed when typical activity is resumed, suggesting the importance of proprioceptive feedback in promoting typical motor function development.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Pascaline Lantoine, Mathieu Lecocq, Clement Bougard, Erick Dousset, Tanguy Marqueste, Christophe Bourdin, Jean-Marc Allegre, Laurent Bauvineau, Serge Mesure
Summary: This study evaluated the effects of three different seats on driver's sitting behavior and discomfort during prolonged driving under real conditions. Soft seats (S-1 & S-3) were found to limit local perceived discomfort, especially in areas like the buttocks, thighs, neck, and upper back. Automotive manufacturers could enhance seat design by combining a soft seat cushion, firm backrest, and suspension system for reduced driver discomfort.
Article
Engineering, Industrial
Pascaline Lantoine, Mathieu Lecocq, Clement Bougard, Erick Dousset, Tanguy Marqueste, Christophe Bourdin, Jean-Marc Allegre, Laurent Bauvineau, Serge Mesure
Summary: This study compares the effects of different seats and road types on pressure distribution and perceived discomfort during driving. The softer seat showed better pressure distribution, while mountain and city roads had less homogeneous pressure distribution. Despite pressure differences between seats, both led to similar increases in perceived discomfort during driving, with the neck and lower back areas experiencing the highest discomfort.
APPLIED ERGONOMICS
(2022)
Article
Multidisciplinary Sciences
Mathieu Lecocq, Pascaline Lantoine, Clement Bougard, Jean-Marc Allegre, Laurent Bauvineau, Damian Gonzalez, Christophe Bourdin, Tanguy Marqueste, Erick Dousset
Summary: Through long duration real driving sessions, we found that the suspended seat (S-3) may be the most suitable seat to delay discomfort and neuromuscular fatigue appearance.
Review
Biochemistry & Molecular Biology
Mostafa Seblani, Patrick Decherchi, Jean-Michel Brezun
Summary: Edema after spinal cord injury is a significant concern and can worsen the condition. The mechanisms behind the increase in water content after SCI are still not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychology, Biological
Nicolas Hugues, Caroline Pin-Barre, Thomas Brioche, Christophe Pellegrino, Eric Berton, Claudio Rivera, Jerome Laurin
Summary: This study aimed to assess the effects of individualized high-intensity interval training (HIIT) on neurotrophic factors, apoptosis markers, and cation-chloride cotransporters in rats with cerebral ischemia. The results showed that HIIT improved aerobic performance and influenced cortical functions through the regulation of neurotrophic factors and chloride homeostasis. These findings suggest that HIIT is clinically relevant for stroke rehabilitation.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Clinical Neurology
Caroline Pin-Barre, Nicolas Hugues, Annabelle Constans, Eric Berton, Christophe Pellegrino, Jerome Laurin
Summary: This study compared the effects of high-intensity interval training with long versus short intervals on endurance and motor performance in rats, and found that both regimens were effective in improving performance but short interval training showed faster results. Neuroplasticity markers were upregulated in the contralesional cortex and hippocampus after training, which promotes functional recovery.
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.
